37 results about "Hematological Diseases" patented technology

The present disclosure provides compounds of Formula (I), (II), and (III). The provided compounds are able to bind protein kinases (e.g., SIK) and may be useful in modulating (e.g., inhibiting) the activity of a protein kinase (e.g., SIK, (e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease (e.g., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.

The application discloses a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative and a synthesis method and application thereof, and relates to a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative which is a compound with the following general formula (I): wherein R1 is selected from,,,,,,,,, and R2 is selected from,,, and. The compound can significantly inhibit the proliferation of leukemia, multiple myeloma, lymphoma, breast cancer, liver cancer and the like at a low dose (nanomole), can effectively degrade IKZF1, IKZF3, BRD4, GSPT1 and CK1 alpha, and has the prospect of being developed into an anti-tumor drug. The application solves the problem that the existing malignant hematological disease treatment drugs have a high safety risk.

This invention discloses the application and method of a STAT1-targeting inhibitor in the treatment of immune thrombocytopenic purpura (ITP). It employs ivermectin, a STAT1 nuclear translocation inhibitor, and fludarabine, a STAT1 activation inhibitor. By injecting either the activation inhibitor or the nuclear translocation inhibitor, the platelet count in a mouse model of ITP is increased. Fludarabine, a fluorinated nucleotide analog of vidarabine, is non-radioactive and a small-molecule phosphorylation inhibitor. Ivermectin is a small-molecule inhibitor of nuclear translocation mediated by α / β1 introgression protein. Both have high bioavailability and are widely used to treat various hematological diseases with good safety profiles. Their application in treating ITP is safe, effective, and shows high compliance.

Lentiviral vector (LV) formulations, and pharmaceutical compositions comprising such LV formulations, with improved stability and suitable for systemic administration are provided. Methods for treating disorders, especially blood disorders, using systemic administration of LV formulations are also provided.

The invention provides a blood disease AI diagnosis assisting system. The system comprises a data acquisition module used for acquiring multi-modal data; the feature extraction module is used for performing feature extraction on the multi-modal data based on a preset fusion feature extraction strategy to obtain fusion features; the scheme generation module is used for generating a reference scheme which corresponds to the fusion features and is used for blood disease auxiliary diagnosis through a preset diagnosis-assisting scheme generation strategy according to the fusion features; the score acquisition module is used for acquiring a score matrix; the evaluation module is used for determining a comprehensive score of the reference scheme as an evaluation result according to the score matrix; and the feedback adjustment module is used for adjusting hyper-parameters in a preset fusion feature extraction strategy and / or a preset diagnosis assisting scheme generation strategy according to the evaluation result. Therefore, the problem that the finally output reference pathology recognition result is inaccurate due to the fact that the data mode of pathology recognition is single in the traditional hematological disease assisted diagnosis and assisted teaching process can be solved.

The present invention relates to diarylheptanoid-based compounds and a method for inducing ex vivo expansion of hematopoietic stem cell populations. This method comprises incubating HSCs in a culture medium comprising diarylheptanoid-based compounds, leading to improved ex vivo expansion of HSCs and preservation of their major specific properties. This includes self-renewal and multilineage differentiation. These resultant enhancements demonstrate the potential of HSCs for use in treating hematological diseases and blood cancers prior to HSCT.

The invention discloses a traditional Chinese medicine composition for treating chemotherapy-related oral mucositis and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 6-12 parts of radix rehmanniae recen, 6-12 parts of radix ophiopogonis, 6-12 parts of radix scrophulariae, 6-12 parts of honeysuckle, 6-12 parts of fructus forsythiae, 3-7 parts of radix scutellariae, 1-3 parts of lotus plumule, 3-7 parts of mint and 3-7 parts of borneol. The composition has the effects of nourishing yin, clearing heat, astringing sores and promoting tissue regeneration, and clinical tests prove that the composition can remarkably reduce the occurrence rate of chemotherapy-related oral mucositis of hematological malignancy patients, relieve the damage degree of oral mucosa, shorten the lasting time of ulcer and pain and effectively improve clinical symptoms of traditional Chinese medicine, and is high in safety.

The present invention relates to compounds and compositions for the treatment of hematological disorders. The present invention provides methods for the treatment of hematological disorders, such as acute myeloid leukemia, using substituted heterocyclic compounds and pharmaceutically acceptable salts thereof. The compounds inhibit IRAK4 and FLT-3 kinases.

Devices and methods for reducing or limiting bleeding in an animal by stimulating the spleen with focused ultrasound (FUS). The devices and methods can be used to treat blood disorders such as hemophilia, or to reduce bleeding during surgery or due to trauma. The methods can be administered to a patient non-invasively by applying ultrasound energy transcutaneously.

The invention belongs to the technical field of biological detection, and particularly relates to an immunodetection reagent for blood virus screening and a preparation method of the immunodetection reagent. The immunodetection reagent comprises the following raw materials in parts by weight: 100 parts of a capture reagent, 300 parts of a sealing agent, 300 parts of a cracking agent, 1 part of an HCV recombinant antigen, 1 part of an anti-HCVcAg monoclonal antibody, 0.2-0.6 part of hydroxymethylcoumarin, 10 parts of BSA, 2-6 parts of glutaric anhydride, 4-8 parts of TEOS and 100 parts of a PBS buffer solution. According to the present invention, the silica microsphere with the HCV recombinant antigen and the anti-HCVcAg monoclonal antibody coupled on the surface and the hydroxymethylcoumarin signal molecule loaded inside is constructed, and the HCV antigen and the HCV antibody in the serum are specifically recognized so as to achieve the efficient diagnosis and detection of the HCV infection in the whole cycle;

Provided herein are antibodies, compositions, and methods of use thereof. The disclosed antibodies bind to von Willebrand factor in blood plasma of a subject. Such antibodies are useful for methods of treatment, such methods of treating one or more blood disorders characterized by excessive bleeding. Also provided herein are methods of treating blood disorders by administering a combination of an anti-VWF antibody and von Willebrand Factor.

The present invention relates to a controlled-release pharmaceutical composition comprising at least a controlled-release pharmaceutical dosage form containing EPAG, the controlled-release pharmaceutical composition being suitable for local injection into an affected area. The present invention also relates to a controlled-release pharmaceutical composition in powder form for preparing the pharmaceutical composition suitable for local injection, and a kit for preparing the pharmaceutical composition comprising an aqueous injection vehicle and a controlled-release dosage form or a mixture of controlled and immediate-release dosage forms containing EPAG, the pharmaceutical composition optionally including an excipient. The composition is useful for local injection in patients to improve stem cell homing and / or treat non-malignant hematological disorders, malignant hematological diseases, primary immunodeficiencies, autoimmune diseases, inborn errors of metabolism, and / or degenerative diseases / injuries.

This application relates to the field of medical technology, providing an automated control method and system for hematological medical devices. The method includes: acquiring operating status information of a fluid infusion device; determining whether there is an infusion abnormality in the target fluid within the infusion line based on the operating status information of the fluid infusion device; when an infusion abnormality exists in the target fluid within the infusion line, acquiring acoustic information generated by the target fluid flowing in the infusion line; determining the viscosity coefficient of the target fluid based on the acoustic information; acquiring the actual pumping efficiency of the fluid infusion device; and determining an infusion control strategy for the fluid infusion device based on the actual pumping efficiency and the viscosity coefficient of the target fluid. This solution can improve the accuracy of medical device control.

KLRB1-binding agents (particularly anti-KLRB1 antibodies and antigen-binding portions thereof) and compositions thereof, and therapeutic methods using such agents, for example, to deplete or inhibit cells or activate cells (particularly Th17, Th17.1, ex-Th17, Tc17, MAIT, iNKT, peTh2, ILC2, ILC3, NK cells, and / or neoplastic T or NK cells in vivo) for the treatment of autoimmune diseases, allergic diseases, transplant rejection, malignant hematological diseases, and cancer.

Relates to the field of biological medicine, in particular to a specific recognition MASP3 antibody and application thereof, and the antibody has high human MASP3 affinity and alternative pathway inhibitory activity. The invention further relates to a multispecific antibody which specifically binds to MASP3 and MASP2, and a pharmaceutical composition comprising the antibody which specifically binds to MASP3 and the antibody which specifically binds to MASP2 and / or the multispecific antibody, the antibody or the composition is used for preparing a medicament for treating autoimmune diseases, transplantation-related diseases, inflammatory diseases, hematological diseases, coagulation diseases, angiogenesis-dependent diseases and / or virus infectious diseases.

The application provides a gene set and kit for evaluating the curative effect after allogeneic hematopoietic stem cell transplantation of hematopathy, and belongs to the field of gene detection. The application develops a new post-transplantation curative effect evaluation panel detection design method. The panel comprises: 1. single nucleotide polymorphism (SNP) sites characteristic of individual genetic characteristics, which can be used for graft implantation evaluation; 2. high-frequency mutation sites of blood tumor hotspot genes, which can be used for MRD detection and disease state evaluation; and 3. HLA gene characteristic SNP sites on the short arm of human chromosome 6, which can be used for HLA gene typing, combined with the state of graft implantation, to analyze the occurrence of HLA-loss. The technical scheme of the application can solve the above-mentioned multiple contents of post-transplantation curative effect evaluation at one time, is more accurate and sensitive than the previous detection method, and can greatly reduce the detection cost and shorten the clinical report time.

This invention discloses a method and system for managing and analyzing medical report data in hematological diseases, belonging to the field of medical information processing technology. The system includes: S1, data acquisition and fingerprint generation; S2, time-series reconstruction and correction; S3, semantic parsing and standardization; S4, feature coupling and secure computation; and S5, report generation and audit updates. This invention utilizes a time-frequency domain dual-domain correction technique, which effectively eliminates periodic errors and fluctuations between different data sources and different acquisition time points, improving the accuracy and consistency of data processing. This correction method goes beyond traditional time alignment; it identifies and removes periodic interference in the signal through frequency domain analysis, ensuring time-series consistency between different sources. This ensures that even with multi-source data, the analysis results maintain high accuracy and reliability, avoiding erroneous diagnoses and recommendations due to data errors, thus providing a more accurate and reliable basis for clinical decision-making.

The application discloses a child blood disease isolation ward self-adaptive protection system based on physiological-environment closed-loop feedback and belongs to the technical field of medical environment control. The system comprises a physiological sensing layer, an environment sensing layer, an infection risk prediction engine, a laminar air curtain active isolation module, a physiological-environment closed-loop controller and an edge control unit. Through multi-modal environment sensing, feedforward control, edge computing and self-learning mechanism, the system realizes accurate and self-adaptive adjustment of ward temperature and humidity, cleanliness, air distribution and microbial concentration, guarantees the safety of sick children and improves environmental comfort and system reliability.

The invention discloses an application of a cationic polysaccharide photosensitizer as a blood pathogen inactivation material. The cationic polysaccharide photosensitizer has a repetitive structure unit as shown in a formula I. The invention further discloses a preparation method of the cationic polysaccharide photosensitizer. As an inactivator, the cationic polysaccharide photosensitizer can selectively recognize pathogens, efficiently generate ROS (reactive oxygen species) under illumination and kill the pathogens, and has important practical value.

The present application relates to the field of biotechnology, in particular, the application of E4BP4 in hematological diseases such as multiple myeloma. The present application proves that E4BP4 can be used as a potential biomarker and prognostic indicator for predicting the development of multiple myeloma, which is helpful for the treatment of multiple myeloma. Moreover, the E4BP4 protein can be used in the preparation of MM promoting reagents, which can be further used in the amplification of MM cells, the preparation of MM tumor metastasis models, the screening of MM treatment drugs and the like. After knocking down E4BP4, autophagy is induced and MM cell apoptosis is promoted, thereby enhancing the anti-myeloma effect of dexamethasone on MM. E4BP4 inhibitory drugs can be used as anti-myeloma drugs together with dexamethasone.

This invention relates to the field of medical informatics technology, specifically to a knowledge graph-based auxiliary system for hematological transplantation diagnosis and treatment. The system includes a knowledge graph structure optimization module, a reasoning path constraint module, a candidate solution generation module, a strategy consistency verification module, and a graph repair guidance module. In this invention, by optimizing the structure of the hematological disease knowledge graph, identifying and correcting the feature density and sparse connection regions between nodes, the adaptability and information density of the knowledge graph are enhanced, improving the accuracy and comprehensiveness of the reasoning path, enhancing the medical rationality of decision-making and the accuracy of reasoning, and ensuring the practicality and accuracy of recommended solutions. Combined with candidate strategy generation and consistency verification, the logical closure between strategies is strengthened, ensuring the feasibility and rationality of transplantation diagnosis and treatment strategies. Through graph repair guidance, the structure and integrity of the knowledge graph are optimized, solving the problems of incomplete information and inaccurate reasoning in traditional systems.

The invention provides compositions and methods for treating cancers and proliferative disorders, including solid tumor cancers and non-myeloid hematological malignancies, using radioconjugates targeting CD33, alone or in combination with one or more radioconjugates targeting other cancer-associated targets such as DR5, 5T4, HER2, HER3, and TROP2, antibody drug conjugates targeting these or other cancer-associated targets, therapeutic antibodies targeting these or other cancer-associated targets, chemotherapy agents and regimens, and immune checkpoint inhibitors.

This invention provides a method, device, system, and equipment for directional pressure relief and infection control in a hematology ward, belonging to the field of medical environment control technology. The method includes: determining a first operating state of the hematology ward based on acquired signals; when the first operating state meets a first control precondition, generating a predictive control signal and a feedback control signal based on the acquired signals; performing signal fusion to obtain a comprehensive control command; adjusting the opening of a pressure relief valve in the pressure relief duct between the ward and the waste corridor according to the comprehensive control command, so as to stabilize the ward pressure within a target range and direct the ward air out through the pressure relief duct under pressure differential, allowing the exhausted air to be filtered and purified by a filtration device and then subjected to deep microbial inactivation treatment by a deep microbial inactivation module. This invention improves the stability of pressure control, achieving stable maintenance of a positive pressure environment and safe directional discharge of polluted air in a hematology ward under structurally constrained conditions.

The present disclosure provides epitopes of CD45, and binding agents such as antibodies, antibody fragments, peptides, and small molecules capable of binding to those epitopes. The present disclosure also provides methods of treating cancers, hematological diseases and disorders, and immune diseases and disorders, using these binding agents.

Provided herein are methods and compositions for the inhibition complement component (C5). The methods and compositions involve the use of aptamer-containing molecules, comprising one or more moieties that bind to and inhibit C5. The application further provides aptamer-containing molecules for the treatment of retinal diseases and / or hematological diseases.

This disclosure provides a blood analyzer, comprising: a sample aspiration device, a sample preparation device, an optical detection device, and a processor. The blood analyzer performs a first detection on a portion of a blood sample via a DIFF channel. The processor is configured to obtain first information characterizing malignant hematological diseases based at least on first scattered light information and first fluorescence information obtained from the first detection. A judgment is made based on the first information characterizing the risk of malignant hematological diseases. When the first information indicates a risk of malignant hematological diseases, the blood analyzer automatically initiates a second detection, treating another portion of the blood sample with a hemolytic agent capable of differentiating the scattered light characteristics of mature and immature leukocytes. The processor is further configured to obtain second information characterizing the risk of malignant hematological diseases based at least on second scattered light information and / or second fluorescence information obtained from the second detection. The blood analyzer can provide rapid and more accurate alarms for malignant hematological diseases while simultaneously saving detection costs and time.

The present invention relates to the use of the proportion of plasma cells, lymphocytes or blasts expressing GLUT1 among total plasma cells, lymphocytes or blasts in a method for stratifying prognosis of subjects suffering from a hematologic disorder, and in a method for determining whether a subject suffering from a hematologic disorder will achieve or is achieving a response with a modulator of the BCL-2 family proteins. The present invention also relates to a kit for detecting GLUT1, and optionally ASCT2, for implementing one of these methods.

CD38 is also expressed in a variety of malignant hematological diseases, including multiple myeloma. In the present invention, the inventors have generated a new antibody against CD38 that could be suitable for producing bispecific antibodies as well as CAR-T cells. In particular, the inventors report the development of Bi38-3, a new bispecific T cell engager that targeted CD38 on MM cells and recruited cytotoxic T cells through the CD3ε. Bi38-3 lacked the Fc region of natural mAb, which contributes to resistance processes, but triggered T cells to proliferate, release cytokine and lyse CD38 positive MM cells in vitro. Similarly, Bi38-3 induced autologous T cells to eliminate tumor plasma cells isolated from MM patients both at diagnosis and at relapse. The cytotoxicity triggered by Bi38-3 was restricted to cells expressing high levels of CD38 and preserved the integrity of T, B and NK lymphocytes in vitro. Importantly, Bi38-3 rapidly reduced tumor cells in an MM1.S xenograft mouse model of human MM. Taken together, the results show that the antibody of the present invention is an effective reagent to specifically eliminate CD38 positive malignant cells without significantly affecting CD38 lowly expressing cells and represents a promising novel immunotherapeutic tool for the treatment of malignant hematological diseases, and especially multiple myeloma.

The present invention relates to the field of biomedicine, and in particular to an antibody that specifically recognizes MASP3 and a use thereof. The antibody has high affinity for human MASP3 and inhibitory activity against an alternative pathway. In addition, the present invention further relates to a multi-specific antibody specifically binding to MASP3 and MASP2, and a pharmaceutical composition comprising an antibody specifically binding to MASP3 and an antibody specifically binding to MASP2 and / or the multi-specific antibody. The antibody or the composition is used for preparing a drug for treating autoimmune diseases, transplant-related diseases, inflammatory diseases, hematologic diseases, coagulation diseases, angiogenesis-dependent diseases and / or viral infectious diseases.

Provided herein are lipid compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, co-crystals, tautomers, stereoisomers, solvates, hydrates, polymorphs, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive lipid compounds, compositions, or formulations for treating and / or preventing diseases (e.g., genetic disease, proliferative disease, hematological disease, neurological disease, painful condition, psychiatric disorder, metabolic disorder, long-term medical condition, inflammatory disease, autoinflammatory disease, liver disease, lung disease, spleen disease, familial amyloid neuropathy, cardiovascular disease, viral infection, infectious disease, fibrotic condition, or autoimmune disease) in a subject, methods for synthesizing the compounds described herein, and compounds described herein synthesized by the synthetic methods described herein. The compounds are effective carriers for the delivery of an agent such as a polynucleotide (e.g., RNA) to a tissue or cell in a subject (e.g., a liver, lung, or spleen tissue / cell).