Disclosed are novel A2A
adenosine receptor antagonists of the formula:wherein:R1 is optionally substituted
aryl or optionally substituted heteroaryl;R2 is optionally substituted lower
alkyl or optionally substituted cycloalkyl;R3 is
hydrogen,
halogen, optionally substituted alkoxy, optionally substituted
aryl, optionally substituted heteroaryl, or optionally substituted heterocyclyl;X is —O—, —S—, or —NH—; andY is optionally substituted alkylene;and the pharmaceutically acceptable salts thereof;which are useful for treating various
disease states, for example cardiovascular disorders, including
tissue damage due to
ischemia, CNS diseases, including Parkinson's
disease, depression, and the like.