62 results about "Pancreatitis" patented technology

The invention discloses a pancreatitis severity assessment method based on layered reliable evidence fusion, which comprises the following steps of: constructing a layered reliable evidence fusion model, and sequentially executing three stages of multi-view evidence generation, opinion mapping and opinion fusion: generating an image based on image and clinical data, and clinical and pseudo-view evidence, mapping the opinions into subjective logic opinions containing belief quality and uncertainty, and finally fusing all the opinions by using a logarithmic opinion pool fusion algorithm to generate final fused opinions; then training the layered reliable evidence fusion model based on the training set; then testing, and evaluating the acute pancreatitis severity degree of the patient corresponding to the test sample according to the belief quality of each category in the final fusion suggestion corresponding to the test sample; the method has the advantages that multi-source information can be effectively coordinated, evidence conflicts are converted into uncertainty, an accurate and reliable severity degree evaluation result is output according to belief quality in fused opinions, and powerful support is provided for clinical decision making.

The invention relates to the technical field of medical auxiliary instruments, in particular to a rehabilitation auxiliary device for patients with severe acute pancreatitis, which comprises a device main body, a support adjusting module and a nursing auxiliary module are mounted on the device main body, and a main driving unit is mounted in the device main body. The support adjusting module comprises a trunk support, an abdomen support and a lower limb support which are hinged in sequence, and monitoring assemblies are mounted on the trunk support, the abdomen support and the lower limb support; the main driving unit is in signal connection with a control module, and the control module is used for controlling the main driving unit to perform independent or cooperative angle adjustment on the supporting adjustment module according to the real-time state data of the monitoring assembly; the nursing auxiliary module comprises a flow guide cleaning structure which is detachable from the supporting and adjusting module, the flow guide cleaning structure is used for directionally guiding nursing waste liquid, and the flow guide cleaning structure is automatically unfolded or folded according to the body position change of the supporting and adjusting module. Through multi-module linkage and intelligent control, the risks of abdomen compression, pressure sores, lower limb venous thrombosis and the like are effectively avoided.

The invention provides a pancreatitis patient abdomen mirabilite fixing structure, and belongs to the field of medical instruments. Comprising a sealing box body, the interior of the sealing box body is hollow, a notch is formed in the outer surface of the lower end of the sealing box body in a penetrating mode, a cotton bag used for storing mirabilite is arranged on the lower side of the inner surface of the sealing box body, and the outer surface of the lower end of the cotton bag penetrates to the outer side of the sealing box body through the notch; a folding groove is formed in the outer surface of the upper end of the sealing box body in an embedded mode. By arranging the air guide assembly, the mounting hole is communicated with the air guide pipe through the through hole, and one end of the air guide pipe extends to the outer side of the sealing box body, so that air can flow among the air guide pipe, the through hole and the mounting hole, and air circulation can be realized to a certain extent; and therefore, the probability of contact dermatitis caused by the storage bag in the frequent use and application process can be effectively reduced, and the discomfort of the mirabilite fixing device in the use process can be effectively relieved.

The invention discloses an adjustable external application bellyband based on pancreatitis, and belongs to the field of medical instruments, the adjustable external application bellyband comprises a medicine application section, a bandage and a connecting assembly, and the connecting assembly is located on one side of the medicine application section and used for being connected with the bandage; the adjusting assembly is used for adjusting the tightness degree of the bandage according to the waistline size, the abdominal swelling degree and the comfort degree of the patient, and it is ensured that the bellyband can stably wrap the abdomen without generating too tight pressure feeling; then the pressure of the affected part corresponding to the medicine application section is adjusted in a targeted mode through an adjusting assembly in the medicine application section, and the situation that due to too small pressure, a medicine bag is not tightly attached, the medicine effect is lost, or due to too large pressure, pain of a patient is caused, and local blood circulation is affected is avoided; finally, an abutting assembly on an adjusting assembly mounting frame is matched with a clamping assembly, the medicine bag is firmly connected to the pancreatitis affected part in an abutting mode, it is guaranteed that the medicine bag is in tight contact with the skin all the time, and stable conditions are provided for medicine ingredient permeation and treatment effect exertion.

The invention provides an acute pancreatitis intestinal micro-ecological marker and application thereof, and belongs to the technical field of disease diagnosis. According to the method, 20 intestinal microbe markers with differential expression are screened based on samples of acute pancreatitis patients and healthy people, an acute pancreatitis prediction model is constructed by adopting a random forest model, and results show that the method has relatively high prediction accuracy, and the AUC value is 0.98. The acute pancreatitis intestinal micro-ecological marker and the constructed prediction model thereof can be used for early diagnosis of clinical acute pancreatitis.

The invention relates to the technical field of medical data processing, in particular to a multi-modal data fusion diabetes risk prediction system after acute pancreatitis, and the method comprises the steps: obtaining the feature data and treatment indexes of each dimension of a target patient and a plurality of reference patients after acute pancreatitis; obtaining a weighted similarity index according to the difference between the feature data of the target patient and the feature data of each reference patient in the same dimension; according to the treatment index of each reference patient and the distribution difference of the overall reference patients, a boundary feature length is obtained in combination with weighted similar indexes; fitting the treatment indexes of the reference patients whose diagnosis time lengths are greater than the demarcation characteristic length and less than or equal to the demarcation characteristic length respectively to obtain a pancreas islet compensation function curve; and obtaining a diabetes risk prediction result of the target patient according to a deviation condition between the treatment index of the target patient and the pancreas islet compensation function curve. According to the invention, the accuracy of the risk prediction result of the patient in the compensatory state is good.

The invention discloses an acute pancreatitis early stage grading prediction method comprising the following steps: S1, collecting CT image data of AP patients with different clinical conditions and different equipment sources, and carrying out resampling standardization processing; s2, inputting the CT image into the trained and optimized nnU-Net model, automatically segmenting a pancreas region, and generating a pancreas segmentation mask; s3, extracting multi-dimensional image features by using a radiomics tool, and screening out key prediction features by using a feature screening algorithm; and S4, inputting the screened key prediction features into a pre-trained machine learning model, and outputting a risk prediction result of the patient and a corresponding evaluation index. A pancreas area is automatically segmented by an nnU-Net model, multi-dimensional image features are extracted from a CT image corresponding to a pancreas segmentation mask by using a radiomics tool, objectivity and consistency of feature extraction are ensured, key prediction features are screened out by using a feature screening algorithm, a scientific basis is provided for early recognition and risk assessment of SAP, clinical decision is assisted, and the risk assessment efficiency is improved. The survival rate of the patient is improved.

The application provides a plasma exosome marker and application for early diagnosis of pancreatic cancer, utilizes a metabolomics and proteomics method, analyzes metabolites and proteins with significant differences in exosomes separated from plasma of pancreatic cancer patients, pancreatitis patients and normal persons, screens a series of biomarkers capable of early indicating a pancreatic cancer occurrence risk, and further screens a group of biomarkers to construct a pancreatic cancer diagnosis model, so that the pancreatic cancer diagnosis model can be used for conveniently and efficiently predicting whether an individual is suffering from pancreatic cancer, and meets clinical requirements.

The application relates to the technical field of medical artificial intelligence, and particularly discloses an acute pancreatitis chronicity risk prediction system and method and a storage medium, the system comprises a parameter acquisition module, a model training module, a risk prediction module, a risk stratification module, an AI analysis module and an interface interaction module, the parameter acquisition module is used for acquiring clinical parameters and enhanced variables of a target patient; the model training module is used for constructing a risk prediction model and an enhanced risk prediction model; the risk prediction module is used for predicting a prediction risk probability of the target patient in chronic pancreatitis after being discharged from hospital; the risk stratification module is used for dividing the target patient into a low-risk group, a medium-risk group or a high-risk group, and generating a risk stratification result; the AI analysis module is used for generating a clinical interpretation report; and the interface interaction module is used for displaying the prediction risk probability, the risk stratification result and the clinical interpretation report, so that high-risk patients with chronic pancreatitis can be effectively identified at an early stage, and a personalized follow-up scheme can be assisted in being formulated.

The application discloses an acute pancreatitis complication evaluation method based on artificial intelligence and belongs to the medical information technology field, and specifically comprises the following steps: firstly, a clinical data set containing real-time clinical indexes and basic disease history records is acquired; subsequently, time series analysis is performed on the basic disease history records, long-term influence features are extracted, and basic disease influence factors are generated; then, the real-time clinical indexes and the basic disease influence factors are subjected to standardization treatment, a comprehensive feature vector is generated after the correlation weight between features is calculated; then, the vector is input into a trained artificial intelligence evaluation model, a complication risk probability is output through layer-by-layer nonlinear transformation; finally, the risk probability value is mapped into a risk grade, patient information is integrated to generate a structured risk evaluation report; and an acute pancreatitis complication evaluation scheme fusing acute phase indexes and chronic basic disease influences is established.

The invention relates to the technical field of puncture path planning, in particular to a puncture path planning method for abdominal puncture drainage of severe acute pancreatitis. Firstly, a CT image and an MRI image are fused to construct an abdominal cavity three-dimensional model, tissue areas (an organ area, a blood vessel area and a focus area) are obtained through segmentation, and candidate paths are generated based on a target position and a preset body surface approach point; then, calculating a risk coefficient based on geometric features (including an included angle, a length and proximity to a tissue region) of the candidate path, and screening a preliminary optimal path; determining a puncture body position and a gravity component direction by combining a sagittal plane / coronal plane position relationship, analyzing tissue density distribution, and quantifying a tissue deformation interference index; finally, the risk coefficient and the deformation index are fused, re-screening of the paths is achieved, the optimal and alternative paths are determined, and therefore key tissue structures can be effectively avoided, the intraoperative displacement risk is reduced, and puncture accuracy and stability are improved.

The application belongs to the technical field of medicines, and particularly relates to a pirfenidone co-crystal, a preparation method thereof, a pharmaceutical composition and application. The pirfenidone co-crystal is prepared from pirfenidone and a co-crystal ligand, and the co-crystal ligand is selected from one of heptanedioic acid, cinnamic acid and saccharin. The pirfenidone co-crystal can not only improve the effect of pirfenidone in relieving acute pancreatitis, but also improve the safety of pirfenidone.

The invention discloses an internal reference tissue correction method and system for virtual magnetic resonance elastography of acute pancreatitis, relates to the technical field of medical image processing and quantitative evaluation, and discloses the internal reference tissue correction method and system for virtual magnetic resonance elastography of acute pancreatitis. According to the method, the problems of numerical discreteness and deviation in virtual magnetic resonance elastography of acute pancreatitis are solved by automatically identifying internal reference tissues, calculating correction coefficients, correcting elasticity values in a partitioned manner and generating a structured report, and the repeatability of pancreatic hardness measurement and cross-equipment and cross-time-point data comparability can be improved.

The present disclosure relates to heterogeneous cell compositions derived from canine or feline uterine tissue and methods of producing and use thereof. In some aspects, the heterogeneous cell compositions comprise a mixture of mesenchymal progenitor cells and epithelial progenitor cells. In some aspects, the heterogeneous cell compositions are used as an autologous or allogeneic treatment for the treatment of diseases such as chronic kidney disease, atopic dermatitis, immune mediated arthritis, hepatitis, liver disease, inflammatory bowel disease, osteoarthritis, intravertebral disc disease, keratoconjunctivitis sicca (dry eye), pancreatitis, fibrosis, sclerosis, amyloidosis, immune mediated polyarthritis or wounds in canines and felines.

This invention relates to the field of medical data processing technology, specifically to a multimodal data fusion system for predicting diabetes risk after acute pancreatitis. The system includes: acquiring feature data and treatment indices for each dimension of the target patient and several reference patients after acute pancreatitis; obtaining a weighted similarity index based on the differences in feature data between the target patient and each reference patient in the same dimension; obtaining a cutoff feature length based on the treatment index of each reference patient and the overall distribution differences of the reference patients, combined with the weighted similarity index; fitting the treatment indices of reference patients whose diagnosis time is greater than or less than or equal to the cutoff feature length to obtain pancreatic islet compensation function curves; and obtaining the diabetes risk prediction result for the target patient based on the deviation between the target patient's treatment index and the pancreatic islet compensation function curves. This invention shows better accuracy in predicting the risk of patients in a compensated state.

This invention belongs to the field of biomedical technology and discloses a bile acid-based predictive model for the severity of acute pancreatitis, its detection method, and its application. This invention establishes a combination of biomarkers that accurately reflect the pathological changes of acute pancreatitis by performing targeted metabolomics analysis on multiple small bile acid metabolites in serum, and further constructs a predictive model suitable for early clinical warning and severity stratification. This invention also provides a corresponding detection method for rapid and quantitative detection of the bile acid metabolites, enabling early identification and auxiliary diagnosis of severe acute pancreatitis.

The application relates to a binding fixing device applied to acute pancreatitis treatment and an application method, which comprises a fitting frame matched with a human body, binding belts connected to both ends of the fitting frame, and detachable connections of end portions of the two binding belts; an inner hole of the fitting frame is provided with a track, and a position-adjustable fixing ring is slidably arranged on the track; the device further comprises an adjusting limiting ring, the adjusting limiting ring comprises a left ring body and a right ring body which are both semicircular rings, the left ring body and the right ring body are both slidably arranged on the fixing ring and have consistent sliding directions, the sliding of the left ring body and the right ring body is synchronized through a synchronous assembly, and the locking and unlocking of the positions after the sliding are realized; a plurality of limiting rods are slidably arranged on opposite side surfaces of the left ring body and the right ring body; various sizes of intubations can be well compatible and fixed, different directions of intubations can also be well compatible, the operation is simple, the operation strength of medical staff is effectively reduced, and the patient experience is improved.

The invention relates to a home management method and system for a patient with hypertriglyceridemia acute pancreatitis, and belongs to the technical field of data analysis. The method comprises the following steps: acquiring auxiliary analysis data of the patient; forming multi-modal sequence data in a time dimension based on the auxiliary analysis data; encoding the multi-modal sequence data based on a time sequence Transform of an attention mechanism, and generating a multi-modal feature vector; inputting the multi-modal feature vector into a risk prediction model, and outputting a deterioration risk probability of the patient; and outputting the health guidance of the patient based on the multi-modal feature vector. The multi-modal data is captured through an attention mechanism, the risk probability is quantified according to the multi-modal data, the potential deterioration risk can be perceived in the early stage, the recurrence and illness worsening risks are remarkably reduced, the health guidance is generated based on the individualized features of the patient, the health guidance is more suitable for the actual life of the patient, and the patient experience is improved. And the management participation and compliance of the patient are further improved.

The invention belongs to the technical field of traditional Chinese medicines, and provides a traditional Chinese medicine composition with functions of clearing heat, dispelling effects of alcohol, eliminating carbuncle and relieving pain and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from radix bupleuri, radix scutellariae, wine-treated rhubarb, fructus aurantii immaturus, cortex magnoliae officinalis, radix paeoniae alba, fructus gardeniae, radix salviae miltiorrhizae, semen hoveniae and herba cichorii. The traditional Chinese medicine composition has the advantage of purging internal organs and purging heat, constructs a novel four-in-one treatment pattern of dispelling effects of alcohol, activating collaterals, protecting the liver and nourishing yin and body fluid, realizes more accurate and more comprehensive coverage on the pathogenesis of the alcoholic acute pancreatitis, is definite in curative effect and free of toxic and side effects, and has a remarkable market prospect.

The present disclosure relates to a novel ALPK1 inhibitor of formula (I), or a pharmaceutically acceptable salt, stereoisomer, tautomer, atropisomer, stable isotope variant, prodrug, or crystalline form thereof. The disclosure also relates to pharmaceutical compositions comprising said novel ALPK1 inhibitors, and their use in the treatment of inflammatory related diseases, such as ROSAH syndrome, inflammatory bowel disease (IBD), NASH, gout, diabetes, chronic kidney disease, pancreatitis, Kawasaki disease, inflammatory skin disease, and neurodegenerative diseases including Alzheimer's disease.

The application discloses a biomarker for diagnosing acute pancreatitis and application thereof, and the biomarker is CTRC. The application also discloses a CTRC combined marker lipase for diagnosing acute pancreatitis, especially high triglyceride acute pancreatitis.

The invention belongs to the technical field of image segmentation, and particularly relates to an intelligent segmentation method and system for an acute pancreatitis CT image, and the method comprises the steps: simulating a normal pancreatic CT image, carrying out the virtual lesion generation, fusing a virtual CT image set with a real CT image, extracting the topological structure features of the pancreatic tissue of the fused image, and carrying out the segmentation of the pancreatic tissue; performing unsupervised clustering on the topological structure image by adopting a topological perception diffusion coacervation method, and distinguishing pancreas and background regions; differentiated mechanical parameters are distributed to all areas of the preliminary segmentation mask, and boundary deformation is corrected; carrying out fine correction on the pixels of the optimized mask by adopting an entropy optimization threshold method; and according to the region segmentation mask, automatically calculating a necrotic volume ratio and an exudation maximum sectional area, and outputting a region segmentation result. According to the method, a virtual image is generated through fluid diffusion, topological guide segmentation and mechanical correction are carried out, accurate partitioning and quantitative grading are achieved, and clinical diagnosis is assisted.

The present invention provides a nucleoside derivative for preventing and treating inflammation and an application thereof in the preparation of a drug for preventing and treating inflammatory diseases. The nucleoside derivative for preventing and treating inflammation provided by the present invention can significantly ameliorate conditions of pancreatitis, hepatitis, arthritis and the like, ameliorate organ injury and inflammatory indexes, and have better effects than positive control drug, indometacin. Compared with the conventional anti-inflammatory drugs, aspirin, ibuprofen, indomethacin, phenylbutazone, diclofenac, piroxicam and glucocorticoids, the nucleoside derivative for preventing and treating inflammation provided by the present invention has the advantage of significantly fewer side effects.

The invention discloses application of an L-type calcium channel blocker as a ferroptosis inhibitor in preparation of drugs, and belongs to the technical field of biological medicines. In order to solve the problem that an effective acute pancreatitis and organ injury treatment means is lacked in the prior art, the invention provides application of an L-type calcium channel blocker as a ferroptosis inhibitor in preparation of a medicine for preventing / treating acute pancreatitis and organ injury, and the L-type calcium channel blocker is Benidipine, Xinidipine or Manidipine; proved by detection such as western blot and the like, the L-type calcium channel blocker can inhibit activation of ferroptosis key protein and generation of intracellular lipid active oxygen, is high in safety and provides a new means for disease treatment.

The utility model relates to the technical field of medical auxiliary supplies, in particular to a pancreatitis patient abdomen mirabilite fixator which comprises a placing mechanism, the left portion and the right portion of the outer surface of the placing mechanism are both fixedly connected with connecting belts, and the left end of the connecting belt on the left side is fixedly connected with a first elastic belt. A buckling mechanism is fixedly connected to the end, away from the connecting belts, of the first elastic belt, a second elastic belt is fixedly connected to the right end of the connecting belt on the right side, a connecting block is fixedly connected to the end, away from the connecting belts, of the second elastic belt, and a buckling groove is formed in the left end of the connecting block. According to the abdominal mirabilite fixator for the pancreatitis patient, the situation that the connecting part is loosened due to body movement of the patient can be avoided, so that the mirabilite bag can be prevented from shifting, it is guaranteed that mirabilite can continuously and accurately act on the abdominal area where the pancreas is located, and the therapeutic effects of relieving inflammation exudation, relieving pain and the like are fully exerted; the control and the recovery of the pancreatitis condition are facilitated.

The present invention relates to methods of using compounds of Formula I,wherein R1a, R1b, R2, R3, R4, W, Y, and Z are as described herein, and pharmaceutically acceptable salts thereof. The compounds are potentiators of Cystic Fibrosis Transmembrane conductance Regulator (CFTR). The invention also discloses pharmaceutical compositions comprising the compound, optionally in combination with additional therapeutic agents, and methods of potentiating, in mammals, including humans, CFTR by administration of the compounds. These compounds are useful for the treatment of cystic fibrosis (CF), asthma, bronchiectasis, chronic obstructive pulmonary disease (COPD), constipation, Diabetes mellitus, dry eye disease, pancreatitis, rhinosinusitis, Sjögren's Syndrome, and other CFTR associated disorders.

This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.

The utility model relates to the technical field of medical treatment, in particular to an acute pancreatitis mirabilite external application device which comprises a compress belt body, and binding assemblies used for being bound to the waist are arranged on the left side and the right side of the compress belt body. The binding assembly comprises a first connecting belt fixedly connected to the left side of the compress belt body and a second connecting belt fixedly connected to the right side of the compress belt body. The first connecting belt and the second connecting belt are pasted and fixed through pasting of the first son hook-and-loop fastener and the first mother hook-and-loop fastener, the compress belt body is bound to the abdomen of a patient, and the mirabilite bag is placed on the inner side of the containing groove and is prevented from sliding off; an elastic belt is wound on the outer side of a first roller and the outer side of a second roller and then pasted and fixed to a second female hook-and-loop fastener, the mirabilite bag is fixed and stable, the mirabilite bag is tightly attached to the abdomen of a patient, medicine efficacy can be better exerted, when medicine needs to be heated, the mirabilite bag is heated through a heating pad, and the medicine efficacy can be better exerted; the treatment effect on the patient is improved.

The application provides a kind of pancreatitis patient fluid intake and output quantity comprehensive monitoring method, comprising the following steps: obtaining the fluid intake and output quantity data and blood gas analysis data of pancreatitis patient and other data;Set liquid demand quantity prediction model, according to the preprocessed multidimensional monitoring data set and liquid demand quantity prediction model, liquid demand quantity prediction is carried out;Set the time series risk early warning model based on LSTM, according to the preprocessed multidimensional monitoring data set and liquid demand quantity prediction model, risk prediction is carried out;According to the prediction result of risk prediction, generate liquid management early warning information and fluid replacement scheme adjustment suggestion;According to the prediction result of liquid demand quantity prediction, the risk probability of future occurrence of liquid overload, hypovolemia or abdominal cavity high pressure syndrome of patient is predicted.The application can realize the intelligent prediction of individualized liquid demand quantity and the early dynamic early warning of complication risk, generate liquid management suggestion, to assist clinical precise and predictive liquid treatment.

The disclosure is directed to novel ALPK1 inhibitors having the Formula (I), or a pharmaceutical acceptable salt, a stereoisomer, a tautomer, an atropisomer, a stable isotopic variant, a prodrug, or a crystal form thereof. The disclosure is also directed to pharmaceutical composition comprising the novel ALPK1 inhibitors, and use thereof in treating inflammation related diseases, such as ROSAH syndrome, inflammatory bowel disease (IBD), NASH, gout, diabetes, chronic kidney disease, pancreatitis, Kawasaki disease, inflammatory skin diseases and neurodegenerative diseases including the Alzheimer's disease.