11 results about "Pancreatitis" patented technology

The application provides a plasma exosome marker and application for early diagnosis of pancreatic cancer, utilizes a metabolomics and proteomics method, analyzes metabolites and proteins with significant differences in exosomes separated from plasma of pancreatic cancer patients, pancreatitis patients and normal persons, screens a series of biomarkers capable of early indicating a pancreatic cancer occurrence risk, and further screens a group of biomarkers to construct a pancreatic cancer diagnosis model, so that the pancreatic cancer diagnosis model can be used for conveniently and efficiently predicting whether an individual is suffering from pancreatic cancer, and meets clinical requirements.

This invention belongs to the field of biomedical technology and discloses a bile acid-based predictive model for the severity of acute pancreatitis, its detection method, and its application. This invention establishes a combination of biomarkers that accurately reflect the pathological changes of acute pancreatitis by performing targeted metabolomics analysis on multiple small bile acid metabolites in serum, and further constructs a predictive model suitable for early clinical warning and severity stratification. This invention also provides a corresponding detection method for rapid and quantitative detection of the bile acid metabolites, enabling early identification and auxiliary diagnosis of severe acute pancreatitis.

The application discloses a biomarker for diagnosing acute pancreatitis and application thereof, and the biomarker is CTRC. The application also discloses a CTRC combined marker lipase for diagnosing acute pancreatitis, especially high triglyceride acute pancreatitis.

The application provides a kind of pancreatitis patient fluid intake and output quantity comprehensive monitoring method, comprising the following steps: obtaining the fluid intake and output quantity data and blood gas analysis data of pancreatitis patient and other data;Set liquid demand quantity prediction model, according to the preprocessed multidimensional monitoring data set and liquid demand quantity prediction model, liquid demand quantity prediction is carried out;Set the time series risk early warning model based on LSTM, according to the preprocessed multidimensional monitoring data set and liquid demand quantity prediction model, risk prediction is carried out;According to the prediction result of risk prediction, generate liquid management early warning information and fluid replacement scheme adjustment suggestion;According to the prediction result of liquid demand quantity prediction, the risk probability of future occurrence of liquid overload, hypovolemia or abdominal cavity high pressure syndrome of patient is predicted.The application can realize the intelligent prediction of individualized liquid demand quantity and the early dynamic early warning of complication risk, generate liquid management suggestion, to assist clinical precise and predictive liquid treatment.

The present invention relates to an RNAi composition for inhibiting the expression of apolipoprotein C-III, and the use thereof. The RNAi composition can be used for treating and / or preventing APOC3-associated diseases or conditions such as cardiovascular diseases, hypertriglyceridemia and pancreatitis.

This invention provides an abdominal Glauber's salt fixation structure for pancreatitis patients, belonging to the field of medical devices. It includes a sealed box body, the interior of which is hollow with a slot extending through its lower outer surface. A cotton bag for storing Glauber's salt is placed on the lower side of the inner surface of the sealed box body, with the lower outer surface of the cotton bag extending through the slot to the outside of the sealed box body. Moisture-absorbing cotton is fixedly connected to the lower outer surface of the sealed box body, and a folding groove is embedded in the upper outer surface of the sealed box body. By incorporating an air-guiding component, the mounting hole is connected to an air-guiding tube through a through-hole, and one end of the air-guiding tube extends to the outside of the sealed box body, allowing air to flow between the air-guiding tube, the through-hole, and the mounting hole. This facilitates air circulation and effectively reduces the likelihood of contact dermatitis caused by the storage bag during frequent application, thereby alleviating discomfort during the use of the Glauber's salt fixation device.

This invention discloses the application of DNA methyl donors in the preparation of drugs for treating severe acute pancreatitis and / or its complications, as well as a method for screening candidate drugs. The application of DNA methyl donors provided by this invention in the preparation of drugs for treating severe acute pancreatitis and / or its complications, by supplementing the methyl donor, restores the methylation level of the Foxp1 enhancer, blocks the "FOXP1-CXCR4" axis upstream, significantly reduces pancreatic microthrombus formation and alleviates tissue necrosis, and avoids the systemic side effects of directly antagonizing CXCR4.

This invention discloses a system and method for predicting the risk of ICU transfer in patients with acute pancreatitis, belonging to the field of medical data processing technology. The system includes a data acquisition and preprocessing module, a feature selection module, a machine learning prediction module, and a risk output module. Addressing the shortcomings of existing prediction tools in terms of early immediacy, accuracy, interpretability, and consideration of patient heterogeneity, this invention uses multi-algorithm recursive feature elimination and consistency analysis to select a core prediction feature set, and employs a prediction model trained with a multi-objective optimization framework to calculate the probability of ICU transfer risk. This invention can achieve early risk warning based on routine clinical indicators at patient admission, improving the accuracy and interpretability of predictions, and supporting stratified analysis of heterogeneous factors such as patient origin.

本发明提供一种用于促炎细胞因子、成骨转录因子、骨吸收因子以及内源性p62表达调节的新型p62组合物。因而，这样的p62组合物适用于炎症性疾病的预防和治疗，并且本发明还提供了相关方法。在某些实施例中，炎症性疾病与癌症不相关。在一些实施方式中，炎症性疾病包括，但不限于，骨质疏松症、肥胖症、代谢综合征、2型糖尿病、脂肪肝、炎症性肠道疾病、慢性胰腺炎、哮喘、慢性阻塞性肺病（COPD）、类风湿性关节炎（RA）、骨关节炎、多发性硬化症（MS）、银屑病、充血性心力衰竭（CHF）、动脉粥样硬化、神经退行性疾病（ALS，帕金森症、阿尔兹海默症、亨廷顿病）、抑郁症、精神分裂症、痛风、石棉肺以及矽肺。

FIELD: surgery.SUBSTANCE: used to predict the effectiveness of treatment of acute pancreatitis in the early stages. On the 1st, 4th, 7th and 11th days after hospitalization, venous blood sampling is performed from patients, the level of C-reactive protein, the activity of phospholipase A2 and alpha-amylase in the blood is assessed, and an ultrasound of the abdominal cavity is performed to identify fluid formation in the abdominal cavity. In patients with acute pancreatitis, the probability of developing complications IRO is calculated using the stated formula. With the IRO value less than 3.1 predicts high treatment effectiveness, indicating the absence of the likelihood of complications. With an IRO value from 3.2 to 4.5, average treatment effectiveness is predicted, indicating possible disease progression and development of complications and the need for constant monitoring. If the IRO value is more than 4.5, the treatment is predicted to be ineffective, indicating a high probability of complications and requiring urgent puncture interventions at the site and adjustments to treatment regimens.EFFECT: method provides the possibility of increasing the accuracy of assessing the treatment of acute pancreatitis in the early stages, predicting the course of acute pancreatitis and optimizing treatment by preventing the risk of fluid formations, due to the assessment of the state of the components of the homeostasis system: pancreatogenic, immunoinflammatory, membrane-destabilizing, and visual diagnostics of the abdominal cavity to identify fluid formations in it.1 cl, 4 tbl, 3 ex

This invention discloses a nursing monitoring method and system for patients undergoing surgery for acute pancreatitis. By collecting multi-dimensional physiological parameters at set times within a preset monitoring period after the patient's surgery, and performing weighted fusion, a postoperative recovery index for pancreatitis involving multi-dimensional parameters is constructed. This enables continuous and quantitative assessment of the patient's condition and early risk warning, thereby promoting the patient's rapid and safe recovery.