276 results about "Hepatic inflammation" patented technology

The compound represented by formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof specifically binds CCR5, so it is useful for preventing and / or treating CCR5-related diseases, for example, various inflammatory diseases (asthma, nephritis, nephropathy, hepatitis, arthritis, rheumatoid arthritis, rhinitis, conjunctivitis, ulcerative colitis, etc.), immunological diseases (autoimmune diseases, rejection in organ transplantation, immunosuppression, psoriasis, multiple sclerosis, etc.), infectious diseases (infection with human immunodeficiency virus, acquired immunodeficiency syndrome, etc.), allergic diseases (atopic dermatitis, urticaria, allergic bronchopulmonary aspergillosis, allergic eosinophilic gastroenteritis, etc.), ischemic reperfusion injury, acute respiratory distress syndrome, shock accompanying bacterial infection diabetes cancer metastasis and so on.Wherein all symbols in formula are as defined in the specification

An antibody against AILIM (alternatively called JTT-1 antigen, JTT-2 antigen, ICOS and 8F4) was found to have a significant therapeutic effect on arthrosis, for example, rheumatoid arthritis and osteoarthritis, graft versus host disease, graft immune rejection, inflammation (hepatitis and inflammatory bowel diseases), diseased condition accompanied by the excessive production of an antibody against a foreign antigen triggered by immunological sensitization by the antigen.

The present invention provides for the treatment or prevention of Hepadnaviridae infection and disease caused by Hepadnaviridae infection. In particular, the invention provides compositions and methods that affect the ability of Hepadnaviridae to utilize the host's cellular machinery as part of the virus' lifecycle. The invention relates to the discovery that interfering with the normal ability of viruses to utilize the host cell machinery with LSD1 inhibitors reduces HBV replication. Thus, the treatment and prevention of Hepadnaviridae infection and disease caused by Hepadnaviridae according to the invention comprises administering to an individual in need of treatment, a therapeutically effective amount of a LSD1 inhibitor. The individual in need of treatment can be a human or, e.g., another mammal.

A health-care cold tea is prepared from prunella spike, honeysuckle flower, artemisia scoparia and common bombax flower through decocting in clean water. Its advantage is high effect to prevent and cure headache, rhinitis, laryngitis, diabetes, hypertension, etc.

The invention discloses a method for extracting squalene by using camellia oleosa seeds as raw materials and tea oil and squalene soft capsules and relates to the technical field of biomedicine. The extraction method comprises the following process flows of material preparation, grinding, leaching, concentration, methyl esterification, complexant-borax reaction, macroporous resin chromatographic separation and purification, concentration, extraction, washing, concentration, preparation of squalene crude oil and supercritical carbon dioxide extraction, so that squalene essential oil with the squalene content of more than or equal to 80 percent is obtained. The tea oil and squalene soft capsules are prepared from the following raw materials in percentage by weight: 87 to 90 percent of squalene essential oil with the squalene content of more than or equal to 80 percent, 3 to 5 percent of polyethylene glycol 400, 2 to 3 percent of beewax and 2 to 5 percent of phospholipid. The raw material resources are wide. The prepared tea oil and squalene soft capsules not only can be used for medicine, but also can be used for food therapy, are particularly suitable for administration of treatment and food therapy of patients suffering from hepatitis, fatty liver, acute and chronic inflammation, tumor, chemotherapy, diabetes mellitus and cardio-cerebrovascular disease and have no toxic or side effects.

The present invention is directed to a System characterization of NASH that combines Modeling and Biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and / or prevention of Non Alcoholic Fatty Liver Disease (NAFLD) and Non Alcoholic Steatohepatitis (NASH). Said conditions are Liver related complications among the array of manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, abdominal obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of NASH and NAFLD complications in patients with hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and / or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, metabolic syndrome complications including cardiovascular diseases, neurodegenerative diseases and premature ageing, among other disease states or conditions.

The invention is related to methods of treating hepatic fibrosis using A2B adenosine receptor antagonists and utility in the treatment of liver damage caused by alcohol abuse, surgical intervention, viral hepatitis, the ingestion of hepatotoxic drugs, or other hepatic diseases.

A Chinese medicine in the form of honeyed pills for treating chronic hepatism and hepatic fibrosis is prepared from 13 Chinese-medicinal materials including saffron, red sage root, astragalus root, Chinese angelica root, etc through cleaning, pulverizing, sieving, proportionally mixing, adding honey, pilling and Co-60 sterilizing. Its advantage is high curative effect up to 94%.

The invention discloses a traditional Chinese medicine composition used for curing chronic hepatitis and a preparation method thereof. The traditional Chinese medicine composition is made of raw material medicines with the weight proportion by parts: 40 to 160 parts of Chinese thorowax root, 40 to 160 parts of debark peony root, 40 to 160 parts of angelica, 40 to 160 parts of India madder root, 40 to 160 parts of largehead atractylodes rhizome, 40 to 160 parts of Tuckahoe, 40 to 160 parts of turtle carapace, 40 to 160 parts of massa medicata fermentata hunanensis, 60 to 240 parts of Codonopsis pilosula nannfeldt, 60 to 240 parts of Lalang Grass Rhizome, 24 to 96 parts of immature orange fruit, 20 to 80 parts of green tangerine peel, 12 to 48 parts of villous amomum fruit, 12 to 48 parts of earthworm and 12 to 48 parts of liguorice. The traditional Chinese medicine composition of the invention has the pharmacological efficacies of antagonizing hepatic damage, protecting liver, regulating immune function, reducing aminopherase, improving liver function and on the like, and the clinical efficacy observation experiments prove that the traditional Chinese medicine composition has the exact efficacies to the chronic hepatitis, in particular to chronic active hepatitis, chronic persisting hepatitis and early cirrhosis; and the clinical application is of safety and no toxicity and side effects.

The present invention is directed to pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and / or prevention of an array of the manifestations of metabolic syndromes, including Type 2 diabetes, hyperlipidemia, weight gain, obesity, insulin resistance, hypertension, atherosclerosis, fatty liver diseases and certain chronic inflammatory states that lead to these manifestations, among others. In additional aspects, the present invention relates to compositions and methods which may be used to treat, inhibit or reduce the likelihood of hepatitis viral infections, including Hepatitis B and Hepatitis C viral infections, as well as the secondary disease states and / or conditions which are often associated with such viral infections, including hepatic steatosis (steatohepatitis), cirrhosis, fatty liver and hepatocellular cancer, among other disease states or conditions.

The invention aims to provide a cultivation method for nano-selenium containing Tie Guanying organic tea plant and the nano-selenium containing Tie Guanying organic tea plant. One hundred grams of organic tea leaves obtained through the cultivation method contains 40 to 65 micrograms of nano-selenium with a granular diameter of 50 to 200 nanometers, 4.36 to 5.45 grams of ether extracts and the balance dietary fibers, carbohydrates, proteins, microelements such asmanganese, magnesium, phosphorus, zinc, iron, copper, sodium, calcium and potassium, and vitamins including A, A1, B1, B2, B5, E and renieratene. The organic tea leaves meet standards of Green Organic Tea Certification and requirements and standards of organic tea production, processing and trade. Selenium has functions of free radical removal, prevention of cancers, beauty treatment and aging resistance, weight reduction, radiation resistance, adjustment of immunity, treatment of Keshan disease, etc., and nutritional anticancer agent accepted by medical community. The organic tea leaves, after long term drinking, have better prevention and cure effect on hepatitis, arthritis, cataract, angiocardiopathy and hemorrhagic fever and other diseases and is benefit to health and longevity of the middle-aged and old.

The invention relates to the technical field of medicaments and discloses the novel application of a penthorum chinense pursh extract or compounds of ursolic acid, pinocembrin, scopoletin, gallic acid, ursolic acid-28-xylose-(1-3)-glucoside, pinocembrin-7-glucoside, pinocembrin-7-neohesperidoside, scopolin or galloyl glucoside separated from the penthorum chinense pursh extract. Pharmacological and pharmacodynamic tests show that the penthorum chinense pursh extract or the compounds can obviously reduce the rising of aspartate aminotransferase (AST), glutamic-pyruvic transaminase (ALT) and alkaline phosphatase (ALP), caused by acute liver injury, alcoholic liver and virus hepatitis in mice, chronic hepatic fibrosis in rats and the like, has an obvious inhabitation effect on HepG2 tumor cells and can reduce the cholesterol and triglycercide content of blood serum. The penthorum chinense pursh extract or the compounds are simple in preparation method and low in cost. The invention provides a new medicament source for preventing and treating hepatitides, liver injury, hepatic fibrosis, cirrhosis, alcoholic liver, liver cancer and diseases associated with high blood fat.

The present invention relates to an oral formulation to lower serum or hepatic lipid and triglyceride concentrations, hepatic inflammation and / or insulin resistance in a patient comprising live feruloyl esterase producing microorganisms alone or in association with a pharmaceutically acceptable carrier resistant to gastric conditions, and wherein the microorganisms are wild type, genetically modified, or combination thereof. The present invention is also directed to an oral formulation to lower serum or hepatic lipid and triglyceride concentrations, hepatic inflammation and / or insulin resistance in a patient, which comprises polymeric microcapsules containing live feruloyl esterase producing microorganisms in suspension in a pharmaceutically acceptable carrier, wherein said microcapsules are semipermeable and resistant to gastro-intestinal conditions, and wherein said microorganism are wild type, genetically modified, or combination thereof as well as methods of preventing or improving liver diseases and disorders and uses thereof.

The present invention relates to an inhibitor of matrix metalloprotease (MMP) production and tumor necrosis factor (TNF) production, and medicines for the treatment of diseases such as chronic rheumatoid arthritis, osteoarthritis, allergic diseases, psoriasis, transplant rejection, arterial sclerosis, ischemic re-perfusion disorder, diabetic nephritic and ocular diseases, cancer, autoimmune glomerulonephritis, infectious diseases, Crohn's disease, inflammatory intestinal diseases and autoimmune hepatitis, each comprising certain polyazanaphthalene compounds or pharmaceutically acceptable salts thereof as active ingredients.

The invention provides a traditional Chinese medicine preparation for treating liver cancer, comprising the following raw medicines in parts by weight: 10-20 parts of acanthopanax, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix astragali, 10-20 parts of cambogia, 10-20 parts of glossy privet fruit, 10-20 parts of white atractylodes rhizome, 10-20 parts of radix polygoni multiflori preparata, 10-20 parts of oriental wormwood, 10-20 parts of turmeric, 10-20 parts of selfheal, 10-20 parts of umbellate pore fungus, 10-20 parts of magnolia vine fruit, 10-20 parts of curcuma zedoary, 10-20 parts of tuckahoe, 10-20 parts of eclipta, 10-20 parts of root of red-rooted salvia, 10-20 parts of white peony root, 10-20 parts of barbed skullcap herb, 10-20 parts of baical skullcap root, 10-20 parts of epimedium, 1-10 parts of toad venom and 1-10 parts of scorpion. The traditional Chinese medicine preparation for treating liver cancer has the beneficial effects of prolonging the life time of inoperable patients, playing an adjuvant treating effect on patients treated mainly by operation, radiation treatment and chemo-treatment, and having certain curative effects on liver cancer-specific backgrounds of liver diseases such as hepatitis and liver cirrhosis.

The invention relates to a method for detecting the necrosis degree of hepatic cells through the level of plasma free DNA, and belongs to the technical field of biology. In the method, through the separation and extraction method and quantification of the plasma free DNA, the necrosis degree of the hepatic cells is reflected by the level of the free DNA. The method comprises the following steps of: preparing a primer beta-globin serving as a standard substance; extracting the plasma DNA in a plasma specimen of hepatopath; performing a real-time fluorescent quantitative polymerase chain reaction on the plasma DNA extracted in the plasma specimen; and measuring and calculating the concentration of the plasma free DNA. The method provides a new diagnostic index for the diagnosis of severe hepatitis.

The invention belongs to the technical field of medical animal model feed and discloses feed for preparation of an alcoholic liver animal model. The feed for mice is prepared from casein, L-cystine, DL-methionine, maltodextrin, meal cellulose, xanthan gum, choline bitartrate, a mineral premix, a vitamin premix, cholesterol, sodium cholate, fish oil, alcohol and water. The feed for preparation of an alcoholic liver animal model can gradually cause mouse alcoholic fatty liver, hepatitis and liver fibrosis. The model has features similar to human diseases and pathology has a certain development process. A modeling method is simple and easy and has a high success rate, a low death rate, good repeatability and a wide application prospect.

The invention relates to a medicine for treating liver disease, which is made from the following raw materials comprising kudzuvine root, peppermint, white hyacinth bean, sharpleaf galangal fruit, tangerine peel, amomum fruit, pseudostellaria root, trogopterus dung, red sage root and membrane of chicken gizzard. The amomum fruit, white hyacinth bean, sharpleaf galangal fruit, tangerine peel and kudzuvine root are processed into fine powder; the peppermint is soaked to obtain a supernatant; the pseudostellaria root, the trogopterus dung, the red sage root and the membrane of chicken gizzard are added with water for decoction, cooled and filtered to obtain a filtrate; the drug dregs are added with water for another decoction, then cooled and filtered to obtain another filtrate; the filtrates are combined; the fine powder, the supernatant and the filtrates are mixed, and added with ethanol for lixiviation, thus preparing a semi-finished extractum product; then the extractum product is made into capsules or tablets or medicinal granule or aqua. The medicine has important effects of expelling the toxin and protecting the liver for chemical liver injuries which include alcohol liver injury and also liver injuries caused by medical, industrial and chemical harmful substances. The medicine has obvious curative effect on a plurality of liver diseases such as alcohol liver injury, fatty liver, hepatic cirrhosis, hepatitis, etc.

The invention provides a preparation method of a malan straw extract, a malan straw product, a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: selecting a right amount of malan straw, crushing into coarse powder or intermediate powder, extracting 2-3 times by decoction in water or by ethanol / petroleum ether refluxing with 1-2 hours for each time, filtering, merging the filtrates, concentrating, and drying to obtain the malan straw extract. The preparation process of the malan straw extract is simple and practicable, and the obtained extract has obvious anti-inflammatory effect and pain-relieving effect and shows good effects for treating hepatitis, gynecologic inflammation, inflammation of urinary system, pneumonia and nephritis diseases, thereby achieving favorable application prospects.

The present invention discloses a Chinese medicine compound for curing hepatic disease and a preparation method thereof. The Chinese medicine compound is made from according to milk veteh, kudzuvine root, Chinese thorowax, ganoderma, red paeonia, turtle shell, salvia miltiorrhiza, gynura segetum, canton love-pea vine and leafflower according to a certain weight portion. The present invention can be made into any common dosage form. The medicine compound provided by the present invention has the efficacy of replenishing qi and relieving liver-qi, invigorating blood circulation and softening hard masses, which is used to cure hepatitis, hepatic fibrosis, hepatocirrhosis and other hepatic diseases.

The present invention relates to belongs to the field of Chinese medicine technology, relates to compound Chinese medicine preparation for treating chronic hepatosis, and is especially compound Chinese medicine preparation for treating hepatitis and hepatic fibrosis and its preparation process. The compound Chinese medicine preparation is prepared with red sage, fermented aweto powder, peach kernel, pine pollen, gynostemma pentaphylla, schisandra extract and medicinal supplementary material, and may be in different orally taken preparation forms. The compound Chinese medicine preparation has high effect of preventing and treating hepatic fibrosis and treating hepatitis and no obvious toxic side effect.

The pharmaceutical composition comprising the compound of the invention having 8-azaprostaglandin skeleton represented by formula (I) (wherein, all the symbols have the same meanings as that of the specification.) a salt thereof, a solvate thereof or a cyclodextrin clathrate thereof, or a prodrug thereof and them as active ingredient have EP4 agonistic action and thus are considered useful for the prevention and / or treatment of immunological diseases, asthma, neuronal cell death, arthritis, lung failure, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, liver damage, acute hepatitis, nephritis, renal insufficiency, hypertension, myocardial ischemia, systemic inflammatory response syndrome, sepsis, hemophagous syndrome, macrophage activation syndrome, Still's disease, Kawasaki disease, burn, systemic granulomatosis, ulcerative colitis, Crohn's disease, hypercytokinemia at dialysis, multiple organ failure, shock and glaucoma, etc. Furthermore, the compounds also have an action of accelerating bone formation, so it is expected to be useful for the prevention and / or treatment of diseases associated with loss in bone mass, for example, primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Paget's disease, bone loss, osteonecrosis, bone formation after bone operation, alternative treatment for bone grafting.

The invention discloses a traditional Chinese medicine composition for treating an autoimmune liver disease, and a preparation method thereof. The traditional Chinese medicine composition comprises the following medicinal raw materials in parts by weight: 15-30 parts of astragalus membranaceus, 10-30 parts of cooked rhubarb, 10-30 parts of glossy privet fruit, 10-30 parts of radix curcumae, 10-30 parts of large-leaved gentian, 10-30 parts of caulis spatholobi, 10-30 parts of caulis sinomenii, 10-30 parts of radix rubiae, 10-30 parts of sedum sarmentosum and 5-15 parts of liquorice. The traditional Chinese medicine has the effects of strengthening body resistance, detoxifying, dispersing stagnated liver qi for promoting bile flow, promoting blood circulation to remove blood stasis, expelling wind and removing dampness; the main treatment range comprises autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and overlap syndrome of any two in the three diseases; and the traditional Chinese medicine composition has the treatment effects of restoring immune balance, inhibiting liver inflammation, protecting liver function, resisting hepatic fibrosis, improving clinical symptoms, improving survival quality and the like, and has high safety.

The invention provides novel liver function controlling agents and others. The liver function controlling agents of the present invention are useful as preventive / therapeutic agents for diseases such as hepatic dysfunction, hepatitis, liver cancer, liver cirrhosis, etc.

The invention belongs to the field of marine drugs, and in particular relates to an application of oligoguluronates in preparation of drugs for prevention and treatment of liver damage and various hepatitis, liver fibrosis or cirrhosis. The oligoguluronates are used in preparation of the drugs for protection of livers and treatment of various hepatitis, liver fibrosis or cirrhosis; the oligoguluronates adopt algin as a raw material, and oligoguluronic acids with different molecular weights are obtained through a chemical degradation method or a physical degradation or a combination of the two degradation methods; the oligoguluronic acids are neutralized to prepare lithium salts, sodium salts, potassium salts, calcium salts or magnesium salts of the oligoguluronic acids with different molecular weights, wherein a molecular skeleton is a linear oligosaccharide compound formed by connecting L-guluronic acid (G) through alpha-(1,4)-glycosidic bonds. The products are derived from the marine natural product, have many advantages of abundant resources, easy industrialization, safety, effectivity and the like, and have broad development and application prospects in prevention and treatment of liver damage and various hepatitis, liver fibrosis or cirrhosis.

The invention discloses application of chloro-substituted tetrahydrophenethyl chromone derivatives and a pharmaceutical composition thereof which are extracted and separated from agilawood in prevention or treatment of inflammation-related diseases, autoimmune diseases and organ transplantation rejection, especially prevention or treatment of systemic inflammatory response, pneumonia, bronchitis, hepatitis, enteritis, rheumatoid arthritis, systemic lupus erythematosus, kidney transplantation rejection, liver transplantation rejection and hematopoietic stem cell transplantation rejection.

The invention discloses a medicament for treating fatty liver, prostatitis, nephralgia, nephritis, hypertension and diabetes. The medicament is prepared by jointly pickling poultry eggs (chicken eggs or duck eggs) by using eighteen traditional Chinese medicinal components such as inonotuso bliquus(Fr) pilat, huidouba, rhodiola rosea, momordica cochinchinensis seed, polygonum multiflorum, scindapsus aureus, lucid ganoderma, lethariella cladonioides, tall gastrodia fruit, rhodobryum giganteum par, thamnolia vermicularia and gymnadenia conopsea and edible salts, or mixing the pickled poultry eggs with medicinal juice. The medicament can be used for effectively treating the prostatitis, the diabetes, the nephralgia and the nephritis, also has a good effect for treating fatty liver and hepatitis patients and realizes efficacy of protecting liver and kidney.

Compounds that are fatty acid synthesis modulators are provided. The compounds may be used to treat disorders characterized by disregulation of the fatty acid synthase function by modulating the function and / or the fatty acid synthase pathway. Methods are provided for treating such disorders including viral infections, such as hepatits C infection, cancer and metabolic disorders.

The invention relates to an antagonist of CB1 receptor for use in the treatment of a pathologic condition or disorder selected from the group consisting of bladder and gastrointestinal disorders; inflammatory diseases; cardiovascular diseases; nephropathies; glaucoma; spasticity; cancer; osteoporosis; metabolic disorders; obesity; addiction, dependence, abuse and relapse related disorders; psychiatric and neurological disorders; neurodegenerative disorders; autoimmune hepatitis and encephalitis; pain; reproductive disorders and skin inflammatory and fibrotic diseases.

The invention discloses an intestine positioning preparation of glycyrrhetic acid, glycyrrhetinic acid and salts of glycyrrhetic acid and glycyrrhetinic acid, a preparation method thereof and application thereof. The key point is to wrap glycyrrhetic acid or glycyrrhetinic acid or diammonium glycyrrhizinate and salt compounds thereof in the intestine positioning preparation. The preparation method comprises the following steps of: spraying a liquid medicament onto empty pill cores in a fluidized bed to prepare medicament carrying pill cores, and then wrapping an isolation layer, an enzyme sensitive coating and a pH sensitive coating on the pill cores. The preparation is applied to the preparation of medicaments for treating inflammatory bowel diseases, hepatitis, rheumatoid arthritis, asthma, bronchitis and skin inflammation.