201 results about "Lignan" patented technology

The invention belongs to the technical field of pharmaceutical preparations, and relates to traditional Chinese medicine self-assembled nanoparticles for enhancing anti-inflammatory activity as well as a preparation method and application of the traditional Chinese medicine self-assembled nanoparticles. The traditional Chinese medicine self-assembled nanoparticles are prepared from biphenyl cyclooctene type lignan and an oleanane type pentacyclic triterpenoid compound, wherein the mass ratio of the biphenyl cyclooctene type lignan to the oleanane type pentacyclic triterpenoid compound is 1 to (0.125 to 8). Through an anti-solvent exchange method, the carrier-free nanoparticles based on self-assembly of the traditional Chinese medicine active ingredients are prepared by utilizing spontaneous non-covalent interaction between the biphenyl cyclooctene lignan and the oleanane pentacyclic triterpenoid, so that the cytotoxicity is remarkably reduced, the biocompatibility is enhanced, and the toxic and side effects are reduced; meanwhile, the traditional Chinese medicine self-assembled nano-particles have a remarkable cellular uptake effect, the absorption and utilization efficiency of the medicine is improved, and more efficient anti-inflammatory biological activity is shown.

The invention relates to the technical field of cosmetic functional raw material preparation methods, in particular to a plant extract and an extraction method and application thereof. The invention provides a plant extraction method, which comprises the following steps: adding a glycol ether or polyhydric alcohol solvent containing 5-7 carbon atoms into a product containing phenolic acid compound components and lignan compound components, carrying out homogeneous reaction, carrying out heating extraction, and collecting the extract. By adopting a supramolecular technology, phenolic acid compound components can form a supramolecular solvent with glycol ether or polyol solvents containing 5-7 carbon atoms, and the supramolecular solvent is further combined with lignan compound components to form a supramolecular structure, so that the stability of an extracting solution is remarkably enhanced, the specific enrichment of the lignan compound components is realized, and the specific enrichment of the lignan compound components is realized. The problems that an existing extraction technology is poor in stability, poor in formula applicability, not prominent in effect and the like are successfully solved.

The present invention discloses a dibenzylbutane lignan LCA derivative or a pharmaceutical salt thereof, the structure of which is shown below: #imgabs0# The dibenzylbutane lignan LCA derivative prepared by the present invention has been shown through pharmacological experiments to have significant anti-inflammatory activity, can significantly inhibit the release of inflammatory factors, and can be used to prepare anti-inflammatory drugs for diseases such as rheumatoid arthritis.

The invention relates to the field of biological medicine, and discloses application of a biphenyl cyclooctene lignan compound and a chemotherapy sensitizing drug. The biphenyl cyclooctene lignan compound can be used for preparing a chemotherapy sensitizing drug, and the chemotherapy sensitizing drug is an ovarian cancer chemotherapy sensitizing drug, and can improve the sensitivity of cells to paclitaxel and inhibit the activity, proliferation and migration of the cells. The biphenyl cyclooctene lignan compound is combined with paclitaxel, so that the cell activity of the ovarian cancer paclitaxel drug-resistant cell A2780 / Taxol can be remarkably reduced, and the cell survival rate is only 31.13%. The combination of the biphenyl cyclooctene lignan compound and paclitaxel can also be used for preparing chemotherapy sensitizing drugs.

The invention provides lignan, and belongs to the technical field of medicines. According to the invention, a compound shown as a formula I and a compound shown as a formula II are extracted, separated and identified from schisandra chinensis oil for the first time, and the compound shown as the formula I and the compound shown as the formula II are superior to a positive drug group arbutin in the aspect of inhibiting generation of melanin of mouse skin melanoma cells (B16F10); an inflammatory factor release inhibition experiment research shows that the compound shown in the formula I and the compound shown in the formula II have relatively good activity in the aspect of inhibiting LPS-induced mouse mononuclear macrophage RAW264.7 from releasing IL-6 and TNF-alpha; in a skin irritation experiment, the schisandra chinensis non-saponifiable matter containing the compound shown in the formula I and the compound shown in the formula II is non-irritant to the skin of a white rabbit, and it is proved that the compound shown in the formula I and the compound shown in the formula II can be applied to preparation of whitening and anti-inflammatory products. Formula I; formula II.

This invention discloses a novel chalcone gypsum glycoside compound with the structure shown in Formula I. The chalcone gypsum glycoside compound of this invention has a novel and unique structure, and for the first time, it is disclosed that this compound possesses significant hepatoprotective activity and can be used in the preparation of hepatoprotective drugs. This invention also discloses the use of the aforementioned novel chalcone gypsum glycoside compound in the preparation of hepatoprotective drugs.

Disclosed in the present invention are a lignan derivative, a preparation method therefor and the use thereof. The structure of the lignan derivative is as shown in a formula I, wherein in the formula, the definition of each substituent is as described in the description and claims. The lignan derivative of the present invention can be used as an inhibitor of mitochondrial respiratory chain complex I to inhibit mitochondrial oxidative phosphorylation and ATP generation, and can also be used for preventing and / or treating diseases associated with the elevated activity or expression of the mitochondrial respiratory chain complex I or enhanced mitochondrial oxidative phosphorylation.

Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.

The invention relates to the technical field of pharmacy, in particular to a dibenzyl butane type lignan LCA analogue as well as a preparation method and application thereof. Based on the structural characteristics of a JAK1 inhibitor, LCA is taken as a skeleton, druggability optimization and a direct drug design and structure simplification strategy based on a receptor structure are comprehensively utilized, a nitrogen-containing heterocyclic ring and a nitrogen-containing functional group are introduced into a side chain, systematic structural modification and simplification are carried out, and a series of novel LCA derivatives are designed and synthesized. The invention aims to obtain an anti-RA JAK1 inhibition candidate compound with higher activity, higher selectivity and potential.

Provided are compositions comprising a plant mass, e.g., a hemp hull fiber, comprising a cellulose, a hemicellulose, a lignan, a lignin, or a combination thereof (e.g., a prebiotic composition), such compositions further comprising a plurality of bacteria (e.g., a synbiotic composition), and methods of preparing and using the same. The compositions are useful as food or dietary supplements or for the treatment or prevention of disease.

The invention discloses a tetrahydrofuran lignan compound as well as a preparation method and application thereof, the tetrahydrofuran lignan compound is a compound shown as a formula (I) or pharmaceutically acceptable salt thereof, the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity, and can be used for preparing a medicine for treating tumors. The compound has the potential of being developed into anti-inflammatory or anti-tumor drugs and can be used as a lead compound.

The application discloses a method for simultaneously producing five components in flaxseed, comprising the following steps: (1) preliminarily extracting flaxseed gum and lignan from flaxseed; (2) preparing flaxseed oil by cold pressing of degummed flaxseed through a hydraulic oil press; (3) performing skin kernel separation on the degummed and defatted flaxseed; (4) crushing the flaxseed skin after the skin kernel separation to extract flaxseed gum and flax lignan again; (5) preparing flaxseed oil again from the flaxseed kernel after the skin kernel separation; (6) extracting flaxseed protein from the defatted flaxseed kernel; (7) separating flax cyclic peptide from the flaxseed oil prepared twice; and (8) extracting flax cyclic peptide again from the defatted and deproteinized flaxseed kernel. The method is interlocked, the preliminary extraction or preparation of partial components provides favorable conditions for the flaxseed skin kernel separation, and after the flaxseed skin kernel separation, the extraction or preparation rate of the components and other components is improved, the components are complementary, the method has low cost, simple and easy-to-operate process, is green and environment-friendly, can be produced on a large scale, and in addition, the five components are simultaneously produced, so that the added value of the flaxseed is greatly improved.

The invention provides an ultra-high performance liquid chromatography-quadrupole rod / electrostatic field orbitrap high-resolution mass spectrometry detection method for a four-season antiviral mixture, which adopts ultra-high performance liquid chromatography-quadrupole rod / electrostatic field orbitrap high-resolution mass spectrometry, and the optimal chromatographic conditions are as follows: 0-1.0 min, 98%-98% A and 2.0%-2.0% B; 1.0-14.0 min, 98%-70% of A and 2.0%-30.0% of B are added; in 14.0-25.0 min, 70%-0% of A is adopted, and 30%-100% of B is adopted; 25.0-28.0 min, 0%-0% of A and 100%-100% of B are included; from 28.0 min to 28.1 min, 0%-98% of A is adopted, and 100%-2% of B is adopted; 28.1-30.0 min, 98%-98% of A and 2%-2% of B are included; 148 chemical components, including 31 glycosides, 14 terpenoids, 54 flavonoids, 10 lignans, 23 organic acids, 3 alkaloids and 13 other types, are identified in total. The detection method can provide reference for internal quality detection of the traditional Chinese medicine, research on basic components of pharmacodynamic substances of the traditional Chinese medicine and authenticity identification of traditional Chinese medicine components.

The invention discloses an isoxazoline hybridized neolignan compound as well as a preparation method and application of the isoxazoline hybridized neolignan compound. The neolignan compound disclosed by the invention is one of isoxazoline magnolol, isoxazoline honokiol, isoxazoline nitrated magnolol and isoxazoline nitrated honokiol derivatives, and has the following chemical general formula: # imgabs0. The neolignan compound disclosed by the invention takes one of magnolol, honokiol, nitrated magnolol or nitrated mangnolia officinalis as a raw material; the preparation method comprises the following steps: by taking triethylamine as alkali and dichloromethane as a solvent, carrying out 1, 3-dipolar cycloaddition reaction on a raw material and alpha-chlorooxime, and separating and purifying to obtain the isoxazoline hybridized neolignan compound. The compound disclosed by the invention has relatively good insecticidal activity on plutella xylostella Linnaeus and Mythimna separata Walker, can be used for preparing a novel efficient insecticide, and is applied to prevention and treatment on the plutella xylostella Linnaeus and the Mythimna separata Walker.

This invention provides a high-performance liquid chromatography (HPLC) method for the detection of magnolamine, lignans, and asaran in *Zanthoxylum bungeanum* slices. The chromatographic conditions are as follows: a CAPCELL PAK C18 column (250 mm × 4.6 mm, 5 μm); mobile phase A: 0.3% phosphoric acid solution; mobile phase B: acetonitrile; detection wavelengths: magnolamine 217 nm, lignans: 201 nm, asaran: 201 nm; column temperature: 25–35 °C; mobile phase flow rate: 0.5–0.8 mL / min; gradient elution. This method achieves complete separation of magnolamine, lignans, and asaran, enabling the detection of their contents in *Zanthoxylum bungeanum* slices. It features high sensitivity, strong specificity, simple experimental operation, and the ability to simultaneously determine both alkaloids and lignans, allowing for more comprehensive quality control of *Zanthoxylum bungeanum* slices.

A method and formulation for improvement in at least the texture and shelf stability of starch-based foods is disclosed, such as but not limited to gummy candies, through the incorporation of polyphenols, wherein said polyphenols may include but are not limited to one or more of flavonoids, phenolic acids, lignans, stilbenes, and tannins. This method and formulation comprises the use of polyphenol molecules to improve and stabilize starch-based foods for extended periods of time without the use of artificial preservatives. The method and formulation including one or more polyphenols also allows utilization of specific beneficial qualities of the polyphenols including: flavor, aroma, color and the numerous associated health benefits. Thus, the method and formulation facilitates the production of various starch-based foods (e.g., chewy candies, mochi, breads, cakes, pastas, etc.) with unique and previously unattainable qualities that are advantageous for consumer-packaged foods.

The application provides a luffa bath liquid with antibacterial and anti-inflammatory functions, which comprises the following components by weight: 10-18 parts of a ketone compound extract as a first component, 22-35 parts of a lignan compound extract as a second component, 2-5 parts of a triterpene compound as a third component, and 20-30 parts of butyl avocadoate as a fourth component. The luffa bath liquid has an effect of inhibiting the respiratory burst of neutrophils to a certain extent, and can prevent the occurrence of allergic diseases and some cardiovascular and cerebrovascular diseases. The effect is obtained by combining the first component, the second component and the third component.

The invention relates to the technical field of enzymic method auxiliary extraction devices, and provides a schisandra chinensis lignan enzymic method auxiliary extraction device which comprises a top cover detachably installed on equipment and a box cover arranged in the top cover, a sliding open groove is formed in the box cover, two sets of symmetrical sliding grooves are formed in the two sides of the sliding open groove, and the sliding open groove is formed in the box cover. Two symmetrical first limiting rods are fixedly installed in each sliding groove, and a scattering device for preventing fructus schisandrae from being attached to each other is installed on the box cover. The bottom of the conical filter screen is driven by the connecting rod to move upwards, schisandra chinensis deposited at the bottom of the conical filter screen can be pulled to the top of the conical filter screen, the schisandra chinensis can be diffused in enzyme solutions, the internal space of the conical filter screen is reduced, and the enzyme solutions inside and outside can be exchanged through the filter plate; the concentration of enzyme solutions inside and outside the conical filter screen is uniform, and the situation that the extraction efficiency of lignans is low due to the fact that schisandra chinensis sinks to the bottom and is accumulated in the reaction process is avoided.

The invention relates to the technical field of pharmacy, in particular to an aryl dihydronaphthalene type lignan analogue with antibacterial activity as well as a preparation method and application thereof, and the aryl dihydronaphthalene type lignan analogue is a compound with a structure as shown in a formula (I) or a pharmaceutically acceptable prodrug thereof. The specific preparation method comprises the following steps: (1) carrying out ring opening on sesamin ether bonds to prepare acetate 2; (2) performing deacetylation protection on the compound 2 to prepare alcohol 3; and (3) carrying out Des-Martin oxidation on the alcohol 3 to prepare aldehyde 4 and aldehyde 5. The aryl dihydronaphthalene lignan analogue synthesized by the invention has certain activity on Candida albicans (C.albicans), Cryptococcus neoformans (C.neoformans) and T.mentagrophytes (T.mentagrophytes), the compound 5 has good activity on the three types of bacteria, the IC50 values of the three types of bacteria are respectively 28.96 mu M, 17.13 mu M and 41.35 mu M, and the aryl dihydronaphthalene lignan analogue has certain application prospects in the development of corresponding medicines.

The invention discloses a preparation method of high-activity flaxseed powder, which comprises the following steps: (1) detoxification treatment: mixing flaxseeds and water according to a mass ratio of 1: 4-1: 6, carrying out microwave treatment, washing with water, and drying; (2) pulping treatment: mixing and pulping the detoxified flaxseeds and water according to a mass ratio of 1: 3.5-1: 4.5, adjusting the solid content of the pulp to 12-14%, and then carrying out enzymolysis treatment; (3) emulsification treatment: adding soybean lecithin into the enzymolysis product, and shearing and emulsifying to obtain an emulsion; (4) homogenizing treatment: adopting two-stage homogenizing; and (5) performing spray drying to obtain the high-activity flaxseed powder. According to the preparation method disclosed by the invention, multiple steps of microwave detoxification, enzymolysis treatment, composite emulsification, secondary homogenization and the like are cooperated, so that cyanogenic glycoside is efficiently removed, meanwhile, the retention rate of alpha-linolenic acid and lignan is remarkably increased, and the product is endowed with excellent solubility, emulsification stability and brewing performance.

The invention discloses novel lignan in Chinese starjasmine stem as well as an extraction method and application of the novel lignan. The novel lignan extract in the Chinese starjasmine stem is obtained by crushing the Chinese starjasmine stem, soaking the Chinese starjasmine stem in methanol, carrying out vacuum concentration, carrying out macroporous resin adsorption, eluting, carrying out Sephadex LH-20 gel column chromatography, carrying out silica gel column chromatography and carrying out ChiralCore Cel-J chromatographic column separation. The lignan compound can inhibit the expression of IL-1beta and IL-6 in RAW 264.7 cells induced by lipopolysaccharide (LPS), and shows potential anti-inflammatory activity. The extraction method is simple, stable, reliable, convenient to operate and low in production cost, the novel lignan compound with the unique chemical structure can be extracted, and the novel lignan compound is high in purity, small in dosage of harmful reagents, low in toxicity and suitable for industrial production.

The present invention provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent comprising a polyamine, or a mixture of polyamines, to a biomass to dissolve at least part of solid biomass in the solvent, wherein the polyamine is a Brønsted or Lewis base, and / or the polyamine is a hydrogen bond donor and / or acceptor; (b) optionally introducing an enzyme and / or a microbe to the solubilized biomass mixture such that the enzyme and / or microbe produces a sugar from the solubilized biomass mixture; (c) optionally separating the sugar from the solubilized biomass mixture; and (d) optionally separating the lignan from the solubilized biomass mixture.

The invention discloses environment-friendly functional nail polish with Chinese herbal medicines as main components, and relates to the technical field of cosmetics. The nail polish adopts a nail penetration absorption technology and has a natural film-forming system and an anti-corrosion system. Through the nanoscale molecular design, the permeability of liver protection components such as schisandra chinensis lignan, radix pseudostellariae saponin and polysaccharide is improved by 6 times, and the accuracy of fingertip health maintenance is achieved; arabic gum and tributyl citrate are combined to form a breathable protective film, so that the color persistence (7-10 days) is kept, and the current situation that nails are suffocated due to existing nail polish can be avoided; the tea tree essential oil is used for replacing a traditional preservative, the inhibition rate on mould reaches 92%, diseases caused by fungal infection can be reduced, and meanwhile the allergy risk can also be reduced. The nail polish has the effects of protecting nails and nourishing, and is beneficial to improving nail health; the problems that only nails are beautified and protected, the nail protecting effect is not achieved, and the nails are possibly damaged after long-term use are solved.

The invention discloses flaxseed and wheat oligopeptide mixed powder with an effect of improving sarcopenia, and belongs to the field of biological medicines. The invention relates to a composition with an effect of improving sarcopenia. The composition comprises active ingredients including wheat oligopeptide and flaxseed meal, wherein the flaxseed powder contains secoisolariciresinol diglucoside, and a mixture of small molecules with the molecular weight smaller than 1000 Da in the wheat oligopeptide accounts for 90% or above. The invention discloses a differentiated molecular path on which the two components play roles, the wheat oligopeptide has outstanding effects in the aspects of remarkably activating a PI3K / Akt pathway and promoting FOXO3a phosphorylation inactivation, the mechanism complementarity of'upstream regulation 'and'downstream blocking' lays a solid theoretical foundation for realizing a more comprehensive anti-atrophy effect through combined use, and the wheat oligopeptide has a good application prospect. And a composite scheme with a fuzzy mechanism in the prior art is exceeded. In addition, the formula disclosed by the invention can also improve the in-vivo environment which is not beneficial to muscle maintenance from the source by relieving chronic inflammation and oxidative stress.

The invention belongs to the technical field of traditional Chinese medicine extraction and preparations, and relates to a caulis kadsurae extract, a preparation method thereof, a cyclodextrin inclusion compound containing the caulis kadsurae extract, a pharmaceutical composition and a pharmaceutical preparation. The kadsurae caulis extract is prepared by adopting a supercritical carbon dioxide fluid extraction method, and the lignan content of the prepared kadsurae caulis extract is remarkably improved. After the caulis kadsurae extract is prepared into the cyclodextrin inclusion compound, pulverization is realized, the material characteristics are obviously improved, and the cyclodextrin inclusion compound can be conveniently used for preparing granules, tablets, pellets and the like. After the cyclodextrin inclusion compound is further prepared into a pharmaceutical composition and a pharmaceutical preparation (especially pellets), the solubility and the dissolution speed of lignan are obviously improved, and the bioavailability and the drug effect are obviously improved.

The invention discloses a lignan compound and medical application thereof.The structure of the lignan compound is shown in the formula (I), the lignan compound is derived from amomum tsao-ko and has excellent anti-oxidative stress capacity, the performance of the lignan compound is better than that of edaravone, and the lignan compound is lower in toxicity and can be used for preparing medicines for preventing and treating diseases. Therefore, the compound or the pharmaceutically acceptable salt or glycoside thereof can be used for preparing drugs for treatment or adjuvant treatment or prognosis improvement or prevention of diseases related to imbalance of the antioxidant stress system. # imgabs0 #

The application discloses a composition containing sesame lignan compounds and application thereof, and selects at least one of sesame lignan or similar compounds, glycoside compounds as a main active ingredient, so that the obtained composition can significantly improve physiological activities in the aspects of controlling fat in vivo, regulating intestinal flora, maintaining blood fat, blood sugar, blood pressure, protecting liver, controlling appetite, antioxidation and anti-aging, etc. Compared with single components, two or more than two compound combinations have a better synergistic effect. Meanwhile, the components in the composition are pure natural plant food raw materials, and have no toxic side effects. Therefore, the composition has a good application prospect.

The invention discloses an application of lignan B in preparation of a medicine for preventing and / or treating neurodegenerative diseases or neurological diseases. In-vitro cell experiments and animal model researches find that the Licarin B can significantly reduce the expression level of ABAD or inhibit the enzymatic activity of ABAD, so that the nerve cell activity is improved, neuroinflammation is reduced, the epileptic seizure frequency is reduced, and the cognitive function is improved. The invention provides the new application of the Licarin B in preparing the medicine for preventing or treating the neurodegenerative diseases and the epilepsy for the first time, and a new way and means are developed for preventing and treating the neurodegenerative diseases and the epilepsy.

The invention provides a lignan compound in phyllanthus emblica and application of the lignan compound in preparation of cosmetics and medicines, and belongs to the technical field of medicines. Five lignan compounds Phyllanthus emblica A-E, namely phyllanthus emblica A-E, are obtained from Phyllanthus emblica L. leaves, a thin layer chromatography method is mainly adopted for guidance, a high performance liquid chromatography separation technology and other plant chemical research means are combined, and a DPPH free radical scavenging activity evaluation model and an LPS-induced NO inhibition model are adopted, so that the phyllanthus emblica A-E can be used for preparing the phyllanthus emblica L. extract, and the phyllanthus emblica L. extract can be used for preparing the phyllanthus emblica L. extract, the phyllanthus emblica L. extract, the phyllanthus emblica L. extract and the phyllanthus emblica L. extract and the phyllanthus emblica L. extract. The traditional Chinese medicine composition is prepared into a solid, liquid or paste dosage form according to a conventional method, so that the anti-oxidation and anti-inflammatory treatment effects are realized. The lignan compound disclosed by the invention is simple and convenient in preparation method, high in yield and excellent in purity, and the obtained compound is a new natural secondary metabolite and has remarkable antioxidant and anti-inflammatory activity.

A method for isolating lignin and synthesizing nanocellulose from lignocellulosic materials is provided. The method describes crushing and grinding the lignocellulosic material under pressure with a solid acid catalyst to induce a solid-solid chemical reaction to depolymerize the lignocellulosic materials into a first product, hydrolyzing the first product into a second product, dissolving the second product in water to form a third product, reslurrying a solid mixture using a flotation reactor, collecting a froth at the top of the reactor and drying the froth to yield lignan. A system is also provided for isolating lignin and synthesizing nanocellulose.