47 results about "Lignan" patented technology

The invention relates to the technical field of cosmetic functional raw material preparation methods, in particular to a plant extract and an extraction method and application thereof. The invention provides a plant extraction method, which comprises the following steps: adding a glycol ether or polyhydric alcohol solvent containing 5-7 carbon atoms into a product containing phenolic acid compound components and lignan compound components, carrying out homogeneous reaction, carrying out heating extraction, and collecting the extract. By adopting a supramolecular technology, phenolic acid compound components can form a supramolecular solvent with glycol ether or polyol solvents containing 5-7 carbon atoms, and the supramolecular solvent is further combined with lignan compound components to form a supramolecular structure, so that the stability of an extracting solution is remarkably enhanced, the specific enrichment of the lignan compound components is realized, and the specific enrichment of the lignan compound components is realized. The problems that an existing extraction technology is poor in stability, poor in formula applicability, not prominent in effect and the like are successfully solved.

The invention relates to the technical field of pharmacy, in particular to a dibenzyl butane type lignan LCA analogue as well as a preparation method and application thereof. Based on the structural characteristics of a JAK1 inhibitor, LCA is taken as a skeleton, druggability optimization and a direct drug design and structure simplification strategy based on a receptor structure are comprehensively utilized, a nitrogen-containing heterocyclic ring and a nitrogen-containing functional group are introduced into a side chain, systematic structural modification and simplification are carried out, and a series of novel LCA derivatives are designed and synthesized. The invention aims to obtain an anti-RA JAK1 inhibition candidate compound with higher activity, higher selectivity and potential.

The invention discloses a tetrahydrofuran lignan compound as well as a preparation method and application thereof, the tetrahydrofuran lignan compound is a compound shown as a formula (I) or pharmaceutically acceptable salt thereof, the compound is a natural compound extracted from rubus corchorifolius stems, has anti-inflammatory activity and anti-tumor activity, and can be used for preparing a medicine for treating tumors. The compound has the potential of being developed into anti-inflammatory or anti-tumor drugs and can be used as a lead compound.

The application discloses a method for simultaneously producing five components in flaxseed, comprising the following steps: (1) preliminarily extracting flaxseed gum and lignan from flaxseed; (2) preparing flaxseed oil by cold pressing of degummed flaxseed through a hydraulic oil press; (3) performing skin kernel separation on the degummed and defatted flaxseed; (4) crushing the flaxseed skin after the skin kernel separation to extract flaxseed gum and flax lignan again; (5) preparing flaxseed oil again from the flaxseed kernel after the skin kernel separation; (6) extracting flaxseed protein from the defatted flaxseed kernel; (7) separating flax cyclic peptide from the flaxseed oil prepared twice; and (8) extracting flax cyclic peptide again from the defatted and deproteinized flaxseed kernel. The method is interlocked, the preliminary extraction or preparation of partial components provides favorable conditions for the flaxseed skin kernel separation, and after the flaxseed skin kernel separation, the extraction or preparation rate of the components and other components is improved, the components are complementary, the method has low cost, simple and easy-to-operate process, is green and environment-friendly, can be produced on a large scale, and in addition, the five components are simultaneously produced, so that the added value of the flaxseed is greatly improved.

This invention provides a high-performance liquid chromatography (HPLC) method for the detection of magnolamine, lignans, and asaran in *Zanthoxylum bungeanum* slices. The chromatographic conditions are as follows: a CAPCELL PAK C18 column (250 mm × 4.6 mm, 5 μm); mobile phase A: 0.3% phosphoric acid solution; mobile phase B: acetonitrile; detection wavelengths: magnolamine 217 nm, lignans: 201 nm, asaran: 201 nm; column temperature: 25–35 °C; mobile phase flow rate: 0.5–0.8 mL / min; gradient elution. This method achieves complete separation of magnolamine, lignans, and asaran, enabling the detection of their contents in *Zanthoxylum bungeanum* slices. It features high sensitivity, strong specificity, simple experimental operation, and the ability to simultaneously determine both alkaloids and lignans, allowing for more comprehensive quality control of *Zanthoxylum bungeanum* slices.

A method and formulation for improvement in at least the texture and shelf stability of starch-based foods is disclosed, such as but not limited to gummy candies, through the incorporation of polyphenols, wherein said polyphenols may include but are not limited to one or more of flavonoids, phenolic acids, lignans, stilbenes, and tannins. This method and formulation comprises the use of polyphenol molecules to improve and stabilize starch-based foods for extended periods of time without the use of artificial preservatives. The method and formulation including one or more polyphenols also allows utilization of specific beneficial qualities of the polyphenols including: flavor, aroma, color and the numerous associated health benefits. Thus, the method and formulation facilitates the production of various starch-based foods (e.g., chewy candies, mochi, breads, cakes, pastas, etc.) with unique and previously unattainable qualities that are advantageous for consumer-packaged foods.

The invention discloses flaxseed and wheat oligopeptide mixed powder with an effect of improving sarcopenia, and belongs to the field of biological medicines. The invention relates to a composition with an effect of improving sarcopenia. The composition comprises active ingredients including wheat oligopeptide and flaxseed meal, wherein the flaxseed powder contains secoisolariciresinol diglucoside, and a mixture of small molecules with the molecular weight smaller than 1000 Da in the wheat oligopeptide accounts for 90% or above. The invention discloses a differentiated molecular path on which the two components play roles, the wheat oligopeptide has outstanding effects in the aspects of remarkably activating a PI3K / Akt pathway and promoting FOXO3a phosphorylation inactivation, the mechanism complementarity of'upstream regulation 'and'downstream blocking' lays a solid theoretical foundation for realizing a more comprehensive anti-atrophy effect through combined use, and the wheat oligopeptide has a good application prospect. And a composite scheme with a fuzzy mechanism in the prior art is exceeded. In addition, the formula disclosed by the invention can also improve the in-vivo environment which is not beneficial to muscle maintenance from the source by relieving chronic inflammation and oxidative stress.

The application discloses a composition containing sesame lignan compounds and application thereof, and selects at least one of sesame lignan or similar compounds, glycoside compounds as a main active ingredient, so that the obtained composition can significantly improve physiological activities in the aspects of controlling fat in vivo, regulating intestinal flora, maintaining blood fat, blood sugar, blood pressure, protecting liver, controlling appetite, antioxidation and anti-aging, etc. Compared with single components, two or more than two compound combinations have a better synergistic effect. Meanwhile, the components in the composition are pure natural plant food raw materials, and have no toxic side effects. Therefore, the composition has a good application prospect.

The invention discloses an application of lignan B in preparation of a medicine for preventing and / or treating neurodegenerative diseases or neurological diseases. In-vitro cell experiments and animal model researches find that the Licarin B can significantly reduce the expression level of ABAD or inhibit the enzymatic activity of ABAD, so that the nerve cell activity is improved, neuroinflammation is reduced, the epileptic seizure frequency is reduced, and the cognitive function is improved. The invention provides the new application of the Licarin B in preparing the medicine for preventing or treating the neurodegenerative diseases and the epilepsy for the first time, and a new way and means are developed for preventing and treating the neurodegenerative diseases and the epilepsy.

The application discloses strigasiaticaside A and an extraction method and application thereof, and finds, through chemical component research on the whole grass of striga asiatica, a new synbinaphthyl tetrahydrofuran lignan glycoside, that is, strigasiaticaside A, identifies the chemical structure of the new compound through nuclear magnetic resonance, mass spectrometry, ultraviolet, infrared and circular dichroism spectrum technology.The structure of the new compound is identified as (-) sesamin-5-O-beta-D-glucopyranoside.The anti-hepatitis activity of the new natural product is evaluated by using LPS stimulated HepG2 cells.The results show that when the concentration is 100 muM, the compound has a significant inhibitory effect on the production of inflammatory factors IL-10 and NF-kappa B protein, and has no cytotoxicity, indicating that the compound may have potential anti-hepatitis activity.

The invention relates to the technical field of preparation methods of cosmetic functional raw materials, in particular to application of a fructus arctii extraction product. The invention provides application of a fructus arctii extraction product in preparation of a product with the effect of improving the fiber structure order of a skin corium layer. According to the invention, a unique preparation process is adopted, and the active ingredients of phenolic acid and lignan substances are enriched, so that the expression of Fibulin-5, LOX, LOXL1 / 2 / 3, BMP1 and ADAMTS2 can be remarkably up-regulated by the fructus arctii extraction product, the ordered crosslinking of collagenous fibers is promoted, the activity of MMP-1 and MMP-12 is inhibited, the content of III-type collagen and elastin is increased, a multi-target and co-synergistic action mechanism is realized, and the effect of the fructus arctii extraction product is enhanced. Therefore, the potential of the fructus arctii extracted product for promoting ordered arrangement of fibers is improved, and reconstruction and reinforcement of a corium layer structure are realized on the molecular level.

The invention discloses a capsule preparation for supporting mood health and improving depression and hormone balance, and relates to the technical field of health food. The capsule preparation comprises the following active components and auxiliary materials in parts by weight: the active components: 3-6 parts of a Malaysia flaxseed extract (containing 12% of lignan), 2-5 parts of Singago pumpkin seed concentrated powder (containing 4mg / g of zinc), 1-3 parts of Indonesia sesame essence (containing lignan), 2-4 parts of a sunflower seed extract (containing vitamin E), 1-3 parts of an olive leaf extract (containing 0.5% of an olive split iridoid compound) and an angelica sinensis extract (containing 0.5% of an olive split iridoid compound). 2-5 parts of Hypericum perforatum (flavonoid gt; 2.5%) 3-7 parts. Through scientific and reasonable formula design, various active components with synergistic effects are organically combined, the dual effects of emotion regulation and hormone balance can be achieved from multiple targets and multiple ways, the content of effective components is stable, bioavailability is high, taking is convenient, safety is high, and the actual requirements of consumers can be met.

The invention relates to the technical field of analytical chemistry detection, in particular to a color developing agent for rapidly measuring the content of lignan and a preparation method thereof.The color developing agent is composed of a liquid component and a solid component dispersed in the liquid component, and the liquid component comprises the following components by volume: a color developing agent, a 2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4-dihydroxy-2, 4- adding an acidic ethanol solution of 2, 4-dinitrophenylhydrazine; the nano signal enhancer is surface modified gold nanorod sol with the concentration of 3 to 8 nM; the catalytic oxidant is iron (III) porphyrin with the concentration of 0.05 to 0.15 mmol / L; a dispersion stabilizer: polyethylene glycol 400 with a volume fraction of 1-3%; the solvent system is a mixed solvent of a buffer solution with the pH value of 2.0-3.0 and ethanol; the solid component is lignan molecularly imprinted polymer microspheres, and the concentration of the lignan molecularly imprinted polymer microspheres in the color developing agent is 0.5-2.0 g / L. According to the method, lignans can be conveniently detected, the sensitivity is high, the molecularly imprinted polymer provides specific recognition capability, and rapid, high-sensitivity and high-selectivity colorimetric detection on lignan components is realized.

The application provides a surgical auxiliary instrument material with bacteriostatic performance and a preparation method thereof, relates to the technical field of bacteriostatic medical instruments, and comprises the following steps: heating and mixing polyethylene, polycaprolactone, styrene-butadiene block copolymer and a bacteriostatic precursor to obtain a mixture of the surgical auxiliary instrument material with bacteriostatic performance, and the raw materials of the bacteriostatic precursor include flax lignan, 4-vinyl-2,6-dichlorophenol and imino methacrylate. In view of the problem of poor wear resistance of the bacteriostatic surgical auxiliary instrument, the bacteriostatic precursor with high polymer coating flax lignan is prepared, the compatibility of flax lignan and the remaining high molecular materials (polyethylene, polylactic acid, styrene-butadiene block copolymer) is improved, the interface bonding performance is improved, the synergistic effect between flax lignan and other materials is exerted, the antibacterial substance is no longer a heterogeneous phase particle in the bacteriostatic surgical instrument, and the continuity, wear resistance and oxidation resistance of the whole material are maintained.

The invention provides a lignan extraction method and a liquid chromatography detection method, and relates to the technical field of plant active ingredient extraction and detection.According to the method, flaxseeds are smashed, seed coats are separated, the enrichment degree of lignan is improved, fatty acid interference is effectively removed through soaking of n-hexane, and in addition, the content of lignan is increased. According to the invention, through the drying of the vacuum drying oven, the volatilization speed of n-hexane is greatly accelerated by utilizing a negative pressure environment, and the drying time is shortened from several hours in the prior art to about 30-60 minutes; alkali hydrolysis pretreatment is replaced with methanol ultrasonic extraction, a 70% methanol solution is used for ultrasonic extraction at the temperature of 40 DEG C, vortex mixing is combined, and the extraction efficiency is improved. In the supernate treatment process, the recovery rate of lignan is increased by repeatedly extracting for three times and combining the supernate. Finally, the pH is adjusted to 4-5 by accurately controlling the adding amount of hydrochloric acid, and the influence of excessive acidification on the stability of the sample is avoided.

The application discloses active components in Selaginella lepidophylla and application of the active components in inhibition of alpha-glucosidase. The active components comprise four sesquiterpenes, three lignans and three biflavones; wherein, compound 1 is a new sesquiterpene compound, and compounds 2-10 are obtained from Selaginella lepidophylla for the first time. The compounds obtained by separation are subjected to in-vitro enzyme inhibition activity evaluation, so as to lay a scientific foundation for reasonable development and utilization of Selaginella lepidophylla plant resources. The alpha-glucosidase inhibition activity test result shows that compounds 7-10 have good alpha-glucosidase inhibition activity.

The invention discloses a coumarin and lignan glycoside compound separated from passiflora foetida and an anti-RA application of the coumarin and lignan glycoside compound. The structure of the coumarin-lignan glycoside compound is shown as a formula I in the specification. According to the invention, 75-95% ethanol is adopted to carry out heating reflux extraction on the phoenix tibetan, and a biological activity tracking separation method is utilized to carry out directional separation and purification on an anti-RA active part of the phoenix tibetan, so that the novel coumarin-lignan glycoside compound is separated from the anti-RA active part of the phoenix tibetan. The coumarin and lignan glycoside compound is novel and unique in structure, the preparation method is simple and easy to operate, and the coumarin and lignan glycoside compound has remarkable anti-RA activity and can be used for preparing anti-RA drugs. The invention also discloses an application of the coumarin and lignan glycoside compound in preparation of a medicine for treating rheumatoid arthritis.

This invention discloses a 7-O-7' lignan (+) / (–)-7- epi -oryzativol, its preparation method, and its applications belong to the field of pharmaceutical chemistry technology. The 7-O-7' lignan (+) / (–)-7- epi -oryzativol has the structure shown in formula C. This class of compounds was first obtained from Artemisia bulbifera (… Laportea bulbifera The compound was isolated from (+) / (–)-7- epi -oryzativol exhibits significant inhibitory activity against cyclooxygenase-2 (COX-2), and compound (+)-7- epi -oryzativol has a high COX-2 selectivity index and exhibits significant anti-inflammatory effects, making it suitable for use in the preparation of anti-inflammatory drugs.

The present invention relates to a cosmetic composition comprising a glutathione precursor and a lignan-based compound derived from magnolia, and provides a cosmetic composition having an excellent antioxidant effect by securing the efficiency of a complex synergistic combination of honokiol and an antioxidant amino acid.

The application discloses a preparation method of a magnolia extract and belongs to the technical field of traditional Chinese medicine extraction. The method comprises the following steps: (1) after the magnolia is crushed and soaked, a solvent is added, and then the magnolia is heated for extraction in a vacuum environment; after cooling, centrifugal filtration is performed to obtain a precipitate A and an oil-water mixture B; (2) the oil-water mixture B is separated into an oil phase and an aqueous phase; the obtained aqueous phase is mixed with the precipitate A to obtain a mixture C; the obtained oil phase is dried and filtered to obtain an oil phase extract P-1; (3) a solvent is added to the mixture C, and then the mixture C is heated for extraction in a vacuum environment; after cooling, filtration is performed to obtain a precipitate D and a mixture E; (4) an organic solvent is added to the mixture E, and then the mixture E is separated into an oil phase and an aqueous phase; the obtained oil phase is dried and filtered to obtain the magnolia extract P-2. The preparation method has the advantages of high extraction efficiency, good retention of volatile components, low energy consumption and environmental friendliness; the prepared magnolia extract has high content of lignan components, stable quality, and is suitable for preparing medicines or health products for resisting inflammation, resisting allergy and treating nasal diseases.

The present invention provides for a method to deconstruct a biomass: the method comprising: (a) introducing a solvent comprising a polyamine, or a mixture of polyamines, to a biomass to dissolve at least part of solid biomass in the solvent, wherein the polyamine is a Brönsted or Lewis base, and / or the polyamine is a hydrogen bond donor and / or acceptor; (b) optionally introducing an enzyme and / or a microbe to the solubilized biomass mixture such that the enzyme and / or microbe produces a sugar from the solubilized biomass mixture; (c) optionally separating the sugar from the solubilized biomass mixture; and (d) optionally separating the lignan from the solubilized biomass mixture.

The invention provides a dextro-aryl substituted dihydronaphthalene lignan compound, the structure of the compound is shown as (I), and the compound plays a role in inhibiting cell lysis death by inhibiting MLKL phosphorylation activation, especially inhibiting COVID-19 symptoms caused by inflammatory factor storm.

The invention belongs to the technical field of gaultheria yunnanensis extraction, and provides a method for separating and purifying effective components of gaultheria yunnanensis. The method for separating and purifying the effective components of the gaultheria yunnanensis comprises the following steps: mixing gaultheria yunnanensis powder and a solvent, and carrying out ultrasonic extraction to obtain an extracting solution; extracting the extracting solution by adopting a mixed solvent to obtain an extraction phase and a raffinate phase; and removing the solvent from the raffinate phase to obtain the lignan effective component. And removing the solvent from the extract phase to obtain the salicylate effective component. According to the method disclosed by the invention, the gaultheria yunnanensis powder is extracted by using the mixed solvent of the ethyl acetate and the methanol, so that lignan active ingredients and salicylate active ingredients in the gaultheria yunnanensis can be extracted at the same time, and efficient co-extraction of multiple ingredients is realized; a mixed solvent of n-butyl alcohol and dichloromethane is adopted to extract an extracting solution, and lignan effective components and salicylate effective components can be efficiently separated at the same time only through one-time extraction.

The present application relates to the technical field of feed additive composition and its preparation, and discloses a feed additive for regulating intestinal microecology to eliminate antibiotic residues, which comprises schisandra chinensis extract and dandelion extract, and is obtained through a co-preparation process, wherein the process forms a stable synergistic inner core microstructure by in-situ encapsulating lignan components of the schisandra chinensis extract in a water-soluble polysaccharide matrix of the dandelion extract through high-speed shearing emulsification and a synergistic alcohol precipitation step, the present application innovates from the source of the preparation process, avoids pharmacological function antagonism among components caused by conventional physical mixing by using the formed specific microstructure, and provides a material basis for realizing synergistic enhancement of host and flora elimination pathways.

The invention belongs to the technical field of livestock and poultry feeds, and particularly discloses a fattening feed for increasing intramuscular fat and snow patterns of black pigs and a preparation method of the fattening feed. The fattening feed is prepared from the following raw materials: corn, puffed soybean meal, rice bran, wheat bran, flaxseed lignan, gamma-linolenic acid, L-carnitine, compound Chinese herbal medicine microcapsule powder, a compound prebiotics preparation, a low-dose vitamin premix, a mineral premix, fructo-oligosaccharide, bentonite, table salt, probiotics and an enzyme preparation combination. According to the fattening feed capable of increasing intramuscular fat and snowflake patterns of black pigs and the preparation method of the fattening feed, the energy raw materials, the protein raw materials and the functional additives are accurately proportioned, and a segmented feeding strategy and an optimized preparation process are combined, so that the intramuscular fat and snowflake patterns of the black pigs are synchronously increased; meanwhile, the growth performance and pork quality safety of the black pigs are guaranteed.

The invention provides a method for extracting and enriching phenylethanoid glycoside and lignan effective components from fructus forsythiae fresh leaves. The method comprises the following steps: extracting phenylethanoid glycoside and lignan compounds, enriching MCI resin components, analyzing by liquid chromatography-mass spectrometry, and identifying. The enrichment extracted by the method provided by the invention is a mixture containing phenylethanoid glycoside and lignan compounds respectively, and can be used as a medicine for resisting the human coronavirus HCoV-229E.

The invention relates to the technical field of preparation methods of cosmetic functional raw materials, in particular to application of a fructus arctii extraction product. The invention provides an application of a fructus arctii extraction product in preparation of a product with the effect of improving skin permeability. Wherein the fructus arctii extraction product is used as a functional component for improving skin permeability; according to the invention, a unique preparation process is adopted, and the active ingredients of phenolic acid and lignan substances are enriched, so that the expression of transglutaminase-1 (TGM1) can be improved; the cuticle cells are more compact, the microstructure is complete and ordered, and release of dirt such as melanin, carboxy methyl lysine (CML) and inflammatory chroma related factors IL-33 in the skin is effectively inhibited. By promoting the expression of fibronectin (FLG), tight junction protein (Claudin-1) and hyaluronic acid (HA), the skin surface is smoother and brighter, and the permeability of the skin is remarkably improved.

This invention provides a lignan, belonging to the field of pharmaceutical technology. This invention is the first to extract, isolate, and identify compounds of formula I and formula II from Schisandra chinensis oil. Both compounds of formula I and formula II are superior to the positive control group arbutin in inhibiting melanin production in mouse skin melanoma cells (B16F10). Through experiments inhibiting the release of inflammatory factors, it was found that compounds of formula I and formula II have good activity in inhibiting the release of IL-6 and TNF-α from LPS-induced mouse monocyte-macrophage RAW264.7 cells. In skin irritation experiments, the unsaponifiables of Schisandra chinensis, including compounds of formula I and formula II, were non-irritating to rabbit skin, proving that compounds of formula I and formula II can be used to prepare whitening and anti-inflammatory products. Formula I; Formula II.

According to one embodiment, the problem to be solved by the present invention is to provide a novel bitter / astringent taste reduction agent in which is used a component that has not heretofore been known to have an effect for reducing bitter / astringent taste. According to one embodiment, the problem to be solved by the present invention is to provide a food / beverage that contains the novel bitter / astringent taste reduction agent. The present invention provides a plant-derived bitter / astringent taste reduction agent that contains a plant-derived lignan.

The invention discloses a lignan component in thesium chinense as well as a preparation method and application thereof, and belongs to the technical field of medicine extraction and separation. The preparation method comprises the following steps: adding an alcoholic solution into thesium chinense and extracting to obtain thesium chinense crude extract; the method comprises the following steps: adding water into a thesium chinense crude extract, suspending, sequentially extracting a water phase by using petroleum ether and dichloromethane, collecting a dichloromethane part, carrying out normal-phase silica gel column chromatography, carrying out gradient elution by using a petroleum ether-ethyl acetate system, reducing the volume fraction gradient of petroleum ether, and collecting an eluent with the volume fraction of petroleum ether being 35-0% as a fraction A; continuously carrying out isocratic elution by adopting the ethyl acetate-methanol system to obtain a fraction B; and combining the fraction A and the fraction B, concentrating and drying to obtain the product. The thesium chinense lignan component obtained by the preparation method disclosed by the invention has a remarkable treatment effect on psoriasis, is high in safety, and provides a new drug choice for new drug research and development and clinical treatment of psoriasis.