Method for extracting high-purity schisandra total lignan

A technology of total lignans and extraction methods, which can be used in pharmaceutical formulations, medical preparations containing active ingredients, anti-toxins, etc., and can solve problems such as large energy consumption, short extraction time, and organic solvent residues

Inactive Publication Date: 2010-06-23
HARBIN RENHUANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method takes a long time to extract, consumes a lot of energy, and the process is cumbersome
Although the ultrasonic extraction method has the advantages of short extraction time, less solvent consumption, and low extraction cost, there are still organic solvent residues.

Method used

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  • Method for extracting high-purity schisandra total lignan
  • Method for extracting high-purity schisandra total lignan

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Statically soak the fruit of Schisandra chinensis in water for 22 hours, and the solid-liquid ratio of fruit and water is 1:8 (w / v, g / mL); filter the soaked fruit of Schisandra chinensis, dry and pulverize the filter residue, and set aside; (2) The pulverized filter residue was treated with supercritical CO 2 extraction, the supercritical CO 2 The extraction method is carried out under the following conditions: the extraction pressure is 30 MPa, the extraction temperature is 40 ° C, CO 2 The flow rate was 12Kg / h, and the dynamic extraction was performed for 1.5 hours; the obtained extract was distilled with steam at 110°C for 6 hours, concentrated under reduced pressure to obtain a concentrate, which was set aside; (3) the concentrate

[0019] Adsorbed by macroporous adsorption resin, 30% ethanol is used to elute part of the fatty oil, and then 85% ethanol is used to elute, the eluate is decolorized by decolorizing resin, the eluate is concentrated and dried, and it is...

Embodiment 2

[0021] Statically soak the fruit of Schisandra chinensis in water for 24 hours, and the solid-liquid ratio of fruit and water is 1:6 (w / v, g / mL); filter the soaked fruit of Schisandra chinensis, dry and pulverize the filter residue, and set aside; (2) The pulverized filter residue was treated with supercritical CO 2 extraction, the supercritical CO 2 The extraction method is carried out under the following conditions: the extraction pressure is 35MPa, the extraction temperature is 50°C, and the CO 2 The flow rate is 12Kg / h, dynamic extraction for 2 hours; the obtained extract is distilled with steam at 120°C for 1 hour, concentrated under reduced pressure to obtain a concentrate, which is set aside; (3) the concentrate

[0022] Adsorbed by macroporous adsorption resin, 20% ethanol is used to elute part of the fatty oil first, and then 95% ethanol is used to elute, the eluate is decolorized by decolorizing resin, the eluate is concentrated and dried, and it is obtained; after ...

Embodiment 3

[0024] Soak Schisandra fruit statically in water for 18 hours, the solid-liquid ratio of fruit and water is 1:10 (w / v, g / mL); filter the soaked Schisandra fruit, dry and pulverize the filter residue, and set aside; (2) The pulverized filter residue was treated with supercritical CO 2 extraction, the supercritical CO 2 The extraction method is carried out under the following conditions: the extraction pressure is 25 MPa, the extraction temperature is 30 ° C, CO 2 The flow rate is 12Kg / h, dynamic extraction for 1 hour; the obtained extract is distilled with steam at 100°C for 8 hours, concentrated under reduced pressure to obtain a concentrate, which is set aside; (3) the concentrate

[0025] After being adsorbed by macroporous adsorption resin, first use 15% ethanol to elute to remove part of the fatty oil, then use 85% ethanol to elute, the eluate is decolorized by decolorizing resin, the eluate is concentrated and dried, and it is obtained; after testing, this The inventive...

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PUM

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Abstract

The invention discloses a method for extracting high-purity schisandra total lignan. The method comprises the following steps: (1) soaking schisandra fruits in water, filtering the soaked schisandra fruits, drying and grinding filter residue for later use; (2) extracting the ground filter residue by a supercritical CO2 method, distilling the obtained extract with steam, concentrating the obtained product under reduced pressure and obtaining concentrate for later use; and (3) purifying the concentrate. The extraction method has the advantages of simple extraction process, high purity of extracted total lignan, thorough impurity removal and the like, and can extract the extract with the total lignan content of over 50 percent from the schisandra fruits.

Description

technical field [0001] The invention relates to a method for extracting effective components in plant fruits, in particular to a method for extracting high-purity total lignans from schisandra chinensis, and belongs to the field of extracting effective components from schisandra chinensis. Background technique [0002] Schisandra chinensis (Turcz.) Ball. is the dried and mature fruit of perennial deciduous woody vines of Magnoliaceae. Its medicinal use has a long history and was first recorded in "Shen Nong's Materia Medica". The effect of promoting body fluid, invigorating the kidney and calming the heart. Modern studies have proved that in addition to protecting the liver and reducing enzymes, the lignans in Schisandra chinensis also have various functions such as central nervous system inhibition, anti-HIV virus, anti-oxidation, anti-cancer, blood pressure regulation and stability. , is an authentic northern precious Chinese herbal medicine. Currently, there are single an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P1/16A61P25/00A61P31/18A61P39/06A61P35/00A61P9/12A61P25/20A61K131/00
Inventor 于喜水孟庆杰
Owner HARBIN RENHUANG PHARMA
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