206results about How to "The source is easy to get" patented technology

The invention relates to application of ring A coupling flavonolignan in preparing medicaments for treating viral hepatitis B, in particular to application of a compound of the formula (1) or a pharmaceutically acceptable salt thereof in preparing medicaments for clearing away HBsAg (Hepatitis B Surface Antigen) and HBeAg (Hepatitis B e Antigen) and suppressing the HBV (Hepatitis B Virus) DNA replication. The intensities of the flavonolignan for clearing away the HBsAg and the HBeAg are respectively 29.4 percent and 29.1 percent in the presence of a concentration of 20 micrograms/milliliter, which is respectively 1.8 times and 1.7 times of the corresponding activity of a positive control medicament (10,000 units/milliliter of alpha-interferon). What is even more exciting is that in the presence of the concentration, the suppression rate of the flavonolignan to the HBV DNA is higher than 83 percent, which is higher than that of Lamivudine which is a positive control and is 2.2 times of that of the alpha-interferon to the HBV DNA. Accordingly, the flavonolignan and the pharmaceutically acceptable salt thereof are indicated to be capable of being expected to be used for preparing non-nucleoside medicaments for clearing away the HBsAg and the HBeAg, suppressing the HBV DNA replication and treating HBV infection diseases.

The invention relates to application of E-ring demethoxy-silibinin for preparing medicaments for treating viral hepatitis B, and particularly to application of compound in formula (1) and pharmaceutically acceptable salt thereof for preparing medicaments for clearing HBsAg and HBeAg and suppressing HBV DNA replication. The invention has extremely superactive activity for suppressing the HBsAg and HBeAg; in the presence of the concentration of 20 microgram per millilitre, the intensities for clearing the HBsAg and HBeAg are 95.0% and 34.4% respectively, which are 5.9 and 2.0 times corresponding activity of a positive control medicament alpha-interferon; and it should be noticed that the suppression ratio of the medicament for HBV DNA at the concentration is about 91.5%, which is 13% higher than lamivudine and 2.4 times alpha-interferon suppression activity. In summary, the flavonolignans or pharmaceutically acceptable salt thereof can be prospectively used for preparing non-nucleoside medicaments for clearing the HBsAg and HBeAg, suppressing HBV DNA replication and treating hepatitis B virus infection disease.

The invention relates to application of diallyl propyl flavonolignan in preparation a medicament for curing hepatitis B, in particular to application of a flavonolignan or pharmaceutically acceptable salts thereof in preparation of the medicament for curing the hepatitis B by clearing hepatitis B e-antigen and inhibiting HBV DNA replication. The flavonolignan has hepatitis B virus e-antigen (HBeAg) inhibiting activities, and has the inhibition strength higher than a positive control first-line medicament, namely lamivudine and alpha-interferon, at a low concentration of 20 mu g/ml; simultaneously, at the concentration of 5 mu g/ml, the compound has an inhibition rate of the HBV DNA of over 70 percent; and therefore, the flavonolignan can be expected for preparing the medicament for curing the hepatitis B virus infection diseases by clearing the hepatitis B e-antigen and inhibiting the HBV DNA replication.

The invention relates to application of dimethyl dehydrated silybin in preparing medicaments for treating virus hepatitis B, in particular to the application of 7 and 20-position methyl substituted dehydrated silybin or pharmaceutically acceptable salts thereof in preparing medicaments for removing HBsAG and HBsAg and medicaments for inhibiting HBV DNA replication. The dehydrated silybin has remarkably HBsAg and HBeAg inhibiting activity, wherein the strength for removing the HBsAg and the HBeAg at the concentration of 20 milligram/milliliter is 88.9 percent and 84.1 percent respectively, which are 5.5 times and 5.0 times that of a positive contrast medicament. More importantly, the dehydrated silybin shows the HBV DNA inhibition ratio of about 99.6 percent at the concentration of 20 milligram/milliliter, the activity exceeds lamivudine by 23 percent, which is 2.6 times that of interferon. Therefore, favonolignan or pharmaceutically acceptable salts thereof can be predictably used for preparing the non-nucleoside reverse transcriptase inhibitor medicaments for removing the HBsAg and HBeAg, inhibiting HBV DNA replication and treating hepatitis B virus infection diseases.

The invention provides a coumarin dyestuff linked by naphthene ketones, method for synthesis and use, wherein the method employs the conventional hydroxyaldehyde condensation reaction and consists of, charging naphthene ketone, corresponding aldehydes with A1 groups into reactor, obtaining semi-naphthene ketone dyestuff with A1 groups, subjecting corresponding third position methyl substituted or fourth position methyl substituted coumarin having A2 group and selenious acid in another catalyst case to obtain coumarin aldehyde having A2 group, subjecting the A1 group semi-naphthene ketone dyestuff and A2 group coumarin aldehydes to reaction at the presence of mixed solvent of dimethylbenzene and alcohol, thus obtaining coumarin type dyestuffs coupled by naphthene ketones.

The invention provides a compound simulating cabin for rat and mice tests. The compound simulating cabin is characterized by comprising a test cabin body, a nitrogen input device, an oxygen input device, a carbon dioxide input device, a concentration and humidity detecting device, a one-way valve, a mixing fan, a PLC and a host computer, wherein force control configuration software is installed on the host computer; outputs of the nitrogen input device, the oxygen input device and the carbon dioxide input device are all connected with the test cabin body; gases in a certain proportion are introduced into the test cabin body by the nitrogen input device, the oxygen input device and the carbon dioxide input device according to a preset environmental model requirement; the numerical values of the gases in the test cabin body are monitored in real time by the concentration and humidity detecting device; and a preset program of the host computer is used for controlling, thereby controlling the switch-on/off of the nitrogen input device, the oxygen input device and the carbon dioxide input device.

The invention relates to a process for synthesizing 3- or 4- carbonyl substituted coumarin connected by naphthenones and its use. The preparation process using general aldol condensation reaction comprises cyclanone and its corresponding aldehyde compounds with A1 group are added in reactor to produce semi-cyclanone with A1 group; 3- or 4- acetyl substituted coumarin with A2 group and selenious acid are added in another reactor to produce coumarin aldehyde with A2 group; said semi-cyclanone with A1 group dye reacts with coumarin aldehyde with A2 group in the presence of xylene and ethanol mixed solvent to form 3- or 4- carbonyl substituted coumarin connected by naphthenones. The product can be used for visible light polymerization of olefine monomer in photosensitized initiation system and used as photo curing materials, etc.

The invention discloses a catalyzing and synthesizing liquid injecting fuel method with cyclopentadiene and bridge dicyclopentadiene relating to an injecting fuel preparing technique, which comprises the following steps: regarding the mixture of cyclopentadiene and bridge dicyclopentadiene as the material; adding ZSM, Y, mordenite or beta molecular sieve accelerant; proceeding the polymerization reaction at 160Deg. C -250Deg. C, 0. 1MPa -3MPa; distilling at 130Deg. C -160Deg. C in order to remove no reaction materials; adding Pd/gamma-Al2O3, Pd/SiO2 or palladium carbon hydrogenation accelerant to the polymer; getting the liquid injecting fuel with at hydrogenation the hydrogen gas pressure of 0. 5-5MPa, 140-80Deg. C. The invention provides a big density, a low freezing point, which provides a simple technique.

The invention relates to a periplaneta americana immunomodulating peptide and a preparation method and medical application thereof. Specifically, the invention relates to an immunomodulating peptide which is extracted from periplaneta americana and has the effects of preventing and treating tumor diseases and improving the immunity function of an organism. The polypeptide substance is a single chain polypeptide of which the amino acid sequence is arginine-arginine-asparagine-leucine-leucine-alanine-alanine-serine-leucine-leucine-asparagine- aspartate, and is prepared by extracting fresh or dry periplaneta americana in water or an organic solvent and a buffer solution and refining through a membrane separation method and an HPLC (High Performance Liquid Chromatography) technology. The immunomodulating peptide has remarkable antitumor activity and immunomodulating effect, and can be used to make medicaments for preventing and treating tumor diseases and/or modulating immunity, daily chemical products or medical devices.

The invention discloses a method for preparing porous nano ferroferric oxide. The method comprises the steps: dissolving two of FeCl2.4H2O, FeSO4.7H2O, FeCl3.6H2O and Fe2(SO4)3 in one of polyvinyl alcohol, ethanol and deionized water or a mixture thereof to obtain a mixed solution containing Fe<2+> and Fe<3+>; adding one of NaHCO3, N2H4.H2O, Na2CO3, (NH4)2CO3 and NH4HCO3 in one of polyvinyl alcohol, ethanol and deionized water or the mixture thereof to obtain an alkaline substance aqueous solution; mixing the mixed solution containing Fe<2+> and Fe<3+> with the alkaline substance aqueous solution in a reaction vessel, heating, and stirring; adjusting the pH of the stirred mixed liquid to 8-13, keeping for 0.5-3 h, gradually adjusting the temperature to 30-60 DEG C, keeping the constant temperature for 2-24 h, allowing the mixed liquid to fully undergo a reaction, and after finishing the reaction, cooling to the room temperature; and washing the precipitate product after reaction with one of anhydrous ethanol and deionized water or a mixture thereof until the pH is 7, and drying for 8-36 h. The reaction process has no need of inert gas protection, and the industrialized production doorsill is low.

The invention discloses a preparation method of a graphene/activated carbon microsphere. The graphene/activated carbon microsphere prepared by the method has the characteristics of spherical structure, large specific surface area and good dispersion, and effectively improves the electrochemical performance of cathode materials. The preparation method of the graphene/activated carbon microsphere includes ultrasonic dispersion, atomization pyrolysis, atomization drying and carbonization, integrates the whole production process, effectively controls the molding of the graphene/activated carbon microsphere, and ensures the material quality. The preparation method has the advantages of simple operation, low cost, energy saving and environmental protection. The prepared graphene/activated carbonmicrosphere has a large specific surface area, not only can be used for electrode materials, and also can be applied to catalyst carriers, water treatment, sewage purification, solvent adsorption andrecovery and other related fields, and has great application prospects.

The invention relates to a special fertilizer for cold water paddy rice, and a preparation and application method thereof. Raw materials of the special fertilizer comprise, by weight, 20 to 25 parts of urea, 10 to 20 parts of diammonium phosphate, 20 to 25 parts of potassium chloride, 15 to 20 parts of calcium magnesium phosphor, 10 to 15 parts of zinc sulfate and 10 to 20 parts of weathered coal. The special fertilizer for cold water paddy rice provided in the invention is developed and prepared by composite granulation on basis of characteristics of soil constraints of cold water fields, pattern of nutrient demands of crops and suitability among fertilizer varieties. According to the invention, the preparation method is simple, and the prepared fertilizer has lasting fertility and can effectively overcome soil constraints of cold water fields.

An asymmetric compound taking triphenylamine as nucleus and containing benzophenone fragment and a synthesis and an application thereof, belonging to the field of organic dye, in particular relating to the application of the asymmetric compound taking triphenylamine as nucleus and containing benzophenone fragment in photopolymerization. The general formula of the typical chemical structure is shown in formula (I), wherein compound in molecular structural formula (I) represents A: R1, R2: H, R3: CH3, OCH3, OCH2CH3, OCH2CH2CH3, OCH2CH2CH2CH3, N(CH3)2, N(CH2CH3)2, N(CH2CH2CH3)2, N(CH2CH2CH2CH3)2, CN, F, NO2; B: (R1, R2,:, R3: OCH3). 4-diethyl benzophenone phosphonate and derivative containing 4-aldehydegroup-triphenylamine compound react in a glass vessel under the alkaline condition to prepare the asymmetric non-conjugated compound taking triphenylamine as nucleus and containing benzophenone fragment, the absorption maximum thereof is at visible region, the organic dye can be used as light trigger to form a photosensitive system together with auxiliary agent trolamine to be used for visible light polymerization of alkene monomer in solution or to be used as photocuring material.