8 results about "E Antigens" patented technology

This invention discloses a monoclonal antibody against human hepatitis B e antigen and its application, relating to the field of hepatitis B detection technology. In the heavy chain variable region of the monoclonal antibody, the amino acid sequences of the complementarity-determining regions (CDR1-3) are as shown in SEQ ID NO. 1-3 or have at least 95% homology with the sequences shown in SEQ ID NO. 1-3; in the light chain variable region, the amino acid sequences of the complementarity-determining regions (CDR1 and CDR3) are as shown in SEQ ID NO. 4 and 5 or have at least 95% homology with the sequences shown in SEQ ID NO. 4 and 5, and the amino acid sequence of the complementarity-determining region (CDR2) is FAS. The monoclonal antibody provided by this invention can effectively recognize natural hepatitis B e antigen, and the titer of the supernatant from B cell culture can reach 1:10000, making it fully applicable to the detection and research of human hepatitis B e antigen. The chemiluminescent reagent prepared using the monoclonal antibody described in this invention has advantages such as high specificity, strong anti-interference ability, high detection sensitivity, and good stability, with almost no missed detections, and can replace imported reagents.

The present disclosure relates to a ribavirin derivative-embedded double-stranded siRNA analogue, a conjugate comprising the same, and salts and uses thereof. The double-stranded siRNA analogue, the conjugate comprising the same, and the salts thereof of the present disclosure can effectively inhibit multiple viral indicators such as hepatitis B virus DNA, pgRNA, S antigen, E antigen, etc., and provide an effective and feasible method for the treatment of hepatitis B.

The application discloses a monoclonal antibody against hepatitis B virus e antigen and a preparation method and application thereof, and relates to the field of hepatitis B antigen detection. Specifically, the antibody provided by the application has HCDR1-3 as shown in SEQ ID NO: 1, 2 and 3 respectively, and LCDR1-3 as shown in SEQ ID NO: 4, 5 and 6 respectively. The provided antibody can specifically recognize human hepatitis B e antigen. The positive coincidence rate, the negative coincidence rate and the total coincidence rate of a detection reagent constructed using the antibody and the Abbott control reagent are all 100%. Compared with an existing antibody 3A3, the stability and the repeatability of detection are significantly improved, and the early detection rate of the reagent kit has important value.

This application discloses a chimeric antigen comprising dengue virus NS5 antigen and E antigen. Specifically, this application relates to a chimeric antigen, a nucleic acid molecule, an expression vector, a host cell, reagents, a kit, and its uses. The chimeric antigen of this application, or its conjugates, possesses enhanced activity and can be used to prepare kits for accurate detection of antibodies against dengue virus.

Provided are a ribavirin derivative-embedded double-stranded siRNA analog, a conjugate comprising the same, and a salt and use thereof. The provided double-stranded siRNA analog, the conjugate comprising the same, and the salt thereof can effectively inhibit multiple viral indicators such as hepatitis B virus DNA, pgRNA, S antigen, E antigen, etc., and provide an effective and feasible method for the treatment of hepatitis B.

The present disclosure relates to immunogenic compositions comprising a varicella zoster vims (VZV) glycoprotein E antigen and a toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide comprising an unmethylated cytidine-phospho-guanosine (CpG) motif. The immunogenic compositions are suitable for stimulating an immune response against VZV in an individual in need thereof.

The present invention provides immunogenic compositions, kits, and methods suitable for stimulating an immune response to varicella-zoster virus (VZV) in individuals requiring such stimulation. [Solution] An immunogenic composition is provided comprising varicella-zoster virus (VZV) glycoprotein E antigen and a Toll-like receptor 9 (TLR9) agonist, such as an oligonucleotide containing a non-methylated cytidine-phospho-guanosine (CpG) motif.

The invention provides a spectrum cell composition as well as a preparation method and application thereof. The cell composition comprises the following blood group system antigens: D, C, c, E and e antigens of an Rh system; a Jka antigen and a Jkb antigen of a Kidd system; m, N, S, s and Mur antigens of an MNS system; an Fya antigen and an Fyb antigen of the Duffy system; a Dia antigen and a Dib antigen of a Diego system; a K, k antigen of the Kell system; a Lea antigen and a Leb antigen of the Lewis system; a P1 antigen of the P system; and Doa and Dob antigens of a Do system. The spectrum cell composition provided by the invention can more accurately identify the Mur antibody, and also considers detection of other common antibodies, so that hemolytic reaction caused by missing detection of the antibody of a blood transfusion patient is avoided, the problem of missing detection of the Mur antibody is effectively solved, and blood transfusion safety is better guaranteed.