The present disclosure relates to a
ribavirin derivative-embedded double-stranded siRNA analogue, a conjugate comprising the same, and salts and uses thereof. The double-stranded siRNA analogue, the conjugate comprising the same, and the salts thereof of the present disclosure can effectively inhibit multiple viral indicators such as
hepatitis B
virus DNA, pgRNA, S
antigen, E
antigen, etc., and provide an effective and feasible method for the treatment of
hepatitis B.