4 results about "Hepatitis B virus DNA" patented technology

The present disclosure relates to a ribavirin derivative-embedded double-stranded siRNA analogue, a conjugate comprising the same, and salts and uses thereof. The double-stranded siRNA analogue, the conjugate comprising the same, and the salts thereof of the present disclosure can effectively inhibit multiple viral indicators such as hepatitis B virus DNA, pgRNA, S antigen, E antigen, etc., and provide an effective and feasible method for the treatment of hepatitis B.

The present application relates to a kind of based on magnetic covalent organic framework material construction biological sensor method for detecting hepatitis B virus, the method includes Au@ZnFe2O4@COF Nanocomposite and intermediate product material: ZnFe2O4@COF.The outstanding creativity of the present application: 1.firstly using magnetic adsorption biological sensor detects HBV.2.design capture probe, signal probe and can specifically recognize the characteristic of hepatitis B virus DNA instead of using antibody to capture hepatitis B virus and utilize CuO laccase activity determination virus concentration sandwich type photochemical immunosensor.

Provided are a ribavirin derivative-embedded double-stranded siRNA analog, a conjugate comprising the same, and a salt and use thereof. The provided double-stranded siRNA analog, the conjugate comprising the same, and the salt thereof can effectively inhibit multiple viral indicators such as hepatitis B virus DNA, pgRNA, S antigen, E antigen, etc., and provide an effective and feasible method for the treatment of hepatitis B.

Provided herein are epigenetically modified DNA targeting systems, such as CRISPR-Cas / Guiding RNA (gRNA) systems, for transcriptional repression of Hepatitis B Virus (HBV) genes to promote cell phenotypes that lead to reduced HBV infection. In some embodiments, the epigenetically modified DNA targeting system binds to or targets a target site of at least one gene in a hepatitis B virus DNA sequence or a regulatory element thereof in a cell. In some aspects, the provided systems relate to transcriptional repression of one or more hepatitis B virus genes and / or regulatory elements thereof. In some aspects, also provided herein are methods and uses related to the provided compositions, for example, in repression of hepatitis B virus replication and expression associated with hepatitis B infection.