85 results about "Quinic acid" patented technology

The invention relates to the technical field of cosmetics, in particular to anti-hair-loss and oil-control shampoo and a preparation method thereof. The hair loss prevention and oil control shampoo is prepared from the following components in parts by weight: 11 to 40 parts of a surfactant, 2 to 20 parts of a platycladus orientalis extract, 0.1 to 0.8 part of a cationic conditioner, 0.05 to 0.2 part of a chelating agent, 0.3 to 1.3 parts of a rheology modifier and 50 to 75 parts of water, the platycladus orientalis extract is prepared from isoquercitrin, afzelin, amentoflavone, pinus koraiensis lactone and dextro-quinic acid in the mass ratio of the isoquercitrin to the afzelin to the amentoflavone to the pinus koraiensis lactone to the dextro-quinic acid being 1 to (2 to 2.7) to (3.5 to 5) to (2 to 2.6) to (650 to 890). Flocculation is generated through the synergistic effect of the platycladus orientalis extract and the cationic conditioner, the composition can be better attached to the scalp, the retention time is prolonged, and the anti-hair-loss and oil-control effects are remarkably improved.

The invention provides an engineering strain for reducing by-products quinic acid and glutamic acid in the process of biosynthesizing shikimic acid and application of the engineering strain, and belongs to the technical field of bioengineering.According to the engineering strain, an escherichia coli recombinant strain HYY1458 serves as an initial strain, quinic acid dehydrogenase (ydiB) is knocked out, so that the synthetic route of quinic acid is blocked, and the yield of the shikimic acid is increased; glutamate synthetase (gltB) and glutamate dehydrogenase (gdhA) are knocked out to partially hinder a glutamic acid synthesis route, the constructed strain is named as an escherichia coli engineering strain YY1127, the escherichia coli engineering strain YY1127 is used for fermentation culture, the content of quinic acid and glutamic acid is reduced by 85.3%, the purity of biosynthesized shikimic acid is improved, and the yield of the shikimic acid is increased. The subsequent separation and purification difficulty is reduced.

The present application provides a method for extracting complex organic acid from the waste liquid of the extract of Rubus corchorifolius L.f. The waste liquid of the column chromatography effluent of the Rubus corchorifolius L.f. extract is taken, the specific gravity of the secondary waste liquid is adjusted to obtain the column loading liquid, the column loading liquid is passed through a resin column A, water washing is performed, the column effluent and the water washing liquid are collected to obtain a combined liquid 1, the combined liquid 1 is passed through a resin column B, water washing is performed, reagent C is used for elution, and the eluate is collected. The combined liquid 2 is obtained by passing through a resin column D and collecting the effluent and the water washing liquid, vacuum concentration is performed, crystallization is performed, and filtration is performed to obtain quinic acid.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The present invention discloses a method for determining the content of organic acid metabolites of black plum in colon tissue and its application. The determination method comprises the following steps: (1) adding sterile physiological saline to the colon tissue, grinding, adding methanol to continue grinding, centrifuging, collecting the supernatant, adding methanol and vortexing, centrifuging, and finally adding water and vortexing to obtain a sample solution to be tested; (2) using high performance liquid chromatography-mass spectrometry to draw standard curves of the three organic acids using citric acid, malic acid, and quinic acid standards, wherein citric acid is used in positive ion mode, and malic acid and quinic acid are used in negative ion mode; (3) using the same method to detect the sample to be tested, and the concentration or content of the three organic acid metabolites (citric acid, malic acid, and quinic acid) can be calculated based on the standard curve. The method of the present invention is simple and highly sensitive and can be used to study the mechanism of the effect of black plum on ulcerative colitis.

The invention provides a method for judging the grade of Zhenmei green tea based on chemical components and a regression equation, and belongs to the technical field of agricultural product quality detection.The method comprises the steps that data of four target chemical components in to-be-detected Zhenmei green tea is obtained, comprising 5-gallic quinic acid, epigallocatechin gallate, gallocatechin gallate and epicatechin gallate, and is prepared from 5-gallic quinic acid, epigallocatechin gallate, gallocatechin gallate and epicatechin gallate; the data of the target chemical components are input into a regression equation, a prediction grade value corresponding to the to-be-detected Zhenmei green tea is obtained through calculation, the four target chemical components are obtained through screening based on data of known different grade sample sets, and the prediction grade value of the to-be-detected Zhenmei green tea is obtained. The regression equation is obtained through ridge regression analysis training based on data and quality grades of four target chemical components of known different-grade sample sets. The method is used for solving the problem that the grade of tea is inaccurately judged through sense organs at present, and the Zhenmei green tea grade judgment method completely based on quantifiable chemical components is achieved.

The application discloses a microbial fermentation process for improving coffee fruit acid flavor and belongs to the technical field of coffee processing. The coffee fermentation process is scientific and reasonable to improve the fruit acid flavor of roasted coffee by additionally adding screened strains under the condition of reserving original bacteria of coffee. The fermentation can improve the organic acid content of roasted coffee, wherein the content of citric acid is 8861.58 mu / g, the content of quinic acid is 9291.51 mu / g, the content of maleic acid is 204.32 mu / g, the content of fumaric acid is 190.23 mu / g, the content of succinic acid is 150.69 mu / g, and the content of nicotinic acid is 50.89 mu / g. The coffee fermentation process can improve the coffee bitterness and quality, and the total score of coffee reaches the level of high-quality coffee.

The present application relates to plant active ingredient extraction technology, particularly to a method for extracting quinic acid in cranberry, specifically, the method comprises the following steps: crushing the cranberry, mixing the crushed cranberry with water to form a slurry, extracting the slurry under low temperature and ultrasonic wave, filtering the slurry after the extraction is completed to remove solid residues, obtaining a filtrate, adding activated carbon to the filtrate for adsorption, adding a desorption agent to the activated carbon for desorption after the adsorption is completed, obtaining quinic acid extract, concentrating the quinic acid extract, and freeze-drying the concentrated quinic acid extract to obtain quinic acid, the extraction device of the present application has high degree of automation and can improve the crushing effect of the cranberry.

The present invention belongs to the technical field of biological medicine, and discloses a ceramide compound shown in Chemical Formula I: #imgabs0# wherein, R 1 is selected from the residues after condensation of sialic acid, chelidamic acid monohydrate, 2,5-furandicarboxylic acid, quinic acid, chlorogenic acid, ectoine, nicotinic acid, shikimic acid, glucuronic acid, salicylic acid, carnosic acid, dihydrooat acylanthranilic acid, abietic acid, ursolic acid, tranexamic acid, syringic acid, gentisic acid, vanillic acid, 5-hydroxyisovanillic acid, orotic acid, 5-aminoorotic acid, 3,5-dihydroxy-4-methylbenzoic acid, glycyrrhizic acid or gallic acid, R 2 is selected from one of the following structures: -C 15 H 29 、-C 15 H 31 、-C 15 H 27 、-CHOHC 14 H 27 、-CHOHC 14 H 29 . The present invention also discloses a preparation method and application of the ceramide compound. The present invention introduces a molecular fragment with physiological activity of a functional carboxylic acid into ceramide, which will enhance the original efficacy of this type of molecule and also improve the physicochemical properties of the ceramide compound.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention provides a coconut milk product capable of improving emulsion stability and a preparation process of the coconut milk product. The coconut milk product is a mechanism for improving emulsion stability through interaction between coffee polyphenol (CP) and main protein coconut globulin (CG) in coconut milk. Caffeic acid (CA), chlorogenic acid (CHA) and ferulic acid (FA) are selected as CP models. The result shows that the hydrogen bond interaction mainly occurs between the CGs and the CPs (Cl-FAslt; cG-CGlt, CG-CGlt; cG-CHA) is used in the method. CHA containing quinic acid preferentially forms a strong interaction with CG. The interaction changes the lipophilicity of the CG and promotes the formation of a compact and thick interfacial film on an oil-water interface. Furthermore, after storage, centrifugation, pH and salt treatment, the CG-CPs stable emulsion shows good stability, especially CG-CHA. The method can provide a theoretical basis for improving the stability of the coconut milk product.

Provided is an oral composition in which sourness of chlorogenic acid and quinic acid is suppressed. The oral composition contains the following components (A), (B), and (C): (A) 0.01% by mass or more and 50% by mass or less of chlorogenic acid, (B) quinic acid, and (C) isovaleric acid, wherein the mass ratio [(B) / (A)] between the component (A) and the component (B) is 0.01 or more and 0.1 or less.

The invention relates to the field of traditional Chinese medicine detection, in particular to a method for detecting chemical components of eight-component kidney-tonifying capsules. Through UPLC-Q-TOF-MS detection, 229 compounds in vitro of the eight-component kidney-tonifying capsule are characterized, 4 alkaloids, 4 quinic acids, 3 sterone, 3 anthraquinones, 3 oligosaccharides and 21 other compounds in the eight-component kidney-tonifying capsule are preliminarily classified and qualitatively determined by adopting the method, and 56 peaks are compared with a standard substance. The detection method provided by the invention can perform qualitative analysis on chemical components of the eight-seed kidney-tonifying capsule, and has guiding significance for subsequent research on in-vivo metabolism, content determination and anti-osteoporosis biological activity evaluation of the eight-seed kidney-tonifying capsule.

The present invention relates to the use of natural protectants comprising a mastic extract and optionally a second component to prevent microbial growth and preserve a product. The invention also relates to the use of natural protectants comprising quinic acid or a salt thereof, ethyl lauroyl arginate or a salt thereof, and optionally a third component to prevent microbial growth and preserve a product.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention provides application of a TaHQT1 gene in regulating and controlling the content of chlorogenic acid in plants, and belongs to the technical field of gene engineering. The invention provides an application of a TaHQT1 gene in regulating and controlling the content of chlorogenic acid in a plant. The invention also proves that a recombinant protein coded by the TaHQT1 gene can generate a product chlorogenic acid by taking caffeoyl-coenzyme A and quinic acid as substrates; meanwhile, overexpression is carried out on the TaHQT1 gene, and it is found that the content of chlorogenic acid in mature grains and leaves is remarkably increased, so that the TaHQT1 gene can be developed and utilized, and the content of wheat chlorogenic acid is increased through overexpression of the TaHQT1 gene, so that the nutritional quality of wheat is improved.

The invention provides application of a TaPAL8 gene in positive regulation of phenolic acid content of wheat, and belongs to the technical field of gene engineering. Wide targeted metabolome detection is carried out on wheat whole growth period materials by utilizing an HPLC-MS / MS technology, specific accumulation of various phenolic acids in stalks is highly related to expression of multiple phenylpropane pathway genes, one gene is annotated as phenylalanine ammonialyase, the gene number is TraesCS6D01G212200, and the gene is named as TaPAL8. According to the embodiment of the invention, the gene TaPAL8 is transformed into a wheat variety Fielder to obtain a transformed plant with overexpression TaPAL8, and in the overexpression mutant, the content of various acyl modified quinic acid substances in stalks and grouted grains is remarkably increased.

The invention relates to a quinic acid salicin ester derivative extracted from shiny feet, a method and application. The quinic acid salicin ester derivative is at least one of a compound 1 and a compound 2. The compound 1 and the compound 2 can be used for preparing medicines or products for preventing or treating myocardial hypertrophy diseases; and when the concentration of the compound 1 and the compound 2 is less than 50 [mu] mol / L, the compound 1 and the compound 2 have no obvious toxicity to cells and show higher biological safety. The invention provides a new choice for development of a cardiac hypertrophy inhibitor.

The invention relates to the field of biological medicine, in particular to application of a quinic acid derivative. The quinic acid derivative comprises one or two of 3-O-p-coumaroyl quinic acid and 4-O-p-coumaroyl quinic acid, and the quinic acid derivative comprises one or two of 3-O-p-coumaroyl quinic acid and 4-O- The applications include treatment and / or prevention of depression. The quinic acid derivatives 3-O-p-coumaroyl quinic acid and 4-O-p-coumaroyl quinic acid can be used for improving the behavioristics of depressive mice; the compound can significantly increase dopamine and noradrenaline in the brain of a depressive mouse, reduce the levels of inflammatory factors IL-6 and TNF-alpha in the brain of the depressive mouse, increase the intestinal microbial diversity of the depressive mouse and significantly increase the BDNF level in the brain of the depressive mouse, and can be used as a drug for treating and / or preventing depression.

To provide a flavor improving agent capable of improving the undesirable flavor of food and drink containing linalool. [Solution] A flavor improver for linalool-containing food and drink, containing quinic acid as an active ingredient. It is also preferable that the amount (a) of quinic acid added to the linalool-containing food and drink is used so that the mass ratio (a / b) of the linalool content (b) in the linalool-containing food and drink is 0.00002 to 180. It is also preferable that the quinic acid content in the food and drink is 0.001 to 9 ppm.

The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.

A method for treating tobacco material, the method comprising: providing a tobacco material, fermenting the tobacco material to obtain fermented tobacco material, the fermenting step including: # incubating the tobacco material under anaerobic conditions; # stopping the fermentation when at least one of the following conditions is satisfied: # the content of Lactic Acid is more than 10 times, preferably more than 20 times, more preferably more than 50 times, more preferably more than 70 times, preferably more than 80 times an initial amount of Lactic Acid in the tobacco material, # the content of Reducing Sugars is lower than 0.5, preferably lower than 0.4, more preferably below 0.2, more preferably below 0.1 an initial amount or Reducing Sugars in the tobacco material, # the content of Indole-3 Lactic Acid is more than 5 times, preferably more than 10 times, preferably more than 20 times, an initial amount of Indole-3 Lactic Acid in the tobacco material, # the content of caffeic acid is more than 4 times, preferably more than 10 times, preferably more than 20 times, an initial amount of caffeic acid in the tobacco material. # the content of quinic acid is more than 2 times, preferably more than 4 times, an initial amount of quinic acid in the tobacco material, # the content of asparagine is lower than 0.5, preferably lower than 0.4, preferably lower than 0.3 an initial amount or asparagine in the tobacco material, # the content of Glutamine is lower than 0.5, preferably lower than 0.4 an initial amount or Glutamine in the tobacco material, # the content of L-Ornithine is more than 10 times, preferably more than 20 times, preferably more than 50 times, preferably more than 100 times an initial amount of L-Ornithine in the tobacco material, # the content of L-Leucine is more than 2 times, preferably more than 4 times, an initial amount of L-Leucine in the tobacco material, # the content of L-Lysine is more than 2 times, preferably more than 6 times, an initial amount of L-Lysine in the tobacco material, # the fermentation index is more than 50, preferably more than 100, more preferably more than 250, more preferably more 400, wherein the fermentation index is obtained dividing the ratio between the content of Lactic Acid in the treated tobacco material and the content of Lactic Acid in the non-fermented tobacco material by the ratio between the content of Reducing Sugars in the treated tobacco material and the content of Reducing Sugars in the non-fermented tobacco material.

The present disclosure relates to a composition comprising quinic acid for preventing, alleviating or treating coccidiosis, and an antiprotozoal composition against Eimeria sporozoites.

The invention relates to the technical field of fermentation liquor, and discloses fermentation liquor for improving fruit tree planting soil, which is characterized by being prepared from the following raw materials in parts by weight: 4 to 8 parts of peanut meal, 10 to 15 parts of wheat bran powder, 75 to 85 parts of brown sugar and 1 to 3 parts of EM bacteria. By using the fermentation liquor, the application of chemical fertilizers can be effectively reduced, meanwhile, the chemical composition of soil is improved, main organic acids in the fermentation liquor comprise quinic acid, acetic acid, succinic acid, tartaric acid, malic acid, oxalic acid and citric acid, and the content of quinic acid, succinic acid, tartaric acid, malic acid and citric acid can be remarkably increased by increasing the content of molasses, so that the soil quality is improved. And the contents of acetic acid and oxalic acid are correspondingly reduced.

The disclosure relates to dried coffee extracts that contain relatively large quantities of caffeine (e.g., from about 4-8 wt %), as well as large quantities of other, health-promoting additives such as, for example, 5-caffeoyl quinic acid and trigonelline. Methods of incorporating the dried coffee extracts into beverages and packaging them in kits are also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The present application discloses a method for preparing a small-particle-size single-crystal positive electrode material, comprising the following steps: taking a lithium source compound, a nickel source compound, a cobalt source compound and a manganese source compound according to a stoichiometric ratio, mixing them with an aqueous solution of a complexing agent A, and reacting to obtain a mixed solution; adding an aqueous solution of a complexing agent B to the mixed solution, and reacting to obtain a sol; heating the sol, evaporating and concentrating it to form a gel; and calcining the gel in steps to obtain a small-particle-size single-crystal positive electrode material. Wherein, the complexing agent A is at least one of 2-hydroxypropionic acid, aspartic acid, quinic acid, succinic acid or formic acid; and the complexing agent B is at least one of ascorbic acid, glucosamine, tyrosine or aminobutyric acid. The present application also discloses a small-particle-size single-crystal positive electrode material and a lithium-ion battery comprising the positive electrode material.

The invention relates to a polyolefin adhesive for stainless steel and a preparation method thereof, and belongs to the technical field of adhesives. According to the invention, quinic acid and shikimic acid are firstly used for modifying sodium carbonate, then modified calcium carbonate and ramie fiber are used as fillers for filling so as to construct an efficient stress transfer system, and meanwhile, maleic anhydride grafted polyethylene is also added for assisting filling of the fillers, so that the impact resistance of the prepared adhesive is effectively improved; besides, malonaldehyde is added to reduce the activity of molecules in the material and limit molecular motion, vinyl neodecanoate with a side group is doped to increase the steric hindrance of molecular motion in the system, and hexanediol diglycidyl ether is doped to increase the density of a cross-linked network of the system, so that the composite material has excellent mechanical properties. The adhesive prepared by the method has relatively high peel strength.

The application clones a functional gene PpHCT5 from peach fruit and realizes the application of the gene in promoting the biosynthesis of chlorogenic acid in plants. PpHCT5 belongs to the BADH acyltransferase family, and the coding region is 1323 bp long and contains 440 amino acids. In vitro enzymatic test analysis shows that PpHCT5 protein is involved in the last step of the chlorogenic acid biosynthesis pathway and can catalyze the formation of chlorogenic acid from caffeoyl-CoA and quinic acid. Further in vivo functional verification shows that overexpression of the PpHCT5 gene promotes the accumulation of chlorogenic acid in transgenic peach fruit, tomato fruit and tobacco leaves. Based on this result, a new idea is provided for promoting the development and application of plant products rich in chlorogenic acid, and a foundation is laid for plant resistance breeding.

The invention relates to construction and quality control of a lung-tonifying and detoxifying granule fingerprint spectrum. An HPLC (High Performance Liquid Chromatography) fingerprint spectrum of the lung-tonifying and detoxifying granules has 17 characteristic fingerprint chromatographic peaks, wherein the peak 1 is guanosine, the peak 3 is protocatechualdehyde, the peak 4 is quinic acid, the peak 6 is chlorogenic acid, the peak 10 is loganin, the peak 14 is forsythiaside A, and the peak 17 is forsythin.

The invention provides a method for synthesizing quinic acid by using escherichia coli whole cells, and belongs to the technical field of microbial metabolism engineering. According to the method for synthesizing quinic acid provided by the invention, through specific genetic engineering modification and fermentation process optimization, efficient bioconversion with renewable saccharides as raw materials is realized, the production process is mild in conditions, free of harmful chemical reagents, environment-friendly and relatively low in energy consumption, and the production cost and environmental protection pressure are effectively reduced. The yield of the quinic acid product prepared by the method can reach 17.1 g / L, the quality is stable, a reliable raw material source is provided for the fields of medicine, food, health care products and the like, and green manufacturing and industrial development of related high-added-value natural products are promoted.