48 results about "Quinic acid" patented technology

The present application provides a method for extracting complex organic acid from the waste liquid of the extract of Rubus corchorifolius L.f. The waste liquid of the column chromatography effluent of the Rubus corchorifolius L.f. extract is taken, the specific gravity of the secondary waste liquid is adjusted to obtain the column loading liquid, the column loading liquid is passed through a resin column A, water washing is performed, the column effluent and the water washing liquid are collected to obtain a combined liquid 1, the combined liquid 1 is passed through a resin column B, water washing is performed, reagent C is used for elution, and the eluate is collected. The combined liquid 2 is obtained by passing through a resin column D and collecting the effluent and the water washing liquid, vacuum concentration is performed, crystallization is performed, and filtration is performed to obtain quinic acid.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The present invention discloses a method for determining the content of organic acid metabolites of black plum in colon tissue and its application. The determination method comprises the following steps: (1) adding sterile physiological saline to the colon tissue, grinding, adding methanol to continue grinding, centrifuging, collecting the supernatant, adding methanol and vortexing, centrifuging, and finally adding water and vortexing to obtain a sample solution to be tested; (2) using high performance liquid chromatography-mass spectrometry to draw standard curves of the three organic acids using citric acid, malic acid, and quinic acid standards, wherein citric acid is used in positive ion mode, and malic acid and quinic acid are used in negative ion mode; (3) using the same method to detect the sample to be tested, and the concentration or content of the three organic acid metabolites (citric acid, malic acid, and quinic acid) can be calculated based on the standard curve. The method of the present invention is simple and highly sensitive and can be used to study the mechanism of the effect of black plum on ulcerative colitis.

The invention provides a method for judging the grade of Zhenmei green tea based on chemical components and a regression equation, and belongs to the technical field of agricultural product quality detection.The method comprises the steps that data of four target chemical components in to-be-detected Zhenmei green tea is obtained, comprising 5-gallic quinic acid, epigallocatechin gallate, gallocatechin gallate and epicatechin gallate, and is prepared from 5-gallic quinic acid, epigallocatechin gallate, gallocatechin gallate and epicatechin gallate; the data of the target chemical components are input into a regression equation, a prediction grade value corresponding to the to-be-detected Zhenmei green tea is obtained through calculation, the four target chemical components are obtained through screening based on data of known different grade sample sets, and the prediction grade value of the to-be-detected Zhenmei green tea is obtained. The regression equation is obtained through ridge regression analysis training based on data and quality grades of four target chemical components of known different-grade sample sets. The method is used for solving the problem that the grade of tea is inaccurately judged through sense organs at present, and the Zhenmei green tea grade judgment method completely based on quantifiable chemical components is achieved.

The application discloses a microbial fermentation process for improving coffee fruit acid flavor and belongs to the technical field of coffee processing. The coffee fermentation process is scientific and reasonable to improve the fruit acid flavor of roasted coffee by additionally adding screened strains under the condition of reserving original bacteria of coffee. The fermentation can improve the organic acid content of roasted coffee, wherein the content of citric acid is 8861.58 mu / g, the content of quinic acid is 9291.51 mu / g, the content of maleic acid is 204.32 mu / g, the content of fumaric acid is 190.23 mu / g, the content of succinic acid is 150.69 mu / g, and the content of nicotinic acid is 50.89 mu / g. The coffee fermentation process can improve the coffee bitterness and quality, and the total score of coffee reaches the level of high-quality coffee.

The present application relates to plant active ingredient extraction technology, particularly to a method for extracting quinic acid in cranberry, specifically, the method comprises the following steps: crushing the cranberry, mixing the crushed cranberry with water to form a slurry, extracting the slurry under low temperature and ultrasonic wave, filtering the slurry after the extraction is completed to remove solid residues, obtaining a filtrate, adding activated carbon to the filtrate for adsorption, adding a desorption agent to the activated carbon for desorption after the adsorption is completed, obtaining quinic acid extract, concentrating the quinic acid extract, and freeze-drying the concentrated quinic acid extract to obtain quinic acid, the extraction device of the present application has high degree of automation and can improve the crushing effect of the cranberry.

The present invention belongs to the technical field of biological medicine, and discloses a ceramide compound shown in Chemical Formula I: #imgabs0# wherein, R 1 is selected from the residues after condensation of sialic acid, chelidamic acid monohydrate, 2,5-furandicarboxylic acid, quinic acid, chlorogenic acid, ectoine, nicotinic acid, shikimic acid, glucuronic acid, salicylic acid, carnosic acid, dihydrooat acylanthranilic acid, abietic acid, ursolic acid, tranexamic acid, syringic acid, gentisic acid, vanillic acid, 5-hydroxyisovanillic acid, orotic acid, 5-aminoorotic acid, 3,5-dihydroxy-4-methylbenzoic acid, glycyrrhizic acid or gallic acid, R 2 is selected from one of the following structures: -C 15 H 29 、-C 15 H 31 、-C 15 H 27 、-CHOHC 14 H 27 、-CHOHC 14 H 29 . The present invention also discloses a preparation method and application of the ceramide compound. The present invention introduces a molecular fragment with physiological activity of a functional carboxylic acid into ceramide, which will enhance the original efficacy of this type of molecule and also improve the physicochemical properties of the ceramide compound.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

Provided is an oral composition in which sourness of chlorogenic acid and quinic acid is suppressed. The oral composition contains the following components (A), (B), and (C): (A) 0.01% by mass or more and 50% by mass or less of chlorogenic acid, (B) quinic acid, and (C) isovaleric acid, wherein the mass ratio [(B) / (A)] between the component (A) and the component (B) is 0.01 or more and 0.1 or less.

The present invention relates to the use of natural protectants comprising a mastic extract and optionally a second component to prevent microbial growth and preserve a product. The invention also relates to the use of natural protectants comprising quinic acid or a salt thereof, ethyl lauroyl arginate or a salt thereof, and optionally a third component to prevent microbial growth and preserve a product.

The invention discloses a generalized pustular psoriasis diagnosis marker based on metabonomics and application of the generalized pustular psoriasis diagnosis marker. The diagnostic marker is prepared from one or more of the following 35 compounds: pyruvic acid, alpha-ketoisovaleric acid, 2-hydroxybutyric acid, 3-hydroxybutyric acid, methane thiophosphoric acid, proline, uracil, tranexamic acid, 4-aminobutyric acid, threonine, scopoletin, dodecanol, N-methyl-L-leucine, L-cysteine-glycine and L-kynurenine. The feed additive is prepared from the following raw materials: 3-hydroxybenzoic acid, allantoin, delta-tocopherol, xylofuranose, glucose-1-phosphoric acid, pyrophosphate, taurine, L-asparagine, phthalic acid, 4-(dimethylamino) azobenzene, 5-tert-butyl-1h-indole-2, 3-dione, quinic acid, glucose, histidine, lysine, palmitic acid, 7-methylguanine, oleic acid and whale acid. The marker can be used for accurately distinguishing patients with generalized pustular psoriasis from healthy people.

The invention provides application of a TaHQT1 gene in regulating and controlling the content of chlorogenic acid in plants, and belongs to the technical field of gene engineering. The invention provides an application of a TaHQT1 gene in regulating and controlling the content of chlorogenic acid in a plant. The invention also proves that a recombinant protein coded by the TaHQT1 gene can generate a product chlorogenic acid by taking caffeoyl-coenzyme A and quinic acid as substrates; meanwhile, overexpression is carried out on the TaHQT1 gene, and it is found that the content of chlorogenic acid in mature grains and leaves is remarkably increased, so that the TaHQT1 gene can be developed and utilized, and the content of wheat chlorogenic acid is increased through overexpression of the TaHQT1 gene, so that the nutritional quality of wheat is improved.

The invention provides application of a TaPAL8 gene in positive regulation of phenolic acid content of wheat, and belongs to the technical field of gene engineering. Wide targeted metabolome detection is carried out on wheat whole growth period materials by utilizing an HPLC-MS / MS technology, specific accumulation of various phenolic acids in stalks is highly related to expression of multiple phenylpropane pathway genes, one gene is annotated as phenylalanine ammonialyase, the gene number is TraesCS6D01G212200, and the gene is named as TaPAL8. According to the embodiment of the invention, the gene TaPAL8 is transformed into a wheat variety Fielder to obtain a transformed plant with overexpression TaPAL8, and in the overexpression mutant, the content of various acyl modified quinic acid substances in stalks and grouted grains is remarkably increased.

The invention relates to a quinic acid salicin ester derivative extracted from shiny feet, a method and application. The quinic acid salicin ester derivative is at least one of a compound 1 and a compound 2. The compound 1 and the compound 2 can be used for preparing medicines or products for preventing or treating myocardial hypertrophy diseases; and when the concentration of the compound 1 and the compound 2 is less than 50 [mu] mol / L, the compound 1 and the compound 2 have no obvious toxicity to cells and show higher biological safety. The invention provides a new choice for development of a cardiac hypertrophy inhibitor.

The invention relates to the field of biological medicine, in particular to application of a quinic acid derivative. The quinic acid derivative comprises one or two of 3-O-p-coumaroyl quinic acid and 4-O-p-coumaroyl quinic acid, and the quinic acid derivative comprises one or two of 3-O-p-coumaroyl quinic acid and 4-O- The applications include treatment and / or prevention of depression. The quinic acid derivatives 3-O-p-coumaroyl quinic acid and 4-O-p-coumaroyl quinic acid can be used for improving the behavioristics of depressive mice; the compound can significantly increase dopamine and noradrenaline in the brain of a depressive mouse, reduce the levels of inflammatory factors IL-6 and TNF-alpha in the brain of the depressive mouse, increase the intestinal microbial diversity of the depressive mouse and significantly increase the BDNF level in the brain of the depressive mouse, and can be used as a drug for treating and / or preventing depression.

The invention provides methods for treating auditory impairments in a subject in need of treatment comprising administering to said subject an effective amount of a composition comprising, as an active agent, one or more of a carboxy alkyl ester, a quinic acid derivative, a caffeic acid derivative, a ferulic acid derivative, or a quinic acid lactone or derivative thereof or pharmaceutically acceptable salt thereof and an acceptable carrier or excipient, so as to treat auditory impairments in the subject.

A method for treating tobacco material, the method comprising: providing a tobacco material, fermenting the tobacco material to obtain fermented tobacco material, the fermenting step including: # incubating the tobacco material under anaerobic conditions; # stopping the fermentation when at least one of the following conditions is satisfied: # the content of Lactic Acid is more than 10 times, preferably more than 20 times, more preferably more than 50 times, more preferably more than 70 times, preferably more than 80 times an initial amount of Lactic Acid in the tobacco material, # the content of Reducing Sugars is lower than 0.5, preferably lower than 0.4, more preferably below 0.2, more preferably below 0.1 an initial amount or Reducing Sugars in the tobacco material, # the content of Indole-3 Lactic Acid is more than 5 times, preferably more than 10 times, preferably more than 20 times, an initial amount of Indole-3 Lactic Acid in the tobacco material, # the content of caffeic acid is more than 4 times, preferably more than 10 times, preferably more than 20 times, an initial amount of caffeic acid in the tobacco material. # the content of quinic acid is more than 2 times, preferably more than 4 times, an initial amount of quinic acid in the tobacco material, # the content of asparagine is lower than 0.5, preferably lower than 0.4, preferably lower than 0.3 an initial amount or asparagine in the tobacco material, # the content of Glutamine is lower than 0.5, preferably lower than 0.4 an initial amount or Glutamine in the tobacco material, # the content of L-Ornithine is more than 10 times, preferably more than 20 times, preferably more than 50 times, preferably more than 100 times an initial amount of L-Ornithine in the tobacco material, # the content of L-Leucine is more than 2 times, preferably more than 4 times, an initial amount of L-Leucine in the tobacco material, # the content of L-Lysine is more than 2 times, preferably more than 6 times, an initial amount of L-Lysine in the tobacco material, # the fermentation index is more than 50, preferably more than 100, more preferably more than 250, more preferably more 400, wherein the fermentation index is obtained dividing the ratio between the content of Lactic Acid in the treated tobacco material and the content of Lactic Acid in the non-fermented tobacco material by the ratio between the content of Reducing Sugars in the treated tobacco material and the content of Reducing Sugars in the non-fermented tobacco material.

The present disclosure relates to a composition comprising quinic acid for preventing, alleviating or treating coccidiosis, and an antiprotozoal composition against Eimeria sporozoites.

The disclosure relates to dried coffee extracts that contain relatively large quantities of caffeine (e.g., from about 4-8 wt %), as well as large quantities of other, health-promoting additives such as, for example, 5-caffeoyl quinic acid and trigonelline. Methods of incorporating the dried coffee extracts into beverages and packaging them in kits are also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

The invention relates to a polyolefin adhesive for stainless steel and a preparation method thereof, and belongs to the technical field of adhesives. According to the invention, quinic acid and shikimic acid are firstly used for modifying sodium carbonate, then modified calcium carbonate and ramie fiber are used as fillers for filling so as to construct an efficient stress transfer system, and meanwhile, maleic anhydride grafted polyethylene is also added for assisting filling of the fillers, so that the impact resistance of the prepared adhesive is effectively improved; besides, malonaldehyde is added to reduce the activity of molecules in the material and limit molecular motion, vinyl neodecanoate with a side group is doped to increase the steric hindrance of molecular motion in the system, and hexanediol diglycidyl ether is doped to increase the density of a cross-linked network of the system, so that the composite material has excellent mechanical properties. The adhesive prepared by the method has relatively high peel strength.

The application clones a functional gene PpHCT5 from peach fruit and realizes the application of the gene in promoting the biosynthesis of chlorogenic acid in plants. PpHCT5 belongs to the BADH acyltransferase family, and the coding region is 1323 bp long and contains 440 amino acids. In vitro enzymatic test analysis shows that PpHCT5 protein is involved in the last step of the chlorogenic acid biosynthesis pathway and can catalyze the formation of chlorogenic acid from caffeoyl-CoA and quinic acid. Further in vivo functional verification shows that overexpression of the PpHCT5 gene promotes the accumulation of chlorogenic acid in transgenic peach fruit, tomato fruit and tobacco leaves. Based on this result, a new idea is provided for promoting the development and application of plant products rich in chlorogenic acid, and a foundation is laid for plant resistance breeding.

The invention relates to construction and quality control of a lung-tonifying and detoxifying granule fingerprint spectrum. An HPLC (High Performance Liquid Chromatography) fingerprint spectrum of the lung-tonifying and detoxifying granules has 17 characteristic fingerprint chromatographic peaks, wherein the peak 1 is guanosine, the peak 3 is protocatechualdehyde, the peak 4 is quinic acid, the peak 6 is chlorogenic acid, the peak 10 is loganin, the peak 14 is forsythiaside A, and the peak 17 is forsythin.

The invention provides a method for synthesizing quinic acid by using escherichia coli whole cells, and belongs to the technical field of microbial metabolism engineering. According to the method for synthesizing quinic acid provided by the invention, through specific genetic engineering modification and fermentation process optimization, efficient bioconversion with renewable saccharides as raw materials is realized, the production process is mild in conditions, free of harmful chemical reagents, environment-friendly and relatively low in energy consumption, and the production cost and environmental protection pressure are effectively reduced. The yield of the quinic acid product prepared by the method can reach 17.1 g / L, the quality is stable, a reliable raw material source is provided for the fields of medicine, food, health care products and the like, and green manufacturing and industrial development of related high-added-value natural products are promoted.

The application provides a method for simultaneously preparing gallic acid and quinic acid by using tara powder enzymatic method, wherein a seed liquid of Aspergillus niger is fermented, an inducing substrate tara powder or tara tannic acid is added for culture, a tara tannin enzyme crude enzyme liquid is prepared, the crude enzyme liquid catalyzes tara powder for enzymolysis reaction, the liquid after reaction is subjected to ultrafiltration, the permeate is subjected to 2-stage nanofiltration treatment, the concentrated liquid of the 2-stage nanofiltration is added with an ionic liquid for extraction, upper liquid and lower liquid are obtained, the upper liquid contains gallic acid, and the lower liquid contains quinic acid; the upper liquid and the lower liquid are respectively neutralized by alkali for recycling of the ionic liquid; the upper liquid and the lower liquid after removal of the ionic liquid are respectively subjected to cooling crystallization, alcohol is added after acidification for recrystallization, and gallic acid and quinic acid are obtained. The application does not need operations such as activated carbon decolorization and ion exchange adsorption, the total recovery rate of quinic acid reaches more than 81%, and the total recovery rate of gallic acid reaches more than 85%.

The present application relates to a composition containing chlorogenic acid, caffeic acid, and quinic acid. The polyphenol-containing composition of the present application may be used for reducing an off-taste or off-flavor. In addition, the polyphenol-containing composition of the present application may be used as a preservative of a product, in particular an antioxidant or browning inhibitor of a product.

The invention discloses application of a ThHQT gene in promoting synthesis of chlorogenic acid in leaves of radix tetrastigme, and the ThHQT gene has a base sequence as shown in SEQ ID NO.1 in a sequence table. The gene disclosed by the invention is over-expressed in tobacco leaves, so that the contents of 3-coffee quinic acid, 4-coffee quinic acid and 5-coffee quinic acid in the tobacco leaves can be increased. If the gene is used for transforming plants such as rice, pepper, eggplant, strawberry, tomato and the like, the content of chlorogenic acid compounds and the resistance of the plants can be improved.

Provided is a method for effectively producing hydroxycinnamoyl-quinic acids.　Disclosed is a method for producing tri(hydroxycinnamoyl) quinic acid and / or tetra(hydroxycinnamoyl) quinic acid, the method including: a first step for protecting the phenolic hydroxy groups of hydroxycinnamic acid with silyl protecting groups; after the first step, a second step for forming ester bonds between carboxy groups of hydroxycinnamic acid and hydroxy groups of quinic acid; and after the second step, a third step for removing the silyl protecting groups from the phenolic hydroxy groups protected by the silyl protecting groups.

The invention discloses a method for inhibiting browning and microbial growth of fresh-cut potatoes, and belongs to the technical field of fresh-cut potato preservation. It is verified that quinic acid can effectively inhibit browning of the potato slurry, the fresh-cut potato shreds and the potato chips, the original color and flavor are kept, and the total number of bacterial colonies of the fresh-cut potatoes is inhibited. The use method is simple, and only a small amount of quinic acid needs to be directly added into the potato slurry, or the peeled and cut fresh-cut potatoes are soaked in a quinic acid aqueous solution. Experiments show that the compounding of quinic acid and aconitic acid can significantly inhibit browning of the fresh-cut potatoes; however, the browning of peaches, pears and apples cannot be obviously inhibited when applied to peaches, pears and apples; metabolite of the potatoes treated by quinic acid is obviously changed, and 3-methylthiopropionate and nicotinamide ribose obviously inhibit browning of the potatoes. The method is safe, free of toxic and side effects, simple in treatment, easy to operate and popularize and suitable for large-scale production and use.

The invention discloses an anti-saccharification and anti-carbonylation composition as well as a preparation method and application thereof, and the composition comprises quinic acid and 2, 3, 4, 5-tetracaffeoyl-D-glucaric acid. According to the invention, quinic acid and 2, 3, 4, 5-tetracaffeoyl-D-glucaric acid are specifically compounded, and the prepared composition can significantly improve the anti-saccharification effect. And a product containing the composition has obvious effects of resisting saccharification, resisting carbonylation, brightening skin color and improving skin darkness, is good in stability and can be applied to cosmetics with corresponding effects.

The present application relates to the technical field of textiles, and discloses a plant dyeing and finishing process, which comprises the following steps: S1, pretreating wool / cashmere fabric to obtain pretreated fabric; S2, sequentially performing piece dyeing, opening, first drying, raising, first shearing, first wet brushing, second drying, second shearing, continuous steaming, second wet brushing, third drying, closed steaming, and steaming treatment on the pretreated fabric to obtain dyed and finished fabric; in step S1, the pretreatment agent used in the pretreatment comprises component alkylphenol polyoxyethylene ether, chitosan quaternary ammonium salt, and quinic acid. The above technical solution solves the problem of poor dyeing durability of plant dyeing and finishing fabric in the prior art.