885 results about "Free acid" patented technology

A stable continuous method for producing ethanol from the anaerobic bacterial fermentation of a gaseous substrate containing at least one reducing gas involves culturing a fermentation bioreactor anaerobic, acetogenic bacteria in a liquid nutrient medium; supplying the gaseous substrate to the bioreactor; and manipulating the bacteria in the bioreactor by reducing the redox potential, or increasing the NAD(P)H TO NAD(P) ratio, in the fermentation broth after the bacteria achieves a steady state and stable cell concentration in the bioreactor. The free acetic acid concentration in the bioreactor is maintained at less than 5 g/L free acid. This method allows ethanol to be produced in the fermentation broth in the bioreactor at a productivity greater than 10 g/L per day. Both ethanol and acetate are produced in a ratio of ethanol to acetate ranging from 1:1 to 20:1.

The present invention relates to the use of individual fumaric acid derivatives or mixtures thereof for preparing a pharmaceutical composition for treating mitochondrial diseases, especially for treating Parkinson's syndrome, Alzheimer's disease, Chorea Huntington disease, retinopathia pigmentosa and mitochondrial encephalomyopathy. Preferably, the fumaric acid derivative(s) is/are those selected from the group consisting of fumaric acid dialkyl esters or fumaric acid monoalkyl esters in the form of the free acid or a salt thereof.

Drug delivery devices comprising a non-bioabsorbable polymer structure and a composition comprising an active agent have been discovered. The drug delivery devices may be used to treat ocular conditions, among other diseases and conditions. In addition, a method of treating an ocular condition has been discovered comprising implanting a drug delivery device which releases the active agent at a rate of

Q=0.001×N×C

wherein C is the topical effective concentration (in milligram/mL) of the active agent and N=0.01 to 0.5 for prostaglandins in their ester, amide, free acid or salt form, and N=0.5 to 5 for any active agent other than prostaglandins in their ester, amide, free acid or salt form.

A method of administering beta-hydroxy-beta-methylbutyric acid (HMB) is described, and specifically administering HMB-acid to a person such that the administration of free acid HMB results in an increase in effectiveness of HMB over administration of other forms of HMB, including a calcium salt HMB composition is described. Administration of HMB-acid results in an increase in the peak level of HMB in plasma compared with administration of a similar dose of a calcium salt HMB composition. Administration of HMB-acid results in a faster time to reach peak plasma levels of HMB relative to administration of a similar dosage of a calcium salt HMB composition.

A process for recovering nickel and cobalt values from nickel- and cobalt-containing laterite ores as an enriched mixed nickel and cobalt sulphide intermediate and for producing nickel and cobalt metal from the nickel and cobalt sulphide intermediate. The laterite ore is leached as a slurry in a pressure acid leach containing an excess of aqueous sulphuric acid at high pressure and temperature, excess free acid in the leach slurry is partially neutralized to a range of 5 to 10 g/L residual free H₂SO₄ and washed to yield a nickel- and cobalt-containing product liquor, the product liquor is subjected to a reductant to reduce any Cr(VI) in solution to Cr(III), the reduced product liquor is neutralized to precipitate ferric iron and silicon at a pH of about 3.5 to 4.0, and the neutralized and reduced product liquor is contacted with hydrogen sulphide gas to precipitate nickel and cobalt sulphides. The precipitated nickel and cobalt sulphides can be leached in a water slurry in a pressure oxidation leach, the leach solution subjected to iron hydrolysis and precipitation, the iron-free solution contacted with zinc sulphide to precipitate copper, the iron- and copper-free solution subjected to zinc and cobalt extraction by solvent extraction to produce a nickel raffinate, the nickel raffinate contacted with hydrogen gas to produce nickel powder and the cobalt strip solution from the solvent extraction step contacted with hydrogen gas to produce cobalt powder.

Provided are methods of trimming photoresist patterns. The methods involve coating a photoresist trimming composition over a photoresist pattern, wherein the trimming composition includes a matrix polymer, a free acid having fluorine substitution and a solvent, the trimming composition being free of cross-linking agents. The coated semiconductor substrate is heated to cause a change in polarity of the resist polymer in a surface region of the photoresist pattern. The photoresist pattern is contacted with a developing solution to remove the surface region of the photoresist pattern. The methods find particular applicability in the formation of very fine lithographic features in the manufacture of semiconductor devices.

The present invention features formulations of indolinones which compounds are ionizable as free acids or free bases. The formulation is suitable for parenteral or oral administration, wherein the formulation comprises an ionizable substituted indolinone, and a pharmaceutically acceptable carrier therefor. The term “ionizable substituted indolinone” includes pyrrole substituted 2-indolinones which, in addition to being otherwise optionally substituted on both the pyrrole and 2-indolinone portions of the compound, are necessarily substituted on the pyrrole moiety with one or more hydrocarbon chains which themselves are substituted with at least one polar group. The formulations and the compounds themselves are useful for the treatment of protein kinase related disorders as discussed herein.

This invention is directed to a suspension stable protein containing acid beverage composition, comprising; (A) at least one protein material, (B) at least one flavoring material, (C) at least one sweetener, (D) at least one food grade acid, and (E) water; wherein the suspension stable protein containing acid beverage composition is free of a stabilizing agent, has a pH of from 3.0 to 3.7, and wherein for a 3 gram protein per 8 ounce composition has a viscosity at 25° C. of from 2 to 3 centipoise, less than 3% sediment and less than 1% serum, or wherein for a 6.5 gram protein per 8 ounce composition has a viscosity at 25° C. of from 3 to 5 centipoise, less than 5% sediment and less than 1% serum, or wherein for a 11 gram protein per 8 ounce composition has a viscosity at 25° C. of from 4 to 6 centipoise, less than 10% sediment and less than 1% serum.

A method of treating a subterranean formation with a retarded self-diverting fluid system. The method includes contacting the formation with a mixture of acid, chelating agent, and betaine surfactant in which the betaine surfactant is mixed with an aqueous solution of the chelating agent in which the pH has been adjusted to a pH of below about 3.0, but above the pH at which the free acid of the chelating agent precipitates, and the resulting fluid system is utilized for both acid fracturing and matrix stimulation, as well as workover procedures such as scale and filter cake removal, especially in high temperature formations.

The invention discloses a method for preparing soil amendment for southern dry and acid soil. It comprises following steps: mixing calcinated shell product of 40- 64% (proportion by weight), calcium magnesium silicate of 15- 30% and ammoniomagnesium phosphate of 10- 28%, getting mixed material; disintegrating mixed material, sifting, and getting soil amendment. The product can improve cluster structure for soil, reduce water loss and fertilizer loss problem in southern dry and acid soil, prevent soil consolidation; it can moderate the pH value for southern dry and scid soil, neutralizing free acid, inactivating the activity of active aluminium, improve microenvironment for root soil and increase microbe diversity in southern sry and acid soil, increase the enzyme functions, improve nutrition supply of magnesium and calcium and other microelement, and provides good basis for high crop productivity.

The present invention relates to a porphyrazine coloring matter represented by the following formula (1):

(wherein, A, B, C and D independently represent a 6-membered ring having aromaticity, at least one or more of them are benzene rings and at least one or more of them contain nitrogen-containing heteroaromatic rings; E represents alkylene, X is a substituted anilino group and have at least one or more of sulfo group, carboxy group and phosphono group as a substituent, Y represents a hydroxy group or an amino group, b is respectively 0 to 2.9, c is 0.1 to 3, and the sum of b and c is 1 to 3) in free acid form, which is suitable for inkjet recording because it has good hue as a cyan ink, is excellent in light fastness, ozone fastness and moisture fastness, and does not cause bronzing phenomenon.

An osmotic controlled release dosage form is described comprising a core comprising a first drug composition, wherein the first drug composition comprises topiramate and/or its pharmaceutically acceptable salt; a semi-permeable wall surrounding the core; and an exit orifice through the semi-permeable wall for releasing the first drug composition from the dosage form over a prolonged period of time.

The invention provides an electrolyte, and the electrolyte comprises a lithium salt, an organic solvent and an additive A; the additive A comprises one or more kinds of alkylamine compounds, silicon nitrogen compounds and siloxane compounds. In order to improve the electrolyte, the non-aqueous electrolyte has one or more kinds of the alkylamines, compounds with Si-N bonds (the silicon nitrogen compounds) and the siloxane compounds. The non-aqueous electrolyte has extremely low free acid content, is applied to a lithium-ion battery with a high-nickel ternary cathode material and can effectively improve the circulation performance, high-temperature circulation performance and high-temperature storage performance of the lithium-ion battery.

The invention discloses a method for preparing a silica aerogel composite material by adopting a chloride-free and alcohol-free process. The method comprises the following steps: S1, adopting a water-based silicon source as a raw material, regulating the pH value of sol with a chloridion-free acid, adding an additive after desalting, and uniformly stirring to obtain a first mixed solution; S2, immersing a fiber reinforced material into the first mixed solution, and completing gel curing; S3, standing the obtained composite gel material so as to obtain an aged composite gel material; S4, placing the aged composite gel material in a chloride-free and alcohol-free displacer to realize uniform solution infiltration; S5, performing surface methylsilane modification on the composite gel by usinga chloride-free surface modifier; S6, drying the modified composite gel, thereby obtaining the silica aerogel composite material. The invention provides a method for preparing the silica aerogel composite material without any chloride ion or alcohol substance in the formula.

Azo compounds whose free acid forms are represented by the general formula (1) are extremely useful as the dichroic dye to be used in polarizing plates which are excellent in polarization performance and endurance and reduced in the color cross-talk within the visible light region or in polarizers for liquid crystal projectors made by using them; (1) wherein R1 is sulfo, carboxy, or lower alkoxy and R2 is sulfo, carboxy, lower alkyl, or lower alkoxy, with the proviso that a case wherein both R1 and R2 are each sulfo is excepted; R3 to R6 are each independently hydrogen, lower alkyl, or lower alkoxy; and R7 and R8 are each independently hydrogen, amino, hydroxy, sulfo, or carboxy.