516 results about "Hydroxyproline" patented technology

Skin care compositions containing N-acyl amino acid, particularly N-acyl derivatives of Phenylalanine or Tyrosine, their isomers, or their salts; at least one other skin care active selected from sugar amines, vitamin B₃, retinoids, peptides, dialkanoyl hydroxyproline, hexamidine, salicylic acid, and phytosterol; and a dermatologically acceptable carrier for the N-acyl amino acid and the skin care active. The invention further relates to methods for regulating the condition of mammalian keratinous tissue wherein the methods each comprise the step of topically applying to the keratinous tissue of a mammal needing such treatment, a safe and effective amount of the skin care composition of the invention.

A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.

Glutamic acid derivatives, in particular monatin, may be conveniently prepared by alkylating a 4-protected hydroxyl pyroglutamic acid derivative with an alkylating agent to prepare a 4-protected hydroxyl-4-alkylglutamic acid derivative, followed by the steps of hydrolysis and deprotection. The 4-protected hydroxyl pyroglutamic acid derivative is easy to produce from hydroxyproline. The 4-protected hydroxyl pyroglutamic acid derivative is particularly suitable for use in the efficient manufacture of monatin of high optical purity, since it can be alkylated selectively at the 4-position and stereoselectively and after its alkylation, it can easily be converted to a glutamic acid derivative.

Abstract of Disclosure The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one functional group in the side chain;B is a chemical compound covalently bound to a functional group of the side chain of A, chosen from the group consisting of (a) oligopeptides having a chain length of up to 20 amino acids, (b) homopolymers of glycine consisting of up to 6 glycine monomers, and (c) polyethylene glycols having molar masses of up to 20 000 g/mol; and C is a group amide-bonded to A chosen from the group consisting of thiazolidine, pyrrolidine, cyanopyrrolidine, hydroxyproline, dehydroproline or piperidine. The invention further relates to the use of said compounds for targeted intervention in local immunological processes (chemotaxis, inflammatory processes, autoimmune diseases), as well as effective and targeted treatment of pathophysiological and physiological processes related thereto (psoriasis, periodontitis, arthritis, allergies, inflammation), inter alia.

The acid soluble fish skin collagen is prepared with sea fish skin as material and through the steps of cutting, NaCl solution soaking to eliminate impurity, alcohol and acetone defatting, soaking in mixed citric acid-acetic acid solution to extract, centrifugally separating to obtain acid soluble fish skin collagen solution, solid NaCl salt separation to obtain acid soluble fish skin collagen precipitate, dissolving in acetic acid solution, dialysis in Na2HPO4 solution or ultrafiltering with hollow acetate fiber film of molecular weight greater than 60 KDa, and vacuum freeze drying to obtain the product. The product is white, without fishy smell and spongy, and has purity over 97 %. It contains rich glycin, proline and hydroxyproline, as well as physiologically active peptide in its hydrolysate, and the collagen has molecular weight greater than 60 KDa.

The invention relates to an oral nutrition composition for beautifying skin, which contains collagen, hyaluronicacid and vitamin C, wherein the collagen is active small molecule peptide with the molecular weight of 2000-6000Dalton, the hyaluronicacid is sodium salt, zinc salt and kali salt, and the vitamin C is natural or synthesized. The invention overcomes the defects that the collagen can not be absorbed by a human body or hydrolyzed into amino acid because the molecular weight is too big, and most of the collagen loses the beautifying efficacy and the like. Hydroxyproline in collagen peptide is promoted to generate by using the vitamin C through active prolyl hydroxylases, the collagen forms big molecule collagen required by beautifying the skin by crosslinked with the hydroxyproline, the hyaluronicacid is also a better nutrient absorption promoting agent except for special water-holding function and is matched with the vitamin C and the collagen for use, which can achieve more ideal effect of promoting the hyaluronicacid to be absorbed.

There is provided a coated powder having a high skin care effect and a high anti-aging effect. The powder which can be used in cosmetics is coated with a mixture (lipoamino acid composition) comprising N-acyl derivatives (also including the form of a salt) of (1) at least one amino acid selected from proline and hydroxyproline, (2) at least one amino acid selected from alanine, glycine and sarcosine and (3) at least one amino acid selected from aspartic acid and glutamic acid, and at least one selected from fatty acids (and/or metal salts thereof) having a carbon number of at least 12 and at most 22.

The invention discloses a method for producing CIS-4-hydroxyproline. The method comprises the steps of obtaining a recombinant strain by constructing an overexpression prolyl hydroxylase gene Ecp4H in a host bacteria cell and inhibiting expressions of a prolyl hydroxylase gene putA during degradation pathway of proline and succinate dehydrogenase genes sucA and sucB, an isocitrate lyase gene aceA and an isocitrate kinase gene aceK during degradation pathway of alpha-ketoglutaric acid by utilizing a CRISPR-Cas9 technology, and conducting whole-cell transformation and production on the CIS -4- hydroxyproline after conducting fermentation and cultivation on the recombinant strain. The method for the CIS -4- hydroxyproline is simple in cultivation mode and high in strain vigor and product yield.

A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.

The invention discloses a method for preparing collagen peptide rich in hydroxyproline. The method comprises the following steps: firstly, extracting collagen from anglerfish as a raw material by using an acid liquid, subsequently performing salting-out and dialysis purification, hydrolyzing fishskin collagen by using pepsase and flavourzyme under the condition of ultrasonic wave in different steps, removing the fragrance and the color, performing centrifugal separation, and subsequently freeze-drying so as to obtain the collagen peptide rich in hydroxyproline. By adopting the method, waste of anglerfish skin is effectively utilized, and the collagen peptide rich in hydroxyproline is prepared by hydrolyzing anglerfish skin, so that not only is high nutrition value of the collagen peptide extracted from the anglerfish skin utilized, but also the problems that the waste of the anglerfish skin pollutes the environment and the resource is wasted are solved. The method for preparing the collagen peptide rich in hydroxyproline provided by the invention not only is applicable to a fish skin raw material, but also can be applicable to other raw materials, so that the method has a good application prospect.

A skin external preparation includes at least arginine, aspartic acid, isoleucine, leucine, lysine, threonine, glycine, histidine, serine, valine, tyrosine, cysteine, phenylalanine, hydroxyproline and acylglutamine among amino acids, or salts thereof, and a skin external preparation includes: at least arginine, aspartic acid, isoleucine, leucine, lysine and threonine among amino acids, or salts thereof, and a hydrolyzed silk.

The invention relates to the technical field of food, and discloses a hot pot base and a preparation method thereof. In the hot pot base, a bovine bone soup powder, bovine bone marrow powder and a beef extract which are rich in bone collagen, various amino acids such as hydroxyproline and the like, vitamins and various trace elements such as calcium, phosphorus, ferrum and the like are added into beef tallow, glutinous rice cake hot pepper, ginger, garlic, broad bean paste, fermented soya beans, table salt, white sugar, spice and monosodium glutamate which serve as raw materials, so that the hot pot base has the abundant nutrition while having fresh and fragrant taste. Compared with the hot pot base in the prior art, the hot pot base has the characteristic of fresh and fragrant taste and nutrition. The hot pot base prepared by the method is peppery but not dry, pungent but not bitter and fresh but not thin, is greased and mellow, has moderate mouthfeel and abundant nutrition, and is suitable to be eaten by people which have different dietary habits in every place.

The invention discloses a non-additivated antisenescence cosmetic, which comprises the following components by weight: a component A composed of glycerin, propylene glycol, hydroxyethyl urea, allantoin, sodium hyaluronate and water; a component B composed of MONTANOV68, dipalmitoyl hydroxyproline, caprylic/capric triglyceride, shea butter, jojoba oil, tocopheryl acetate, polydimethylsiloxane, wheat germ oil and COSMOFERMMI XIII; a component C composed of hydroxyethyl acrylate/acryloyl dimethyltaurate crosspolymer; a component D composed of nicotinamide, panthenol, beta-glucan, mycose and water; a component E composed of acetyl Hexapeptide-8 and water; and a component F composed of SYMDIOL68T and SYMTRIOL. The antisenescence cosmetic has good antisenescence effect, simultaneously, no harmful antiseptic is added in the cosmetic.

The invention discloses a collagen peptide-oligosaccharide-aloe gel liquid beverage. The liquid beverage comprises the following ingredients by weight percent: 9%-13% of collagen peptide, 3%-10% of oligosaccharide, 1%-3.5% of concentrated juice/juice powder, 2%-7% of plant extracts and the balance of water, wherein the plant extracts comprise aloe gel. Hydroxyproline, oligopeptide and aloe polysaccharide in the liquid beverage disclosed by the invention can play roles in increasing skin elasticity, reducing wrinkles, and comprehensively caring skin and beautifying in a human body. Experiments prove that the liquid beverage has an obvious effect of increasing skin water content and solves the problem that a common collagen oral solution cannot have comprehensive effects of skin care and beautification.

Pesticidal concentrate and spray compositions are described which exhibit enhanced efficacy due to the addition thereto of a compound which increases cell membrane permeability, suppresses oxidative burst, or increases expression of hydroxyproline-rich glycoproteins.

A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabino-galactan proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.

A composition comprising an amphoteric or pseudo-amphoteric agent and a polyhydroxy alpha hydroxyacid existing as a free acid, lactone, or salt, and isomeric or non-isomeric forms thereof is provided. The amphoteric or pseudo-amphoteric agent can be selected from amino acids, dipeptides, aminoaldonic acid, aminouronic acid, lauryl aminoproplyglycine, aminoaldaric acid, neuraminic acid desulfated heparin, deacetylated hyaluronic acid, hyalobiuronic acid, chondrosine, deacetylated chondroitin, creatine, creatinine, hydroxyproline, homocysteine, homocystine, homoserine, ornithine, citrulline, phosphatidylserine, and sphingomyelin. The composition may contain other additives, including cosmetic or pharmaceutical agents for topical treatment of dermatological disorders.

A new approach in the field of plant gums is described which presents a new solution to the production of hydroxyproline(Hyp)-rich glycoproteins (HRGPs), repetitive proline-rich proteins (RPRPs) and arabinogalactan-proteins (AGPs). The expression of synthetic genes designed from repetitive peptide sequences of such glycoproteins, including the peptide sequences of gum arabic glycoprotein (GAGP), is taught in host cells, including plant host cells.

The invention discloses a donkey-hide gelatin drink and a preparation method thereof, belonging to the technical field of drinks. The donkey-hide gelatin health care drink comprises the main raw materials of donkey-hide gelatin, red dates, brown sugar, high fructose corn syrup, citric acid, vitamin C, stabilizer and purified water, and is prepared by the steps of dissolving, filtrating, mixing, homogenizing, sterilizing, tinning and the like. The donkey-hide gelatin drink has the effects of beautifying human skin, enriching the blood, soothing the nerves, preventing cold and flu and the like, wherein the donkey-hide gelatin drink contains a special amino acid-hydroxyproline which is a purified collagen protein and is the best way of ensuring the collagen synthesis of skin regeneration, therefore, the donkey-hide gelatin drink has the effects of moisture preservation, anti-wrinkle, skin repair, hair moisturizing and the like; meanwhile, because of containing the red dates and the brown sugar, the donkey-hide gelatin drink not only has the nutrition of the red dates and the brown sugar, but also has the pleasant aroma of the red dates and the sweet aroma of the brown sugar; the donkey-hide gelatin drink has a taste and an aroma which can not be blended out by food additives; and the donkey-hide gelatin drink has better beautifying effect by the complement of the skin whitening function of the brown sugar and the beautifying skin effect of the donkey-hide gelatin.

The invention belongs to the field of gene engineering, and discloses a method for production of L-4-hydroxyproline by using recombinant escherichia coli fermentation. Recombinant escherichia coli is constructed by the following method: according to a published proline-4-hydroxylase gene and tryptophan promoter sequence, first optimally designing a tryptophan tandem promoter and a proline-4-hydroxylase structure gene, then after the total gene synthesis of the tryptophan tandem gene promoter and the proline-4-hydroxylase structure gene, connecting the promoter and the structure gene to pAMP plasmid to construct recombinant plasmid pAMP-P2trp-Hyp for overexpression of proline-4-hydroxylase. The invention also discloses the application of the escherichia coli in the production of the 4-hydroxyproline, the shake flask fermentation results show that the 4-hydroxyproline prepared by the recombinant escherichia coli has a yield reached 0.31g / L, and suggest that the recombinant escherichia coli has good industrial development prospects.

Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO₂F₂) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active α-hydroxyesters and optically active 4-hydroxyprolines are particularly preferable. By performing the reaction in a two-phase system in the presence of a reaction solvent immiscible with water, a desired reaction proceeds particularly well. The present invention is a production method solving all the problems involved in conventional techniques while being industrially practicable.

The present invention relates to pharmaceuticals, foods and drinks, food additives, animal feeds and feed additives comprising an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof as active ingredients, use of an Nacylated hydroxyproline derivative or a salt thereof for the production of an arthritis preventing or treating agent, and a method for preventing or treating arthritis which comprises administering an N-acylated hydroxyproline derivative or a salt thereof, and an amino sugar or a salt thereof and/or a glycosaminoglycan or a salt thereof.