18 results about "Hydroxytyrosol" patented technology

The application discloses a green preparation method of a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative and application of the derivative in mitochondrial-targeted antioxidation, and relates to the following steps: taking hydroxytyrosol and saturated halogenated fatty acids with medium-chain length C8-C12 as raw materials, and synthesizing a medium-chain hydroxytyrosol lipoid compound through a low-field ultrasonic coupling immobilized lipase synergistic directional alcohol hydroxyl acylation reaction; and further synthesizing the lipoid compound through high-speed stirring reaction with a triphenylphosphine compound to obtain a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative. The derivative has the antioxidation effect of mitochondrial-targeted enrichment and active oxygen radical scavenging. The hydroxytyrosol derivative prepared by the application has the characteristics of green efficiency, directional bonding and simple operation. The acylation reaction of hydroxytyrosol does not need to involve flammable and explosive, easily oxidized and corrosive concentrated sulfuric acid and concentrated nitric acid, and the medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative has mitochondrial targeting, can be used as a potential mitochondrial nutritional supplement product, and has a wide application prospect in the health care functions of anti-aging, cardiovascular protection, diabetes prevention and the like.

The present application relates to a kind of synthetic hydroxytyrosol multi-enzyme catalytic method.The synthetic hydroxytyrosol multi-enzyme catalytic method described in the present application includes first module reaction, second module reaction, third module reaction in turn;The first module reaction is that glycerol is synthesized pyruvic acid by catalysis, wherein the concentration of the glycerol is 1-5mM;The second module reaction is that pyruvic acid is condensed with catechol and ammonium chloride to be L-levodopa by catalysis;Wherein, the concentration of the catechol is 1-5mM, and the concentration of the catechol is greater than the concentration of the glycerol in the first module reaction;The third module reaction is that L-levodopa is synthesized hydroxytyrosol by catalysis.The synthetic hydroxytyrosol multi-enzyme catalytic method described in the present application, reaction 4 hours hydroxytyrosol molar conversion rate can reach 71.5%, compared with one-pot method has obvious advantage, in the same reaction time molar conversion rate is compared with one-pot method and increased nearly 6 times.

This invention provides a high-esterified persimmon pectin olive oil-based anti-fatigue beverage and its preparation method. The beverage comprises: extra virgin olive oil, high-esterified persimmon pectin, maltitol, freeze-dried peach powder, L-carnitine, vitamin E, hydroxytyrosol, and distilled water. The preparation process of this invention eliminates the need for processing aids such as emulsifiers and dispersants. High-esterified persimmon pectin is prepared through a pulsed electric field pretreatment-weak acid extraction process to obtain a highly active interfacial structure. This structure allows it to form a dense composite interfacial layer with other formulation components during two-stage shear emulsification, preferentially forming a stable oil-in-water emulsion system. This achieves long-term stable dispersion of the oil and water phases and masks the original spiciness and irritation of olive oil. Simultaneously, L-carnitine is added as a fatty acid metabolism support factor, and vitamin E and hydroxytyrosol are added as synergistic antioxidant components. The anti-fatigue effect is achieved through the synergistic effect of slow-release energy from the oil phase and interfacial structure regulation.

The application provides a co-crystal mixture for improving stability and antibacterial activity of hydroxytyrosol and a preparation method and application thereof, and belongs to the technical field of cosmetics and biological medicine. The co-crystal mixture is composed of the following chemical components in mass fraction: high-melting-point hydrogen bond acceptor: 20-95%, sulfur-containing strong reducing agent: 4-35%, and hydroxytyrosol: 5-60%; wherein the high-melting-point hydrogen bond acceptor includes high-melting-point amino acid or amino acid derivative. The co-crystal mixture can significantly improve the melting point of hydroxytyrosol, prevent or slow down the moisture absorption and deterioration of hydroxytyrosol, thereby reducing the transportation cost and storage cost of hydroxytyrosol. In addition, the co-crystal mixture can be configured into an aqueous solution preparation with different proportions, can be stored for a long time without discoloration in room temperature, refrigeration and high-temperature environments, and significantly improves the storage stability and biological activity of hydroxytyrosol.

Compositions are described including a synergistic combination of hydroxytyrosol and 3-0-acetyl-11-keto-B-boswellic acid. The hydroxytyrosol may be sourced from an olive extract and the 3-0-acetyl-11-keto-B-boswellic acid may be sourced from a Boswellia serrata extract. The compositions may be formulated for oral administration to a mammalian or an avian subject. Methods for treating, repairing, or reducing damage to connective tissue caused by one or more inflammatory mediators and for reducing levels of one or more inflammatory mediators in connective tissue are provided, the methods comprising orally administering the compositions to a subject in need thereof. 20 25 20 28 75 23 A pr 2 02 5 2 4 4 2 0 6 7 4 . 1 : D C C 3 1 / 0 5 / 2 0 2 3 C O M P O S I T I O N S C O M P R I S I N G H Y D R O X Y T Y R O S O L A N D B O S W E L L I C A C I D 2 0 2 5 2 0 2 8 7 5 2 3 2 0 2 5 A p r A B S T R A C T

Stabilized oils including an edible oil and an antioxidant composition comprising α-lipoic acid and least one of ascorbic acid, ascorbyl palmitate, green tea extract, lecithin, and rosemary extract or at least one of 1,2,4-benzenetriol, carnosic acid, dihydromyricetin, dihydrorobinetin, epigallocatechin, gallic acid, 3-hydroxytyrosol, myricetin, and nepodin, and methods of preparing such stabilized edible oils. The stabilized oils may have an Oxidative Stability Index (“OSI”) at 110° C. of at least 30 hours.

This invention discloses a diglyceride-based edible oil for assisting in lowering uric acid and its preparation method, relating to the field of edible oil technology. This diglyceride-based edible oil for assisting in lowering uric acid comprises the following ingredients in parts by weight: 42-50 parts modified high-oleic sunflower seed oil, 8-12 parts food-grade glycerol, 1.5-2.5 parts immobilized Rhizopus oryzae lipase, 0.3-0.8 parts modified apigenin, 0.2-0.4 parts vitamin E, 0.3-0.5 parts monoglyceride citrate, and 1.0-1.5 parts hydroxytyrosol. This composite edible oil combines the health benefits of diglycerides with the function of assisting in lowering uric acid. It exhibits good compatibility and stability of active ingredients, high bioavailability, excellent physicochemical properties, suitability for various cooking methods, and easy storage.

The present invention relates to compositions containing a mixture of three active substances, which are derived from dive extract and are hydroxytyrosol, oleuropein, and oleocanthal, said compositions being suitable for cardioprotection.

This application discloses a modified hydroxytyrosol, cosmetics, a preparation method, and applications. The provided method for preparing the modified hydroxytyrosol includes the following steps: mixing hydroxytyrosol, lipase, oleic acid, and water; adjusting the pH to acidic; reacting the mixture; centrifuging the reaction product; allowing it to separate into layers; collecting the middle layer; and obtaining the modified hydroxytyrosol. In this method, lipase is used to catalyze the modification of hydroxytyrosol with oleic acid, preparing an ester-grafted hydroxytyrosol derivative. Compared to unmodified hydroxytyrosol, the prepared modified hydroxytyrosol exhibits significantly enhanced antibacterial effects. The prepared modified hydroxytyrosol can be used as a preservative in cosmetics or food.

The present application belongs to the field of bioengineering technology, and particularly relates to an alcohol dehydrogenase YugJ mutant and its application in fermentative production of tyrosol or hydroxytyrosol. The present application adopts a method of site-directed mutation to mutate the serine at the 41st position, the threonine at the 138th position and the valine at the 183rd position of alcohol dehydrogenase YugJ from Bacillus licheniformis into proline, serine and leucine respectively to obtain a mutant PSI (S41P / T138S / V183I). The mutant PSI improves the enzyme activity of alcohol dehydrogenase, effectively solves the problem of low alcohol performance of alcohol dehydrogenase at present, and is successfully applied to the fermentative production of tyrosol and / or hydroxytyrosol, thereby providing a new idea for improving the production level of alcohol compounds.

The application provides a hydroxytyrosol supramolecular complex and a preparation method and application thereof, and belongs to the fields of cosmetics and biological medicine technology.The supramolecular complex contains the following chemical components in mass fraction: 0.01-10% of hydroxytyrosol, 2-45% of an amino acid compound, 2-20% of alpha hydroxy acid, 2-30% of urea and 15-92% of water.The supramolecular complex can promote the transdermal delivery of hydroxytyrosol and keep the biological activity of hydroxytyrosol, and meanwhile, the supramolecular complex has high biocompatibility and can be applied to product development in the fields of antibacterial, regeneration and anti-aging.

This application relates to the field of antibacterial agents, and particularly to modified hydroxytyrosol, its preparation method, application, antibacterial agents, and cosmetics. The preparation method of the modified hydroxytyrosol includes mixing hydroxytyrosol, collagen, acidic protease, and copper peptide in an aqueous solvent, reacting them under stirring conditions at pH 4.5-5; mixing the reaction mixture with an extractant, centrifuging to separate the layers to form an upper extract layer containing the modified hydroxytyrosol, collecting the upper extract layer to obtain the modified hydroxytyrosol. This modified hydroxytyrosol exhibits significantly enhanced antibacterial activity compared to unmodified hydroxytyrosol and can be used as an antibacterial agent in cosmetics.

The application relates to the technical field of bacteriostatic product preparation, in particular to application of modified hydroxytyrosol in preparation of bacteriostatic products and bacteriostatic preparations, cosmetic substrates and cosmetics. The application comprises application of the modified hydroxytyrosol in preparation of bacteriostatic products, and the modified hydroxytyrosol is prepared by the following method: hydroxytyrosol, lipase and fatty acid raw materials are mixed in an aqueous solvent, an enzymolysis reaction is carried out under the condition that the pH is 6-6.8, the reaction product is centrifuged, and the components in the aqueous phase are collected to prepare the modified hydroxytyrosol. The modified hydroxytyrosol is used as a bacteriostatic preparation in cosmetics, the use amount of other bacteriostatic preparations in a cosmetic formula can be reduced or the composition of the bacteriostatic preparations can be simplified, and the cosmetic formula can be simplified while the cosmetic efficacy is maintained.

The application relates to the technical field of spectral analysis, in particular to a hydroxytyrosol content detection method and system for food quality inspection, which comprises the following steps: collecting spectral data of an olive oil food sample, acquiring liquid chromatography data of the food sample, determining peak points, a chromatographic peak sequence and a chromatographic peak pair half sequence, acquiring a chromatographic peak shape interference coefficient, acquiring a peak shape symmetry tilt coefficient based on the chromatographic peak shape interference coefficient and the difference between the peak points in the chromatographic peak pair half sequence, determining an adaptive asymmetric penalty coefficient, acquiring corrected olive oil food sample chromatography data, and judging whether the content of hydroxytyrosol in the olive oil food sample meets the standard. The application aims to solve the problems that the asymmetric penalty factor in the traditional BEADS algorithm cannot be dynamically adjusted according to the liquid chromatography data of the olive oil food sample, leading to overcorrection and insufficient correction of the liquid chromatography data of the olive oil food sample.

The present application relates to the technical field of skin care products, in particular to a composition for inhibiting tyrosinase activity, a whitening compound and a daily chemical product. The composition for inhibiting tyrosinase activity comprises 0.5-2.0 parts of hydroxytyrosol and 0.8-2.0 parts of resveratrol by weight. The composition can effectively inhibit the activity of tyrosinase and reduce the formation of melanin. Meanwhile, the compound provided by the present application can effectively reduce the occurrence of various skin diseases, has better biological activities such as whitening, antioxidant, anti-inflammatory, anti-aging, moisturizing and emollient, and has a good application prospect in the daily chemical market.

This application relates to the field of cosmetic technology, and particularly to the application of modified hydroxytyrosol in the preparation of moisturizing skin care oils, and the skin care oils themselves. In this application, modified hydroxytyrosol is prepared by the following method: hydroxytyrosol, lipase, and fatty acid raw materials are mixed in an aqueous solvent, and an enzymatic hydrolysis reaction is carried out under conditions of pH 6-6.8. The reaction product is centrifuged, and the components in the aqueous phase are collected to obtain modified hydroxytyrosol. Compared with unmodified hydroxytyrosol, the modified hydroxytyrosol exhibits significantly improved moisturizing, antioxidant, and lipid solubility, and can effectively prevent oil spoilage and odor deterioration in skin care oils.

This application relates to the field of cosmetic formulation technology, and particularly to a method for preparing modified hydroxytyrosol, its application, and cosmetics. The preparation method includes the following steps: hydroxytyrosol, collagen, alkaline protease, and arginine are reacted in an oxygen-containing environment in an aqueous solvent with a pH of 9-10 under stirring conditions to prepare a reaction product containing the modified hydroxytyrosol; wherein the pH of the aqueous solvent is adjusted by arginine. The modified hydroxytyrosol prepared by this method exhibits significantly enhanced free radical scavenging ability, can inhibit the expression of inflammatory factors TNF-α and IL-6, inhibit hyaluronidase activity, and thus possesses soothing and antioxidant effects. It is stable in an alkaline environment and also has moisturizing effects, making it suitable as an active ingredient in cosmetics, endowing cosmetics with at least one of the following effects: antioxidant, soothing, and moisturizing.

Present invention relates to the use of hydroxytyrosol (HT), maslinic acid (MA) and oleanolic acid (OA) as additive in feed for a domesticated animal at very early days of life or from birth. The invention provides an additive with particular amounts of these three ingredients and an additivated feedstuff ready to use comprising said additive.