184 results about "Hydroxytyrosol" patented technology

The invention discloses a hydroxytyrosol-ergothioneine eutectic crystal as well as a preparation method and application thereof, and belongs to the technical fields of medicines, foods, daily chemicals and the like. The invention provides a hydroxytyrosol-ergothioneine eutectic crystal. The X-ray powder diffraction pattern of the hydroxytyrosol-ergothioneine eutectic crystal has characteristic diffraction peaks at least corresponding to the positions where the 2 theta value is 4.21 degrees + / -0.2 degrees, 8.36 degrees + / -0.2 degrees, 12.29 degrees + / -0.2 degrees, 15.29 degrees + / -0.2 degrees, 19.40 degrees + / -0.2 degrees, 20.98 degrees + / -0.2 degrees, 23.12 degrees + / -0.2 degrees and 28.73 degrees + / -0.2 degrees. According to the hydroxytyrosol-ergothioneine eutectic, the melting point of hydroxytyrosol is increased, the hygroscopicity of hydroxytyrosol is remarkably reduced, and meanwhile the stability of hydroxytyrosol and ergothioneine is enhanced. In addition, after the ergothioneine hydroxytyrosol forms the eutectic crystal, the ergothioneine hydroxytyrosol can also play better anti-oxidation and anti-aging effects.

The invention relates to an anti-oxidation composition based on a reverse micelle synergistic technology and a preparation method and application thereof, the anti-oxidation composition comprises a reverse micelle structure and an aqueous solution containing an anti-oxidation active matter, and the reverse micelle structure wraps the aqueous solution containing the anti-oxidation active matter. The reverse micelle structure is used for wrapping the water-soluble antioxidant active matter, oxidation or degradation discoloration of the water-soluble antioxidant active matter is prevented, after the antioxidant active matter such as hydroxytyrosol, ergothioneine and dipotassium glycyrrhizinate is wrapped by the reverse micelle, the stability and the effect are remarkably improved, and after the reverse micelle wrapping, the effect of the antioxidant active matter is improved by 17% or above compared with an aqueous solution before wrapping.

The invention discloses an anti-aging face cream suitable for sensitive skin and a preparation method of the anti-aging face cream. The anti-aging face cream comprises 1-10 wt% of a supramolecular eutectic compound, 10-30 wt% of an auxiliary material and the balance of deionized water, the supramolecular eutectic compound comprises an anti-aging component, a supramolecular eutectic agent and Neosol-Aqulio, wherein the supramolecular eutectic agent is used for forming a supramolecular eutectic with the anti-aging component, and the Neosol-Aqulio is dispersed in the supramolecular eutectic; wherein the anti-aging component comprises oleuropein and hydroxytyrosol, and the supramolecular eutectic agent is nicotinamide, or a mixture of capryloyl glycine and betaine. Neosol-Aqulio, a supramolecular eutectic agent and an anti-aging component are utilized to form a supramolecular eutectic, so that active component delivery is facilitated, efficient transdermal absorption is realized, permeability, stability and mildness of the anti-aging active component are improved, the problem of sensitive skin cuticle permeation is solved, irritation of a traditional penetration enhancer is avoided, and the penetration enhancer is suitable for clinical application. The double effects of efficient permeation and mild anti-aging are realized.

The invention provides a hydroxytyrosol supramolecular compound and a preparation method and application thereof, and belongs to the technical field of cosmetics and biological medicine, the supramolecular compound comprises the following chemical components by mass: 0.01-10% of hydroxytyrosol, 2-45% of an amino acid compound, 2-20% of alpha hydroxy acid, 2-30% of urea, and 15-92% of water. The supramolecular compound can promote transdermal delivery of hydroxytyrosol and maintain the biological activity of hydroxytyrosol, shows high biocompatibility, and can be applied to product development in the antibacterial field, the regeneration field and the anti-aging field.

The invention discloses a hydroxytyrosol ectoine eutectic as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The molar ratio of hydroxytyrosol to Ectoine in the hydroxytyrosol Ectoine eutectic is 1: 1. The preparation method comprises the following steps: (1) weighing hydroxytyrosol and Ectoin according to a molar ratio, adding the hydroxytyrosol and Ectoin into a solvent, and carrying out heat preservation and stirring until the hydroxytyrosol and Ectoin are completely dissolved; (2) depressurizing the solution in the step (1) to remove the solvent to obtain a concentrated solution; and (3) carrying out low-temperature stirring crystallization on the concentrated solution, and drying to obtain the hydroxytyrosol Ectoine eutectic. The hydroxytyrosol Ectoin eutectic can be used for preparing anti-inflammatory drugs, vascular dilation drugs, antibacterial drugs or anti-cancer drugs, and can also be used for preparing moisturizing cosmetics, anti-aging cosmetics, anti-oxidation cosmetics, anti-wrinkle cosmetics and repair cosmetics. According to the hydroxytyrosol Ectoine eutectic prepared by the invention, the melting point of hydroxytyrosol can be increased from the molecular level, the stability of hydroxytyrosol is improved, and the application field of hydroxytyrosol is widened.

The invention provides a hydroxytyrosol-loaded soluble microneedle as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. The microneedle comprises a substrate layer and a needle body arranged on the surface of the substrate layer, the needle body comprises 0.01%-20% of hydroxytyrosol and 1%-10% of hyaluronic acid, the molecular weight of the hyaluronic acid is 100-1000 kDa, and the% is mass percentage content w / w or mass volume percentage content w / v. The soluble microneedle is mild and controllable in preparation process, does not need high temperature, is simple in preparation and use method, and is green, safe and pollution-free; the matrix material is simple, no organic solvent is used, only water is used as a solvent and an adhesive, and no extra cross-linking agent needs to be added; the hydrogel is good in needle forming property, good in biocompatibility, high in safety, high in mechanical strength, excellent in transdermal drug delivery effect and capable of remarkably improving skin photoaging.

The invention belongs to the technical field of functional food processing, and particularly relates to a method for synergistically improving functional characteristics by utilizing casein peptide and hydroxytyrosol self-assembly. According to the research, casein peptide with an excellent antioxidant function is used as a raw material, and hydroxytyrosol is added to be self-assembled with the casein peptide, so that the antioxidant activity is synergistically improved in an in-vitro digestion stage. Compared with a traditional protein and polyphenol combination technology, the casein peptide and polyphenol self-assembly method is provided, the antioxidant activity after digestion is improved, no toxic chemical reagent is introduced or added, and the casein peptide and polyphenol self-assembly method is safer, more efficient, more environmentally friendly and more sustainable. The method can be widely applied to functional food or health care products.

The invention discloses modified hydroxytyrosol as well as a preparation method and application thereof. The provided preparation method of the modified hydroxytyrosol comprises the following steps: in the presence of an acidic solvent, mixing hydroxytyrosol, protease and collagen for reaction, mixing a reaction product with an extraction agent, performing centrifugal layering, and collecting upper-layer components, thereby obtaining the modified hydroxytyrosol, the protease comprises one or two of neutral protease and trypsin. Under the enzymolysis action of protease, the collagen can be decomposed into amino acid monomers such as glycine, proline and hydroxyproline, and the amino acid monomers can be subjected to graft modification with hydroxytyrosol; meanwhile, collagen fragments which are not subjected to enzymolysis also exist, and are subjected to graft modification with hydroxytyrosol in the form of collagen characteristic fragments. The oxidation resistance and the stability of the obtained modified hydroxytyrosol are obviously improved compared with those of unmodified hydroxytyrosol.

The invention discloses modified hydroxytyrosol as well as a preparation method and application thereof. The provided preparation method of the modified hydroxytyrosol comprises the following steps: in the presence of an acidic buffer solution, mixing hydroxytyrosol and vitamin C ethyl ether, and carrying out a dehydration condensation reaction to prepare the modified hydroxytyrosol. According to the provided preparation method of the modified hydroxytyrosol, the vitamin C ethyl ether is adopted to modify the hydroxytyrosol, the preparation method is simple and easy to operate, and the prepared modified hydroxytyrosol has high oxidation resistance and inflammation resistance.

The invention discloses a novel application of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside in promotion of melanogenesis, and relates to a preparation method of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol. Hydroxytyrosol is a phenolic plant chemical substance, has good pharmacological effects in the aspects of microorganism resistance, inflammation resistance, tumor resistance, oxidation resistance, cardiovascular disease and metabolic syndrome treatment, detoxification and the like, and is widely applied to various fields. The pharmacological action of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside in promoting melanogenesis is verified by analyzing the melanogenesis condition of hydroxytyrosol or 3, 4-dihydroxyphenethyl alcohol-O-beta-D-glucoside on recombinant human tyrosinase, mouse B16 cells and wild zebra fish melanin of AB strains. The invention finds that the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside can obviously promote the generation of melanin, a new thought can be provided for blackening, treating hypopigmentation diseases, blackening hair and the like by utilizing the new biological activity of the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside, and the new medical application of the hydroxytyrosol or the 3, 4-dihydroxyphenylethanol-O-beta-D-glucoside is expanded.

The invention discloses an anti-aging composition, a preparation method and application of the anti-aging composition in skin aging resistance, belongs to the technical field of cosmetics, and aims at solving the problems that in related technologies, anti-aging cosmetics are instable in functional components, and the skin aging resistance of transdermal absorbability and functional component combination needs to be further improved. The anti-aging composition is prepared from the following components in percentage by total weight of the composition: 10 to 20 percent of an anti-aging functional composition and 80 to 90 percent of an auxiliary material matrix, the composition with the anti-aging effect is prepared from the following main components: ascorbyl tetraisopalmitate, epigallocatechin gallate, hydroxytyrosol, a calendula extract, curcumin, resveratrol and glutathione. The anti-aging composition prepared by the invention has good stability, transdermal absorbability and capability of improving skin aging resistance.

The invention discloses modified hydroxytyrosol as well as a preparation method, cosmetics and application thereof. The provided preparation method of the modified hydroxytyrosol comprises the following steps: in the presence of an acidic solvent, hydroxytyrosol and bromelain are mixed for an enzymatic hydrolysis reaction, and the modified hydroxytyrosol is prepared. According to the provided preparation method of the modified hydroxytyrosol, the hydroxytyrosol is subjected to catalytic modification through bromelain, bromelain serves as typical sulfydryl protease and is subjected to an enzymolysis reaction with the hydroxytyrosol, the hydroxytyrosol enzymolysis derivative is generated, and the generated hydroxytyrosol enzymolysis derivative contains various substances with aromatic smells, so that the hydroxytyrosol can be used for preparing the modified hydroxytyrosol. The obvious pungent smell of the hydroxytyrosol raw material is effectively improved.

The invention relates to the technical field of active ingredient extraction, in particular to an ergothioneine-hydroxytyrosol mixture and a preparation method and application thereof, and optimizes a culture medium formula for producing ergothioneine through submerged liquid fermentation of pleurotus citrinopileatus mycelium. In the later stage of the process of producing ergothioneine by mycelium fermentation, a culture medium formula is designed according to nutritional ingredients required by hydroxytyrosol biosynthesis to supplement a sterile culture medium, and meanwhile, secondary metabolites and residual nutritional ingredients generated by fermentation of pleurotus citrinopileatus mycelium are fully utilized; the ergothioneine-hydroxytyrosol mixture is obtained through biosynthesis fermentation of hydroxytyrosol, the production period is short, the efficiency is high, the energy consumption is low, the ergothioneine-hydroxytyrosol mixture is green and safe, nutritional ingredients of a culture solution can be fully utilized, the overall production cost is reduced, the comprehensive production efficiency and productivity are improved, no waste liquid is discharged, and the subsequent application requirements are better met.

The invention relates to an anti-allergy and repairing skin care composition and a preparation method and application thereof.The anti-allergy and repairing skin care composition comprises an oil-phase raw material, a water-phase raw material and a surfactant which are emulsified, the oil-phase raw material comprises hydroxytyrosol, olive oil and kojic acid dipalmitate, and the water-phase raw material comprises hydroxytyrosol, olive oil and kojic acid dipalmitate; the water-phase raw materials comprise a cyclodextrin-included eurotium cristatum fermentation extract, Ectoine and water. According to the skin care composition disclosed by the invention, the eurotium cristatum fermentation extract is included by the cyclodextrin, so that the stability, the solubility and the bioavailability of the eurotium cristatum fermentation extract are improved, and the irritation is reduced; according to the skin care composition, the hydroxytyrosol, the olive oil, the kojic acid dipalmitate, the cyclodextrin-included eurotium cristatum fermentation extract and the Ectoine are compounded, and all the components have a synergistic effect in the aspect of improving the allergy-relieving and repairing effects of the product.

The invention discloses a redness repairing and relieving composition as well as a preparation method and application thereof. The red repairing and relieving composition comprises a red repairing and relieving functional agent, wherein the components of the red repairing and relieving functional agent comprise a phenolic compound and a phenolic acid compound; the phenolic compound is selected from at least one of hydroxytyrosol and tyrosol; the phenolic acid compound is selected from at least one of caffeic acid, protocatechuic acid, plateau catechuic acid and ethyl protocatechuate. The composition can inhibit release of inflammatory factors, relieve itching, resist inflammation, calm skin and reduce angiogenesis, and meanwhile can enhance the skin water locking capacity, improve the skin water shortage condition and enable the skin to recover to be moisturized, tender and smooth.

The invention discloses modified hydroxytyrosol, a cosmetic, a preparation method and application. The provided preparation method of the modified hydroxytyrosol comprises the following steps: in the presence of an acidic solvent, mixing hydroxytyrosol, lipase and fatty acid ester for reaction, centrifugally layering a reaction product, and collecting components of a middle layer to prepare the modified hydroxytyrosol. According to the provided preparation method of the modified hydroxytyrosol, lipase and fatty acid ester are subjected to an enzyme digestion reaction, an active hydroxyl group in a product obtained through the enzyme digestion reaction and hydroxytyrosol are subjected to a dehydration reaction, so that an ester group molecular chain is grafted into hydroxytyrosol, and a modified hydroxytyrosol product with an ester group is prepared. And the obtained modified hydroxytyrosol has relatively high fat solubility and oxidation resistance.

The invention discloses a heterozygote of 3-hydroxylase and application of the heterozygote in production of levodopa, caffeic acid or hydroxytyrosol, and relates to the technical field of biology. The heterozygote of the 3-hydroxylase comprises HpaB and HpaC, and the 3-hydroxylase comprises HpaB and HpaC. The limitation of the catalytic efficiency of hydroxylase in the prior art is overcome, the production efficiency of levodopa, caffeic acid or hydroxytyrosol is remarkably improved, and the method has a very good application prospect. The expression levels of HpaB and HpaC are properly regulated and controlled by using connecting element sequences such as a connecting peptide sequence and a 5 '-UTR sequence, so that a better production effect can be obtained.

The invention discloses a strain for de novo synthesis of hydroxytyrosol and application of the strain, and belongs to the technical field of biology. The recombinant escherichia coli E.coli HT delta-glk provided by the invention can realize conversion of glucose and glycerol into hydroxytyrosol, the yield of produced hydroxytyrosol can reach 4.27 g / L, which is 3.62 times of the yield of hydroxytyrosol produced by YMGRH1D1 fermentation, and an inducer does not need to be added in the fermentation process; therefore, the raw materials are cheap and easy to obtain, additives, heavy metals and antibiotics which are harmful to human health are avoided, a good foundation is laid for later product purification, and the requirements of commercial application can be better met.

The invention belongs to the technical field of preparations, and particularly relates to solid lipid nanoparticles wrapping hydroxytyrosol as well as a preparation method and application of the solid lipid nanoparticles. According to the method, an acid environment is created by adjusting the pH value, hydroxytyrosol is dissolved in grease, and then possibility is provided for wrapping hydroxytyrosol by the grease; hydroxytyrosol is wrapped by solid grease, then the solid lipid nanoparticle emulsion is prepared, and the stability of hydroxytyrosol is remarkably improved.

The invention belongs to the technical field of cosmetic preparations, and particularly relates to a composition containing triethanolamine and tranexamic acid modified hydroxytyrosol as well as a preparation method and application of the composition. According to the invention, hydroxytyrosol is modified by using triethanolamine and tranexamic acid through etherification and esterification reactions, the processing mode obviously enhances the electrification capability of hydroxytyrosol, and further obviously enhances the antibacterial strength of hydroxytyrosol, so that hydroxytyrosol is compounded with triethanolamine and tranexamic acid to replace a traditional preservative, and the antibacterial property of hydroxytyrosol is improved. And adverse reactions such as irritation and allergy of common preservatives are improved. According to the invention, the hydroxytyrosol is modified by using triethanolamine and tranexamic acid, and triethanolamine and tranexamic acid are functional components, so that triethanolamine and tranexamic acid can play roles in resisting oxidation, whitening and the like together with hydroxytyrosol in a cosmetic matrix while playing a role in improving the bacteriostasis of hydroxytyrosol.

The invention relates to the technical field of antibacterial peptide extraction, and particularly discloses a marine organism antibacterial peptide component extraction process which comprises the following steps: S1, degreasing treatment; step S2, crude extraction; s3, electric field modification; step S4, performing enzymolysis; step S5, fine purification; according to the technical scheme, a buffer solution is added in the crude extraction process, meanwhile, shearing auxiliary heat treatment is matched, an acid value adjusting solution and hydroxytyrosol are added in the electric field modification process, and functionalized silica gel is added in the fine purification process to adsorb enzymatic hydrolysate. The purity and the yield of the antibacterial peptide component are improved.

The invention discloses saccharomyces cerevisiae with high yield of salidroside as well as a construction method and application of the saccharomyces cerevisiae. According to the recombinant saccharomyces cerevisiae, ribulose-5-phosphate isomerase RKI1 and transketolase TKL1 are expressed in host bacteria, so that precursor supply is increased; reverse methyltransferase ARO2 and phenylalanine decarboxylase ARO10 are expressed at the same time, and a tyrosine branch pathway is adjusted; then, UDP-glycosyl transferase of different sources is expressed, and iterative site-specific mutagenesis is carried out on the UDP-glycosyl transferase to enhance conversion of hydroxytyrosol to salidroside; the salidroside production performance of the recombinant strain is verified on the basis of a precursor supply pathway, a tyrosine regulation pathway and key enzyme screening, and the salidroside production capacity of the saccharomyces cerevisiae is further improved.

The invention discloses modified hydroxytyrosol, flavored hydroxytyrosol, a preparation method of the modified hydroxytyrosol, a preparation method of the flavored hydroxytyrosol, functional food and cosmetics. Activated carbon loaded p-toluenesulfonic acid is used as a catalyst to catalyze papain to modify hydroxytyrosol, so that the effect activity of the modified hydroxytyrosol raw material is reserved, and meanwhile, the bad flavor generated by impurities in industrial production of the hydroxytyrosol raw material is remarkably reduced; furthermore, the smell and the flavor of the hydroxytyrosol raw material are remarkably improved, the application effect of the hydroxytyrosol raw material in related fields is improved, and the use sensory experience of the product is improved. The flavor of hydroxytyrosol is improved in an enzyme preparation catalysis mode, and the process method is green and safe.

The invention relates to the technical field of cosmetics, and particularly discloses a water-based system for improving EUK-134 stability and application of the water-based system in preparation of cosmetics. The water-based system for improving the stability of the EUK-134 is prepared from the EUK-134, hydroxytyrosol, 1, 3-butanediol and water. Most preferably, in the aqueous system, the mass percentages of EUK-134, hydroxytyrosol, 1, 3-butanediol and water are as follows: 0.1% of EUK-134, 0.1% of hydroxytyrosol, 0.1% of 1, 3-butanediol and the balance of water. 2% of hydroxytyrosol; 20% of 1, 3-butanediol; and 77.9% of water. Researches show that hydroxytyrosol, 1, 3-butanediol and EUK-134 are added into water together to prepare a water-based system; and the stability is greatly higher than that of an EUK-134 aqueous solution.

The application discloses a chemical synthesis method of hydroxytyrosol glucoside. The method uses hydroxytyrosol as a starting material, and acetyl protection, glycosylation, hydrolysis and other steps are performed to prepare the hydroxytyrosol glucoside. The synthesis method of the hydroxytyrosol glucoside has the characteristics of low cost, simple process and industrialization.

Triphenylphosphonium hydroxytyrosol TPP-HT, its synthesis method and application in the preparation of drugs for improving aortic endothelial cell function. TPP-HT can significantly increase the reduction of human aortic endothelial cell activity caused by saturated fatty acids, inhibit the inflammatory response and oxidative stress caused by saturated fatty acids, and at the same time increase the synthesis of ATP in vascular endothelial cells and the expression of mitochondrial complex II. By anti-inflammatory and protecting mitochondrial function, it can prevent the occurrence and development of atherosclerosis. Therefore, TPP-HT has good application prospects in preventing cardiovascular diseases such as atherosclerosis caused by high-fat-induced endothelial damage, opening up a new medical approach for preventing a series of problems of cardiovascular diseases such as atherosclerosis caused by endothelial damage due to unbalanced dietary structure, and providing a new basis for the development of new drugs.

The present invention discloses a method for synthesizing hydroxytyrosol by multi-enzyme cascade, comprising: 1) preparing a hydroxytyrosol product by using 3,4-dihydroxybenzaldehyde, L-threonine, sodium formate, NAD + As raw material, L-threonine transaldolase, alcohol dehydrogenase, and formate dehydrogenase are used to catalyze the synthesis of L-threo-3-(3,4-dihydroxyphenyl)serine; 2) L-threo-3-(3,4-dihydroxyphenyl)serine is used as substrate, glucose, NAD + Hydroxytyrosol is synthesized through a cascade catalysis of phenylserine dehydratase, α-ketoacid decarboxylase, aldehyde reductase, and glucose dehydrogenase. The synthesis method provided by the present invention achieves a hydroxytyrosol yield of >99% and a space-time yield of 0.88 g / L / h, currently the highest, showing great potential for industrial application and suitable for further promotion and application.

The application discloses a green preparation method of a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative and application of the derivative in mitochondrial-targeted antioxidation, and relates to the following steps: taking hydroxytyrosol and saturated halogenated fatty acids with medium-chain length C8-C12 as raw materials, and synthesizing a medium-chain hydroxytyrosol lipoid compound through a low-field ultrasonic coupling immobilized lipase synergistic directional alcohol hydroxyl acylation reaction; and further synthesizing the lipoid compound through high-speed stirring reaction with a triphenylphosphine compound to obtain a medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative. The derivative has the antioxidation effect of mitochondrial-targeted enrichment and active oxygen radical scavenging. The hydroxytyrosol derivative prepared by the application has the characteristics of green efficiency, directional bonding and simple operation. The acylation reaction of hydroxytyrosol does not need to involve flammable and explosive, easily oxidized and corrosive concentrated sulfuric acid and concentrated nitric acid, and the medium-chain acylated hydroxytyrosol lipoid-triphenylphosphine derivative has mitochondrial targeting, can be used as a potential mitochondrial nutritional supplement product, and has a wide application prospect in the health care functions of anti-aging, cardiovascular protection, diabetes prevention and the like.

The application provides a kind of dynamic monitoring method and system of olive leaf polyphenol components based on principal component analysis, it is related to computer technology field, comprising: obtaining original data;According to the original data, the spectrum interval is separated, and the purified polyphenol characteristic spectrum sequence is obtained;According to the purified polyphenol characteristic spectrum sequence, spectral deconvolution processing is carried out, and the polyphenol subcomponent concentration evolution matrix is obtained;According to the polyphenol subcomponent concentration evolution matrix, the principal component is reconstructed, and the reconstruction result is obtained;According to the reconstruction result, track fitting is carried out, by fitting the principal component score track into the kinetic network model containing hydroxytyrosol glycoside hydrolysis and oxidative condensation step, the fitting result is obtained;According to the fitting result, prediction is carried out, the evolution end point of hydroxytyrosol free state content and its derivative relative proportion is predicted, and the dynamic monitoring result is obtained.The application realizes the accurate monitoring and prediction of the dynamic conversion process of specific polyphenol components such as hydroxytyrosol glycoside and oleuropein in olive leaves.

The invention relates to the technical field of spectral analysis, in particular to a hydroxytyrosol content detection method and system for food quality inspection.The method comprises the steps that spectral data of an olive oil food sample are collected, liquid chromatographic data of the food sample are obtained, a peak point, a chromatographic peak sequence and a chromatographic peak half-and-half sequence are determined, a chromatographic peak shape interference coefficient is obtained, and a hydroxytyrosol content detection result is obtained. Acquiring a peak shape symmetric inclination coefficient based on the chromatographic peak shape interference coefficient and the difference before and after peak points in the chromatographic peak half-and-half sequence, determining a self-adaptive asymmetric penalty coefficient, acquiring chromatographic data of the corrected olive oil food sample, and judging whether the content of hydroxytyrosol in the olive oil food sample reaches the standard or not. The method aims at solving the problems that in a traditional BEADS algorithm, an asymmetric penalty factor cannot be dynamically adjusted according to the liquid chromatogram data of the olive oil food sample, so that the liquid chromatogram data of the olive oil food sample is excessively corrected and is not sufficiently corrected.