109 results about "Nicotinamide riboside" patented technology

The invention belongs to the technical field of stem cell biological preparations, and particularly relates to an anti-aging compound preparation based on stem cells and application of the anti-aging compound preparation in delaying skin aging. The composition is composed of an inner water phase, a middle oil phase and an outer water phase, wherein the inner water phase is prepared from the following components: stem cell exosomes, hyaluronic acid, nicotinamide ribose, trehalose, mannitol, glycine and a citric acid buffer solution; the medium oil phase is prepared from the following components: medium chain triglyceride, shea butter, vitamin E succinate, PEG (Polyethylene Glycol) modified ceramide NP and cholesterol succinic acid monoester; the external water phase is prepared from the following components: polydatin, cellulose nanocrystals and an emulsifying agent. On the basis of a W / O / W emulsion system, a multi-layer anti-aging mechanism is constructed by utilizing a three-dimensional delivery framework of an inner water phase, an oil phase and an outer water phase and space-time synergy of active ingredients, the exosome permeation efficiency is improved through microneedle introduction, and the anti-oxidation and barrier repair effects are achieved by using multiple ingredients.

The invention belongs to the technical field of biochemistry, and particularly relates to application of nicotinamide ribose malate in light aging resistance. The invention provides an application of nicotinamide ribose malate in light aging resistance, and particularly relates to an application of nicotinamide ribose malate in quantitative light aging resistance of human immortalized keratinocytes. According to the invention, 0.375 mg / mL to 1.50 mg / mL of nicotinamide ribose malate is used for resisting light aging of the skin, and the light aging resisting effect is improved by 12.13% to 35.09%. Particularly, 1.50 mg / mL of nicotinamide ribose malate is used for resisting light aging of human immortalized keratinocytes, the light aging resisting effect is improved by 35.09%, and the light aging resisting effect is obvious.

The invention relates to an engineering bacterium for synthesizing mannitol by using fructose and nicotinamide ribose and application thereof. The invention provides genetic recombination escherichia coli for synthesizing D-mannitol by using D-fructose and nicotinamide ribose, which comprises the following modifications: insertion or enhanced expression of a gene cluster 1, the gene cluster 1 comprises a D-mannitol dehydrogenase coding gene MDH and a formate dehydrogenase coding gene FDH; deletion or inhibitory expression of a gene cluster 2, wherein the gene cluster 2 comprises a 6-phosphofructokinase 1 coding gene pfkA; and insertion or enhanced expression of a gene cluster 3, wherein the gene cluster 3 comprises a nicotinamide ribokinase coding gene NRK, a nicotinamide mononucleotide adenosine transferase coding gene NMNAT, a polyphosphate kinase coding gene PPK2 and a pyrophosphohydrolase coding gene IPPa. The strain disclosed by the invention can effectively synthesize high-purity D-mannitol by using D-fructose as a production raw material and nicotinamide ribose as a co-substrate through an enzyme catalytic reaction under the condition of not additionally adding NAD < + > or NADP < + >, so that the production cost is greatly reduced.

The present invention discloses the use of a nonspecific 5'-nucleotidase in the preparation of nicotinamide riboside. The nonspecific 5'-nucleotidase is selected from a nonspecific 5'-nucleotidase derived from Shewanella sp. HN-41. The nonspecific 5'-nucleotidase of the present invention can efficiently catalyze the hydrolysis of high-concentration nicotinamide mononucleotide (NMN) to produce nicotinamide riboside (NR), exhibits high enzymatic activity, and has value for industrial application.

The invention relates to an anti-aging capsule compounded by PQQ and mitochondrial nutrients, and discloses an anti-aging capsule which is prepared by synergistically compounding a plurality of mitochondrial nutrients according to a scientific proportion and supplementing high-purity raw materials and slow-release dosage forms to realize energy metabolism activation and anti-oxidation synergistic intervention. Therefore, the anti-aging capsule systematically delays aging through multi-target regulation and control of mitochondrial functions. The capsule is characterized by comprising the following components in parts by weight: 1-20 mg of pyrroloquinoline quinone disodium salt (PQQ), 20-100 mg of coenzyme Q10, 50-200 mg of L-carnitine tartrate, 10-100 mg of alpha-lipoic acid, 50-300 mg of nicotinamide mononucleotide (NMN) or nicotinamide nucleoside (NR), and 10-50 [mu] g of selenoprotein or organic selenium yeast, and a capsule carrier comprises 100 mg of gelatin or a plant-derived capsule shell, 180 mg of microcrystalline cellulose, 5 mg of magnesium stearate and 5 mg of silicon dioxide.

According to the lipid nanoparticles and the synthesis method thereof, the lipid nanoparticles comprise lipidosome, curcumin and nicotinamide ribose. The mass ratio of curcumin to nicotinamide ribose ranges from 1: 1 to 1: 10. Adding nicotinamide ribose into water to form a water-phase liquid; adding curcumin into the basic lipid to form an oil-phase liquid; and mixing the oil-phase liquid with the water-phase liquid to form a lipid nanoparticle solution. The medicine can be delivered through the nasal cavity, bypasses the blood brain barrier and directly and quickly enters the brain, has better targeting property on nerve diseases, and can make key components of the medicine directly reach nerves, so that the medicine has a better treatment effect on the nerve diseases.

A nicotinamide riboside hydrogen malate crystal has characteristic peaks respectively at 2θ values of 3.1703±0.2, 6.6434±0.2, 12.5953±0.2, 14.7209±0.2, 15.8502±0.2, 16.5144±0.2, 17.0509±0.2, 17.7053±0.2, 18.6569±0.2, 18.9470±0.2, 19.7757±0.2, 21.4535±0.2, 21.9161±0.2, 22.3721±0.2, 22.9562±0.2, 24.0469±0.2, 24.8641±0.2, 25.2183±0.2, 25.7679±0.2, 27.2584±0.2, 28.5494±0.2, 36.5968±0.2 and 36.8355±0.2. In the preparation of such crystal, DL-malic acid is dissolved in a solvent under stirring, to which a nicotinamide riboside chloride and a base are added for reaction. The reaction mixture is cooled, crystallized at a constant temperature, filtered and dried to give the desired crystal.

The invention relates to the field of chemical raw materials, in particular to an organic acid salt of nicotinamide ribose, a crystal form and a preparation method thereof. The invention discloses an organic acid salt of nicotinamide ribose, and in the organic acid salt of nicotinamide ribose, organic acid is selected from acetic acid, citric acid or fumaric acid; the molar ratio of the nicotinamide ribose to the organic acid is 1: (1-1.5). The invention also discloses a preparation method of the organic acid salt of nicotinamide ribose. The invention also discloses a crystal form A and a crystal form B of the nicotinamide ribose hydrogen fumarate. The nicotinamide ribose hydrogen fumarate in two crystal forms is good in flowability, low in hygroscopicity, good in stability, free of color change, capable of keeping a solid form, low in effective concentration, capable of reducing the use cost, more suitable for batch production and wider in application scene.

The invention discloses a multi-system function regeneration factor composition as well as a preparation method and application thereof. The multi-system function regeneration factor composition is prepared from the following components in parts by mass: 0.8 to 2.4 parts of melatonin, 84 to 126 parts of nicotinamide ribose and 42 to 84 parts of resveratrol. According to the multi-system functional regeneration factor composition disclosed by the invention, through scientific proportioning and synergistic effect of melatonin, nicotinamide ribose and resveratrol, the functions of stem cells are strongly activated, proliferation of the stem cells is remarkably promoted, the stemness maintaining capability of the stem cells is improved, osteogenesis and adipogenesis differentiation potential is enhanced, and the regeneration effect of the stem cells is improved. Meanwhile, an NAD < + > metabolic pathway is activated so as to strengthen cell energy and anti-aging capability. The capsule adopts the design of combining quick-release pellets and sustained-release pellets, the quick-release part can quickly release melatonin, the local drug concentration can be increased in a short time, and stem cell activation signals can be quickly started; and the sustained release part slowly releases nicotinamide ribose and resveratrol to maintain the long-acting stability of the drug concentration, so that the effect taking speed is ensured, the action time is prolonged, and the bioavailability is greatly improved.

The invention discloses a production method for improving the ring opening rate of monascus milovastatin, and belongs to the technical field of monascus rice production. According to the method, a monascus purpureus high-yield strain is selected and inoculated into a solid indica rice matrix containing a specific additive for fermentation after spore activation, and the matrix comprises 1, 5-p-coumaroylquinic acid, sodium acetate, sodium citrate, a thermally modified soybean protein isolate polysaccharide sulfate compound and other components. Wherein sodium acetate and sodium citrate can serve as short-chain fatty acid precursors, the activity of closed-loop lactonase is inhibited through pH regulation, and generation of lactone type products is reduced; 1, 5-p-coumaroylquinic acid activates the expression of a polyketide synthase gene cluster, so that the synthesis flux of the Monacolin K with an open-loop structure is improved; nicotinamide ribose enhances the electron transfer efficiency of glycolysis and TCA circulation, provides sufficient ATP for polyketone synthesis, and promotes synthesis of Monacolin K. The compound further strengthens the synthesis flux of secondary metabolites by changing the form of hyphae and continuously releasing a nitrogen / carbon source, and promotes intracellular products to be transferred to extracellular.

The invention belongs to the technical field of formula foods for special medical purposes, and particularly relates to a fat component for treating Alzheimer's disease and a preparation method of the fat component. The fat component is prepared from the following raw materials in parts by weight: medium-chain triglyceride, starch sugar, silicon dioxide, sodium caseinate, starch sodium octenylsuccinate, mono-glycerol fatty acid ester, diglycerol fatty acid ester and potassium hydroxide. And a neuroprotective nutrient combination. According to the invention, the medium-chain triglyceride capable of supplying energy quickly is creatively combined with the nerve protection nutrient with a specific mechanism. The medium-chain triglyceride provides efficient ketone energy; magnesium citrate stabilizes the excitability of neurons; the nicotinamide ribose supports cell energy metabolism; the omega-3 fatty acid plays roles in resisting inflammation and repairing nerve cell membranes. The four components provide protection from energy supply, neuron stabilization, metabolism support and structure repair, and bring better neurological function prognosis while controlling the Alzheimer's disease.

The present invention relates to the technical field of ribose preparation, specifically a preparation device and a preparation method for preparing nicotinamide riboside by using a biological enzyme method, including a reaction kettle, on which an adjustment mechanism is arranged, and a pH balance mechanism is also arranged; the reaction kettle includes a motor, on which a rotating rod is arranged, on the rotating rod there are stirring paddles, and an outlet plate is also arranged on the reaction kettle, and a handle is arranged on the outlet plate; the adjustment mechanism includes a first piston rod, on which a second piston rod is arranged, on the second piston rod there is a first insertion rod, and the first piston rod penetrates through the second piston rod. The purpose of the present invention is to provide the insertion of the first insertion rod with the first piston rod and the second piston rod, control whether the first insertion rod is connected to the first piston rod, and respectively control the amount of raw materials added and the amount of catalyst added as needed, so that the reaction proceeds maximally and the product nicotinamide riboside can be obtained to the greatest extent.

A composition containing nicotinamide mononucleotide (NMN) or an analog thereof, and certain antioxidants, more specifically resveratrol and at least one of ergothioneine and hydroxytyrosol, can be used in an anti-aging and / or anti-inflammatory method. The composition can contain NMN or nicotinamide riboside (NR) in an amount of from about 101 mg to about 1500 mg; the resveratrol in an amount of from about 50 mg to about 500 mg; ergothioneine or salt thereof, when present, in an amount of from about 3 mg to about 25 mg; and the hydroxytyrosol, when present, in an amount of from about 20 mg to about 100 mg.

The invention relates to the technical field of ribose preparation, in particular to a preparation device and method for preparing nicotinamide ribose by applying a biological enzyme method, the preparation device comprises a reaction kettle, an adjusting mechanism is arranged on the reaction kettle, and a pH balance mechanism is further arranged on the reaction kettle; the reaction kettle comprises a motor, a rotating rod is arranged on the motor, a stirring paddle is arranged on the rotating rod, a discharging plate is further arranged on the reaction kettle, and a handle is arranged on the discharging plate; the adjusting mechanism comprises a first piston rod, a second piston rod is arranged on the first piston rod, a first inserting rod is arranged on the second piston rod, and the first piston rod penetrates through the second piston rod. The amount of the added raw materials and the amount of the added catalyst can be respectively controlled according to needs, so that the reaction is carried out to the maximum extent, and the product nicotinamide ribose is obtained to the maximum extent.

The present application relates to the technical field of organic synthesis, and particularly relates to a preparation method of beta-nicotinamide mononucleotide. The present application provides a preparation method of beta-nicotinamide mononucleotide, comprising the following steps: mixing a salt corresponding to nicotinamide riboside, phosphorus oxychloride and a polar aprotic organic solvent, performing a phosphorylation reaction, and obtaining beta-nicotinamide mononucleotide. The present application takes nicotinamide riboside as a raw material, takes phosphorus oxychloride as a phosphorylation reagent, and is prepared through a phosphorylation reaction. Compared with a conventional method, the reaction has less by-products and is simple to operate. The subsequent high-purity and high-yield end product can be obtained through simple post-treatment. Meanwhile, the present application is also beneficial to industrial production.

The invention relates to an anti-aging composition, and belongs to the field of medicines and health-care product preparations. The composition is a microcapsule assembled by a water-soluble wall material, a first core material, a fat-soluble wall material and a second core material which are sequentially coated from outside to inside, and the first core material comprises beta-nicotinamide mononucleotide (NMN), nicotinamide ribose (NR), ergothioneine and trimethylglycine (TMG); the second core material comprises resveratrol, curcumin, pyrroloquinoline quinone (PQQ) and spermidine, and is dissolved in medium chain triglyceride (MCT oil) containing an antioxidant tocopherol. According to the dosage form, physical isolation and differentiated release of water-soluble and fat-soluble components are realized, and the problems of incompatibility among the components, poor stability, low bioavailability and the like are solved. Through the multi-target synergistic effect, the composition can effectively improve the NAD + level and enhance the mitochondrial function so as to improve the skin state and delay senescence.

The invention provides alpha-ketoglutarate of nicotinamide ribose as well as a preparation method and application of the alpha-ketoglutarate, and belongs to the technical field of medicines. In the alpha-ketoglutaric acid salt of nicotinamide ribose, the molar ratio of nicotinamide ribose to alpha-ketoglutaric acid is 1: 1. Through efficient combination of the nicotinamide ribose and the alpha-ketoglutaric acid, the synergistic bioavailability of the nicotinamide ribose and the alpha-ketoglutaric acid is optimized, the stability of the nicotinamide ribose is remarkably improved, and the anti-aging effect of the nicotinamide ribose composition is remarkably higher than that of single nicotinamide ribose and alpha-ketoglutaric acid and physical mixing of the nicotinamide ribose and the alpha-ketoglutaric acid.

The invention provides a moringa oleifera extract containing an anti-aging functional component nicotinamide ribose as well as a preparation method and application of the moringa oleifera extract. Belongs to the technical field of food and medicine. The invention provides the moringa oleifera extract containing a trace amount of natural anti-aging component nicotinamide ribose (NR) in fresh moringa oleifera seeds, and the moringa oleifera seed extract freeze-dried powder product contains 23.77 mu g / g of nicotinamide ribose, has anti-aging activity, and can be used for preparing new anti-aging drugs or anti-aging cosmetics or prepared into food. The invention also provides a simple and fast preparation technology of the moringa seed extract containing nicotinamide ribose (NR). The preparation method is high in operability, high in efficiency and high in yield.

The invention discloses application of nicotinamide ribose (NR) in preparation of anti-influenza virus products, and belongs to the technical field of biotechnology and medicine. The NR is used as a human endogenous metabolite, has excellent safety, activates SIRT1 by increasing the NAD + level in cells, and further inhibits influenza virus NP protein nucleus input and virus RNA synthesis. Experiments prove that NR has a remarkable inhibition effect on replication of various subtype influenza A viruses such as H1N1, H9N2 and H3N2, still has an inhibition effect under high-MOI infection, has a good use effect at the early stage of infection, and provides a new choice for anti-influenza virus drugs.

The present invention relates to the field of biosynthesis technology, and more particularly to a β-nicotinamide mononucleotide production system and a method for preparing β-nicotinamide mononucleotide in a dual-enzyme collaborative manner. The β-nicotinamide mononucleotide production system comprises an NRK-HS01 whole-cell catalyst, an ADK whole-cell catalyst, nicotinamide riboside, adenosine triphosphate, and MgCl2. The present invention couples the NRK-HS01 whole-cell catalyst with an ATP regeneration system (ADK whole-cell catalyst) to catalyze the conversion of nicotinamide riboside and adenosine triphosphate to produce NMN in a single step. This method achieves an NMN molar yield exceeding 99%, reduces ATP costs by 50%, and reduces feedback inhibition of the synthesis reaction caused by the accumulation of the byproduct ADP. This method also enables the recycling of ATP, thereby improving synthesis efficiency and saving production costs. This method is of great significance for the industrial development of biosynthesis of NMN.

Provided are efficient heterologous expression of a nicotinamide ribokinase mutant in Escherichia coli and a use thereof. Provided are nicotinamide ribokinase capable of being heterologously expressed in Escherichia coli and a mutant thereof. The activity of the nicotinamide ribokinase of the mutant is significantly improved as compared with that of a parent. On the basis of the nicotinamide ribokinase and the mutant thereof, further provided is a method for the efficient heterologous expression of the nicotinamide ribokinase, that is, during the construction of a recombinant plasmid, by introducing a ribosome binding site into the plasmid, inserting a specific promoter sequence, etc., the enzyme activity of the expressed nicotinamide ribokinase is made higher than that of a control. In addition, further provided is a method for culturing a recombinant bacterium expressing the nicotinamide ribokinase, such that the highest enzyme activity of the expressed nicotinamide ribokinase is 208.3 U / mL. The present invention is conducive to efficient biosynthesis of β-nicotinamide mononucleotide and is suitable for industrial production and use.

The invention belongs to the technical field of biological catalysis, and particularly relates to an anchor peptide mediated fusion protein and an immobilized enzyme biofilm reactor, the fusion protein comprises a functional enzyme protein and an anchor peptide mutant; the anchoring peptide mutant is obtained by mutating proline at the fifth position of an amino acid sequence as shown in SEQ ID No.2 into valine; the functional enzyme protein is nicotinamide ribokinase or polyphosphate kinase. The functional enzyme protein and the anchoring peptide mutant are connected by using the connecting peptide, and then the obtained fusion protein is anchored on the polypropylene hollow fiber membrane wire material, so that the obtained fusion protein has good anchoring effect and catalytic activity, the batch reaction yield stability can be obviously improved, and the preparation method is suitable for industrial production. An immobilized enzyme bio-membrane reactor is designed, and nicotinamide mononucleotide can be synthesized through biological catalysis.

The invention discloses a synthesis method of nicotinamide ribose chloride and an intermediate thereof. The preparation method comprises the following steps: mixing chlorinated triacetyl ribose, nicotinamide, zinc chloride, tin tetrachloride and an organic solvent, and reacting to obtain triacetyl nicotinamide ribose chloride; or mixing tetraacetyl ribose, nicotinamide, zinc chloride, tin tetrachloride and an organic solvent, and reacting to obtain triacetyl nicotinamide ribose acetate; and adding the triacetyl nicotinamide ribose into an organic solvent solution of hydrogen chloride for deacetylation to obtain the nicotinamide ribose chloride. According to the method, the triacetyl nicotinamide ribose chloride is prepared by catalyzing the glycosylation of the chlorinated triacetyl ribose through the composite catalyst of zinc chloride and tin tetrachloride, so that the total yield, the product content and the purity are obviously improved; or a composite catalyst of zinc chloride and stannic chloride is used for catalyzing glycosylation of tetraacetyl ribose to prepare triacetyl nicotinamide ribose acetate, the purity is obviously improved, and further the preparation of nicotinamide ribose chloride also has obvious advantages.

The invention provides nicotinamide riboside organic acid salt as well as a preparation method and application thereof, and relates to the technical field of preparation of nicotinamide riboside salt. Organic acid basic metal salt and nicotinamide riboside react to generate the nicotinamide riboside organic salt. According to the method, high-yield nicotinamide riboside organic acid salt can be prepared, the preparation process is simple, an organic toxic reagent is almost not used, and the method is conveniently applied to the dietary supplement industry; the dietary supplement containing the nicotinamide riboside organic acid salt provided by the invention has high stability, can significantly promote the active substance nicotinamide riboside organic acid salt to play a role, and has a wide industrial application prospect.

The invention belongs to the technical field of biological catalytic synthesis, and particularly relates to a method for synthesizing beta-nicotinamide mononucleotide (NMN) by enzyme catalysis, which comprises the following steps: by taking D-ribose as a starting substrate, and utilizing a three-step enzyme catalysis reaction system which is synergistically completed by an S-methyl-5-thioribose kinase mutant (SMTK), purine nucleotidase (PNP) and nicotinamide ribose kinase (NRK), synthesizing beta-nicotinamide mononucleotide (NMN) by enzyme catalysis. And efficient synthesis of the NMN is realized. In order to further optimize the cost, an ATP (adenosine triphosphate) regeneration system is innovatively introduced in the process, so that the consumption of ATP in the reaction process is effectively reduced. On the basis, by combining an enzyme directed evolution technology, an immobilized enzyme technology and a continuous reactor design, the catalytic reaction efficiency and the product purity level are remarkably improved. The whole process has the characteristics of greenness and environmental protection, the reaction conditions are mild and controllable, the product yield stably reaches more than or equal to 85%, and the requirements of industrial large-scale production are completely met.

A stable intravenous (IV) composition comprises, in the intravenous form, nicotinamide riboside (NR) as described, or another nicotinyl riboside compound that is an NAD+ precursor. NR chloride may be provided in an intravenous (IV) formulation for administration to human subjects.

The invention discloses a bone marrow mesenchymal stem cell osteogenesis induction enhancing solution, which is prepared from the following components: 6.5 to 9.5 mg / ml of sodium hydrosulfite, 8.5 to 13.5 mg / ml of nicotinamide ribose, 1.5 to 2.1 mg / ml of deoxycholic acid, 45.0 to 55.0 mu g / ml of estradiol, 0.2 to 0.6 mg / ml of calcitriol, and 90.0 to 110.0 mu g / ml of rrBMP-2. Traditional osteogenic induction and 1% osteogenic induction enhancing liquid have high cell activity on BMSC cell proliferation, and compared with traditional osteogenic induction (containing 0.2 mmol / L of ascorbic acid, 10 mmol / L of beta-sodium glycerophosphate and 100 nmol / L of dexamethasone), the alkaline phosphatase staining color is deeper, the positive area is larger, the alkaline phosphatase activity is higher, more calcium nodules are formed, and the BMSC cell proliferation effect is better. It is shown that the osteogenic induction enhancing liquid provided by the invention enhances the osteogenic ability of the rat BMSC.

The present application aims to provide a composition having an effect of increasing NAD concentration. The present application relates to a composition characterized by containing one or more selected from nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), and salts thereof and one or more sesamin as an effective ingredient.

The invention provides a method for improving the shake flask fermentation level of nicotinamide ribose, which comprises the following steps: S1, preparing a seed solution, namely coating a bacterial solution capable of producing nicotinamide riboside on an LB resistant plate of Kan and Sm, and culturing at 37 DEG C for 16 hours; picking a single colony, inoculating the single colony into an LB shake flask, adding Kan and Sm with the final concentration of 50mg / L, and culturing at 37 DEG C and 200rpm until OD600 is equal to 3-4; s2, fermentation culture of nicotinamide ribose: transferring the seed solution prepared in S1 into a fermentation culture medium according to the transferring amount of 4%, adding 50mg / L of Kan and Sm into the fermentation solution, and culturing at 37 DEG C and 220rpm for 1-4 hours; after the temperature is reduced to 30 DEG C, 0.1 g / L CoCl2 and 0.5 mM IPTG are added for induction, and 3.5 g / L nicotinamide is added 0-2 h after induction; kan and Sm are supplemented 9-15 hours after induction; nicotinamide ribose is collected to determine the culture time before induction and the substrate adding time after induction, so that the shake flask yield of the nicotinamide ribose is greatly increased. The corn steep liquor solution is properly added to provide growth factors and improve the glucose metabolism flux. According to the method, the problem that a large amount of plasmids are lost after induction is solved by additionally supplementing resistance, and the industrialization of nicotinamide ribose is accelerated.

A composition that exerts aging-delaying and anti-inflammatory effects by improving energy metabolism and mitochondrial function, a preparation method therefor, and use thereof. The composition comprises the following starting materials in parts by weight: 1-100 parts by weight of ergothioneine, 1-100 parts by weight of pyrroloquinoline quinone (PQQ) or a derivative thereof, and 20-1000 parts by weight of component C. The component C is β-nicotinamide mononucleotide (NMN), or nicotinamide riboside (NR) or a derivative thereof. Research has found that the combination of ergothioneine, PQQ or the derivative thereof, and NR or the derivative thereof or NMN can achieve a synergistic effect, with the anti-aging and anti-inflammatory effects being more significant than those of ergothioneine, PQQ or the derivative thereof, NR or the derivative thereof, or NMN alone.