75 results about "Pterostilbene" patented technology

The invention discloses a triggering probiotic-drug conjugate and a preparation method and application thereof, and belongs to the technical field of oral drug delivery systems, the triggering probiotic-drug conjugate comprises probiotics, an adhesive inner layer formed by coordination of tannic acid and Fe < 3 + >, and an outer layer formed by pterostilbene-phospholipid bridged by ROS-responsive thioether bonds and cholesterol; the inner layer coats the surfaces of the probiotics through coordination, and the outer layer coats the outer part of the inner layer through self-assembly. An outer lipid layer is decomposed under high-concentration ROS in an inflammation colon area, and probiotics coated with pterostilbene and a tannic acid layer are released. Pterostilbene relieves inflammation and rebuilds a pathological microenvironment, and catechol groups in a tannic acid layer and the surface of the intestinal tract generate multiple interactions to promote planting of probiotics. In UC mouse models, the conjugates exhibit enhanced therapeutic effects by inhibiting inflammation, restoring intestinal barrier function, and improving intestinal microbiota homeostasis. The invention has important transformation potential in clinical application of gastrointestinal diseases.

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The invention relates to a pterostilbene compound, a pharmaceutical composition and application of the pterostilbene compound in preparation of anti-inflammatory drugs. The compound shown in the formula (I) or the pharmaceutically acceptable salt thereof provided by the invention has relatively high stability and high bioavailability, can effectively improve symptoms such as colon shortening, diarrhea, hematochezia and weight loss caused by DSS-induced mouse colitis, has a remarkable inhibition effect on intestinal inflammation, and can be used for preparing anti-inflammatory drugs. # imgabs0 #

The invention relates to pterostilbene flexible liposome as well as a preparation method and application thereof. The pterostilbene flexible liposome is mainly prepared from the following components in percentage by mass: 0.5%-1.25% of pterostilbene, 2%-4% of phospholipid, 0.06%-0.2% of cholesterol, 1%-2.5% of an emulsifying agent, 0.1%-0.6% of a membrane softening agent, 5.08%-12.1% of an auxiliary agent and 79.35%-91.26% of water, the emulsifier is a single-chain surfactant; the membrane softener is dipotassium glycyrrhizinate. The pterostilbene flexible liposome has good solubility in water, is mild to a human body, has good skin physiological effects of oxidation resistance, whitening, aging resistance and inflammation resistance, has good stability and good transdermal property, can penetrate through a skin surface layer to reach a deep layer and slowly release pterostilbene to play a role, improves the dose-effect relationship and bioavailability of pterostilbene, and has a good application prospect. The composition can be well used in the field of cosmetics.

The present application relates to a kind of pterostilbene piperidine amide derivatives, its preparation method and medical use, belong to the field of medicinal chemistry and pharmacotherapy.The present application uses pterostilbene as raw material, designs, synthesizes a series of pterostilbene piperidine amide compounds with new structure, and its structure is characterized.The method used in the present application to prepare these compounds has the characteristics of easy-to-get raw material, simple operation and high yield, and can quickly synthesize target compounds.Compared with pterostilbene, the pterostilbene piperidine amide derivatives provided in the present application have significant cell proliferation inhibitory effect on tumor cells.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

The invention provides a whitening composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. According to the whitening composition provided by the invention, the isopropyl lauroyl sarcosinate, the diisopropyl sebacate, the PPG-14 polyglycerol-2 ether, the bis-diethoxy diglycol cyclohexane 1, 4-dicarboxylate and the poly C10-30 alkanol acrylate are used as oil phases to wrap the whitening components (magnolol, pterostilbene, ferulic acid and dimethyl methoxy benzodihydropyranol) so as to form oil sacs, so that the whitening composition can be used for whitening the skin; and then dispersing in a polyhydric alcohol and carbomer matrix to control the composition of the oil phase and the whitening component, so that the whitening effect and the transdermal absorption effect of the whitening composition are improved.

This invention relates to the field of agricultural biotechnology, specifically to a rumen methane inhibitory composition for ruminants containing *Asparagus yew* and *Pterostilbene*. The active components of the composition include *Asparagus yew* and its preparations, and *Pterostilbene*, which are used in a predetermined ratio to reduce rumen methane production and alleviate hydrogen accumulation in ruminants.

The invention discloses an ursodesoxycholic acid-pterostilbene conjugate, a preparation method thereof and application of the ursodesoxycholic acid-pterostilbene conjugate in preparation of drugs for treating non-alcoholic fatty liver diseases, and belongs to the technical field of biological medicines. According to the conjugate, ursodesoxycholic acid and pterostilbene are covalently connected through specific chemical bridging, and the structural general formula is shown in the specification. The preparation method comprises the following steps: respectively preparing the alkynyl-containing pterostilbene derivative and the azido-containing ursodesoxycholic acid derivative through esterification and amidation reactions, and then realizing efficient coupling through a click chemical reaction. The conjugate provided by the invention can realize hepatic targeting delivery by virtue of a bile acid transporter, synchronously releases two active components in hepatic cells, plays a therapeutic role through multiple mechanisms such as synergistic regulation of lipid metabolism, inhibition of oxidative stress and inflammation, anti-fibrosis and the like, and is obviously superior to a single component or a physical mixture; and a new strategy is provided for treatment of the non-alcoholic fatty liver disease.

The present invention discloses a pterostilbene chalcone compound represented by general formula (I) or a pharmaceutically acceptable salt thereof. The compound has a strong inhibitory effect on LPS-induced NO production in RAW264.7 cells, significantly superior to indomethacin, and can be developed into a new anti-inflammatory drug. The preparation method of the compound of the present invention is characterized by readily available raw materials, simple operation, and high yield.

The invention discloses a nano composition of pterostilbene, a preparation method of the nano composition, and application of the pterostilbene in preparation of an anti-hair loss product. Comprising the following components in percentage by mass: 0.1-25% of pterostilbene, 0.1-30% of polyol ether, 0.1-8% of terpene essential oil, 0.5-30% of a flexible agent, 0.1-20% of phospholipid and / or phospholipid derivative, 0-2% of honokiol, 0-3% of cinnamic acid, 0-35% of an additive and the balance of water. The invention proves that the pterostilbene has an excellent anti-hair loss effect and has relatively strong 5 alpha-reductase inhibitory activity, and the nano composition containing the pterostilbene, honokiol and cinnamic acid can synergistically enhance the 5 alpha-reductase inhibitory and anti-hair loss effects of the pterostilbene, and meanwhile, the nano composition enhances the solubility and stability of the pterostilbene, so that the anti-hair loss effect of the pterostilbene is improved, and the anti-hair loss effect of the pterostilbene is improved. The application of the pterostilbene is expanded.

The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.

The application belongs to the technical field of biological medicine, and proposes a use of a pterostilbene derivative and a preparation of a medicine for treating and / or preventing diseases caused by oxidative stress. The chemical structure of the pterostilbene derivative is shown as formula (I)-(III). The scavenging effect of the obtained derivative on DPPH·, O2 ‑ · and ABTS + · free radicals and its total reducing capacity are detected respectively. In terms of DPPH· and total reducing capacity, it is found that the scavenging capacity of some derivatives is equivalent to that of pterostilbene or vitamin C. Derivatives 2a, 4a, 4c, 4e, 4h, 4i and 4m-4p have the same scavenging effect on O2 ‑ · free radicals as pterostilbene or vitamin C; the scavenging effect of derivative 2b on ABTS + · is equivalent to that of vitamin C and is superior to that of pterostilbene. The pterostilbene derivative has potential application prospects in the preparation of antioxidants.

The application belongs to the technical fields of synthesis of compounds and pharmaceutical applications, and discloses an anti-tumor pterostilbene piperazine conjugate as well as a preparation method and application thereof. The pterostilbene, piperazine and various substituents are spliced in one molecule by using a molecular hybridization method, a novel anti-tumor pterostilbene piperazine conjugate is synthesized, and it is found through anti-tumor activity research that the anti-tumor activity of the conjugate is obviously higher than that of the two pharmacophores alone, and the conjugate has the potential to become a novel anti-tumor drug. The pterostilbene piperazine conjugate is synthesized, and it is found for the first time that the compound has good anti-tumor activity, can significantly inhibit the proliferation of various tumor cells in vitro, including hepatocarcinoma, triple-negative breast cancer, colon cancer and ovarian cancer cells, has little toxicity to normal cells, and can inhibit the migration ability of tumor cells. Therefore, the compound synthesized by the application has good anti-tumor application prospect.

The application discloses a bifendate biomimetic oral nanodelivery system based on lactobacillus helveticus exosomes and a preparation method and application thereof. The preparation method comprises the following steps: extracting lactobacillus helveticus exosomes from a lactobacillus helveticus culture solution by adopting a method combining continuous differential centrifugation and microporous membrane filtration; and mixing the lactobacillus helveticus exosomes with bifendate, and performing ultrasonic treatment and incubation treatment to prepare the lactobacillus helveticus exosome-bifendate biomimetic oral nanodelivery system. The application successfully extracts a lactobacillus helveticus source exosome with high yield and expandable advantages for the first time, and improves the clinical limitations of high cost and low productivity of animal source and plant source exosomes as oral delivery carriers; meanwhile, the prepared lactobacillus helveticus exosome-bifendate biomimetic oral nanodelivery system combines the natural characteristics of exosomes and the high biological safety of probiotics, and can realize the balance between the oral delivery performance and the biological safety of the nanocarrier.

The invention relates to the technical field of traditional Chinese medicines, and particularly discloses a traditional Chinese medicine composition and application thereof in preparation of medicines for improving yin deficiency constitution. The traditional Chinese medicine composition comprises the following traditional Chinese medicine raw material components: lily, mulberry, momordica grosvenori, folium mori, scaphium scaphigerum, radix polygonati officinalis, fructus cannabis and honey-fried licorice root. In addition, the composition also contains semen armeniacae amarae and fructus mume. Researches show that the traditional Chinese medicine composition has the effect of improving the constitution with yin deficiency; therefore, the traditional Chinese medicine composition disclosed by the invention can be used as a medicine for improving the yin-deficiency constitution and has an important application value.

The invention discloses azelaic acid-pterostilbene ester and application thereof, and belongs to the technical field of compound synthesis. According to the invention, pterostilbene and azelaic acid are combined to form a new compound. The azelaic acid compound prepared by the invention not only is helpful for overcoming the limitations of poor permeability, higher irritation and the like of azelaic acid, but also can improve the overall efficacy of the azelaic acid compound through a synergistic effect, and provides a better solution for skin care and treatment.

The invention belongs to the field of functional composite films, and relates to a PTE-atbeta-CD ICs clathrate compound, a multifunctional antibacterial composite film and application of the PTE-atbeta-CD ICs clathrate compound and the multifunctional antibacterial composite film. The clathrate compound comprises beta-cyclodextrin and pterostilbene which is encapsulated in the beta-cyclodextrin through a non-covalent bond. According to the invention, the PTE-atbeta-CD ICs clathrate compound is synthesized and optimized, and the multifunctional composite film with the humidity response characteristic is constructed by using the PTE-atbeta-CD ICs clathrate compound, CMC and zein. According to the invention, the active clathrate compound with a slow release characteristic is added into the biodegradable material for the first time to be used as a film-forming material for fresh-keeping of picked fruits and vegetables, and the composite film has the advantages of good fresh-keeping effect, low cost, good biocompatibility, biodegradability and the like.

The present invention discloses a plant whitening sunscreen composition and its preparation method and application, and relates to the field of cosmetic technology. The present invention provides a plant whitening sunscreen composition, comprising the following components in parts by weight: 0.5-5 parts of a P / O / W composite carrier, 0.1-3 parts of bakuchiol, and 0.1-3 parts of a thyme extract. The present invention stabilizes two components, pterostilbene and verbascoside, in a P / O / W pickering multiple emulsion system to form a P / O / W composite carrier, which is mixed with bakuchiol and thyme extract in specific parts by weight. On the one hand, it can achieve safe and efficient whitening by repairing, inhibiting melanin production, inhibiting melanin transport, and promoting the synergistic enhancement of multiple pathways of melanin autophagy; on the other hand, it can achieve safe and efficient whitening and sun protection, achieve the effect of "external protection and internal whitening", and can synergistically strengthen the skin's defensive barrier and improve problems such as dull skin in sensitive skin.

The invention discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The invention aims to solve the technical problems of drug resistance, high skin irritation and the like of the existing acne treatment means. Meanwhile, antibacterial core materials such as totarol and the like have the problems of poor solubility, poor transdermal absorption, burst release stimulation and the like. According to the key point of the technical scheme, the bacteriostatic liposome with lipase responsiveness is provided, and a wall material of the bacteriostatic liposome comprises soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterol, PEG-7 olivate, glyceryl stearate and ceramide NP, the inner core material is prepared from at least one of totarol, paeonol, honokiol, capryloyl glycine, glabridin, ascorbyl tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core material is regulated and controlled by utilizing the reaction of lipase and the wall material, the slow release and controlled release effects are achieved, and industrial production is easy.

The application discloses a breeding method for synthesizing resveratrol and pterostilbene in rice seed endosperm, and relates to the technical field of biology.The transgenic breeding method comprises the steps of transforming a recombinant carrier into rice callus and then cultivating the rice callus into a transgenic rice plant; the recombinant carrier comprises a gene expression cassette for expressing VvSTS protein, a gene expression cassette for expressing VvROMT protein, a gene expression cassette for expressing At4CL protein and a gene expression cassette for expressing transcription factor OsMYBP1 protein.The application realizes the synthesis of resveratrol and pterostilbene in rice endosperm, and the product can be used as raw material for producing resveratrol and pterostilbene, and has important guiding significance for new functional breeding.

The invention discloses a medicine composition for treating endometriosis. The pharmaceutical composition for treating the endometriosis, disclosed by the invention, is prepared from the following raw materials: curcumin and epigallocatechin gallate co-delivery liposome and pterostilbene nano-structure liposome. The curcumin and the EGCG are prepared into the co-delivery liposome, so that the solubility of the curcumin in water can be remarkably improved; meanwhile, the co-delivery liposome can protect the two from being influenced by light, oxygen, temperature and pH value, and the chemical stability, the antioxidant activity and the drug effect of the liposome are improved. According to the pterostilbene nanostructure liposome prepared by the invention, the water solubility of pterostilbene is improved, the in-vitro drug release of the pterostilbene is promoted, the in-vivo stability of the pterostilbene is improved, the full absorption of drugs is facilitated, and the bioavailability of the pterostilbene is improved.

The invention discloses a breeding method for synthesizing resveratrol and pterostilbene in rice seed endosperm, and relates to the technical field of biology. The transgenic breeding method comprises the following steps: transforming a recombinant vector into a rice callus, and culturing into a transgenic rice plant, the recombinant vector comprises a gene expression cassette for expressing VvSTS protein, a gene expression cassette for expressing VvROMT protein, a gene expression cassette for expressing At4CL protein and a gene expression cassette for expressing transcription factor OsMYBP1 protein. The synthesis of the resveratrol and the pterostilbene in the rice endosperm is realized, and the product can be used as a raw material for producing the resveratrol and the pterostilbene, and has important guiding significance for novel functional breeding.

The present disclosure relates to a cocrystal of pterostilbene and a coformer capable to form hydrogen bond interactions, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The present disclosure also relates to a composition comprising the cocrystal.

The invention discloses a bionic amino acid surfactant and a preparation method thereof.The bionic amino acid surfactant is provided with a hydrophobic part formed by a resveratrol compound and a hydrophilic part formed by amino acid, and the preparation method comprises the steps that the resveratrol compound including resveratrol or pterostilbene is added into the hydrophobic part, corresponding o-benzoquinone obtained by oxidizing 2-iodoxybenzoic acid (IBX) is further subjected to Michael addition reaction and / or Schiff base reaction with amino acid, covalent linkage of a monophenol substrate and the amino acid is achieved, and the bionic amino acid surfactant is obtained. The preparation method provided by the invention successfully realizes simulation and bionics of a melanin biosynthesis pathway, and provides a new synthesis thought of the amino acid surfactant. And the preparation process is simple, the energy consumption is low, the reaction is rapid, and the obtained surfactant is novel in structure, green, environment-friendly and excellent in surface performance and has excellent foaming performance, emulsifying performance and dispersing performance.

The application belongs to the technical field of pharmaceutical chemistry, and proposes a class of amine derivatives of pterostilbene and the application of the amine derivatives in the preparation of anti-breast cancer drugs. The chemical structure of the amine derivatives of pterostilbene is shown as formula (I), and R is an amine compound. The method for preparing the amine derivatives of pterostilbene has the characteristics of easy availability of raw materials and simple operation. At the same time, the in-vitro anti-breast cancer activity test results show that most amine derivatives of pterostilbene (2a-2c, 2e, 2g, 2i, 2l and 2m) have good inhibitory effects on breast cancer cells MDA-MB-231 (IC 50 = 7.92-26.42 μM) and MCF-7 (IC 50 = 7.84-25.78 μM). The pterostilbene compound is expected to be used as an active ingredient for preparing a lead drug for treating / preventing breast cancer, and has a pharmaceutical prospect.

The invention discloses a preparation method of stilbene such as pterostilbene and resveratrol. More particularly, the present invention discloses the synthesis of stilbene using the new intermediates 5-(4-(1-ethoxyethoxy) styryl)-benzene 1, 3 diol and 1-(4-(1-ethoxyethoxy) styryl)-3, 5-dimethoxy-benzene.

The application discloses a kind of composite microecological preparation and preparation method and application, belong to microbial technical field.The composite microecological preparation is core-shell structure, the core-shell structure is divided into inside and shell layer, inside includes Bifidobacterium adolescentis, shell layer includes metal polyphenol network and ficoll polysaccharide;The metal polyphenol network includes the complex coating formed by pterostilbene and calcium ion.The core is BA, the shell is made of FCPS, PTE, Ca 2+ Network composition, can protect Bifidobacterium adolescentis to reach intestine successfully and colonize, directly inhibit inflammatory response, and relieve CDI-induced mouse colitis and oxidative stress damage by regulating intestinal flora, indole and the generation of indole derivatives, solve the pain point that traditional microecological preparation probiotic survival rate is low, poor targeting, limited effect.

The invention relates to the technical field of cosmetics, and particularly discloses an anti-oxidation and anti-aging skin repair composition and a preparation method thereof, the anti-oxidation and anti-aging skin repair composition comprises pterostilbene, ergothioneine, a repair soothing component, a plant fermentation extract, Ectoine, a composite antioxidant, polyol, a surfactant, and the balance purified water. The preparation method comprises the following steps: step 1, adding polyhydric alcohol and Ectoine into purified water to obtain a water phase; adding a surfactant into the composite antioxidant, and uniformly stirring to obtain an oil phase; pumping the oil phase into the water phase, and uniformly stirring at the temperature of 60-65 DEG C to obtain an emulsion; and step 2, homogenizing the emulsion, adding a repairing and relieving component, cooling, adding pterostilbene, ergothioneine and a plant fermentation extract, adjusting the pH value, and filtering to obtain the antioxidant and anti-aging skin repairing composition which has the effects of long-acting moisturizing, skin smoothing, tightening and elastic moistening.

The invention discloses a preparation method of a hydrogenated lysolecithin-entrapped whitening composition and application of the hydrogenated lysolecithin-entrapped whitening composition in preparation of cosmetics, and provides a synergistic ratio of pterostilbene and tetrahydromagnolol which are whitening active matters, a nano entrapment technology is adopted, hydrogenated lysolecithin is used as a main emulsifier, and the hydrogenated lysolecithin-entrapped whitening composition is prepared into a cosmetic. The proper co-emulsifier and polyol are searched to entrap the grease which efficiently dissolves the whitening active matter into a stable nano-emulsion, so that pterostilbene and tetrahydromagnolol can permeate into the deep layer of the skin to play an efficient mild whitening role.