46 results about "Pterostilbene" patented technology

The invention relates to the technical field of functional antioxidants, in particular to a stability-enhanced antioxidant based on pterostilbene and a preparation method and application thereof. The pterostilbene tablet comprises the following components in percentage by weight: 10-30% of pterostilbene, 8-20% of Arabic gum, 5-15% of tocopheryl succinate, 1-5% of disodium ethylene diamine tetraacetate, 30-60% of beta-cyclodextrin, 2-8% of rosmarinic acid, 1-6% of chitosan quaternary ammonium salt, 0.5-3% of nano silicon dioxide and 2-7% of polyglycerol fatty acid ester. In the preparation process, beta-cyclodextrin and pterostilbene form an inclusion compound, the dispersity of nano silicon dioxide and chitosan quaternary ammonium salt is improved through hydrogen bonds, and tea polyphenol or ascorbyl palmitate can be added to enhance the synergistic effect. The antioxidant is high in stability, high in pterostilbene retention rate, uniform in dispersion, free of agglomeration, excellent in antioxidant activity, suitable for the fields of foods, cosmetics and medicines, simple in preparation process, low in consumption and suitable for industrial production.

The present application relates to a kind of bone repair compositions and its preparation method, belong to biological medicine technical field, pharmaceutical composition includes acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide, yak bone peptide, loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract;Acid anhydride bovine beta-lactoglobulin peptide is prepared using special enzymolysis method.Acid anhydride bovine beta-lactoglobulin peptide, casein phosphopeptide and yak bone peptide are loaded using carboxymethyl chitosan-hydroxyapatite composite microspheres, then using sodium alginate-sodium carboxymethyl cellulose containing loquat leaf extract, pterostilbene, honeysuckle chlorogenic acid and cyperus rotundus extract one coating, then using sodium alginate-sodium carboxymethyl cellulose secondary coating.The present application develops high-efficiency pharmaceutical combination component, using polymer material to coat drug to form sustained-release system, improve bioavailability, using granular carrier to increase the stability and solubility of drug, promote intestinal absorption, improve bone repair process.

This invention relates to the field of agricultural biotechnology, specifically to a rumen methane inhibitory composition for ruminants containing *Asparagus yew* and *Pterostilbene*. The active components of the composition include *Asparagus yew* and its preparations, and *Pterostilbene*, which are used in a predetermined ratio to reduce rumen methane production and alleviate hydrogen accumulation in ruminants.

The invention discloses an ursodesoxycholic acid-pterostilbene conjugate, a preparation method thereof and application of the ursodesoxycholic acid-pterostilbene conjugate in preparation of drugs for treating non-alcoholic fatty liver diseases, and belongs to the technical field of biological medicines. According to the conjugate, ursodesoxycholic acid and pterostilbene are covalently connected through specific chemical bridging, and the structural general formula is shown in the specification. The preparation method comprises the following steps: respectively preparing the alkynyl-containing pterostilbene derivative and the azido-containing ursodesoxycholic acid derivative through esterification and amidation reactions, and then realizing efficient coupling through a click chemical reaction. The conjugate provided by the invention can realize hepatic targeting delivery by virtue of a bile acid transporter, synchronously releases two active components in hepatic cells, plays a therapeutic role through multiple mechanisms such as synergistic regulation of lipid metabolism, inhibition of oxidative stress and inflammation, anti-fibrosis and the like, and is obviously superior to a single component or a physical mixture; and a new strategy is provided for treatment of the non-alcoholic fatty liver disease.

The invention discloses a nano composition of pterostilbene, a preparation method of the nano composition, and application of the pterostilbene in preparation of an anti-hair loss product. Comprising the following components in percentage by mass: 0.1-25% of pterostilbene, 0.1-30% of polyol ether, 0.1-8% of terpene essential oil, 0.5-30% of a flexible agent, 0.1-20% of phospholipid and / or phospholipid derivative, 0-2% of honokiol, 0-3% of cinnamic acid, 0-35% of an additive and the balance of water. The invention proves that the pterostilbene has an excellent anti-hair loss effect and has relatively strong 5 alpha-reductase inhibitory activity, and the nano composition containing the pterostilbene, honokiol and cinnamic acid can synergistically enhance the 5 alpha-reductase inhibitory and anti-hair loss effects of the pterostilbene, and meanwhile, the nano composition enhances the solubility and stability of the pterostilbene, so that the anti-hair loss effect of the pterostilbene is improved, and the anti-hair loss effect of the pterostilbene is improved. The application of the pterostilbene is expanded.

The application discloses a method for constructing a characteristic map of a traditional Chinese medicine and the characteristic map, wherein the method adopts an HPLC method to determine the content of an effective component, imperatorin, in Zhikang capsules, and constructs a high performance liquid chromatography characteristic map of the Zhikang capsules; 10 characteristic peaks are determined as the characteristic map, which are respectively from dragon's blood, rhubarb and Bai Zhi; the components from the dragon's blood are dracorhodin B (peak 2) and pterostilbene (peak 4); the components from the rhubarb are peak 1 (aloe-emodin), peak 3, peak 6 (emodin), peak 9 and peak 10; and the components from the Bai Zhi are imperatorin (peak 5), peak 7 and peak 8; the method covers polyphenols, anthraquinones and furanocoumarins and other main components, and constructs a quality evaluation system of the Zhikang capsules; the method has good specificity, precision, repeatability and solution stability, and can be used for standardizing the production of the Zhikang capsules and guaranteeing the uniformity and stability of the internal quality of products to provide comprehensive quality control.

The application belongs to the technical field of biological medicine, and proposes a use of a pterostilbene derivative and a preparation of a medicine for treating and / or preventing diseases caused by oxidative stress. The chemical structure of the pterostilbene derivative is shown as formula (I)-(III). The scavenging effect of the obtained derivative on DPPH·, O2 ‑ · and ABTS + · free radicals and its total reducing capacity are detected respectively. In terms of DPPH· and total reducing capacity, it is found that the scavenging capacity of some derivatives is equivalent to that of pterostilbene or vitamin C. Derivatives 2a, 4a, 4c, 4e, 4h, 4i and 4m-4p have the same scavenging effect on O2 ‑ · free radicals as pterostilbene or vitamin C; the scavenging effect of derivative 2b on ABTS + · is equivalent to that of vitamin C and is superior to that of pterostilbene. The pterostilbene derivative has potential application prospects in the preparation of antioxidants.

The application belongs to the technical fields of synthesis of compounds and pharmaceutical applications, and discloses an anti-tumor pterostilbene piperazine conjugate as well as a preparation method and application thereof. The pterostilbene, piperazine and various substituents are spliced in one molecule by using a molecular hybridization method, a novel anti-tumor pterostilbene piperazine conjugate is synthesized, and it is found through anti-tumor activity research that the anti-tumor activity of the conjugate is obviously higher than that of the two pharmacophores alone, and the conjugate has the potential to become a novel anti-tumor drug. The pterostilbene piperazine conjugate is synthesized, and it is found for the first time that the compound has good anti-tumor activity, can significantly inhibit the proliferation of various tumor cells in vitro, including hepatocarcinoma, triple-negative breast cancer, colon cancer and ovarian cancer cells, has little toxicity to normal cells, and can inhibit the migration ability of tumor cells. Therefore, the compound synthesized by the application has good anti-tumor application prospect.

The application discloses a bifendate biomimetic oral nanodelivery system based on lactobacillus helveticus exosomes and a preparation method and application thereof. The preparation method comprises the following steps: extracting lactobacillus helveticus exosomes from a lactobacillus helveticus culture solution by adopting a method combining continuous differential centrifugation and microporous membrane filtration; and mixing the lactobacillus helveticus exosomes with bifendate, and performing ultrasonic treatment and incubation treatment to prepare the lactobacillus helveticus exosome-bifendate biomimetic oral nanodelivery system. The application successfully extracts a lactobacillus helveticus source exosome with high yield and expandable advantages for the first time, and improves the clinical limitations of high cost and low productivity of animal source and plant source exosomes as oral delivery carriers; meanwhile, the prepared lactobacillus helveticus exosome-bifendate biomimetic oral nanodelivery system combines the natural characteristics of exosomes and the high biological safety of probiotics, and can realize the balance between the oral delivery performance and the biological safety of the nanocarrier.

The invention discloses a bacteriostatic liposome with lipase responsiveness, a preparation method and application thereof and a product, and belongs to the technical field of cosmetics. The invention aims to solve the technical problems of drug resistance, high skin irritation and the like of the existing acne treatment means. Meanwhile, antibacterial core materials such as totarol and the like have the problems of poor solubility, poor transdermal absorption, burst release stimulation and the like. According to the key point of the technical scheme, the bacteriostatic liposome with lipase responsiveness is provided, and a wall material of the bacteriostatic liposome comprises soybean phosphatidylcholine, hydrogenated phosphatidylcholine, cholesterol, PEG-7 olivate, glyceryl stearate and ceramide NP, the inner core material is prepared from at least one of totarol, paeonol, honokiol, capryloyl glycine, glabridin, ascorbyl tetraisopalmitate, tetrahydrocurcumin or pterostilbene. Through a specific preparation method, the release speed of the core material is regulated and controlled by utilizing the reaction of lipase and the wall material, the slow release and controlled release effects are achieved, and industrial production is easy.

The application discloses a breeding method for synthesizing resveratrol and pterostilbene in rice seed endosperm, and relates to the technical field of biology.The transgenic breeding method comprises the steps of transforming a recombinant carrier into rice callus and then cultivating the rice callus into a transgenic rice plant; the recombinant carrier comprises a gene expression cassette for expressing VvSTS protein, a gene expression cassette for expressing VvROMT protein, a gene expression cassette for expressing At4CL protein and a gene expression cassette for expressing transcription factor OsMYBP1 protein.The application realizes the synthesis of resveratrol and pterostilbene in rice endosperm, and the product can be used as raw material for producing resveratrol and pterostilbene, and has important guiding significance for new functional breeding.

The invention discloses a medicine composition for treating endometriosis. The pharmaceutical composition for treating the endometriosis, disclosed by the invention, is prepared from the following raw materials: curcumin and epigallocatechin gallate co-delivery liposome and pterostilbene nano-structure liposome. The curcumin and the EGCG are prepared into the co-delivery liposome, so that the solubility of the curcumin in water can be remarkably improved; meanwhile, the co-delivery liposome can protect the two from being influenced by light, oxygen, temperature and pH value, and the chemical stability, the antioxidant activity and the drug effect of the liposome are improved. According to the pterostilbene nanostructure liposome prepared by the invention, the water solubility of pterostilbene is improved, the in-vitro drug release of the pterostilbene is promoted, the in-vivo stability of the pterostilbene is improved, the full absorption of drugs is facilitated, and the bioavailability of the pterostilbene is improved.

The invention discloses a breeding method for synthesizing resveratrol and pterostilbene in rice seed endosperm, and relates to the technical field of biology. The transgenic breeding method comprises the following steps: transforming a recombinant vector into a rice callus, and culturing into a transgenic rice plant, the recombinant vector comprises a gene expression cassette for expressing VvSTS protein, a gene expression cassette for expressing VvROMT protein, a gene expression cassette for expressing At4CL protein and a gene expression cassette for expressing transcription factor OsMYBP1 protein. The synthesis of the resveratrol and the pterostilbene in the rice endosperm is realized, and the product can be used as a raw material for producing the resveratrol and the pterostilbene, and has important guiding significance for novel functional breeding.

The present disclosure relates to a cocrystal of pterostilbene and a coformer capable to form hydrogen bond interactions, to a process for the preparation thereof, and to its use as a medicament or a dietary supplement. The present disclosure also relates to a composition comprising the cocrystal.

The application discloses a kind of composite microecological preparation and preparation method and application, belong to microbial technical field.The composite microecological preparation is core-shell structure, the core-shell structure is divided into inside and shell layer, inside includes Bifidobacterium adolescentis, shell layer includes metal polyphenol network and ficoll polysaccharide;The metal polyphenol network includes the complex coating formed by pterostilbene and calcium ion.The core is BA, the shell is made of FCPS, PTE, Ca 2+ Network composition, can protect Bifidobacterium adolescentis to reach intestine successfully and colonize, directly inhibit inflammatory response, and relieve CDI-induced mouse colitis and oxidative stress damage by regulating intestinal flora, indole and the generation of indole derivatives, solve the pain point that traditional microecological preparation probiotic survival rate is low, poor targeting, limited effect.

The invention relates to the technical field of cosmetics, and particularly discloses an anti-oxidation and anti-aging skin repair composition and a preparation method thereof, the anti-oxidation and anti-aging skin repair composition comprises pterostilbene, ergothioneine, a repair soothing component, a plant fermentation extract, Ectoine, a composite antioxidant, polyol, a surfactant, and the balance purified water. The preparation method comprises the following steps: step 1, adding polyhydric alcohol and Ectoine into purified water to obtain a water phase; adding a surfactant into the composite antioxidant, and uniformly stirring to obtain an oil phase; pumping the oil phase into the water phase, and uniformly stirring at the temperature of 60-65 DEG C to obtain an emulsion; and step 2, homogenizing the emulsion, adding a repairing and relieving component, cooling, adding pterostilbene, ergothioneine and a plant fermentation extract, adjusting the pH value, and filtering to obtain the antioxidant and anti-aging skin repairing composition which has the effects of long-acting moisturizing, skin smoothing, tightening and elastic moistening.

This invention belongs to the field of cosmetic technology, specifically relating to a composition containing 10-hydroxy-2-decenoic acid and its application. The composition is obtained by compounding probiotic-fermented brown algae, pterostilbene, and 10-hydroxy-2-decenoic acid in a certain proportion. Experiments have shown that the components of the above composition can produce a synergistic effect, significantly inhibiting the production of inflammatory factors, resisting inflammatory aging, and inhibiting lipid peroxidation. Furthermore, this invention unexpectedly discovered that compounding probiotic-fermented brown algae, 10-hydroxy-2-decenoic acid, and pterostilbene can significantly improve the light and heat stability of pterostilbene, thus possessing good practical application value.

The application relates to a preparation method of a protein conjugate with pH sensitivity and potential colon targeting, and belongs to the technical field of functional food composite nanoparticle preparation. The conjugate is prepared by an enzyme-induced method, and the nanoparticle is prepared by a reverse solvent precipitation method. The whey protein isolate-tannic acid protein conjugate prepared by the method has extremely high grafting degree, the antioxidant property of the system is obviously improved, the encapsulation stability of the pterostilbene is high, the stability in the extreme pH environment of the gastrointestinal tract is good, and the protein conjugate has the dual characteristics of pH sensitivity and intestinal tract targeting.

The present invention discloses a process for preparing stilbenes, such as pterostilbene and resveratrol. More specifically, the present invention discloses the synthesis of stilbenes using novel intermediates, 5-(4-(1-ethoxyethoxy)styryl)-benzene-1,3-diol and 1-(4-(1-ethoxyethoxy)styryl)-3,5-dimethoxy-benzene.

The invention discloses pterostilbene hydrogel for treating dark eye circles with dual black fading and a preparation method of the pterostilbene hydrogel, and belongs to the technical field of medicines. The pterostilbene hydrogel for treating dark circles with dual black fading comprises a melanocyte targeting carrier and hydrogel, the melanocyte targeting carrier is prepared from pterostilbene, soya bean lecithin, deoxidized sodium carbonate, tween-80 and undecylenoyl phenylalanine grafted chitosan; the hydrogel is prepared from chitosan, hyaluronic acid, beta-sodium glycerophosphate and water. The double black fading pterostilbene hydrogel for treating dark circles has double black fading effects of'source inhibition 'and'result evacuation', and has strong dark circle treatment potential.

The invention discloses an ergothioneine supramolecular compound as well as a preparation method and application of the ergothioneine supramolecular compound, and the ergothioneine supramolecular compound is prepared from the following components in parts by mass: 0.001 to 10 parts of ergothioneine, 0.001 to 5 parts of pterostilbene and 0.0001 to 3 parts of fibroin. The ergothioneine, the pterostilbene and the fibroin are combined through hydrogen bonds to form supramolecules, and pungent smell generated when the ergothioneine is used in skin care products can be obviously reduced.

The invention belongs to the technical field of cosmetic manufacturing, and particularly relates to a co-amorphous substance as well as a preparation method and application thereof. The preparation method of the co-amorphous substance comprises the following steps: taking at least one of glabridin, retinol, curcumin and pterostilbene as a raw material, reacting the raw material with a ligand in a solvent, and then desolventizing and drying to obtain the co-amorphous substance, the molar ratio of the raw material to the ligand is 1: (1-8); the ligand comprises hydroxypropyl-beta-cyclodextrin or glycyrrhizic acid. According to the invention, the problems of poorer water solubility and stability of alcohol-soluble raw materials such as glabridin, retinol, curcumin, pterostilbene and the like are effectively solved. The co-amorphous substance prepared by the invention can significantly improve the water solubility and dispersity of the raw materials. The selected ligand glycyrrhizic acid also has a certain anti-oxidation effect, so that synergistic interaction can be realized.

The invention discloses a methyltransferase mutant, a recombinant genetic engineering strain and application thereof, and belongs to the technical field of biology. According to the invention, site-specific mutagenesis is carried out on key sites of an active pocket of the ryegrass-derived methyltransferase LpCOMT, so that the activity of a methyltransferase mutant can be further improved, and the yield of pterostilbene is further improved; furthermore, the obtained methyltransferase mutant gene is integrated into a genome of a yarrowia lipolytica jz502 strain, the obtained engineering strain can efficiently produce pterostilbene from glucose, the shake flask fermentation yield reaches 405mg / L, the shake flask fermentation yield is expanded in a 1L fermentation tank, the pterostilbene yield can reach 8.2 g / L, the highest value is reported by a yarrowia lipolytica system, and the yield of pterostilbene can reach 8.2 g / L. The method has a remarkable industrial application value.

This invention discloses a pigment for scalp micropigmentation and its packaging bottle, relating to the field of cosmetic packaging technology. The pigment comprises a base carrier, a biomimetic coloring system, a stabilizing and bioactive system, additives, and water. It utilizes a compound coloring process of nano-plant carbon black, γ-iron oxide, and anatase titanium dioxide microspheres, combined with components such as pterostilbene, sodium hyaluronate, and ceramide NP, to achieve three-dimensional biomimicry, high stability, low irritation, and minimal smudging. The accompanying packaging bottle features a narrow medical-grade PETG bottle body, a bottom material-gathering cone, a hydrophobic inner wall, a one-way valve, and a controlled-discharge nozzle, with a residual rate ≤2%, aseptic sealing, and precise dispensing. This invention provides natural coloring, good compatibility, and high utilization, making it suitable for clinical and commercial promotion of scalp micropigmentation.

The invention provides a dendrobium officinale exosome delivery system loaded with active oxygen responsive pterostilbene as well as a preparation method and application of the dendrobium officinale exosome delivery system, and belongs to the technical field of biological medicines. Comprising the following steps: 1) mixing 4-(hydroxymethyl) phenylboronic acid pinacol ester and N, N '-carbonyldiimidazole, and carrying out a first reaction to obtain a H2O2 cleavable phenylboronic acid ester derivative; (2) mixing pterostilbene with the phenylboronic acid ester derivative, and carrying out second reaction to obtain boronic acid ester-pterostilbene; and 3) mixing the dendrobium officinale cell exosome with the borate-pterostilbene, and co-incubating to obtain the dendrobium officinale cell exosome loaded with the active oxygen responsive pterostilbene. According to the invention, the pterostilbene is modified by boric acid ester bonds to construct an ROS-sensitive prodrug (Bor-PTE), and the Bor-PTE is entrapped by using the natural carrier characteristics of the dendrobium officinale exosome, so that the bioavailability and targeting problems of the pterostilbene are synergistically solved.

The application provides a whitening composition, a preparation method and application thereof, and belongs to the technical field of cosmetics. In the whitening composition provided by the application, lauroyl sarcosine isopropyl ester, diisopropyl sebacate, PPG-14 polyglyceryl-2 ether, bis-diethoxydiglycol cyclohexane 1,4-dicarboxylic acid ester and poly C10-30 alkylol propenoate are used as oil phases to wrap whitening components (magnolia alcohol, pterostilbene, ferulic acid and dimethyl methoxy benzodihydro pyranol) to form oil capsule beads, and then the oil capsule beads are dispersed in a polyol and carbomer matrix, the composition of the oil phase and the whitening components is controlled, and the whitening effect and transdermal absorption effect of the whitening composition are improved.

The application belongs to the technical field of medicine, and particularly relates to a blood vessel targeting anti-aging oral composition and application thereof. In view of problems such as endothelial dysfunction, matrix sclerosis and accumulation of senescent cells caused by vascular aging, the composition comprises active ingredients: beetroot extract, fisetin, salvianolic acid B, panax notoginseng total saponins, cocoa flavanol, pterostilbene, procyanidin B2, luteolin, nicotinamide riboside and astaxanthin. The composition is prepared by a process of adsorbing astaxanthin on beetroot extract, mixing other active ingredients, fillers and glidants after fisetin and salvianolic acid B are prepared into a solid dispersion, and sequentially cooperating each module, so that the pulse wave transmission velocity can be significantly reduced and the skeletal muscle capillary density can be increased, and the composition is mainly used for preparing a medicine for improving vascular stiffness, promoting microcirculation and removing vascular senescent cells.

The invention discloses a pterostilbene supramolecular nano-composite, the composition comprises an active component pterostilbene, water, a main component and polyhydric alcohol, and the content of the main component is 0.1-40%, the content of the polyhydric alcohol is 0.1-30%, the content of the pterostilbene is 0.1-8%, and the balance is water based on the total weight of the nano-composite. The main component comprises an ether bond, and is selected from one or more of vitamin E polyethylene glycol succinate, PEG-40 hydrogenated castor oil, PEG-6 decyl tetradecyl alcohol polyether-30, polyoxyethylene sorbitan ester, PPG-5-cetyl alcohol polyether-20, and polyglycerol-10 laurate. The invention also discloses a preparation method of the pterostilbene supramolecular nano-composite and application of the pterostilbene supramolecular nano-composite in cosmetics. The pterostilbene supramolecular nano-composite can load pterostilbene with high content without additionally adding an oil-phase solvent, does not crystallize and precipitate, can be directly added into cosmetics or added into cosmetics as a composition, can effectively improve the permeation effect of pterostilbene on skin, and effectively improves the utilization rate of pterostilbene.

The invention provides a preparation method and application of a pH / ROS dual response type pterostilbene nanocomposite, the pterostilbene nanocomposite is composed of an outer ROS response layer, a middle pH response layer and an inner core, tannic acid and Fe < 3 + > are coordinated to form a network structure to encapsulate pterostilbene, drug loading stability and solubility are improved, and the inner core is formed; a middle layer is coated on the surface of the inner core, namely, pH response is realized through galactose-modified aminated hyaluronic acid, the medicine is protected in a gastric acid environment, galactose-targeted liver cell ASGPR receptors are exposed in an intestinal environment, and medicine release is triggered by pH drop of a focus area; the ROS response coating on the outermost layer is formed by the gallic acid-carrageenan copolymer, the ROS response coating is kept complete in gastric acid, and when the ROS in the liver is excessive, the gallic acid is released to synergistically remove the ROS, so that the bioavailability of the pterostilbene is improved, and a good improvement effect on the alcoholic liver injury is achieved.

The invention provides an anti-wrinkle, whitening and freckle-removing skin care product and a preparation method thereof, and belongs to the technical field of cosmetics. The skin care product comprises the following components: a phase A: shea butter, simmondsia chinensis seed oil, tocopherol, cetostearyl alcohol, isooctyl palmitate, squalane and polyglycerol-3 methyl glucose distearate; the phase B is prepared from glycerol, 1, 2-hexanediol, sodium ascorbate phosphate and disodium ethylene diamine tetraacetate; a phase C: pterostilbene, nicotinamide, an ethyl ferulate compound, a ginseng extract and a sea-buckthorn extract; phase D: methylparaben and a stabilizer; and the balance of deionized water. Through the synergistic effect of the raw materials, the prepared skin care product not only has the effects of removing wrinkles, whitening and removing freckles, but also is good in stability and high in safety.