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173 results about "Pterostilbene" patented technology
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Pterostilbene (/ˌtɛrəˈstɪlbiːn/) (trans-3,5-dimethoxy-4-hydroxystilbene) is a stilbenoid chemically related to resveratrol. In plants, it serves a defensive phytoalexin role.
Anti-aging composition containing resveratrol and method of administration
InactiveUS20090163580A1Improve athletic performanceBiocideNervous disorderActive agentExercise performance
Formulations and methods of treatment and putative prevention for aging (anti-aging composition) and for diseases or conditions of all reactive oxygen species-dependant illnesses, such as Alzheimer's disease, Parkinson's disease, diabetes mellitus, cardiovascular disease, cancer, hepatitis, and disorders associated with estrogen deficiencies including osteoporosis and breast cancer and for improving athletic performance of humans include resveratrol and two (2) or more of the following features or additional active ingredients: (1) slow release formulation of resveratrol; (2) pterostilbene; (3) quercetin; (4) fisetin, and (5) naringenin. Slow release is defined for the purposes of the present invention as releasing 95% of the active agent or agents in eight (8) hours through normal human gastrointestinal absorption.
Owner:NATROL
Dietary supplement system for multifunctional anti-aging management and method of use
A dietary supplement system includes a dietary supplement composition for oral administration by an individual in the morning, the composition, including (a) a telomere maintenance complex including: Purslane extract (aerial parts); Turmeric rhizome extract (95% curcuminoids); Quercetin dehydrate, Cayenne pepper fruit; Vanadium (as vanadyl sulfate); Fenugreek seed; Astragalus root extract, Omega fatty acid complex including linoleic acid; alpha-linolenic acid; oleic acid borage seed oil gamma-linolenic acid), evening primrose oil fish body oil (eicosapentaenoic acid; docosahexaenoic acid); (b) a calorie restriction mimetics and gene expression complex including Trans-resveratrol (from Polygonum cuspidatum root extract); Pterostilbene Fisetin 50% (Buxus microphlla Sieb (stem and leaf; Alpha lipoic acid, Coenzyme Q-10, Betaine HCl, Sulfur (from methylsulfonylmethane); L-Carnitine tartrate; L-Carnitine HCl, and (c) a free radical scavenger complex, including Green tea leaf extract catechin and polyphenols); Anthocyanins (from bilberry fruit and grape skin extracts).
Owner:LIFE SCI INT
Method and compositions for administering resveratrol and pterostilbene
InactiveUS20090175803A1Potent antidiabetic agentEqual potencyBiocideDispersion deliveryMedicineMucous membrane
Resveratrol and / or pterostilbene are added to a chewable carrier, to enhance absorption of resveratrol and / or pterostilbene buccally or through the mucous membranes of the mouth. The composition containing the resveratrol and / or pterostilbene is designed to be retained in the mouth for at least 20 seconds and up to 20 minutes to ensure absorption of the resveratrol and / or pterostilbene through the mucous membranes of the mouth.
Owner:RUBIN DAVID +1
Synthetic method of pterostilbene
InactiveCN1955153ASimple processMild reaction conditionsOrganic chemistryOrganic compound preparationAlcoholBenzaldehyde
This invention relates to a composing preparation of pterostilbene, this preparation uses 3,5-dipl-methoxyl Chlorobenzyl and P-hydroxy benzaldehyde or uses 3,5-dipl-methoxybenzaldehyde and p-hydroxyl group alcohol benzyl (first protected, second chlorinated), by method of protecting 4'-hydroxy group and producing phosphonate agentia, carry out Wittig-Horner reaction, then pterostilbene is produced by hydrolization and schizolysis.
Owner:NAN JING RHINE PHARM TECH
Method for oxidation synthesis of stilbenes by hexamethylenetetramine
InactiveCN101531571ACreate pollutionSimple methodOrganic chemistryOrganic compound preparationHexamethylenetetramineBenzaldehyde
The invention discloses a method for oxidation synthesis of stilbenes by hexamethylenetetramine, comprising the following steps: preparing halogenated hydrocarbon by substituted benzyl alcohol, oxidizing the halogenated hydrocarbon by the hexamethylenetetramine to prepare corresponding substituted benzaldehydes, and preparing stilbene derivatives by condensation of Wittig-Horner. The method is simple and easy to implement; the reactants involved in the process of synthesis are safe; the resultants produce no pollution to the environment, have low cost and high yield and are suitable for industrially producing stilbenes having antibacterial action, such as resveratrol, pterostilbene and 3, 5-dimethoxy-4-isopropyl stilbene, etc.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Method for generating pterostilbene by utilizing grape resveratrol-oxygen-methyl transferase to catalyze resveratrol
InactiveCN102120996AMicrobiological testing/measurementFermentationRapid amplification of cDNA endsBiotechnology
The invention discloses a method for generating pterostilbene by utilizing grape resveratrol-oxygen-methyltransferase to catalyze resveratrol, grape ROMT (resveratrol-oxygen-methyl transferase) genes are cloned by utilizing 5' and 3' RACE (rapid amplification of cDNA ends) full-length gene cloning technology according to EST (expressed sequence tag) sequence of the ROMT genes of Chinese wild grapes in East China, and the full length of an open reading frame of the genes is 1074bp; and the cloned grape STS (steroid sulfatase) and ROMT genes can be simultaneously transferred into model plant tobacco, tobacco plant analysis is utilized for analyzing the biological synthesis path of generating the pterostilbene by utilizing the grape ROMT to catalyze the resveratrol, a grape ROMT gene sequence is obtained for orientation, and the ROMT genes can catalyze the resveratrol to generate the pterostilbene in the transgenic tobacco, thereby providing the sequence of the ROMT genes and the method for synthesizing the pterostilbene by utilizing plants and providing a basis for getting high-quality, disease-resistant and health care crops.
Owner:NORTHWEST A & F UNIV
Huperzia serrata endogenetic epiphyte and uses thereof
The invention discloses endophytic fungi from huperzia serrata. The invention is obtained through being separated from the living body of pteridophyta huperzia serrata by adopting endophytic fungi separation and purification technology, and is identified through biosystematics to be acremonium endophytium. The preservation number of the strain is CCTCC M 206118. The invention generates Huperzine A analogous compound through the strain liquid fermentation of the endophytic fungi from huperzia serrata, and is significant micro organism for searching the Huperzine A new resource of the active component for curing the presenile dementia.
Owner:SHANGHAI UNIV OF T C M
Method for synthesizing stilbenoids by hydrochloric acid heterogeneous chlorination
The invention discloses a method for synthesizing stilbenoids of styrenemod, pterostilbene, piceatannol and resveratrol oxide by hydrochloric acid heterogeneous chlorination. The method takes substituted benzyl alcohol as a raw material, adopts hydrochloric acid for preparing chlorinated hydrocarbons under heterogeneous conditions and prepares the stilbenes compounds by Wittig-Horner condensation. The method is simple and easy to operate, the reactants involved in the synthesis process are safe, the products can not cause environmental pollution, the cost is low, and the yield is high, thereby being applicable to industrial production of styrenemod, pterostilbene, piceatannol and resveratrol oxide.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Chitosan coating medicine slow release microsphere and preparation method thereof
InactiveCN101618021AGood biocompatibilityLow toxicityHydroxy compound active ingredientsDigestive systemChitosan coatingAlcohol
The invention discloses a chitosan coating medicine slow release microsphere and a preparation method thereof. The chitosan coating medicine slow release microsphere comprises a condensate capsule shell of chitosan and glutaric dialdehyde, core medicine resveratrol, oxidative resveratrol, pterostilbene or white cedar alcohol, wherein the core medicine resveratrol, the oxidative resveratrol, the pterostilbene or the white cedar alcohol are coated into the capsule shell. The preparation method is simple and easy, the preparation cost is low, the microsphere envelop rate is 10-50 percent, the microsphere is round and has good dispersivity, the stability of the original medicine is increased, and the chitosan coating medicine slow release microsphere realizes the function of medicine slow control and release and can be conveniently matched with other medicines. The chitosan coating medicine slow release microsphere is suitable for preparing a slow release formulation of medical resveratrol, oxidative resveratrol, pterostilbene and white cedar alcohol.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
(E)-3,5-dimethox-4'-hydroxy diphenyl ethylene synthesis method
InactiveCN1876613AImprove economySimple reaction stepsOrganic chemistryOrganic compound preparationAcetic acidDecarboxylation
The invention discloses the synthesis of pterostilbene. The method comprises the following steps: using p-hydroxyphenyl acetic acid and veratraldehyde as raw material, carryingout Perkin reaction, getting (Z)-2(4-acetoxylation phenyl)-3-(3, 5- dimethoxy benzoic) acroleic acid, deacetylation, decarboxylation, and getting pterostilbene. The invention has the advantages of cheap raw material, simple technology, easy operation and high productivity. The invention has the advantages of low cost, good economy benefit and environment protection.
Owner:GUANGZHOU INST OF GEOCHEMISTRY - CHINESE ACAD OF SCI
Method and compositions for preserving wine
InactiveUS20090175984A1Avoid contactAvoid decompositionDispersion deliveryHydroxy compound active ingredientsGrape wineBacteria
Resveratrol and / or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi. The resveratrol and / or pterostilbene can be added to grape must prior to fermentation and / or to fermented wine prior to bottling.
Owner:RESWINE LLC
Preparation method of water-soluble toluylene compound prodrugs
The invention discloses a preparation method of water-soluble toluylene compound prodrugs. PEG (Polyethylene Glycol) or mPEG (monomethoxy-Polyethylene Glycol)-carboxybutyryl or acetyl-amino acid is taken as a modifier for modifying toluylene compounds such as (E)-3,5-dihydroxy-4-isopropyltoluylene, resveratrol oxide, pterostilbene, piceatannol, resveratrol and the like to prepare prodrugs thereof. By adopting the modified prodrugs, the water solubility and stability of these compounds are improved, the bioactivity is increased, the aim of releasing under control is fulfilled, and the application ranges of these compounds in the industries of medicines, foods and the like are further expanded. The method is suitable for preparing prodrugs by modifying toluylene compounds with the PEG (Polyethylene Glycol) or mPEG (monomethoxy-Polyethylene Glycol)-carboxybutyryl or acetyl-amino acid. The prepared prodrugs are further used for preventing and treating diseases such as fungi, eczema, arteriosclerosis, coronary heart disease, virus hepatitis, AIDS, cancers and the like.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Method and compositions for perserving wine
ActiveUS20110104328A1Avoid contactLess water solubleDispersion deliveryHydroxy compound active ingredientsBiotechnologyPolyphenol
Owner:RESWINE LLC
Dragon's blood extract as well as preparation method and application thereof
ActiveCN101411833AIncreased protectionReduced survival rateSenses disorderNervous disorderPhenolNerve cells
The invention discloses a dragon blood extract. Based on 3-methoxy resveratrol and loureirin B, according to weight percentage, the content of total phenol is more than 50 percent, the content of loureirin A is between 0.5 and 4.0 percent, the content of the loureirin B is between 0.4 and 2.0 percent, the content of resveratrol is between 0.1 and 2.0 percent, the content of pterostilbene is between 0.3 and 4.0 percent, and the content of the 3-methoxy resveratrol is between 0.1 and 2.5 percent. Besides, the invention also discloses a method for preparing the dragon blood extract, a method for controlling the quality, and application of a pharmaceutical composition containing the dragon blood extract. The extraction process route of the dragon blood is simple and is suitable for industrial mass production; besides, the dragon's blood extract has better nerve cell protection function, and can serve as a protective agent for nerve cells.
Owner:北京理工亘舒科技有限公司
Sustained/controlled release microsphere of biological extract Genipin cross-linked chitosan coated stilbene compound and preparation method thereof
InactiveCN102240268ALow toxicityUniform qualityAntimycoticsHydroxy compound active ingredientsCross-linkMicrosphere
The invention discloses a sustained / controlled release microsphere of a chitosan coated stilbene compound using a biological extract Genipin as a cross-linking agent and a preparation method thereof. In the microsphere, a cross-linked condensation compound layer of the chitosan and the Genipin serves as a capsule shell and is used for coating a medicament 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol or piceatannol; the medicament stability of the product is improved; the sustained / controlled release of the medicament is realized; and the released Genipin after in vivo metabolism of the capsule shell has the characteristics of biocompatibility, no cytotoxicity and the like. The invention is applicable to the sustained / controlled release microspheresof Genipin cross-linked chitosan coated 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol, piceatannol and other stilbene compounds and a preparation method thereof. The preparation method is low in requirements on the control condition and easy to operate. In the microspheres, the quality is uniform; the grain size is 0.1 to 100 mu m; the surface of the microsphere has a multiporous structure; and the entrapment rate of the capsule shell to the medicament is 30 to 90 percent.
Owner:HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
Whitening and freckle-fading composition and application thereof
ActiveCN111743851AInhibitionImprove securityCosmetic preparationsToilet preparationsBiotechnologyYolk
The invention discloses a whitening and freckle-fading composition and application thereof. The whitening and freckle-fading composition is prepared from the following raw materials: egg yolk oil andshea butter, pterostilbene and vitamin E, hydrolyzed ceramide III, an orange peel extract, a yeast extract, a thyme extract, a white willow bark extract, a verbascose flower extract, a sea lily nerveactivity whitening factor, a scutellaria baicalensis extract, oxyresveratrol, a lactobacillus fermentation lysate, tranexamic acid, VC ethyl ether, water-soluble fullerene, 4-butyl resorcinol and Ectoin; the invention also discloses application of the whitening and freckle-fading composition in cosmetics. The whitening and freckle-fading composition is good in safety and free of toxic and side effects, the whitening active ingredients are compounded, generation of melanin is inhibited from two ways of inhibiting saccharification and tyrosinase activity, and the whitening and freckle-fading effects are remarkable.
Owner:广州市胜梅化妆品有限公司
Method for inducing udp-glucuronosyltransferase activity using pterostilbene
ActiveUS20120289605A1High activityLower Level RequirementsBiocideNervous disorderUDP glucuronosyltransferase activityGlucuronosyltransferase activity
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein UDP-glucuronosyltransferase (UGT) activity is increased. In an embodiment, 12-HETE levels can be reduced by administration of pterostilbene.
Owner:CHROMADEX +1
Use of pterostilbene in preparation of drugs for inhibiting liver cancer cell proliferation and inducing liver cancer cell apoptosis
InactiveCN105012281APrevent proliferationInduce apoptosisDigestive systemEther/acetal active ingredientsWestern blotCancer cell proliferation
Owner:QIQIHAR UNIVERSITY
Application of pterostilbene to prevention and treatment of botrytis cinerea and peronophythora litchii
ActiveCN106615071AGood for healthMeet safety requirementsFruit and vegetables preservationBiotechnologyAntibiosis
The invention discloses application of pterostilbene to prevention and treatment of botrytis cinerea and peronophythora litchii, provides application of pterostilbene or a solution thereof to inhibition of peronophythora litchii and also provides application of pterostilbene or a solution thereof to prevention and treatment of peronophythora litchii. Experiments show that pterostilbene can be used for preventing and treating botrytis cinerea and peronophythora litchii of harvested grapes and litchis; and pterostilbene can be separately used, can also be combined with other antibacterial agents for improving the antibacterial effect or reducing the toxic and side effects, is green and safe, is beneficial to human health, meets the food safety requirements and achieves the effects of preventing and treating botrytis cinerea and peronophythora litchi and retaining freshness of fruits.
Owner:CHINA AGRI UNIV +1
Pterostilbene submicron lipid particle and preparation method thereof
ActiveCN105581935AGood dispersionImprove stabilityCosmetic preparationsToilet preparationsLipid formationLipid particle
The invention provides a pterostilbene submicron lipid particle and a preparation method thereof, and belongs to the technical field of a carrier system in cosmetic preparation technology. The pterostilbene submicron lipid particle consists of pterostilbene, lipid, an emulsifier, a co-emulsifier, a stabilizer and water. According to the invention, the color change situation of the pterostilbene caused by long-time illumination is solved. The pterostilbene submicron lipid particle prepared by the invention can be well dispersed in the water, with high stability, and the pterostilbene submicron lipid particle, after dispersed in hot water, is fully transparent while the lipid particle is not separated out at low temperature; and the pterostilbene submicron lipid particle can be optionally matched with any cosmetic formulas.
Owner:SHANGHAI ZHONGYI DAILY CHEM CO LTD
Key intermediate for the preparation of stilbenes, solid forms of pterostilbene, and methods for making the same
The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4′-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4′-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4′-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4′-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.
Owner:LAURUS LABS
Composition, and external preparation for the skin or functional food each containing said composition
The present invention provides: a composition which has an effect of preventing or improving skin conditions including the formation of small wrinkles and the sagging of the skin; and an external preparation for the skin or a functional food, each of which contains the composition. The present invention relates to: a composition comprising carotenoid and pterostilbene; and an external preparation for the skin or a functional food, each of which contains the composition.
Owner:FUJIFILM CORP
Pterostilbene (PTER) for use in the prevention and/or treatment of skin diseases, damages or injures
Owner:GREEN MOLECULAR
Pterostilbene nano-capsules and preparation method thereof
ActiveCN105686961APromote degradationEasy to prepareCosmetic preparationsToilet preparationsPolyolLiquid state
The invention relates to pterostilbene nano-capsules and a preparation method thereof. The pterostilbene nano-capsules are prepared from, by weight, liquid oil 0.1-20%, pterostilbene active substance 0.1%-15%, an emulsifier 1%-35%, polyols 40-85% and deionized water 8-50%. The preparation method comprises the steps that (A) the liquid oil and the emulsifier are mixed together and heated for dissolution, then the pterostilbene is added, and stirring is performed till the pterostilbene is completely dissolved; (B) the polyols and the water are mixed and heated for dissolution, and even stirring is performed; (C) the solution obtained in the step (B) is added to the solution obtained in the step (A), even mixing and stirring are performed, and the solution is taken out and cooled to obtain transparent blue gel, namely the pterostilbene nano-capsules. The pterostilbene nano-capsules are simple, controllable, mild in operation, good in repeatability, high in pterostilbene load and high in stability, and the problem that the pterostilbene is insoluble in water and the content drops rapidly during high-temperature operation is solved.
Owner:SOUTHEAST UNIV
Method for synthesizing pterostilbene and derivatives thereof
ActiveCN105367390AThe synthesis method is simpleOrganic chemistryOrganic compound preparationCopperCoupling reaction
The present invention relates to a method for synthesizing pterostilbene and derivatives thereof. The method comprises the steps of: by using cinnamic acid derivatives as a raw material, carrying out a reaction with Cu+ under a Cs catalytic condition to generate an intermediate styryl copper; and carrying out an Heck decarboxylation coupling reaction on the intermediate with 3, 5-dimethoxy bromobenzene under a Pd catalytic condition to generate pterostilbene and derivatives thereof. The method provided by the present invention is simple in step, high in yield and suitable for large-scale synthesis of pterostilbene and derivatives thereof.
Owner:HUNAN UNIV OF CHINESE MEDICINE
Dietary supplement system for multifunctional anti-aging management and method of use
Owner:LIFE SCI INT
Methods of using O-methyltransferase for biosynthetic production of pterostilbene
ActiveCN106102454ASolve the technical problem of generating pterostilbenePromote generationBryophytesNervous disorderStilbene synthaseP-Coumaric acid
A biosynthetic method of making pterostilbene including expressing a 4- coumaratexoenzyme A ligase (4CL) in a cellular system, expressing a stilbene synthase (STS) in the cellular system, expressing a resveratrol O-methyltransferase (ROMT) in the cellular system, feeding p-coumaric acid to the cellular system, growing the cellular system in a medium, and producing pterostilbene.
Owner:CONAGEN INC
Pterostilbene cocrystals
ActiveUS20110189275A1Physical stabilityImprove physical stabilityBiocideOrganic chemistryGlutaric acidCarbamazepine
Cocrystals of pterostilbene are disclosed, including: pterostilbene:caffeine cocrystal, pterostilbene:carbamazepine cocrystal, pterostilbene:glutaric acid cocrystal, and pterostilbene:piperazine cocrystal. The pterostilbene:caffeine cocrystal is polymorphic. Forms I and II of the pterostilbene:caffeine cocrystal are disclosed. The therapeutic uses of the pterostilbene cocrystals and of pharmaceutical / nutraceutical compositions containing them are also disclosed. The disclosure sets out various methods of making and characterizing the pterostilbene cocrystals.
Owner:LAURUS LABS
Pterostilbene phosphate disodium salt synthesis method
ActiveCN103408591AMild reaction conditionsShort reaction timeGroup 5/15 element organic compoundsPhosphorylationPhosphate
The present invention provides a pterostilbene phosphate disodium salt synthesis method, wherein an aprotic solvent is adopted to dissolve pterostilbene, a dialkoxyl phosphoryl halide is adopted as a phosphorylation regent, acylation is performed under catalysis effects of an acid removing agent and 4-dimethylaminopyridine to obtain pterostilbene-alkoxyl-phosphate ester, and hydrolysis, salt formation and crystallization are performed to obtain the pterostilbene phosphate disodium salt. The method has characteristics of mild reaction conditions, short reaction time, no requirement of purification of the phosphorylation intermediate, simple process, high yield, good product quality and low energy consumption, and is suitable for industrial production.
Owner:ZHANG JIA GANG VINSCE BIO PHARM
Composition for treating degenerative diseases and application of composition
InactiveCN106955290ARaw materials are easy to obtainReasonable ratioNervous disorderMetabolism disorderDegenerative DisorderPsicose
The invention relates to the technical field of medicines, foods and cosmetics and in particular relates to a composition containing nicotinamide ribose, pterostilbene, psicose and lipoic acid for treating degenerative diseases and application of the composition. The composition contains nicotinamide ribose, pterostilbene, psicose, lipoic acid and microcrystalline cellulose according to a mass ratio of (2-12.5):(1):(0.24-2.4):(0.08-1.5):(0.48-3). The composition containing the nicotinamide ribose, the pterostilbene, the psicose and the lipoic acid is first applied to treatment of the degenerative diseases, the raw materials are simple and readily available, the ratio is reasonable, the effects of reducing blood glucose and reducing blood fat are obvious, and the production cost is low.
Owner:南京顺昌医药科技有限公司
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