18 results about "Fisetin" patented technology

A nutraceutical composition, consisting of Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

The invention discloses an oral hard capsule health-care product with an anti-aging function as well as a preparation method and application of the oral hard capsule health-care product. The health-care product is mainly prepared from eight active ingredients including EGT (Ergothioneine), Ca-AKG (alpha-ketoglutarate), PQQ (pyrroloquinoline quinone), fisetin, salidroside, urolithin A, spermidine and an apple stem cell extract. Through scientific compatibility of the various components, the composition disclosed by the invention can comprehensively intervene in a cell aging process through a synergistic effect of a plurality of pathways of enhancing the cell antioxidant capacity, improving the mitochondrial function, activating cell autophagy, promoting cell regeneration and repair and the like. The invention also provides a preferred content range of the health-care product, a preparation method of the health-care product and application of the health-care product in preparation of health-care foods for delaying senescence, improving cell viability or improving mitochondrial functions. The product provided by the invention has the characteristics of multiple targets and synergistic interaction, and provides a new effective scheme for anti-aging intervention.

The present invention relates to the use of a composition comprising an effective amount of a combination of fesoterodine and / or a derivative thereof and quercetin and / or a derivative for preventing or treating a bone disorder or maintaining bone health in an individual.

The inventors' primary objective was to provide a technology that suppresses inflammation, particularly in aging tissues. [Solution] The above problem can be solved by a composition containing at least one selected from the group consisting of genistein, quercetin, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof.

This invention relates to compounds that are 4′-substituted analogues of the flavonol Fisetin. In particular, the invention relates to such compounds wherein the 4′ position on the B-ring is substituted with a ring deactivating group which has a para-Hammett constant greater than zero, and the use of these compounds in the treatment of cancer, including epithelial cancers.

Provided herein are methods and compositions utilizing a urolithin A agent, a fisetin agent, and an isoflavone agent for treatment of neurodegenerative diseases.

A nutraceutical composition, consisting of Nicotinamide Riboside in a range of 100-2000 mg or Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

The present application provides a kind of drug composition and its application for targeting neuroinflammation, the composition is composed of active ingredient and natural nanometer delivery carrier for encapsulating active ingredient, the active ingredient includes fisetin, pyrrole quinoline quinone, resveratrol, bauhinia A, apigenin, saffron, quercetin and hair monkey element;The natural nanometer delivery carrier is the plant source extracellular vesicle of surface modification brain targeting molecule.The composition of the present application realizes the intervention to vascular cognitive impairment by multi-component scientific compatibility, combined with two-stage brain targeting delivery design, solves the pain points of low blood-brain barrier penetration rate and poor bioavailability of natural active ingredient, has the effect of strong anti-inflammatory and significantly improving cognitive function, excellent safety, can be used for preparing the medicine for preventing or adjuvant therapy neuroinflammation related vascular cognitive impairment, has very high clinical conversion value.

The application belongs to the technical field of medicine, and particularly relates to a blood vessel targeting anti-aging oral composition and application thereof. In view of problems such as endothelial dysfunction, matrix sclerosis and accumulation of senescent cells caused by vascular aging, the composition comprises active ingredients: beetroot extract, fisetin, salvianolic acid B, panax notoginseng total saponins, cocoa flavanol, pterostilbene, procyanidin B2, luteolin, nicotinamide riboside and astaxanthin. The composition is prepared by a process of adsorbing astaxanthin on beetroot extract, mixing other active ingredients, fillers and glidants after fisetin and salvianolic acid B are prepared into a solid dispersion, and sequentially cooperating each module, so that the pulse wave transmission velocity can be significantly reduced and the skeletal muscle capillary density can be increased, and the composition is mainly used for preparing a medicine for improving vascular stiffness, promoting microcirculation and removing vascular senescent cells.

The application discloses a fisetin-4'-O-alpha-D-glucopyranoside for resisting lung cancer and a preparation method and application thereof, and the preparation method comprises the following steps: taking sucrose as a glycosyl donor, taking fisetin as a glycosyl acceptor, and performing an enzymatic transglycosylation reaction under the catalysis of sucrose phosphorylase to direct the glucose group generated by decomposing the sucrose to be transferred to a hydroxyl group at a C4' position of the fisetin, so that a target product is obtained; and the sucrose phosphorylase is derived from Bifidobacterium adolescentis. The application retains the original core biological activities of the fisetin, such as antioxidation and anti-inflammation, provides high-quality raw materials for the application of the fisetin in the fields of innovative drug development for resisting lung cancer and preparation of medical intermediates, and expands the clinical transformation potential of fisetin compounds.

The invention relates to the technical field of medicine and cosmetic equipment, in particular to a whitening micro-emulsion preparation and a preparation device thereof, and the preparation comprises the following components in parts by weight: 2-3 parts of nicotinamide, 1-2 parts of ascorbyl glucoside, 0.5-1 part of fisetin, 65-75 parts of a water phase solvent, 8-12 parts of an oil phase solvent, 3-5 parts of an emulsifier and 0.5-1 part of a stabilizer. The stability of the whitening preparation under extreme temperature and humidity conditions can be improved, meanwhile, the preparation device is optimized, and the stirring uniformity of the whitening preparation in the production stirring process is improved.

The present invention relates to the use of a composition comprising an effective amount of oleuropein and / or its metabolites in combination with fesoterodine and / or derivatives for the prevention or treatment of bone disorders or for the maintenance of bone health in an individual.

The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity.　The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.

The invention relates to the technical field of biological medicines, in particular to a pharmaceutical composition with a synergistic anti-aging effect as well as a preparation method and application of the pharmaceutical composition. The pharmaceutical composition specifically consists of dihydroquercetin and fisetin. According to the invention, two core anti-aging mechanisms of oxidation resistance and senescence cell removal are organically integrated for the first time, and multi-target collaborative intervention on the senescence process is realized. Compared with a single component, the composition not only can effectively repair oxidative damage, but also can selectively remove accumulated senescent cells, plays a role from the source and the result at the same time, overcomes the defects that a traditional single strategy is single in action path and limited in effect, and has a good application prospect. A more comprehensive and efficient new scheme is provided for delaying senescence and preventing and treating senescence-related diseases.

The invention discloses a YBX1 protein degradation agent fisetin and application thereof in preparation of medicines for preventing and treating obesity or fatty liver, and belongs to the technical field of medicines. The embodiment of the invention proves that fisetin as a YBX1 protein degradation agent can relieve obesity induced by high-fat diet and reduce the accumulation of triglyceride in the liver of a mouse with high-fat diet. Meanwhile, the fisetin improves the glucose tolerance of the mouse induced by the high fat diet and improves the insulin resistance of the mouse induced by the high fat diet. In addition, fisetin can also reduce the liver weight and fat content of mice induced by high fat diet, and relieve liver injury and ferroptosis. Fisetin belongs to polyphenol flavonoids, exists in various fruits and vegetables, is low in price, wide in source, smaller in toxic and side effects, extremely easy to obtain and lower in cost, and has a wide application prospect in preparation of medicines for preventing and treating obesity or fatty liver.