44 results about "Fisetin" patented technology

The invention discloses application of fisetin or a salt thereof in medicine preparation, the compound is used for treating or preventing obesity cardiomyopathy, preferably heart diseases caused by hyperlipidemia, but is not limited to the inducer, and specifically, the medicine can inhibit or improve various obesity cardiomyopathy.

The present invention discloses a method for preventing or treating atrial fibrillation (AF) in a subject by administering a therapeutically effective amount of a flavonol compound (Formula 1 or a tautomer thereof), a pharmaceutically acceptable salt, hydrate, or solvate thereof. The method involves obtaining a subject in need of AF prevention or treatment, suspected to require such prevention or treatment, or a normal healthy subject, and administering the compound to the subject Formula 1 comprises specific atoms and substituents, including - H, -OCH3, -OH, -I, -Br, -F, or Cl. By utilizing the flavonol compound of Formula 1, the risk of AF development or the prevalence of AF in the subject is reduced, providing an effective approach for managing AF in individuals.

A nutraceutical composition, consisting of Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

The invention belongs to the technical field of health care products or daily chemical products, and particularly relates to a composition with anti-wrinkle, firming, whitening and brightening effects and application. The composition is prepared from the following components in parts by weight: 72 to 180 parts of fisetin, 120 to 180 parts of urolithin A and 5 to 15 parts of ergothioneine. Through precise component compounding, the synergistic interaction among fisetin, urolithin A and ergothioneine is brought into full play, the skin care composition integrating anti-wrinkle, firming, whitening and brightening functions is successfully developed, and the natural components of the skin care composition ensure the use safety of the product, so that the skin care composition has a good application prospect. The requirements of consumers on efficient skin care are effectively met.

According to the fisetin nanoparticle preparation method, the fisetin nanoparticle product and the application, the synergistic effect of amino acid catalysis and a microwave or ultrasonic energy field is matched with mixing self-assembly and subsequent spray drying forming under the acidic condition, on one hand, the traditional Maillard reaction period is greatly shortened, and energy consumption is reduced; on one hand, the whole technological process of wall material preparation and active ingredient loading is simplified, the large-scale production requirement is met, on the other hand, the fisetin encapsulation effect and the nanoparticle structure stability are improved, the defects that fisetin is poor in water solubility and low in bioavailability are overcome, meanwhile, it is guaranteed that the nanoparticle product quality is uniform, the technology efficiency and the product performance superiority are considered, and the method is suitable for industrial production. The core pain points of low efficiency, poor drug loading effect and insufficient product stability of the existing traditional process are effectively overcome.

The invention relates to the technical field of biomedical materials, in particular to a hydrogel microneedle for skin improvement and a preparation method thereof.The hydrogel microneedle for skin improvement comprises a microneedle matrix and fisetin, the microneedle matrix is a hydrogel matrix, and the fisetin is embedded in the microneedle matrix. According to the hydrogel microneedle for skin improvement, the hydrogel microneedle has good mechanical performance, biocompatibility and degradability, the effect of slowly releasing medicine can be achieved, the hydrogel matrix wraps fisetin, the targeting performance of anti-aging active ingredients can be effectively enhanced, and the anti-aging effect of the skin is improved. The anti-aging agent is slowly released in a corium layer to play an anti-aging role, and has a wide application prospect in medical beauty and skin care products.

The invention discloses an oral hard capsule health-care product with an anti-aging function as well as a preparation method and application of the oral hard capsule health-care product. The health-care product is mainly prepared from eight active ingredients including EGT (Ergothioneine), Ca-AKG (alpha-ketoglutarate), PQQ (pyrroloquinoline quinone), fisetin, salidroside, urolithin A, spermidine and an apple stem cell extract. Through scientific compatibility of the various components, the composition disclosed by the invention can comprehensively intervene in a cell aging process through a synergistic effect of a plurality of pathways of enhancing the cell antioxidant capacity, improving the mitochondrial function, activating cell autophagy, promoting cell regeneration and repair and the like. The invention also provides a preferred content range of the health-care product, a preparation method of the health-care product and application of the health-care product in preparation of health-care foods for delaying senescence, improving cell viability or improving mitochondrial functions. The product provided by the invention has the characteristics of multiple targets and synergistic interaction, and provides a new effective scheme for anti-aging intervention.

The invention discloses a new application of fisetin and an application of a composition containing the fisetin. The new application comprises preparation of a medicine for treating hypertension, preparation of functional food or health care products for improving the blood pressure level, preparation of a medicine for reducing blood pressure, preparation of a medicine for inducing diuresis and discharging sodium and preparation of a preparation for reducing the Sik1 level. Experiments find that fisetin intervention can reduce the blood pressure of spontaneously hypertensive rats for the first time. The fisetin can increase the GSH-Px activity of the kidney, reduce the ROS level, improve the urinary sodium retention state by reducing the expression level of kidney Sik1 and further reduce the hypertension blood pressure level, and it is indicated that fisetin has the effect of preventing and / or treating primary hypertension and / or spontaneous hypertension. The invention provides application of fisetin in reducing hypertension, and provides a new thought for preventing and treating primary hypertension and / or spontaneous hypertension by reducing blood pressure.

A composition is provided that comprises a combination of fisetin or a derivative thereof and quercetin or a derivative thereof. The composition can be an oral nutritional composition, such as a nutritional supplement, an oral nutritional supplement, a food product, a food for special medical purposes (FSMP). The composition can be administered to an individual in need thereof for (i) improving a physiological state associated with metabolic fatigue in one or more cells, (ii) increasing mitochondrial energy and mitochondrial calcium uptake in one or more cells, and (iii) enhancing antioxidant capacity, reducing oxidative stress and / or enhancing mitochondrial function, (iv) treating or preventing calcium deficiency / depletion disorders in an individual. Additionally or alternatively, by the present method, mitochondrial-related diseases or conditions associated with changes in mitochondrial function can be treated or prevented in individuals in need of such treatment or at risk thereof.

The present invention relates to the technical field of compound extraction, discloses a kind of extraction process of fisetin in cotinus coggygria, including: S1: take the branch and / or leaves of cotinus coggygria and crush them to obtain cotinus coggygria crushed material;S2: cotinus coggygria crushed material is added into a continuous countercurrent extraction tank, water is added, extraction is started, and extraction temperature is 90-95 DEG C to obtain extract;The extract is filtered and filtrate is taken, heated and concentrated to obtain a crude extract;S3: the crude extract is rinsed, filter and take filter cake, obtain solid, solid is added to ethanol for dissolution, after adding water and filtering, reduced pressure is concentrated to ethanol concentration of 60%-75%, crystallization, filter and take filter cake, obtain refined extract;S4: ethanol is added to the refined extract, heated to dissolve and continue 1-1.5h, filter and take filtrate, after reduced pressure is concentrated to ethanol concentration of 70%-75%, stand crystallization filtration and drying, obtain fisetin finished product. The extraction process of the present invention has high extraction efficiency, large conversion rate and is green and environmentally friendly.

The present invention relates to the use of a composition comprising an effective amount of a combination of fesoterodine and / or a derivative thereof and quercetin and / or a derivative for preventing or treating a bone disorder or maintaining bone health in an individual.

The present invention relates to compositions and methods for treating aging-related diseases. The present invention provides a composition comprising at least three substances selected from the group consisting of alpha-ketoglutaric acid, malic acid, pterostilbene, micro-dose lithium, glycine, ginger, Rhodiola rosea, acetylglucosamine, vitamin C, glucosamine, fisetin, L-theanine, oxaloacetic acid, fumaric acid, succinic acid, hyaluronic acid, butyric acid, anthocyanins, piper longum amide, quercetin, curcumin, and a pharmaceutically acceptable salt thereof. And caffeine, trehalose and spermidine. The present invention also provides related pharmaceutical compositions, methods for improving senescence profiles, and articles of manufacture.

This invention relates to compounds that are 4'-substituted analogues of the flavonol Fisetin. In particular, the invention relates to such compounds wherein the 4' position on the B-ring is substitut

The inventors' primary objective was to provide a technology that suppresses inflammation, particularly in aging tissues. [Solution] The above problem can be solved by a composition containing at least one selected from the group consisting of genistein, quercetin, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof.

The present invention relates to new solid forms (NSF) of a flavonoid and a coformer. The NSF are co-amorphous solids of flavonoids and amino acids, as well as the solvates of said co-amorphous solids. The flavonoid is selected from quercetin, genistein, fisetin, apigenin, naringenin, rutin, diosmin, among others. The coformer is selected from lysine and arginine. The NSF have enhanced stability, solubility and pharmacological properties over parent polyphenols. The new solid forms are suitable to be used in pharmaceutical compositions, food products, nutritional supplements and the like.

The present invention relates to use of a composition comprising an effective amount of a combination of oleuropein and / or metabolite thereof and fisetin and / or derivative for maintenance of joint health or prevention or treatment of joint disorders in an individual. In particular, the invention relates to a composition comprising an effective amount of a combination of oleuropein and / or metabolite thereof and fisetin and / or derivative for use to prevent or treat cartilage degeneration in an individual.

The present invention relates to use of a composition comprising an effective amount of a combination of fisetin and / or derivative thereof and quercetin and / or derivative for for use to prevent or treat bone disorders or maintenance of bone health in an individual.

The present invention relates to use of a composition comprising an effective amount of a combination of oleuropein and / or metabolite thereof and fisetin and / or derivative for use to prevent or treat bone disorders or maintenance of bone health in an individual.

The present application relates to the technical field of biological medicine, and particularly relates to the use of fisetin in preventing / treating KIF1A related neurological diseases. The inventor of the present application first discovers and confirms that treating Caenorhabditis elegans with R11Q mutation with plant flavonol fisetin can improve the movement of the animals. The discovery of the present application makes it possible to rescue R11Q deficiency at the biochemical and animal levels, and provides a new clue for the treatment of KIF1A related neurological diseases.

A composition for administering to a subject includes a first compound chosen from S-5'-adenosyl-L-methionine (SAM), methionine, betaine, choline, folate, vitamin B12, glycine, serine, threonine, and any combination thereof, and a second compound chosen from spermidine, spermine, calcium peroxide, zinc, N-Acetylcysteine, cysteine, α-ketoglutarate, fucoidans, harmine, taurine, ergothioneine, urolithin A, terpenoids, berberine, O3, H2O2, hydrogen sulfide (H2S), sodium hydrosulfide (NaSH), sodium sulfide (Na2S), metformin, acetaminophen, curcumin, quercetin, ginseng, R-alpha-lipoic acid, apigenin, fisetin, melatonin, ginger, astaxanthin methylene blue and optionally, a carrier, and any combination thereof

This invention relates to compounds that are 4′-substituted analogues of the flavonol Fisetin. In particular, the invention relates to such compounds wherein the 4′ position on the B-ring is substituted with a ring deactivating group which has a para-Hammett constant greater than zero, and the use of these compounds in the treatment of cancer, including epithelial cancers.

Provided herein are methods and compositions utilizing a urolithin A agent, a fisetin agent, and an isoflavone agent for treatment of neurodegenerative diseases.

The invention discloses an anti-aging composition, which is prepared from fisetin and dihydroberberine, or is prepared from the fisetin and the dihydroberberine. The invention also discloses application of the anti-aging composition in preparation of a product for delaying skin fibroblast aging, and discloses an anti-aging preparation containing the anti-aging composition. According to the anti-aging composition provided by the invention, fisetin and dihydroberberine contained in the anti-aging composition show a remarkable synergistic effect in cell anti-aging and function maintenance, so that aging of skin fibroblasts can be remarkably delayed, and healing and repairing of skin are promoted.

A nutraceutical composition, consisting of Nicotinamide Riboside in a range of 100-2000 mg or Nicotinamide Mononucleotide in a range 250-1000 mg, Spermidine in a range 0.5-10 mg, Rhodiola Rosea in a range 200-600 mg, Cacao in a range 1000-10,000 mg, L-Theanine in a range 50-200 mg, Glucosamine in a range 500-3000 mg, and Hyaluronic acid in a range 50-240 mg, or consisting of Epigallocatechin-3-gallate in a range 100-500 mg, Quercetin in a range 250-1000 mg, Resveratrol in a range 150-1000 mg, Sulforaphane in a range 1-50 mg, and Calcium Alphaketoglutarate in a range 300-2000 mg, or consisting of Microdose Lithium in a range 1-5 mg, Trimethylglycine in a range 500-2000 mg, Glutathione in a range 250-1000 mg, Fisetin in a range 100-1000 mg, Urolithin A in a range 250-2000 mg, Sodium Butyrate in a range 100-3000 mg, Berberine in a range 500-1500 mg, Apigenin in a range 50-500 mg, Cinnamon in a range 1000-6000 mg, and Malate in a range 1000-6000 mg.

The present application provides a kind of drug composition and its application for targeting neuroinflammation, the composition is composed of active ingredient and natural nanometer delivery carrier for encapsulating active ingredient, the active ingredient includes fisetin, pyrrole quinoline quinone, resveratrol, bauhinia A, apigenin, saffron, quercetin and hair monkey element;The natural nanometer delivery carrier is the plant source extracellular vesicle of surface modification brain targeting molecule.The composition of the present application realizes the intervention to vascular cognitive impairment by multi-component scientific compatibility, combined with two-stage brain targeting delivery design, solves the pain points of low blood-brain barrier penetration rate and poor bioavailability of natural active ingredient, has the effect of strong anti-inflammatory and significantly improving cognitive function, excellent safety, can be used for preparing the medicine for preventing or adjuvant therapy neuroinflammation related vascular cognitive impairment, has very high clinical conversion value.

The application belongs to the technical field of medicine, and particularly relates to a blood vessel targeting anti-aging oral composition and application thereof. In view of problems such as endothelial dysfunction, matrix sclerosis and accumulation of senescent cells caused by vascular aging, the composition comprises active ingredients: beetroot extract, fisetin, salvianolic acid B, panax notoginseng total saponins, cocoa flavanol, pterostilbene, procyanidin B2, luteolin, nicotinamide riboside and astaxanthin. The composition is prepared by a process of adsorbing astaxanthin on beetroot extract, mixing other active ingredients, fillers and glidants after fisetin and salvianolic acid B are prepared into a solid dispersion, and sequentially cooperating each module, so that the pulse wave transmission velocity can be significantly reduced and the skeletal muscle capillary density can be increased, and the composition is mainly used for preparing a medicine for improving vascular stiffness, promoting microcirculation and removing vascular senescent cells.

The application discloses a fisetin-4'-O-alpha-D-glucopyranoside for resisting lung cancer and a preparation method and application thereof, and the preparation method comprises the following steps: taking sucrose as a glycosyl donor, taking fisetin as a glycosyl acceptor, and performing an enzymatic transglycosylation reaction under the catalysis of sucrose phosphorylase to direct the glucose group generated by decomposing the sucrose to be transferred to a hydroxyl group at a C4' position of the fisetin, so that a target product is obtained; and the sucrose phosphorylase is derived from Bifidobacterium adolescentis. The application retains the original core biological activities of the fisetin, such as antioxidation and anti-inflammation, provides high-quality raw materials for the application of the fisetin in the fields of innovative drug development for resisting lung cancer and preparation of medical intermediates, and expands the clinical transformation potential of fisetin compounds.

The invention relates to the technical field of medicine and cosmetic equipment, in particular to a whitening micro-emulsion preparation and a preparation device thereof, and the preparation comprises the following components in parts by weight: 2-3 parts of nicotinamide, 1-2 parts of ascorbyl glucoside, 0.5-1 part of fisetin, 65-75 parts of a water phase solvent, 8-12 parts of an oil phase solvent, 3-5 parts of an emulsifier and 0.5-1 part of a stabilizer. The stability of the whitening preparation under extreme temperature and humidity conditions can be improved, meanwhile, the preparation device is optimized, and the stirring uniformity of the whitening preparation in the production stirring process is improved.

The invention belongs to the technical field of development of health care products or medicines, and particularly relates to a composition with sleep-aiding and memory-improving effects as well as a preparation method and application of the composition. The composition is prepared from the following components in parts by weight: 6 to 15 parts of magnesium ion source, 2 to 6 parts of ferrous sulfate, 0.2 to 2 parts of vitamin B6, 0.8 to 6 parts of gamma-aminobutyric acid, 1 to 6 parts of L-theanine, 1 to 5 parts of urolithin A, 0.5 to 5 parts of fisetin and 2 to 8 parts of plant extract. The magnesium ion source compound is combined with the ferrous sulfate, the urolithin A, the fisetin and other active ingredients to prepare the composition with the sleep aiding and memory improving effects, the composition is screened according to a scientific formula, the sleep quality can be effectively improved, the memory can be improved, meanwhile, the composition has the anti-depression effect, and after the composition is taken, sleepiness and inattention do not occur. The traditional Chinese medicine composition ensures that a user can keep good vigor and state in daily life.