282 results about "Flavonols" patented technology

Pharmaceutical compositions, and methods of using the same, are provided utilizing effective amounts of one or more flavones, flavonols, flavanones, isoflavanones and isoflavones to increase cell proliferation in various tissues and cell lines. As examples, the composition and methods of the present invention can be used to increase proliferation of fibroblast cells and, more particularly, in the treatment of wounds as well as strengthening of the skin.

Disclosed is a method of producing a polyphenol-containing composition derived from grapes, the method including: preparing a liquid grape extract which includes polyphenols; contacting the liquid extract with a separation medium which fractionates the components of the extract; and recovering that fraction in which the polyphenols are present. Also disclosed is a method of enriching the composition with added flavonol.

The invention relates to a use of lignanoid containing benzyloxy flavones in the preparation of drugs for treating viral hepatitis B, in particular to the use of a compound as shown in formula (1) or pharmaceutical salts thereof in the preparation of the drugs for eliminating hepatitis B virus surface antigen and hepatitis B e antigen and the drugs for suppressing HBV DNA replication, and the strength of eliminating HBsAg of flavonol lignanoid under the concentration of 20 mu g/ml is 50.8%, which is 3.2 times of the corresponding activity of a positive control drug; the activity of eliminating the HBeAg under the same concentration is equivalent to 10000 units/ml of alpha-interferon; simultaneously, the flavonol lignanoid shows nearly 60% of suppression rate to HBV DNA under the concentration, which is 1.6 times of the corresponding suppression rate of the alpha-interferon. The results show that the lignanoid containing the flavones or the pharmaceutical salts thereof are expected to be used for preparing the non-nucleoside drugs for eliminating the HBsAg and the HBeAg, suppressing the HBV DNA replication and treating hepatitis B virus infection diseases.

The invention belongs to the technical field of daily cleaning supplies and in particular relates to gingko handmade soap. The gingko handmade soap comprises the following components in percentage by weight: 70 to 99.5 percent of transparent soap base, 0.05 to 20 percent of gingko extract and 0.05 to 3 percent of essential oil or essence. Compared with the prior art, the gingko handmade soap has the advantages that the gingko extract is added into the handmade soap, and oxygen radicals can be effectively eliminated and growth of melanin can be suppressed through the trace elements such as flavone, zinc, manganese and molybdenum, and flavonoid glycosides and flavonol, so that the skin is cleaned, the effects of whitening the skin, resisting wrinkle and delaying senescence are achieved, and the gingko handmade soap is a natural good item of protecting the skin and beautifying; and moreover, the glycerol which is contained in the handmade soap and is hardly extracted has the effect of deeply moisturizing and has mild characteristics, so that the skin is moist, glossy and high in resilience. In addition, preservatives and other chemical substances are not required to be added into the handmade soap, and the handmade soap is healthy and environment-friendly. In addition, the invention also discloses a method for manufacturing the handmade soap.

The invention relates to compositions comprising one or more prebiotics (e.g., one or more dietary fibers) in combination with selenium compounds, flavonoids and/or flavonols, and phosphatides. The invention also relates to methods of regulating disorders, specifically disorders of the intestinal tract and related disorders, by administering a composition of the invention.

The invention provides a real-time release detection method for ginkgo leaf medicinal material. The method comprises the following steps: collecting ginkgo leaf medicinal material in different places of production and different batches; detecting contents of water, extracts and flavonoid glycosides in ginkgo leaves; collecting near-infrared spectroscopic data of ginkgo leaf medicinal material powder; establishing a quantitative analysis model and a real-time release quantitative standard for each quality control index of ginkgo leaves; establishing a qualitative analysis model and a real-time release qualitative standard for quality evaluation of ginkgo leaves. The near-infrared spectroscopic data is introduced into the real-time release detection method for ginkgo leaf medicinal material, the method is used for quickly detecting the contents of water, extracts and flavonoid glycosides in ginkgo leaves and judging whether the quality of the medicinal material is qualified, real-time release detection is performed on the ginkgo leaf medicinal material according to quantitative and qualitative detection results, and only the medicinal material in accordance with both qualitative and quantitative real-time release standards can be released for subsequent production technical process, thus the stability and uniformity of ginkgo leaf preparations in different batches are ensured, and the quality level of the ginkgo leaf preparations is improved.

The invention relates to a method for ultrasonically extracting and preparing flavonoids pigment from chrysanthemum, belonging to the field of food processing and especially used for deep processing chrysanthemum. The process comprises the following steps of: blanching, drying and hermetically storing chrysanthemum at a low temperature, filtering by using a 100-mesh sieve, soaking in 60% ethanol as an extraction solvent in a liquid-material ratio of 40/1 (v/w) for 2 h, ultrasonically extracting a dry base in a water bath at 70 DEG C for 10 min to acquire the yield of 13.34 percent; and evaporating in the water bath at 70 DEG C by using the 60% of ethanol extraction liquid in a rotating way to release an ethanol taste; and freezing and drying in vacuum, wherein analytical compositions reach 52.01% of the dry base and comprise flavonoids, linarin, flavonoids (luteolin, acacetin and apigenin), flavonols (quercetin), phenolic acid (chlorogenic acid and caffeic acid), metal elements, and the like. The invention provides a new method for deep processing the chrysanthemum and has strong maneuverability, good safety and good repetitiveness.

New compositions and methods for treating patients suffering from Amyotrophic Lateral Sclerosis (ALS) and other metabolic and autoimmune disorders, which include glycopeptides such as N-acetyl-D-glucosaminyl(β1-4)-N-Acetyl-muramyl-L-alanyl-D-isoglutamine (GMDP) and peptide analog-L-alanyl-D-glutamic acid (GMDP-A) of at least 98% purity administered either alone, or in combination with a flavone such as luteolin and/or an isoflavone such as genistein, optionally in combination with a flavonol glycoside such as isoquercitrin or rutin. The high purity glycopeptides have a decreased amount immunogenic impurities and demonstrate a synergistic effect when combined with luteolin and/or genistein in presence of isoquercitrin.

The present invention has an object to provide an agent for strengthening calcium-containing tissues, which can be safely applied; and its use: The present invention solves the object by providing an agent for strengthening calcium-containing tissues, which comprises one or more flavones, flavonols, flavanones, flavanonols, anthocyanidins, flavanols, chalcones, and aurones.

The present invention discloses a kind of ginkgo leaf extract, injection containing the said extract and its preparation process. The ginkgo leaf extract contains flavonol glycoside 18-40 wt%, bilobalide 2.5-25 wt%, and heavy metals less than 9.4 ppm, with the bilobalide comprising bilobalide A, bilobalide B and bilobalide C in the weight proportion of 7-27 to 3-20 to 4-40. The ginkgo leaf extract with high effective component content and high purity, and the prepared medicine preparation, especially injection, has obvious curative effect on cardiac and cerebral vascular diseases, clinical use safety and no side effect.

The present invention is directed to extracts of cranberries (Vaccinium macrocarpon) comprising either mixed flavonols that are substantially free of anthocyanins and proanthocyanidins or a purified cranberry flavonol compound, including myricetin-3-β-xylopyranoside, quercetin-3-β-glucoside, quercetin-3-α-arabinopyranoside, 3′-methoxyquercetin-3-α-xylopyranoside, quercetin-3-O-(6″-p-coumaroyl)-β-galactoside, and quercetin-3-O-(6″-benzoyl)-β-galactoside. The present invention also embodies the use of those extracts, as well as extracts comprising the cranberry flavonol compound quercetin-3-α-arabinofuranoside, for the treatment of inflammatory disorders. Pharmaceutical, food, dietary supplement, and cosmetic compositions utilizing the extracts or compounds of the present invention are also recited.

The invention discloses a making method of four new substituted phenyl flavonols (1-4) compound, eight new sesquiterpenoids (5-12), one new dihydrochalcone (13) and eight known compound (14-21), which contains drug composition with effective component of sarcandra glabra as well as the application in the liver-damage protecting drug.

The invention relates to the field of liquor, and particularly relates to a liver-protection kudzuvine root wine and a production method thereof. The production method comprises the steps: slicing and drying fresh kudzuvine root blocks, mixing 30 to 40 percent of dry kudzuvine root slices and 60 to 70 percent of grain to obtain a mixture, soaking, boiling, fermenting and distilling the mixture to obtain the kudzuvine root wine, and storing the kudzuvine root wine so as to improve the quality and taste of the wine. The production procedures are simple, and no special apparatus is needed. The prepared liver-protection kudzuvine root wine is slightly alkaline, can effectively guarantee normal physiological function and material metabolism, contains beneficial substances such as kudzuvine root flavonol, has functions for preventing drunk and improving the capacity for liquor, can effectively protect the liver, and can avoid the situation of discomfort of the body such as headache, dry mouth and the like after being drunk by people.

The invention discloses a method for removing ginkgolic acid from a ginkgo biloba extract. The method comprises the following steps of: extracting, performing column chromatography, and drying, wherein the column chromatography process comprises the following steps of: regulating the relative density of a filtrate obtained by extracting and filtering by using water to be 1.05 to 110 to obtain an extracting solution, allowing the extracting solution to pass through a macroporous adsorption resin exchange column in a ratio of adding 1.5 to 3 milliliters of extracting solution into each gram of resin, washing by using the water, eluting by using 60 to 80 mass percent ethanol solution, and collecting 60 to 80 mass percent ethanol eluent, wherein the macroporous adsorption resin is an LSA series macroporous adsorption resin. According to the ginkgo biloba extract obtained by the method, the content of total flavonol glycosides is more than 35 percent, the content of total terpene lactones is more than 12 percent, and the content of total ginkgolic acid is less than 1 ppm.

The invention discloses a medical antibacterial hydrogel dressing and a preparation method thereof. The hydrogel dressing is prepared from the following raw materials: thiolated chitosan, sodium glycerophosphate hydrate, carbomer, oxidized sodium alginate, L-arginine ethyl ester dihydrochloride, theophylline, glycine fumarate, L-carnitine powder, stachyose, hydroxyethyl methylacrylate, tri(propylene glycol) diacrylate, ginkgo flavonol, polyhexamethylene biguanidine, povidone iodine, alcoholic extract of herba andrographitis, triethanolamine and de-ionized water. The hydrogel dressing prepared by the invention can achieve inhibitory rates 91% and 94% or above on pseudomonas aeruginosa and staphylococcus aureus separately, and the hydrogel dressing has a broad-spectrum antibacterial property and a durable antibacterial effect; and in addition, the hemostasis time of the dressing is just 9-18s and healing time is shorter than 10d, and healed regenerated skin has a smooth and delicate surface; therefore, the hydrogel dressing is excellent in wound healing capacity and quite good in healing effect.

A synthetic composition is provided comprising (a) one or more compounds selected from the group consisting of flavanols and hydroxystilbenes; and (b) one or more compounds selected from the group consisting of flavanones, flavones, flavonols, proanthocyanidins and anthocyanidins. Also provided is a method of reducing neuronal degeneration in an individual which method comprises administering to the individual said composition.

The invention relates to a water-soluble ginkgo leaf extract and its preparation technology, The method of the invention comprises: taking common ginkgo biloba as a raw material, mixing with acetone and extracting, concentrating, diluting by adding water, cryoprecipitating, filtering, performing a gradient elution to a filtrate through macroporous adsorption resin, carrying out an alcohol precipitation by ethanol with high purity, water extraction and cryoprecipitating, concentrating, drying to obtain the water-soluble ginkgo leaf extract, wherein the content of total flavonol glycoside is greater than or equal to 27%; the content of lactone content is 9%-12%, wherein the content of Terpene Lactones A is greater than or equal to 2.1%, the content of Terpene Lactones B is greater than or equal to 0.9%, the content of Terpene Lactones C is greater than or equal to 1.2%, and the lactone ratio of GA:GB:GC is close to 7:3:4; the water-solubility is greater than and equal to 10%; the ginkgolic acid is less than and equal to 1ppm, which can be taken as a raw material used for injection. The invention has the advantages of simple production technology, high and stable product quality, high finished product yield, low cost and good economic benefit.

The invention relates to a combination formula increasing the nutrition of rice and flour, which is technically characterized in that a natural rice hull extract A, a wheat bran extract B, an unsaturated fatty acid composition, a ferment, microelements, a lecithin composition, an anti-free radical composition, a germ extract C, a vitamin composition, a flavonol composition, a mineral matter composition, a protein composition, an amino acid composition and a dietary fibre composition are added into rice and flour to prepare remarkably nutritious rice and flour products.

A compound of the formula (I):

wherein

• • R is selected from the group consisting of H, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl and acyl, each of which may be optionally substituted;
  • R¹ is an organic moiety that is capable of being converted into a charged group;
  • each X and Y is independently selected from the group consisting of H, halogen, —CN, —NO₂, —CF₃, —OCF₃, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, heteroalkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, arylalkenyl, cycloalkylheteroalkyl, arylheteroalkyl, heterocycloalkylheteroalkyl, heteroarylheteroalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkenyloxy, alkynyloxy, cycloalkyloxy, heterocycloalkyloxy, aryloxy, heteroaryloxy, arylalkyloxy, phenoxy, benzyloxy, amino, alkylamino, aminoalkyl, acylamino, arylamino, sulfonylamino, sulfinylamino, —COOH, —COR², —COOR², —CONHR², —NHCOR², —NHCOOR², —NHCONHR², C(═NOH)R², alkoxycarbonyl, alkylaminocarbonyl, sulfonyl, alkylsulfonyl, alkylsulfinyl, arylsulfonyl, arylsulfinyl, aminosulfonyl, SR² and acyl, each of which may be optionally substituted;
  • each R² is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl, and acyl, each of which may be optionally substituted;
  • m is an integer selected from the group consisting of 0, 1, 2, 3, 4 and 5;
  • p is an integer selected from 0, 1, 2 and 3;

or a pharmaceutically acceptable salt or prodrug thereof.