133 results about "Flavonols" patented technology

The invention discloses a carrier-free nano-particle with pH / ROS dual response as well as a preparation method and application of the carrier-free nano-particle. The preparation method comprises the following steps: enabling quinolizidine alkaloid and flavonol to be subjected to self-assembly, so as to prepare quinolizidine alkaloid-flavonol carrier-free nano particles; modifying the quinolizidine alkaloid-flavonol carrier-free nano particles by adopting a phenylboronic acid-hyaluronic acid conjugate, so as to prepare nano particles modified by the phenylboronic acid-hyaluronic acid conjugate; and coating the surfaces of the nano-particles modified by the phenylboronic acid-hyaluronic acid conjugate with a pH sensitive polymer to prepare the pH / ROS dual-response carrier-free nano-particles. The sophocarpidine-kaempferol carrier-free nanoparticles with pH / ROS dual response, prepared by the invention, have the advantages of good targeting property, high biocompatibility, small toxicity and adverse reaction and the like, meanwhile, the nanoparticles have a good anti-inflammatory effect, and a new choice is provided for the treatment of ulcerative colitis.

The invention discloses a method for extracting eucommia ulmoides with an intestinal repair function, and relates to the technical field of natural product extraction.The method comprises the steps that a fresh eucommia ulmoides raw material is subjected to low-temperature drying and smashing, a polysaccharide water extract and filter residues are obtained through water extraction, and then the flavone residual quantity in the polysaccharide water extract is synchronously detected; carrying out enzymolysis on the polysaccharide water extract through beta-glucanase to obtain a small molecular polysaccharide solution, and carrying out alcohol extraction on filter residues to obtain a flavone alcohol extract; the preparation method comprises the following steps: mixing the two components according to a ratio, inoculating compound probiotics for anaerobic fermentation, regulating according to the residual quantity of flavone, regulating an alcohol extraction process by using short-chain fatty acid generated by fermentation when the residual quantity is high, supplementing flavone extract in an enzymolysis system when the residual quantity is low, and finally removing impurities, purifying, adapting intestinal tracts and drying to obtain the product. According to the method, regulation and control operation is correspondingly executed by detecting the residual quantity of flavone in the polysaccharide water extract, so that self-supply of a regulation and control reagent and high efficiency of active ingredients are realized, the conversion rate of small molecular polysaccharide and flavone aglycone is increased, and the intestinal tract tolerance of the product is optimized.

The present invention discloses a method for preventing or treating atrial fibrillation (AF) in a subject by administering a therapeutically effective amount of a flavonol compound (Formula 1 or a tautomer thereof), a pharmaceutically acceptable salt, hydrate, or solvate thereof. The method involves obtaining a subject in need of AF prevention or treatment, suspected to require such prevention or treatment, or a normal healthy subject, and administering the compound to the subject Formula 1 comprises specific atoms and substituents, including - H, -OCH3, -OH, -I, -Br, -F, or Cl. By utilizing the flavonol compound of Formula 1, the risk of AF development or the prevalence of AF in the subject is reduced, providing an effective approach for managing AF in individuals.

The invention belongs to the technical field of medicines, and mainly relates to application of 3 ', 4'-dihydroxy flavonol in treatment of hypertension. The invention firstly provides application of 3 ', 4'-dihydroxy flavonol or pharmaceutically acceptable salt thereof in preparation of products for preventing and / or treating hypertension. The invention also provides an application of the 3 ', 4'-dihydroxy flavonol or the pharmaceutically acceptable salt thereof in preparation of a product, and the product is used for reducing blood pressure; the blood vessel function reduction is improved; the blood vessel wall thickening is improved; the heart function reduction is improved; the 3 ', 4'-dihydroxy flavonol can improve any one or more of myocardial cell hypertrophy, and the invention further provides a product which comprises an effective dose of 3 ', 4'-dihydroxy flavonol or pharmaceutically acceptable salt thereof. The application finds that the 3 ', 4'-dihydroxy flavonol and the pharmaceutically acceptable salt thereof can be effectively used for preventing or treating hypertension, and a new way is opened up for the treatment of hypertension or hypertension-related diseases.

The invention relates to the technical field of flame-retardant materials, and particularly discloses a flavonol hyperbranched flame retardant and a preparation method and application thereof.The flavonol hyperbranched flame retardant has the structural formula shown in the formula I: # imgabs0 #, wavy lines in the structural formula are repeated units in the structure, and Rn (n = 1-7) in the formula I is hydroxyl. The flavonol hyperbranched flame retardant is formed through nucleophilic substitution reaction of the flavonol compound containing reactive hydrogen, the organic phosphorus organic silicon containing dichloro and the like, the flame retardant effect is improved, and meanwhile the effects of improving the mechanical property and reducing the smoke amount are achieved.

The invention belongs to the technical field of medicines, and particularly relates to a composition containing mesenchymal stem cells and application of the composition in preparation of products for resisting premature ovarian failure. The invention relates to a composition containing mesenchymal stem cells. The umbilical cord mesenchymal stem cell gel is prepared from the following components in percentage by weight: 10 percent of umbilical cord mesenchymal stem cells, 4 to 6 percent of human serum albumin stock solution, 1 to 2 percent of ginkgo biloba extract, 1 to 3 percent of coix seed oil, 2 to 2.5 percent of flavonol glycoside, 1.1 to 1.3 percent of vitamin E, 0.4 to 0.8 percent of glutathione, 0.5 to 1.5 percent of sodium hyaluronate, 0.5 to 1.0 percent of phycocyanin, 1.2 to 1.8 percent of zinc gluconate, 0.5 to 0.8 percent of heparin calcium, 0.1 to 0.3 percent of pH regulator and the balance of normal saline. The composition disclosed by the invention can be used for preparing products for resisting premature ovarian failure and has a very good effect.

The invention discloses cloning and functional identification of a liverwort flavone synthetase gene, and belongs to the technical field of gene engineering. According to the invention, one flavone synthase I (flavones synthase I, FNS I) is obtained through screening, and is named as MpFNS I; a prokaryotic expression system is utilized, an MpFNS I recombinant protein is obtained through purification, and the result of in-vitro enzyme activity identification shows that an MpFNS I enzyme substrate is relatively wide in selectivity, has a flavone synthetase function and also has a part of flavonol synthetase function. The liverwort flavonoid has a significant difference on affinity and catalytic efficiency of different substrates, the in-vivo function of the liverwort flavonoid is verified by utilizing heterologous expression of arabidopsis thaliana, experimental evidence is provided for comprehensively analyzing a biosynthetic pathway of the liverwort flavonoid, and meanwhile, a research target is provided for deeply researching a mechanism for synthesizing and responding to UV-B radiation of the liverwort flavonoid.

The invention relates to the technical field of nano materials, and discloses a biomass carbon dot as well as a preparation method and application thereof. The biomass carbon dots are prepared from the following raw materials: aniline and flavonol compounds. According to the biomass carbon dot provided by the invention, flavonol compounds derived from biomass such as luteolin and peanut shells are taken as raw materials, nitrogen doping is carried out through aniline, and the biomass carbon dot has relatively good ultraviolet absorption capacity in UVA and UVB ranges and also has excellent visible light permeability and high-temperature ultraviolet aging resistance; the preparation method of the biomass carbon dots is simple in steps, raw materials are easy to obtain, and one-step synthesis can be achieved through a solvothermal method; the biomass carbon dots are doped on the basis of a common polyurethane film, the ultraviolet absorption capacity of the film in UVA and UVB ranges is remarkably improved, meanwhile, the visible light transmittance of the film is not affected, the weather resistance of the film is good, the film is suitable for the agricultural field, and normal photosynthesis can be guaranteed while ultraviolet damage to crops is reduced.

The invention relates to the technical field of antibacterial gels, and discloses a flavonoid-containing antibacterial gel and a preparation method thereof.The preparation method comprises the steps that carboxymethyl chitosan cross-linked nano sodium hyaluronate, quaternary ammonium salt modified sodium alginate, polyvinyl alcohol, flavonol glycosides, flavanonol and gelatin are added into a stirrer and stirred, and a mixture is obtained; after the reaction is finished, the antibacterial gel containing the flavonoids is obtained. Quaternary ammonium salt groups in the antibacterial gel can destroy cell membranes, enable cellular contents to leak and cause cell death, so that the antibacterial effect is achieved, sodium alginate has more reaction sites, a large amount of quaternary ammonium salt is grafted through reaction, the substitution degree of the quaternary ammonium salt is increased, the antibacterial effect is further improved, and the antibacterial gel has a good antibacterial effect. The sodium alginate and the cardanol have a certain antibacterial effect, so that an antibacterial system is formed by the sodium alginate and the cardanol together.

The present invention discloses a flavonol derivative fluorescent probe for detecting H2S and a preparation method and application thereof. The present invention belongs to the field of fluorescence detection technology. The probe structure is shown in Formula I: #imgabs0# The synthetic process of the probe molecule is easy to control, the reaction conditions are mild, it has high selectivity and sensitivity to H2S, has the characteristics of low detection limit, excellent anti-interference ability, etc., and shows good detection effect in the process of detecting H2S in environmental water samples, food corruption and cancer cells, has important practical application prospects, and has potential application value in the field of drug development.

The present invention discloses the preparation of patchouli flavonoid nanoliposomes and their application in inhalation treatment of acute lung injury, and relates to the field of medical technology. The patchouli flavonoid nanoliposomes provided by the present invention prepare patchouli flavonoids into a liposome dosage form, which has good stability and biocompatibility. The drug is administered to mice with acute lung injury, so that patchouli flavonoids can act on the mouse lungs in a targeted manner, reduce the expression of inflammatory factors such as IL-6, IL-1β and TNF-α in the mouse lungs to relieve inflammation, improve pulmonary edema, and reduce lung tissue damage, while increasing the levels of tight junction factors such as ZO-1, VE-Cadherin, E-Cadherin and Claudin5 to repair lung barrier damage. The present invention is expected to provide an effective strategy for the treatment of acute lung injury.

The present invention provides a medicinally active extract obtained from the plant Polyspora axillaris ( Polygala japonica Houtt. ), which contains flavonol compounds of the following formula (I) as the first active ingredient, and optionally contains xanthone compounds of the following formula (II) as the second active ingredient and glycolipid compounds of the following formula (III-1) or (III-2) as the third active ingredient. Animal experiments have confirmed that the drug of the present invention is significantly superior to potassium sodium hydrogen citrate in typical test indexes such as calcium oxalate crystal aggregation, renal interstitial inflammatory cell infiltration and renal tubular dilation lesions, indicating that it has extremely good potential and market prospects in the treatment of urinary system lithiasis and urinary tract infections or kidney injuries caused by urinary system lithiasis, and as an adjuvant drug after surgical treatment of urinary system lithiasis. (I) (II) (III).

The invention discloses a detection reagent for detecting MHC-II expression of gastric cancer tissue tumor cells. The detection reagent comprises the following components in parts by mass: 10-30 parts of a paraffin section preparation solution, 2-10 parts of a dewaxing solution, 2-10 parts of a sodium citrate antigen repair solution and 20-40 parts of an immunohistochemical staining solution, the dewaxing liquid comprises xylene and at least one of a flavonol aminobenzoate derivative and erucyl amide benzoic acid benzyl trimethyl ammonium salt, the flavonol aminobenzoate derivative has a nitrogen-containing group and a benzene ring, and the erucyl amide benzoic acid benzyl trimethyl ammonium salt has long-chain unsaturated alkane and a nitrogen-containing group. The invention provides a detection reagent for detecting MHC-II expression of gastric cancer tissue tumor cells, and high-quality immunohistochemical staining sections can be obtained, so that the sensitivity and specificity of MHC-II expression detection are improved.

The invention belongs to the technical field of traditional Chinese medicines, and relates to a glycyrrhiza uralensis n-butyl alcohol extract and application of effective components thereof. The invention relates to a glycyrrhiza uralensis n-butyl alcohol extract. The effective components of the glycyrrhiza uralensis n-butyl alcohol extract are prepared from glycyrrhiza uralensis isoflavanone, glycyrrhiza stem alcohol A, licorcidine, dibutyl phthalate, glycyrrhizin I, 3 '-Dimethylallylkievitone, lupinone, glycyrrhiza flavonol, edediol, 1-methoxy phaseolin and isoderrone. The glycyrrhiza uralensis n-butyl alcohol extract is prepared from the following raw materials: glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis, glycyrrhiza uralensis and glycyrrhiza uralensis, the anti-streptococcus mutans activity of the glycyrrhiza uralensis n-butyl alcohol extract provided by the invention is superior to that of an extract extracted by ethanol in the same extraction method. The method has more advantages in the aspect of preventing streptococcus mutans infection and decayed teeth, and a theoretical basis is provided for research and development of new products.

The invention belongs to the technical field of fluorescent nano materials and medical examination, and particularly relates to a high-selectivity carbon dot for detecting flavonol compounds in colorimetric and fluorescent dual modes as well as a preparation method and application of the high-selectivity carbon dot. The preparation method of the carbon dots comprises the following steps: preparing a (PEI) solution; the preparation method comprises the following steps: dispersing D-threonine (D-Thr) and a polyethyleneimine (PEI) solution in deionized water, performing ultrasonic treatment, and performing heating reaction; after the reaction, cooling to room temperature, centrifuging, taking supernate, and filtering to obtain a B-CDs solution; the B-CDs solution is subjected to freeze drying, and the yellowish-brown powder B-CDs carbon dots are obtained. The high-selectivity carbon dot based on polyethyleneimine prepared by the invention shows good water solubility, excellent fluorescent property and optical stability, has been successfully applied to quantitative detection of three flavonol compounds including morin, quercetin and kaempferol in complex matrixes such as human serum and urine, and shows a good linear relationship in a range of 0.5-100 [mu] M.

The present invention provides a protective film agent and a method for processing a workpiece, the protective film agent being capable of forming a protective film suitable for processing with a laser beam. The protective film agent is coated on a workpiece when the workpiece is processed, the protective film agent comprising: a water-soluble resin; a light absorber having a flavone structure, a flavonol structure, or an isoflavone structure; and a solvent that dissolves the resin and the light absorber.

The reagent for detecting MHC-II expression of tumor cells in gastric cancer tissue comprises the following components in parts by mass: 10-30 parts of paraffin section preparation liquid, 2-10 parts of dewaxing liquid, 2-10 parts of sodium citrate antigen repair liquid, and 20-40 parts of immunohistochemical staining liquid; the dewaxing liquid comprises dimethylbenzene, and at least one of flavonol aminobenzoate derivative and sinapamide benzyl trimethylammonium benzoate salt; the flavonol aminobenzoate derivative has a nitrogen-containing group and a benzene ring, and the sinapamide benzyl trimethylammonium benzoate salt has a long-chain unsaturated alkane and a nitrogen-containing group. The reagent for detecting MHC-II expression of tumor cells in gastric cancer tissue can obtain high-quality immunohistochemical staining sections, thereby improving the sensitivity and specificity of MHC-II expression detection.

The application relates to a method for indoor cultivation of medicinal mulberry and application thereof in improving secondary metabolites of indoor cultivated medicinal mulberry, which comprises transplanting, illumination, fertilization and management steps. The application effectively improves the secondary metabolites of indoor cultivated medicinal mulberry by applying inorganic fertilizer during the growth period of the medicinal mulberry. Especially, high-potassium fertilizer is most obvious for improving the active substances of indoor medicinal mulberry. The high-potassium fertilizer can improve the content of flavones and flavonols in the medicinal mulberry by affecting the biosynthetic metabolic pathways of the flavones and the flavonols.

The invention discloses a method for regulating and controlling synthesis of tobacco flavonol and anthocyanin, a target gene and application of the target gene, and aims to solve the technical problem that biosynthesis of anthocyanin and flavonol of a current plant is not easy to regulate and control. According to the invention, a gene AFB capable of regulating and controlling tobacco biosynthesis is cloned from tobacco, an overexpression vector and a CRISPR / Cas9 vector of the gene AFB are constructed, and corresponding overexpression strains and gene knockout plants are respectively obtained through transformation; phenotype and physiological index determination shows that AFB belongs to an HD-ZIP IV family member, can regulate and control development of corolla conical epidermis cells and biosynthesis of plant anthocyanin and flavonol so as to control flower color, and has important application value in the aspects of flower color regulation and control, construction or screening of high-resistance and high-quality plant varieties and the like.

The invention discloses a flavonol-based fluorescent probe for continuously detecting hydrogen sulfide and hypochlorous acid as well as a preparation method and application of the flavonol-based fluorescent probe. The flavonol-based fluorescent probe is 3-(2, 4-dinitrophenoxy)-7-(4-(diphenylamino) phenyl)-2-(4-(thiomorpholinophenyl) chromone, and the structural formula of the flavonol-based fluorescent probe is shown in the specification. According to the invention, 7-(4-(diphenylamino) phenyl)-3-hydroxy-2-(4-thiomorpholinophenyl) chromone is used as an initial raw material, and the 7-(4-(diphenylamino) phenyl)-3-hydroxy-2-(4-thiomorpholinophenyl) chromone and 2, 4-dinitrofluorobenzene are subjected to nucleophilic substitution reaction to obtain the compound 3-(2, 4-dinitrophenoxy)-7-(4-(diphenylamino) phenyl)-2-(4-(thiomorpholinophenyl) chromone. The compound is firstly subjected to selective thiolysis reaction under the action of hydrogen sulfide, the fluorescence color of a solution of the compound is changed from colorless to bright orange under the irradiation of ultraviolet light with the wavelength of 365 nm, then hypochlorous acid is continuously added into the solution, and the compound can be further subjected to specific oxidation reaction with the hypochlorous acid, so that the compound can be obtained. And the fluorescence color of the solution is changed from bright orange to bright cyan. Therefore, the compound can be used as a fluorescent probe for continuously detecting hydrogen sulfide and hypochlorous acid, has the advantages of low detection limit, high response speed, good light stability, wide pH application range and the like, and shows a good application prospect.

Provided are a pharmaceutical composition for preventing, ameliorating or treating atopic diseases comprising a flavonoid derivative as an active ingredient, and a method for preparing the flavonoid derivative, and more specifically, provided are a pharmaceutical composition for preventing, ameliorating or treating atopic diseases comprising a flavonoid derivative 3, 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ', 3', 3 ' The invention relates to a pharmaceutical composition containing 3, 4-dihydroxyflavonol as an active ingredient and a method for preparing the 3, 4-dihydroxyflavonol.

In view of the technical problem that the low solubility of flavonoids restricts the application and development of flavonoids, the application uses biochar and flavonoids to spontaneously form a compound to improve the solubility of flavonoids in aqueous medium, and the method is that biochar and flavonoids are mixed in water at a mass ratio of greater than or equal to 1:1, the solid part is discarded, and the liquid part is obtained; the biochar is prepared from traditional Chinese medicinal materials or solid waste of extracted traditional Chinese medicinal materials by high-temperature carbonization at 250 DEG C to 600 DEG C for 30 to 60 minutes, and then crushed through a screen mesh with a mesh size of greater than or equal to 200; the flavonoids are poorly soluble flavonoids, including flavones, flavonols, dihydroflavones, isoflavones, monosaccharide glycosides, polysaccharide glycosides, and flavones containing saccharide uronic acid glycosides. The method does not need to add additional excipients, so that the solubility of flavones is improved by 10 to 270 times, and the DPPH free radical scavenging rate is improved to more than 70%, which shows a certain development prospect for the application of flavones in drugs, health products, cosmetics and daily chemical products.

The present invention discloses a method for detecting the quality standard of compound ginkgo tongmai oral liquid, including establishing a fingerprint of compound ginkgo tongmai oral liquid, wherein the fingerprint establishment includes: preparing a test solution 1, preparing a reference solution 1, and preparing a reference medicinal material solution 1; respectively determining the reference solution 1, the reference medicinal material solution 1, and multiple batches of test solution 1 by an HPLC liquid chromatograph; importing the chromatograms of multiple batches of test solution 1 into a similarity evaluation system of a Chinese medicine chromatographic fingerprint, using the chromatogram of one batch of test solution 1 as a reference spectrum, and obtaining the fingerprint of compound ginkgo tongmai oral liquid through multi-point correction and data analysis. The present invention may further include analysis of Ligustrum lucidum, Uncaria rhynchophylla, Cyathula officinalis, Eucommia ulmoides, and detection of the contents of total flavonol glycosides, salvianolic acid B, and stilbene glycosides. The present invention can fully reflect product quality information, improve the controllability of product quality, and further improve the quality standard of compound ginkgo tongmai oral liquid.

The invention discloses application of a QUE analogue in preparation of a medicine for relieving acute lung injury caused by bacterial LPS, and belongs to the technical field of biological medicine. The preparation method of the QUE analogue comprises the following steps: dissolving 5-bromo-2, 4-dihydroxybenzoic acid in an organic solvent, then adding EDC, flavonol and DMAP, and purifying after low-temperature reaction to obtain the QUE analogue. The QUE analogue (namely Q8) prepared by the invention can be used for reducing inflammatory response and lung pathological injury caused by bacterial LPS (Lipopolysaccharide).

The present invention relates to the field of traditional Chinese medicine processing technology. The present invention quantifies the three factors of frying temperature, frying time, and auxiliary material dosage, establishes an objective evaluation method, optimizes the processing technology of honey mulberry leaves using the Box-Behnken design-response surface method, detects the index components of honey mulberry leaves using modern instrumental analysis methods, calculates the weight coefficients of seven indicators including chlorogenic acid, rutin, isoquercetin, astragalin, total flavonoids, alcohol extract, and moisture using the CRITIC-AHP composite weighting method, and calculates the overall evaluation "normalization value" to obtain the optimal processing technology results. The final optimized processing process steps are as follows: take 7.5g of refined honey, dilute it with boiling water (mulberry leaf: boiling water = 1:2), pour it into 30g of clean mulberry leaf medicinal materials, mix well, simmer for 4 minutes, place it in a hot pot, fry it at 170°C for 10 minutes, remove it and cool it, and then seal it for storage.

The application discloses application of a flavonoid metabolic pathway network key regulation gene GmCHR1 in Arabidopsis thaliana. Research shows that the expression amount of a soybean chalcone reductase (CHR) gene GmCHR1 in soybean roots is significantly up-regulated under low-phosphorus stress, and the low-phosphorus stress enhances the expression of GmCHR1 in the root system of Arabidopsis thaliana, and GmCHR1 influences the response of the root system of Arabidopsis thaliana to low-phosphorus stress. Through construction of a transgenic plant, overexpression of the GmCHR1 gene in Arabidopsis thaliana can promote the growth of Arabidopsis thaliana, significantly improve the biomass, total root length and total phosphorus content of the transgenic Arabidopsis thaliana under normal phosphorus conditions and low-phosphorus conditions; meanwhile, overexpression of GmCHR1 reduces the accumulation of flavonol in the root tip of the transgenic Arabidopsis thaliana, thereby enhancing the accumulation of auxin in the root tip of the transgenic Arabidopsis thaliana, positively regulating the synthesis of auxin in the root system of Arabidopsis thaliana and improving the content of auxin, and playing an important role in improving the growth and phosphorus efficiency of Arabidopsis thaliana.

The invention discloses a tea tree MYB transcription factor CsMYB330 gene and application, the nucleotide sequence of the MYB transcription factor CsMYB330 gene is shown as SEQ ID NO: 1, the expression of the gene participates in regulating the flavonol content in plants, and the instantaneous silencing of the CsMYB330 gene in the tea tree can significantly reduce the flavonol content in the tea tree by 24.5% and reduce the bitter taste of the finished tea.

This invention relates to compounds that are 4'-substituted analogues of the flavonol Fisetin. In particular, the invention relates to such compounds wherein the 4' position on the B-ring is substitut

This invention provides a composition of Ginkgo biloba extract and its preparation method. The composition consists of Ginkgo biloba extract (calculated as total flavonol glycosides) and dipyridamole in a dosage ratio of 10:4. The preparation method can significantly improve product yield, reduce production costs, and significantly increase the content of the main components of the produced Ginkgo biloba extract, namely total flavonol glycosides and terpene lactones. It can also reduce the content of poorly water-soluble ginkgolides and harmful impurities such as ginkgolic acid, control its microbial level, and improve the stability and safety of the Ginkgo biloba extract preparation product of this invention.

The application discloses a thiazole-containing flavonol derivative and a preparation method and application thereof, and belongs to the technical field of pesticide synthesis. A thiazole-containing flavonol derivative is generated by substitution reaction of 3-(bromoalkyloxy)-7-substituent-2-(4-substituent phenyl)-4H-chromone-4-ketone and 5-substituent-2-thiol-1,3,4-thiadiazole, and a structural formula is shown as formula Y: wherein n is 3 or 4; R1 is hydrogen or an amino group; R2 is hydrogen, an alkyl group or an alkoxy group; and R3 is hydrogen, a halogen, an alkyl group or an alkoxy group. The thiazole-containing flavonol derivative has good bacteriostatic activity and can be applied to the preparation of bacteriostatic medicaments.