The invention provides a comprehensive treatment pneumatic caisson method for indoor environment pollution, and is used for solving the problem that concentrations of indoor formaldehyde, indoor benzene, indoor ammonia and indoor TVOC (total volatile organic compound) exceed the national standard. The comprehensive treatment pneumatic caisson method comprises the step of: applying the following six treatment solutions in an occasion that the concentrations of the indoor formaldehyde, the indoor benzene, the indoor ammonia and the indoor TVOC (total volatile organic compound) exceed the national standard: a nanocomposite catalyst solution, 1%-50% of acetum, a formaldehyde treatment solution containing active amido, a VOC (volatile organic compound) stabilizing solution, a negative oxygen ion generator and a deodorant. According to the application of the comprehensive treatment pneumatic caisson method for the indoor environment pollution, provided by the invention, the concentrations of pollutants after treatment are obviously reduced; and various effects are obtained for reducing the concentrations of the pollutants including the indoor formaldehyde, the indoor benzene, the indoor TVOC, the indoor ammonia and the like caused by furniture, floor, doors and window, carpets, wallpaper, fabrics, paint, coatings, dyes, building materials and the like.