The invention discloses a 12Cr2Mo1R steel plate for ultra-thick hydrogen-contacting equipment and a production method thereof. The 12Cr2Mo1R steel plate comprises the following chemical components, by mass, 0.08-0.15% of C, 0.20-0.50% of Si, 0.30-0.60% of Mn, equal to or less than 0.018% of P, equal to or less than 0.005% of S, equal to or less than 0.020-0.050% of AlS, 2.0-2.5% of Cr, 0.90-1.10%of Mo, and the balance Fe and residual elements. The production method comprises steps of converter smelting, LF refining, vacuum refining, casting, heating, rolling, controlled cooling, slow cooling, and heat processing. A whole production process from molten iron pretreatment to steel plate heat treatment is executed in strict accordance with above technology, so the object quality performance margin of products is large, wherein the yield margin is 40-80MPa, the tensile margin is 55-70MPa, and the elongation margin is 6-9%, thereby the impact performance is uniform and the margin is large.