Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing cefmetazole sodium

A technology for cefmetazole sodium and cefmetazole acid is applied in the field of preparation of cefmetazole sodium, which can solve the problems of high content of degradable substances, products prone to allergies, low product content and the like, and achieves less impurities and a scientific and reasonable preparation method. , the effect of high product content

Inactive Publication Date: 2011-07-20
SHANDONG LUKANG PHARMA
View PDF2 Cites 11 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of cefmetazole sodium: suspending cefmetazole acid in water, adding sodium hydroxide or sodium bicarbonate to dissolve it, and then separating the sodium salt by freeze-drying or spray-drying, this method has low product content and degradation The substance content is high, and the product is prone to allergies and other deficiencies

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing cefmetazole sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Dissolve 4.3 grams of sodium isooctanoate in 50 milliliters of anhydrous methanol, control the temperature at 10-15 ° C, add 10 grams of cefmetazole acid, stir to dissolve, add 0.5 grams of activated carbon, and filter through carbon removal and sterile filtration, and use 10 Wash with one milliliter of anhydrous methanol, combine the filtrate and lotion, control the reaction temperature at 10-15°C, add 180 milliliters of isopropyl ether dropwise in 120 minutes, continue stirring for 60 minutes, filter with suction, and wash with 60 milliliters of isopropanol three times. Finally, dry in vacuum to obtain the cefmetazole sodium product.

Embodiment 2

[0030] Dissolve 4.3 grams of sodium isooctanoate in 50 milliliters of anhydrous methanol, control the temperature at 10-15 ° C, add 10 grams of cefmetazole acid, stir to dissolve, add 0.5 grams of activated carbon, and filter through carbon removal and sterile filtration, and use 10 Wash with one milliliter of anhydrous methanol, combine the filtrate and washing solution, control the reaction temperature at 10-15°C, drop the combined solution into 180 ml of isopropyl ether, continue stirring for 60 minutes, filter with suction, and wash with 60 ml of isopropanol three times. Finally, dry in vacuum to obtain the cefmetazole sodium product.

[0031] The preparation method of the cefmetazole sodium of the present invention is scientific and reasonable, simple and easy to implement, and has the advantages of high product content and less impurities.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for preparing cefmetazole sodium, comprising the following steps of: undergoing a reaction of cefmetazole acid and sodium isocaprylate, then purifying, crystallizing, filtering, washing and drying to obtain a finished product. The method for preparing the cefmetazole sodium, provided by the invention, is scientific and reasonable, simple and practicable; and the obtained product has the advantages of stable quality performance, high content, low impurity content, allergy avoidance, and the like.

Description

technical field [0001] The invention relates to a synthesis method of western medicine, in particular to a preparation method of cefmetazole sodium. Background technique [0002] Cefmetazole is a semi-synthetic Aspergillus cephalosporin antibiotic created by Sankyo Corporation of Japan. At present, the most commonly used method for large-scale production is the reaction of thioglycolic acid and chloroacetonitrile to generate side chains, which react with 7MAC to generate cefmetazole benzyl ester, and then deprotect to generate Cefmetazole acid. [0003] The preparation method of cefmetazole sodium: suspending cefmetazole acid in water, adding sodium hydroxide or sodium bicarbonate to dissolve it, and then separating the sodium salt by freeze-drying or spray-drying, this method has low product content and degradation The substance content is high, and the product is prone to deficiencies such as allergies. Contents of the invention [0004] The purpose of the invention is...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D501/57C07D501/04
Inventor 高占文张琛娜张淑婷张冬梅张宪生王小丹
Owner SHANDONG LUKANG PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com