60 results about "CEFMETAZOLE SODIUM" patented technology

The invention relates to a method for preparing cefmetazole sodium, which comprises the following steps: (1) dissolving sodium hydroxide in water, adding mercaptoacetic acid and chloroacetonitrile into the mixture to perform the reaction, then adding sodium chloride and ethyl acetate into the reaction solution, stirring and dissolving the mixture, standing to separate phases and reserving a solvent phase for later use; (2) dissolving 7-MAC in methylene dichloride, adding organic base and side-chain solution into the mixture, stirring the mixed solution to perform the reaction to carry out phase separation, removing a water phase and carrying out secondary phase separation on the solvent phase to obtain cefmetazole benzyl ester; (3) dissolving ferric trichloride in aether, adding methylene dichloride in the mixture, dropwise adding the obtained product into cefmetazole acid to perform the reaction for 0.5 to 1 hour, then carrying out phase separation, removing the water phase, carrying out back extraction of alkali liquor on the solvent phase, then reserving the water phase, adding seed crystals, stirring the product and carrying out crystallization to obtain cefmetazole acid; and (4) dissolving the cefmetazole acid in alkali water and freezing out the mixture to obtain cefmetazole sodium. The preparation method of the invention has the advantages of 58 to 62 percent of yield, low cost, environment-friendly property, 92 percent of product purity, suitability for industrial production and the like.

The invention relates to a cefmetazole sodium compound and a synthetic method thereof, 7 Beta-amino-7 Alpha-methoxyl-3-(1-methyl-1H-tetrazole-5-sulfidomethyl)-3-cephem-4-benzyl carboxylate and cyanomethylthio acetic acid sodium are mixed and react in the presence of p-toluenesulfonyl chloride to generate cefmetazole; sodium hydroxide is added to obtain cefmetazole sodium. Compared with the prior art, the invention has the advantages of few reaction steps, high productive rate, high product purity and low cost of raw materials, and has a broad prospect.

The invention relates to a method for preparing cefmetazole sodium, comprising the following steps of: undergoing a reaction of cefmetazole acid and sodium isocaprylate, then purifying, crystallizing, filtering, washing and drying to obtain a finished product. The method for preparing the cefmetazole sodium, provided by the invention, is scientific and reasonable, simple and practicable; and the obtained product has the advantages of stable quality performance, high content, low impurity content, allergy avoidance, and the like.

The invention relates to the field of pharmaceutics, specifically to cefmetazole aseptic powder and its preparation method. The preparation method comprises: employing a mixed solvent to recrystallize cefmetazole, using a good solvent to dissolve the cefmetazole raw material, adding activated carbon for injection to remove a pyrogen, then adding a poor solvent for recrystallization, and conducting drying at a low temperature, thus obtaining the cefmetazole aseptic powder with no pyrogen and high purity. Characterized by simple operation and high yield, the preparation method of the invention can prepare cefmetazole aseptic powder with high purity, safe and reliable quality, thus being suitable for preparing cefmetazole aseptic powder injections and widely applicable in large scale production of cefmetazole aseptic powder injections.

The invention relates to cefmetazole sodium composition sterile powder for injection, which comprises 99.0 to 99.9 weight percent of cefmetazole sodium and 0.1 to 1.0 percent of sodium benzoate. The cefmetazole sodium is cefmetazole sodium crystal and the primary granularity of the cefmetazole sodium ranges from 80 to 120 mu m. The cefmetazole sodium composition sterile powder for injection provided by the invention contains the cefmetazole sodium crystal, and has the advantages of large crystal granularity, uniform granularity distribution, qualified quality, and high stability.

The invention provides a pharmaceutical composition containing a cefmetazole sodium compound. The pharmaceutical composition is prepared from cefmetazole acid, sodium carbonate and mannitol. The invention also provides a preparation method of the pharmaceutical composition containing the cefmetazole sodium compound. The preparation method comprises the following steps of: adding the active component cefmetazole acid sterile powder, the cosolvent sodium carbonate and the excipient mannitol to water for injection, adding active carbon and stirring, regulating the pH to be 6 by sodium hydroxide, filtering to remove the active carbon, finely filtering by a filter membrane, filling and lyophilizing. Because a proper amount of excipient mannitol is added to the pharmaceutical composition prepared by the method, the lyophilized powder is more stable in quality and can be stored for a long term. The cefmetazole acid and the sodium carbonate directly react to obtain the cefmetazole sodium, thereby shortening the process flow.

The invention discloses a special ultrafine cefmetazole sodium powder preparation and a preparation method thereof. The preparation method comprises the following steps: carrying out a reaction on a raw material cefmetazole benzyl ester in a dichloromethane, anisole and iron trichloride system, carrying out acidolysis by using a hydrochloric acid and acetone mixed solution, purifying the above collected organic phase by using a sodium chloride solution, carrying out phase inversion by using a sodium bicarbonate solution, decoloring the above collected water phase by active carbon and alumina, carrying out phase inversion by ethyl acetate and hydrochloric acid, crystallizing by adding crystal seeds in order to prepare cefmetazole acid, reacting cefmetazole acid with sodium bicarbonate to prepare cefmetazole sodium, purifying, and carrying out air jet ultrafine crushing to prepare the special ultrafine cefmetazole sodium powder preparation. The special ultrafine cefmetazole sodium powder preparation has the advantages of good clarity, high stability, high purity, few impurities, small particle size, large specific surface area, good solubility, small toxic side effects, difficult allergy and the like.

The invention relates to a novel pharmaceutic preparation composition, especially to an injection preparation of cefmetazole. The injection preparation comprises the following components: cefmetazole, mannitol, EDTA-Ca, vitamin C, sodium hydrogen citrate, a trisodium citrate buffer solution and water for injection.

The invention relates to a cephamycin intermediate compound and a preparation method thereof. The cephamycin intermediate compound has a structure of formula (I), and is prepared by directly reacting 7beta-chloroacetamide-7alpha-methoxy-3-(1-methyl-1H-tetrazole-5-thiomethyl)-3-cephem-4-carboxylic acid and dicyclohexylamine in a specific solvent to form a salt and crystallizing. The cephamycin intermediate compound has the characteristics of high purity, high stability and the like, is conductive to improving the purity of cephamycin final products such as cefminox sodium, cefmetazole sodium and cefotetan disodium, and is beneficial to large-scale production and application.

The invention provides an injection-use pharmaceutical composition comprising cefmetazole sodium and clavulanate potassium, and the pharmaceutical composition has a cooperatively antibacterial effect. The pharmaceutical composition comprises the following ingredients: in parts by weight, 1-4 parts of the cefmetazole sodium; 1-2 parts of the clavulanate potassium; 2-6 parts of polyalkylcyanoacrylate; 0.2-0.5 parts of L-arginine; 0.5-1 parts of PVP; 0.5-1 parts of mannitol; 0.5-1 parts of glycine; 1-2 parts of a tween. The pharmaceutical composition has the advantages of high stability, good redissolubility, simple preparation processes, a good inhibitory effect on ESBLs-producing escherichiacoli, klebsiellapeumoniae, and proteusmirabilis, and a definite curative effect, can reduce the dosage of a single prescription preparation and shorten the treatment cycle, and has broad market prospects.

The invention relates to new cefmetazole sodium for injection and a preparation method thereof, and belongs to the technical field of medicines. The new cefmetazole sodium for injection is prepared from 1 part of cefmetazole sodium, 1.13 to 1.18 parts of gelatin, 1.36 to 1.38 parts of arabic gum, 0.4 to 0.5 part of plasticizer, 0.8 to 1.2 parts of stabilizing agent and 0.9 to 1 part of anti-sticking agent. The stabilizing agent dioxanone-lactide copolymer is a copolymer in a special proportion and plays an important function on stability of a preparation. According to an injection, through a slow release effect of a microcapsule, a medicine application method of 2 to 4 times everyday is changed into medicine application for one time, so that medicine application intervals are shortened, the new cefmetazole sodium is convenient to use, the bioavailability is improved, the medicine using amount is reduced, so that the blood concentration is stable to improve a curative effect, and an adverse reaction is reduced. The preparation process of the cefmetazole sodium for injection provided by the invention is simple, is low-cost, and is suitable for large scale production; therefore, the new cefmetazole sodium is a product having market prospect.

The invention discloses a preparation method of cefmetazole sodium, comprising the following steps: (1) dissolving phosphorus pentachloride in dichloromethane, then adding cyanomethylthio potassium acetate to prepare a side-chain acyl chloride solution; dissolving 7-MAC in dichloromethane, and adding organic base and the above side-chain acyl chloride solution to wash to obtain a cefmetazole benzyl ester solution; (2) adding the cefmetazole benzyl ester solution in an aluminum trichloride anisole solution, washing, regulating the pH value to 6.0-9.0, crystallizing, filtering and drying to obtain cefmetazole amine salt; and (3) dissolving the cefmetazole amine salt in an organic solvent solution, adding cation exchange resin, removing the cation exchange resin by filtration, regulating the pH to 5-8, then removing the organic solvent by distillation at reduced pressure, letting the residual cefmetazole sodium solution be subject to decoloration and aseptic filtration, and then directly conducting freeze-drying to obtain cefmetazole sodium. The method is simple and practicable and has the advantages of high yield, good quality and low cost.

The invention discloses a novel cefmetazole compound, which has the purity greater than 99.5%. The invention further discloses a medicine composition of the cefmetazole compound. The medicine composition comprises the following components in part by weight: 60 to 90 parts of cefmetazole, 0.5 to 2 parts of mannitol, 2 to 7 parts of citrulline, and 1 to 5 parts of sodium citrate. The mannitol, the citrulline, and the sodium citrate contained in the medicine composition can work together to greatly improve light stability and heat stability of cefmetazole medicine composition, the cefmetazole medicine composition is less susceptible to oxygenolysis, and the probability of side effect of cefmetazole is effectively reduced.

The invention provides cefmetazole sodium suspension injection powder and a preparation method thereof. The cefmetazole sodium suspension injection powder comprises the following components by weight part: 10 parts of cefmetazole sodium, 5 to 30 parts of biodegradable polymer receivable on pharmacy, 1 to 20 parts of emulsifier, 6 to 12 parts of emulsion assistant and 2 to 30 parts of skeleton agent. The cefmetazole sodium suspension injection powder has the application for treating body extensive Psoriasis Pustulosa.

The invention relates to a preparation method for a cephamycin intermediate. A compound of the cephamycin intermediate can be seen in the formula (IV). The cephamycin intermediate is obtained by making 7-ACA react with dichloroacetyl chloride in specific solvent, making the obtained product react with MMT under catalysis of a sulfoacid catalyst and conducting crystallization. The cephamycin intermediate has the advantages of being high in purity and stability and the like, is beneficial for improving the purity of final cephamycin products such as cefminox sodium, cefmetazole and cefotetan disodium, and is beneficial to large-scale production and application.

The invention relates to a preparation method of cefmetazole. The preparation method comprises the steps of adopting a one-pot method containing 7-ACA, 1-methyl-5-tetrazole-thione and chloroacetyl chloride, obtaining 7-DCT, then using seven-position methoxy groups of sodium methylate and tert-butyl hypochlorite, and obtaining methoxy cephalosporin mother nuclei which are shared mother nuclei. The cefmetazole can serve as four methoxy cephalosporin products, namely cefminox, cefmetazole, cephalosporin and cefotetan disodium, three steps are omitted, the processing steps are greatly shortened, cost is lowered, and the overall yield is raised to 70%.