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Cefmetazole sodium liposome freeze-dried preparation and preparation method

A technology of cefmetazole sodium lipid and cefmetazole sodium, which is applied in the field of cefmetazole sodium liposome freeze-dried preparation and preparation, can solve the problem of temperature, light, humidity instability, easy precipitation, easy quality change, etc. problems, to achieve good stability

Inactive Publication Date: 2011-06-29
张宏民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because this product is unstable to temperature, light, and humidity, it is prone to precipitation during use, and it is easy to cause quality changes during production, transportation, and use, which increases the safety of clinical medication.

Method used

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  • Cefmetazole sodium liposome freeze-dried preparation and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Cefmetazole sodium 1.0 weight unit

[0026] Sodium chloride 1.5 weight units

[0027] Egg yolk lecithin, distearic acid lecithin, soybean lecithin 1:1 mixed to take 2.5 weight units

[0028] Mannitol 1.0 weight unit

[0029] Sodium hydrogen phosphate 0.5~3.0 weight units

[0030] Weigh the prescription amount of cefmetazole sodium, sodium chloride, and mannitol, mix and dissolve in water, stir evenly, and set aside; Fatty acid lecithin and soybean lecithin are dispersed and dissolved in it, dried under reduced pressure to form a blank film material, added to the above aqueous solution, and ultrasonically treated to the required particle size and uniformity of cefmetazole sodium liposome suspension; container, filling, and vacuum freeze-drying to obtain the cefmetazole sodium liposome freeze-dried preparation.

Embodiment 2

[0032] Cefmetazole sodium 1.0 weight unit

[0033] Sodium chloride 1.5 weight units

[0034] Lecithin disalmitate 5.0 weight units

[0035] Mannitol 1.0 weight unit

[0036] Calcium hydrogen phosphate 0.5~3.0 weight units

[0037] Weigh the prescription amount of cefmetazole sodium, sodium chloride, and mannitol, mix and dissolve in water, stir evenly, and set aside; take an appropriate amount of calcium hydrogen phosphate to prepare 10% buffered saline solution, and dissolve the prescription amount Disperse and dissolve in water, dry under reduced pressure to form a blank membrane material, add to the above aqueous solution, and ultrasonically treat the cefmetazole sodium liposome suspension to the required particle size and uniformity; constant volume, filling, and vacuum freezing After drying, the cefmetazole sodium liposome lyophilized preparation is obtained.

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Abstract

The invention provides a prescription of a cefmetazole sodium liposome freeze-dried preparation and a preparation method. The method comprises the following steps of: adding cefmetazole sodium, a stabilizing agent and an excipient into a blank membrane material made of a liposome carrier, performing ultrasonic processing, fixing volume, filling, and freeze drying to obtain the cefmetazole sodium liposome freeze-dried preparation. The cefmetazole sodium liposome freeze-dried preparation prepared by the method overcomes the defect of formulations appear on the market, has improved stability and is safer in clinical application of medicaments.

Description

Technical field: [0001] The invention relates to a medicine for treating infections caused by Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Proteus, Morganella morganii, Providencia, Peptostreptococcus and Bacteroides The invention relates to cephalosporins, in particular to a cefmetazole sodium liposome freeze-dried preparation and a preparation method. Background technique: [0002] Cefmetazole sodium, chemical name: (6R,7R)-7-[2-[(cyanomethyl)sulfur]acetamido]-7-methoxy-3-[(1-methyl-1H-tetra Azol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. [0003] Chemical Structure: [0004] [0005] Molecular formula: C 15 h 16 N 7 NaO 5 S 3 Molecular weight: 493.52 [0006] Cefmetazole sodium is a second-generation cephalosporin. It is a semi-synthetic antimicrobial drug for parenteral application. It was first introduced into clinical practice in Japan, and a large number of animal and clinical studies...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/127A61K31/546A61K47/24A61P31/04
Inventor 张宏民
Owner 张宏民
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