Novel cefmetazole compound and medicine composition thereof
A technology of cefmetazole sodium and cefmetazole, applied in the field of second-generation cephalosporin compounds and pharmaceutical compositions thereof, can solve the problems of increasing the chance of adverse reactions, reducing the content of cefmetazole sodium, increasing total impurities and the like
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Embodiment 1
[0025] A pharmaceutical composition of cefmetazole sodium, the pharmaceutical composition is an injection, and the preparation method of the injection consists of the following steps:
[0026] (1) Dissolve 6g of cefmetazole sodium, 0.05g of mannitol, 0.2g of citrulline and 0.1g of sodium citrate in water for injection, add water to 1000ml, and stir well;
[0027] (2) Add activated carbon to the solution that has been stirred evenly in step (1), stir, adjust pH=6 with sodium hydroxide, decarburize and filter, filter through membrane, and fill;
[0028] (3) Rapidly cool down the solution filled in step (2) to freezing in a freeze dryer, maintain freezing at -40°C to -30°C for 3-5 hours, vacuumize, freeze and vacuum dry for 24 hours, vacuum press Plastic cap, rolled cap, obtains cefmetazole sodium injection.
Embodiment 2
[0030] A pharmaceutical composition of cefmetazole sodium, the pharmaceutical composition is an injection, and the preparation method of the injection consists of the following steps:
[0031] (1) Dissolve 8g of cefmetazole sodium, 0.2g of mannitol, 0.7g of citrulline and 0.5g of sodium citrate in water for injection, add water to 1000ml, and stir well;
[0032] (2) Add activated carbon to the solution that has been stirred evenly in step (1), stir, adjust pH=6 with sodium hydroxide, decarburize and filter, filter through membrane, and fill;
[0033] (3) Rapidly cool down the solution filled in step (2) to freezing in a freeze dryer, maintain freezing at -40°C to -30°C for 3-5 hours, vacuumize, freeze and vacuum dry for 24 hours, vacuum press Plastic cap, rolled cap, obtains cefmetazole sodium injection.
Embodiment 3
[0035] A pharmaceutical composition of cefmetazole sodium, the pharmaceutical composition is an injection, and the preparation method of the injection consists of the following steps:
[0036] (1) Dissolve 9g of cefmetazole sodium, 0.08g of mannitol, 0.5g of citrulline and 0.25g of sodium citrate in water for injection, add water to 1000ml, and stir well;
[0037] (2) Add activated carbon to the solution that has been stirred evenly in step (1), stir, adjust pH=6 with sodium hydroxide, decarburize and filter, filter through membrane, and fill;
[0038] (3) Rapidly cool down the solution filled in step (2) to freezing in a freeze dryer, maintain freezing at -40°C to -30°C for 3-5 hours, vacuumize, freeze and vacuum dry for 24 hours, vacuum press Plastic cap, rolled cap, obtains cefmetazole sodium injection.
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