Cefmetazole-containing and beta-lactamase inhibitor-containing medicinal composition

A technology of lactamase and cefmetazole, which is applied in the field of medicine, can solve the problems of poor stability, insensitivity or drug resistance of AmpC enzyme, achieve good hydrolytic stability, good synergistic effect, and improve the effect of clinical application

Active Publication Date: 2010-09-01
HAINAN TIANHUANG PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the disadvantages of cefmetazole are: Enterobacter, Pseudomonas, methicillin-resistant Staphylococcus aureus, pneumococcus, and meningococcus are not sensitive or resistant to this product
In recent years, studies have found that cefmetazole is highly stable to ESBLS, but poorly stable to AmpC enzyme, and AmpC enzyme-producing strains are mostly resistant to it (Zhu Demei et al. Study on the antibacterial effect of cefmetazole on ESBLS-producing Enterobacteriaceae in vitro. Chinese Journal of Infection and Chemotherapy. 2009, 9(1): 1-9)

Method used

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  • Cefmetazole-containing and beta-lactamase inhibitor-containing medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1 freeze-dried powder injection

[0038] Composition: 100g of cefmetazole sodium, 50g of sulbactam sodium, 100g of mannitol, an appropriate amount of pH regulator, and water for injection to 2000ml.

[0039] Preparation:

[0040] 1), measure cefmetazole sodium and sulbactam sodium according to the formula;

[0041] 2), dissolving medicine and mannitol in water for injection with 80% prescription water consumption, after the solution is aseptically filtered through a 0.22 μm filter membrane, supplementing the prescription amount of water for injection, adjusting pH, filtering, subpackaging, freeze-drying, to obtain .

Embodiment 2

[0042] Embodiment 2 freeze-dried powder injection

[0043] Composition: 100g of cefmetazole sodium, 25g of sulbactam sodium, 100g of mannitol, an appropriate amount of pH regulator, and water for injection to 2000ml.

[0044] Preparation:

[0045] 1), measure cefmetazole sodium and sulbactam sodium according to the formula;

[0046] 2) Dissolving medicine and mannitol in water for injection with 80% of the prescribed water consumption, after the solution is aseptically filtered through a 0.22 μm filter membrane, supplementing the prescribed amount of water for injection, adjusting pH, filtering, subpackaging, and freeze-drying to obtain .

Embodiment 3

[0047] Embodiment 3 freeze-dried powder injection

[0048] Composition: 100g of cefmetazole sodium, 12.5g of sulbactam sodium, 120g of glucose, appropriate amount of pH regulator, and water for injection to 2000ml.

[0049] Preparation

[0050] 1), measure cefmetazole sodium and sulbactam sodium according to the formula;

[0051] 2) Dissolving medicine and glucose in water for injection with 80% of the prescribed water consumption, after the solution is aseptically filtered through a 0.22 μm filter membrane, supplementing the prescribed amount of water for injection, adjusting pH, filtering, subpackaging, and freeze-drying to obtain final product.

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PUM

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Abstract

The invention provides a cefmetazole-containing and beta-lactanase inhibitor-containing medicinal composition, belongs to the technical field of medicaments, in particular relates to a medicinal composition consisting of 1 to 8 weight parts of cefmetazole and 1 weight part of specific beta-lactamase inhibitor. The beta-lactamase inhibitor is one of sulbactam sodium and tazobactam sodium. The medicinal composition can improve the antimicrobial spectrum of the medicament cefmetazole sodium, and reduce the drug tolerance of bacteria.

Description

technical field [0001] The invention belongs to the technical field of medicine, and more specifically is a pharmaceutical composition composed of cefmetazole sodium and a β-lactamase inhibitor. Background technique [0002] Cefmetazole is a second-generation cefamycin antibacterial drug developed by Japan Sankyo Company. It has good stability to broad-spectrum β-lactamases produced by negative bacilli. Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Shigella, Salmonella and other negative bacilli have good stability to this product. Sensitivity, Staphylococcus aureus, group A hemolytic streptococcus, and Brahamella catarrh are highly sensitive to this product, and have good antibacterial activity against Bacteroides fragilis. It is clinically used for respiratory system infection, biliary tract infection, urinary system infection, obstetrics and gynecology bacterial infection, skin and soft tissue infection and postoperative infection prevention caused by sensi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/546A61P31/04A61K31/43A61K31/431
Inventor 郑飞雄
Owner HAINAN TIANHUANG PHARMA
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