6 results about "Sulbactam Sodium" patented technology

This invention discloses a cefoperazone sodium and sulbactam sodium composition and its preparation method, comprising the following steps: preparing a chitosan-β-glycerophosphate sodium colloidal solution; mixing dry ice and sorbitol evenly, then adding the mixture to the colloidal solution, freezing, heating, and drying under reduced pressure to obtain chitosan-β-glycerophosphate sodium nanospheres; slowly adding cefoperazone sodium, sulbactam sodium, and chitosan-β-glycerophosphate sodium nanospheres to water for injection, stirring to dissolve; adjusting the pH to 7.1-7.5, adding an adsorbent for adsorption and filtration, adding dry ice; freeze-drying to obtain a cefoperazone sodium and sulbactam sodium mixed powder. The nanospheres of this invention, with a certain size gradient, are beneficial for the uniformity of the mixed powder of cefoperazone sodium and sulbactam sodium, resulting in a longer-lasting efficacy, better stability, lower hygroscopicity, and also playing an antibacterial role.

The invention discloses a sulbactam sodium crystal preparation method, and belongs to the technical field of medicines, sodium lactate is adopted as a salt forming agent for preparing sulbactam sodium, and the prepared sulbactam sodium product is high in stability, milder in reaction condition and suitable for industrial mass production.

The invention discloses a preparation method and application of cefoperazone sodium and sulbactam sodium for injection, and relates to the field of preparation methods of cefoperazone sodium and sulbactam sodium, and the preparation method comprises preparation of cefoperazone sodium and preparation of a mixed solution. The preparation of the mixed solution comprises the following steps: weighing sulbactam sodium and the prepared cefoperazone sodium, adding the sulbactam sodium and the prepared cefoperazone sodium into a sodium chloride injection, dissolving, adding a phosphate buffer solution, filtering, adding valine into the solution, dispersing, and filtering to obtain the mixed solution. Sequentially carrying out freeze-drying treatment, drying, crushing, screening and re-drying on the dispersed mixed solution to obtain the cefoperazone sodium sulbactam sodium for injection. The mass ratio of the cefoperazone sodium to the sulbactam sodium is (1-5): 1. The valine is added into the mixed solution and the process is optimized, so that the valine and the cefoperazone sodium can form hydrogen bonds and electrostatic interaction, and the purpose of improving the stability of the cefoperazone sodium sulbactam sodium for injection with high cefoperazone sodium content is achieved.

The utility model relates to the technical field of filling and feeding devices, in particular to a filling and feeding device suitable for cefoperazone sodium and sulbactam sodium for injection. Comprising a bottom plate, a baffle is arranged above the periphery of the bottom plate, and a runner pipe is arranged below the right side of the bottom plate; through the structure of an abutting plate, a fixing column and a sealing ring, a circulation pipe is blocked, under the elastic action of a spring, the circulation pipe is always kept in a closed state without external force under the use mode that the abutting plate is matched with a lifting frame, after a filling bottle is upwards connected with the circulation pipe, the fixing column slides out of the circulation pipe, and liquid medicine can flow out of the filling bottle; through the sliding structure of the sliding frame on the connecting frame, different filling bottles can be adjusted to move and be placed below the runner pipe, through the multi-station switching design of the sliding frame, continuous filling is achieved, manual intervention is reduced, and through clamping connection of a clamping groove and an elastic piece, the situation that in the filling process, the sliding frame slides, liquid medicine overflows, and waste is caused is avoided.

The utility model discloses a filling device for cefoperazone sodium and sulbactam sodium, and relates to the technical field of medicine filling equipment. A filling device for cefoperazone sodium and sulbactam sodium comprises a rotating disc set used for bearing and transporting medicine bottles; the supporting frame is arranged on the side edge of the rotating disc set; the lifting assembly is mounted on the supporting frame; the filling assembly is connected with the bottom of the lifting assembly and used for filling the medicine bottles with cefoperazone sodium and sulbactam sodium; the anti-overflow assembly is fixed to the filling assembly and arranged around the medicine bottle by a circle. The problems that mixed powder flies and is wasted, and the filling weight is insufficient are solved.

The present invention discloses an ampicillin sodium and sulbactam sodium pharmaceutical composition for injection and a preparation method thereof. The preparation method includes Step 1: uniformly mixing ampicillin sodium and sulbactam sodium; Step 2: uniformly mixing water-soluble chitosan microspheres with the mixture obtained in Step 1; Step 3: uniformly mixing sodium carboxymethyl cellulose with the mixture obtained in Step 2. In the present invention, by mixing water-soluble chitosan microspheres with ampicillin sodium and sulbactam sodium, the water-soluble chitosan microspheres can be uniformly dispersed in ampicillin sodium and sulbactam sodium. Then, the added sodium carboxymethyl cellulose forms a hydrogen bond with the water-soluble chitosan microspheres, so that a film is formed on the outside of the water-soluble chitosan microspheres by sodium carboxymethyl cellulose, and ampicillin sodium and sulbactam sodium can be dispersed in the dispersion system formed by sodium carboxymethyl cellulose and water-soluble chitosan microspheres, thereby providing long-term and stable protection for ampicillin sodium and sulbactam sodium.