179 results about "Sulbactam Sodium" patented technology

The invention belongs to the technical field of medicines, and in particular relates to a sulbactam sodium compound and a medical composition of the sulbactam sodium compound and mezlocillin sodium. The sulbactam sodium compound is shown as by an X-ray powder diffraction spectrogram I measured by a Cu-K alpha ray. The sulbactam sodium compound provided by the invention has better storage stability. The invention further provides a preparation method of the sulbactam sodium compound as well as a medical composition of the sulbactam sodium compound and mezlocillin sodium. The medical composition has better storage stability and higher using safety performance.

The invention provides a liposome injection based on a drug combination of mezlocillin sodium and sulbactam sodium. The liposome injection comprises the following components: mezlocillin sodium, sulbactam sodium, liposome carriers, frozen and dried supporting agent and optional existing antioxidant, wherein the liposome carriers are particularly hydrogenated soybean phosphatidylcholine and octadecylamine. The liposome injection of the invention has good preparation stability, prevents the liposome from being cracked under the action of dehydration, fusion and ice crystal generation in the freezing-drying process, and keeps good entrapment rate of the liposome after re-dissolution through hydration.

The invention belongs to the field of medicine and chemical industry. The invention relates to a preparation method of a lyophilization sulbactam sodium material medicine, which comprises the following steps of: (1) adding sodium bicarbonate into sulbactam acid suspension to obtain a lyophilization sulbactam sodium material liquid medicine; (2) filtering the liquid medicine by utilizing a filter; (3) uniformly pouring the sterile liquid medicine into a material disk of a freeze drier, setting the temperature of a baffle plate to be -40 DEG C to -10 DEG C for freezing for 1-6h, then setting the temperature of the baffle plate to be -10 DEG C to 10 DEG for keeping for 1-10h, then setting the temperature of the baffle plate to be 10 DEG C to 20 DEG C for drying 1-20h, then setting the temperature of the baffle plate to be 20-50 DEG C for drying for 1-30h, finally setting the temperature of the baffle plate to be 50-65 DEG C for drying 1-20h; and (4) grinding and uniformly mixing the lyophilization powder prepared from the step (3) to obtain the lyophilization sulbactam sodium material medicine. The products prepared by the preparation method of a lyophilization sulbactam sodium material medicine has the advantages of good clarity index and high content; and bad factors of solvent residues, clarity foreign matters, turbidity and the like prepared by utilizing a solvent method can be avoided.