52 results about "Piperacillin Sodium" patented technology

A sterile pharmaceutical composition having as its active principles piperacillin sodium and tazobactam sodium of substantially the same density, mixed with sodium bicarbonate. The mixture is soluble in water to give injectable reconstituted solutions having high stability with time.

The invention discloses a medicinal composition. The medicinal composition comprises piperacillin sodium and tazobactam sodium serving as raw material medicaments, and is characterized in that: the piperacillin sodium serving as the raw material medicament is prepared from piperacillin acid through ion exchange resin; and the tazobactam sodium serving as the raw material medicament is prepared from tazobactam acid through the ion exchange resin. Experiments prove that a preparation prepared from the medical composition has higher quality.

The invention provides a process for preparing piperacillin sodium by using a solvent method. The process comprises the following steps of: dissolving sodium methoxide into an anhydrous organic solvent; dissolving piperacillin into anhydrous acetone, cooling to the temperature of between 0 and 5 DEG C under the protection of an inert gas, dripwise adding a sodium methoxide solution, controlling the temperature to be between 0 and 5 DEG C, naturally returning the temperature of between 12 and 18 DEG C with stirring after dripwise adding, and preserving heat until the reaction is ended; and performing filter pressing on the reacted product by adopting the inert gas, drying filter cakes at the temperature of between 60 and 70 DEG C under reduced pressure, emptying with the inert gas, discharging, and thus obtaining the piperacillin sodium in accordance with Chinese pharmacopeia (CP2010). The piperacillin sodium in accordance with the Chinese pharmacopeia (CP2010) can be prepared by the process, the preparation method is easier to operate, the equipment requirement is low, and the piperacillin sodium has the characteristics of high purity, high yield, high content and low residue.

The invention discloses a piperacillin sodium and sulbactam sodium drug composite microsphere injection which is characterized by comprising the following components in parts by weight: 2-4 parts of piperacillin sodium, 1 part of sulbactam sodium, 6-10 parts of albumin, 3-5 parts of poloxamer 188, 5-7 parts of polyethylene glycol 600 (PEG600) and 2-5 parts of trehalose. Compared with the prior art, the piperacillin sodium and sulbactam sodium drug composite microsphere injection prepared by the invention has the characteristics of good stability, high entrapment rate, good reproducibility of preparation technology, even particle distribution, small dissolvent residue, good injectability and excellent slow-release property, and is suitable for industrial production.

The invention provides a stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium and the preparation method thereof. The drug compound consists of piperacillin sodium, Beta-lactamases inhibitors and pH-value regulators with the weight proportion of 1 to 100:1:0.001 to 2. Diluted and delivered in any proportion with conventional clinical transfusions, the drug compound can have a stable piperacillin sodium content, dissolve rapidly, generate no crystallization or degradation products and receive no effect from the temperature. The preparation method of the stable-content drug compound containing Beta-lactamases inhibitors and piperacillin sodium has simple preparing method and high efficiency and is fit for a large-scale industrial production.

The invention relates to an eutectic of Piperacillin sodium and Sulbactam sodium, a preparation method thereof, a pharmaceutical composition containing the eutectic and an application of the pharmaceutical composition on treating infection of super bacteria producing NDM-1 and other drug-resistance bacteria. The eutectic of the Piperacillin sodium and the Sulbactam sodium comprises diffraction angles of 14.24 DEG, 16.58 DEG, 16.79 DEG, 17.77 DEG, 19.20 DEG, 20.21 DEG, 20.39 DEG, 23.06 DEG, 27.86 DEG and 32.16 DEG represented by 2[theta] in an X-ray powder diffraction analysis spectra. The eutectic provided by the invention is excellent in solubility, low in hygroscopicity, relatively small in powder volume, high in purity, low in content of related substances, and easy to filter and dry during industrial production. A compound preparation prepared by the eutectic has obviously improved stability; not only is the shelf life of the products prolonged, but also the product safety is improved, thereby reducing potential adverse risks of the drugs and further protecting the health of patients.

The invention relates to suspensoid powder injection of a piperacillin sodium sulbactam medicine composition prepared by applying an emulsification suspensoid technology and freeze drying. The invention further relates to a novel application of the suspensoid powder injection in preparing a medicine treating the infection of the oral cavity.

The invention discloses a piperacillin sodium and sulbactam sodium drug composite microsphere injection which is characterized by comprising the following components in parts by weight: 2-4 parts of piperacillin sodium, 1 part of sulbactam sodium, 6-10 parts of albumin, 3-5 parts of poloxamer 188, 5-7 parts of polyethylene glycol 600 (PEG600) and 2-5 parts of trehalose. Compared with the prior art, the piperacillin sodium and sulbactam sodium drug composite microsphere injection prepared by the invention has the characteristics of good stability, high entrapment rate, good reproducibility of preparation technology, even particle distribution, small dissolvent residue, good injectability and excellent slow-release property, and is suitable for industrial production.

The invention discloses a groove sterilizing cart for preparing piperacillin sodium used for injection. The groove sterilizing cart comprises a tray rack (1) and a transport cart. Supporting legs (2) are arranged at the four corners of the lower surface of the tray rack (1). The transport cart is composed of a cart plate (4) and cart wheels (6). The cart wheels (6) are installed below the cart plate (4), grooves (3) are formed in the two sides of the cart plate (4), and each two supporting legs (2) are arranged in one same groove (3). Due to the arrangement of the grooves and the supporting legs on the groove sterilizing cart, the tray rack is convenient to place on the transport cart, the grooves play a role in limiting the supporting legs and preventing the displacement of the supporting legs, the tray rack is prevented from generating displacement or disengaging from the cart plate, so that the tray rack can be firmly located on the cart plate, and the situation that a whole transportation process of sterilizing is smoothly completed is guaranteed.

The invention provides a piperacillin sodium and sulbactam sodium sterile powder-injection. The piperacillin sodium piperacillin sodium sterile powder-injection is prepared from piperacillin sodium, sulbactam sodium and a stabilizer. The stabilizer is composed of mycose, sodium pyrosulfite and glycine. The piperacillin sodium and sulbactam sodium sterile powder-injection comprises, by weight, 2-4 parts of the piperacillin sodium, 1 part of the sulbactam sodium, 20-40 parts of the mycose, 8-15 parts of the sodium pyrosulfite and 10-20 parts of the glycine. Compared with the prior art, the stabilizer is composed of the mycose, the sodium pyrosulfite and the glycine. Therefore, the stability of the piperacillin sodium and the sulbactam sodium in the preparation and storage process is effectively improved. It is guaranteed that products are qualified within the period of validity. The powder-injection is dissolved fast. No crystallization or turbidity exists. The curative effect and safety of clinical usage are guaranteed. A preparation method is simple. The cost is low. The powder-injection is suitable for industrial mass production.