46 results about "Penicillin Antibiotic" patented technology

The invention discloses a penicillin antibiotic aptamer obtained by the screening technology for an improved aptamer without a fixed point target substance in the field of screening a penicillin antibiotic aptamer without a fixed point target substance, and an application thereof. The unfixed nucleic acid is eluted through a fixed oligonucleotide library; the parent nucleus 6-APA (6-aminopenicillanic acid) of the penicillin antibiotic is added in positive screening to act on the fixed nucleic acid; after eluting the nucleic acid molecules which can be combined with 6-APA, PCR (polymerase chain reaction) amplification is directly performed for next screening; and other antibiotics are added in negative screening, and the nucleic acid molecules in non-specific binding with the penicillin antibiotics are removed by elution. Through multiple rounds of positive and negative screening, 10 nucleic acid aptamers with high specificity and strong affinity with 6-APA are obtained; and the nucleic acid aptamer with a stable secondary structure is selected for developing a nucleic acid aptamer sensor for detecting 6-APA.

The invention relates to a release injection which contains cefradine, wherein it is formed by release micro ball and dissolvent; the release micro ball contains release findings and penicillin antibiotic; the dissolvent is the special one contains sodium carboxymethyl cellulose as suspension agent; the viscosity is 100cp-3000cp (20Deg. C-30Deg. C); the release agent is selected from EVAc, polyphenyl, PLA, PLGA, sebacic acid polymer, protein pastern, and dope; the release micro ball can be made into release implant agent; the release implant agent and release injection is laid on bacteria stove or injected, to release the medicine for 5-30 days, to keep the effective medicine density and reduce the whole toxicity. The invention can be used to cure the infection caused by staphylococcus, streptococcus, etc.

The invention relates to a release injection which contains mycin antibiotic, wherein the invention is formed by release micro ball and dissolvent; the release micro ball contains release findings and penicillin antibiotic; the dissolvent is the special one contains sodium carboxymethyl cellulose as suspension agent; the viscosity is 100cp-3000cp (20Deg. C-30Deg. C); the release agent is selected from EVAc, polyphenyl, PLA, PLGA, sebacic acid polymer, protein pastern, and dope; the release micro ball can be made into release implant agent; the release implant agent and release injection is laid on bacteria stove or injected, to release the medicine for 5-30 days, to keep the effective medicine density and reduce the whole toxicity. The invention can be used to cure the infection caused by staphylococcus, streptococcus, etc.

The invention provides a multi-residual enzyme-linked immunoassay method used for antibiotics such as penicillins and the like, belonging to the technical field of immunoassay. The method obtains a polyclonal antibody by utilizing immunogen immunity synthesized by 6-amino penicillanic acid; the antibiotics such as the penicillins and the like are used as standard products and the conjugate of the 6-amino penicillanic acid and OVA is used as coating antigen, thus establishing the indirect ELISA method of antibiotics such as penicillins and the like in animal foods. The method provides a quick and high-efficiency detection means for the residual detection of the antibiotics such as penicillins and the like in the animal foods; as the polyclonal antibody is adopted, the expense is lower and the stability and repeatability are better; furthermore, the method has the advantages of simple predisposal, high sensitiveness, high precision and the like.

The invention relates to a mouse monoclonal antibody cell strain for resisting both amoxicillin and ampicillin, belonging to the technical field of B cell hybridoma. The mouse monoclonal antibody cell strain for resisting the amoxicillin and the ampicillin has the preservation number of CGMCC NO.2674. The monoclonal antibody aiming at the amoxicillin has 100 percent of cross reaction with the ampicillin which also belongs to the penicillin antibiotics, and has no cross reaction with cefazolin of cephalosporin antibiotics. The invention can be used for rapidly detecting the residual condition of the amoxicillin and the ampicillin in animal-sourced food, and can be further used for developing an immunity detection product rapidly and accurately detecting the amoxicillin and the ampicillin in the animal-sourced food.

The invention discloses a making method of penicillin antibiotic disodium tikaxilin salt, which comprises the following steps: adding diluent in the tikaxilin acid solution at -5-50 deg. c; decoloring through active carbon; filtering; adding salting agent; stirring; culturing crystal at -10-50 deg. c until the crystal is evolved completely; filtering; washing; drying in the vacuum under 20-80 deg. c; obtaining the product.

The invention relates to a novel method for preparing broad-spectrum penicillin antibiotic ticarcillin sodium. The method is characterized in that the method comprises the following steps of: (1) directly carrying out chlorination on 3-thiophenemalonic acid used as raw material and thionyl chloride in the presence of a catalyst, without protecting carboxyl, and chloridizing one carboxyl to obtiana compound (II); (2) carrying out condensation reaction with 6-aminopenicilanic acid (6-APA), controlling the reaction temperature and PH value, dripping the compound (II) and sodium bicarbonate solution, dispensing liquid after reaction, adjusting PH value to wash, adjusting pH value again to 2.0, extracting reaction solution, and drying to obtain a compound (IV); using sodium iso-octoate to salify, and refining crude products, to obtian the ticarcillin sodium salt.

The present invention relates to a preparation method for molecular imprinted polymer which can get rid of the penicillin-like antibiotics in the fresh milk. The present invention belongs to the foodchemistry field. The preparation method lie in that template molecule, functional monomer, cross-linking agent and the initiator are mixed together to be oxygenated, thermal polymerized, grinded, cleaned and dried in vacuum to get molecular imprinted polymer. The present invention is simple and controllable. The required experimental devices are simple. The generated molecular imprinted polymer isof strong stability, long storage time, large adsorption capacity and fast adsorption speed. The counter- imprinted molecular is of strong memory and no toxin and any side effect. The molecular imprinted polymer can effectively get rid f the penicillin-like antibiotics in the fresh milk and can be used in the examination of penicillin-like antibiotics in the fresh milk. The present invention is of very broad prospects for development and application.

The invention relates to a method for removing residual penicillin antibiotics in biomedical waste residues, comprising the following steps: (1) adding an activator to the biomedical waste residues containing penicillin antibiotics, and obtaining waste residue slurry after slurry mixing and dispersion; 2) Adding a catalyst and an oxidizing agent to the waste residue slurry obtained in step (1), and performing a degradation reaction to complete the removal of the residual penicillin antibiotics in the biomedical waste residue. Compared with the prior art, the present invention can quickly and efficiently remove more than 99% of residual antibiotics, and this method degrades penicillin antibiotics into other non-toxic and non-medicinal substances, and the waste residue obtained from the treatment is solid, which is convenient for storage It can be used for the production of fertilizers and soil conditioners, which conforms to the concept of green, coordinated and sustainable development, and meets the requirements of energy conservation and environmental protection advocated by the state.