3 results about "Penicillin Antibiotic" patented technology

This invention discloses a penicillinase mutant, its recombinant strain, and its applications, relating to the field of antibiotic wastewater treatment. Using the wild-type penicillinase of SEQ ID NO:1 as a template, this invention obtains penicillinase mutants of SEQ ID NO:2-7 through site-directed combination mutagenesis, significantly improving wide pH tolerance. While the wild-type enzyme experiences a sharp drop in activity at pH 9-10, the mutant of this invention maintains high enzyme activity at pH 5-10, reaching over 90% of the highest wild-type activity at pH 9-10. It can be directly adapted to the highly alkaline environment of penicillin G production wastewater without significant pH adjustment. This invention also provides the recombinant genetic material encoding the mutant, the recombinant strain, and its application in wastewater purification, exhibiting advantages such as high degradation efficiency, low operating costs, stable process, and environmental friendliness, possessing significant engineering application value in the treatment of penicillin antibiotic wastewater.

To provide a novel antimicrobial product that enables the management of animal diseases while reducing reliance on conventional antibiotics. [Solution] The present invention relates to an antimicrobial composition comprising an extract of a coffee composition and an antibiotic, and to the use of the antimicrobial composition in the manufacture of antimicrobial drugs. The extract of the coffee composition comprises a solid component and water, the solid component comprising coffee beans and auxiliary materials. The antibiotic is selected from the group consisting of penicillin antibiotics, cephalosporin antibiotics, fluoroquinolone antibiotics, tetracycline antibiotics, chloramphenicol antibiotics, aminoglycoside antibiotics and combinations thereof, and the weight ratio of the coffee composition to the antibiotic is from 1.5:1 to 25000:1. The antimicrobial composition of the present invention can exhibit a superior antibacterial effect compared to the use of antibiotics alone, and this antibacterial effect can also be exerted against drug-resistant bacteria.

The invention relates to the synthesis of novel penicillin β-lactam antibiotics with synthetic peptide structures containing C-C and C-N multiple bonds, and the synthesis of their pharmaceutically acceptable salts, via four-component reactions using 6-aminopenicillanic acid (6-APA) as the aldehyde, amine, isonitrile, and carboxylic acid, or 6-aminopenicillanic acid (6-APA) as the aldehyde carboxylic acid and amine.