6 results about "Probenecid" patented technology

Disclosed herein are methods, compounds, and compositions for treating or preventing inflammasome-mediated diseases or conditions, including inflammasome-mediated lung diseases or conditions.

Compositions and methods of treating a coronavirus infection in a subject are provided. The methods generally include administering to the subject an effective amount of a probenecid, metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can be therapeutic and / or prophylactic. The amount of probenecid, metabolite or analog thereof, or a pharmaceutically acceptable salt thereof can be effective, for example, to reduce viral replication, reduce one or more symptoms of a disease, disorder, or illness associated with the virus, or a combination thereof. In preferred embodiments, the virus is a severe acute respiratory syndrome-associated coronavirus, such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-associated coronavirus, such as MERS-CoV, or a coronavirus that causes the common cold.

Disclosed herein are methods, compounds, and compositions for treating or preventing inflammasome-mediated dermatological diseases or conditions.

To provide an ATP production promoter useful for preventing or treating diseases associated with decreased ATP production, particularly renal impairment. [Solution] The present invention comprises an ATP production promoter containing a component having URAT1 inhibitory activity. Preferably, the component having URAT1 inhibitory activity is at least one selected from the group consisting of benzbromarone, probenecid, dotinurad, recinurad, and berinurad. The present invention is expected to be useful as a preventive and therapeutic agent for diseases of decreased ATP production, and is particularly useful as a therapeutic and / or preventive agent for nephrotic syndrome, chronic glomerulonephritis, chronic tubulointerstitial nephritis, chronic pyelonephritis, amyloid kidney, familial juvenile hyperuricemia nephropathy, autosomal dominant tubulointerstitial kidney disease, nephronoplasia, renovascular hypertension, renal vein thrombosis, renal arteriovenous fistula, renal tubular acidosis, Gitelman syndrome, Bartter syndrome, Fanconi syndrome, Lowe syndrome, Alport syndrome, kidney and ureteral stones, and chronic renal failure.

The invention relates to a preparation method for salifying and freeze-drying probenecid, which is characterized by comprising the following steps: reacting probenecid and a salt-forming agent in injection water to form salt, adding a pH regulator to regulate the pH value, adding absolute ethyl alcohol, adsorbing and decolorizing with activated carbon, filtering, and freeze-drying to obtain the product, the probenecid comprises probenecid, sodium hydroxide and sodium carbonate according to a molar ratio of 1: 1: 0.01, a solvent is injection water containing 3%-5% of ethanol, and freeze-drying comprises pre-freezing, annealing, heating to melt small ice crystals, and re-freezing. The probenecid sodium freeze-dried powder is good in appearance property, stable in salt forming rate, controllable in pH and capable of improving the redissolution time, the product freeze-drying process efficiency is improved, and it is guaranteed that the product quality is controllable. The process is simple and suitable for industrial production.