24 results about "Chronic renal failure" patented technology

The invention relates to a weight loss intervention method and device for chronic renal failure and obesity patients based on an individualized prescription. The method comprises the following steps: constructing a multi-modal dynamic time sequence feature vector of a patient; identifying and quantifying potential causal effects of different weight loss intervention measures on physiological outcomes of renal functions, electrolyte balance, anemia states, bone mineral metabolism and weight indexes of the CKD patient according to a dual robust estimator; dynamically constructing a weight loss intervention measure causal model according to the potential causal effect of the physiological outcome of each patient and the physiological and pathological background; and inputting the multi-modal dynamic time sequence feature vector of the patient into a weight loss intervention measure causal model, and generating a daily diet scheme, an exercise scheme and corresponding high-confidence risk early warning and causal explanation of the patient. The method overcomes the limitation that the traditional method only pays attention to correlation and cannot clearly determine the intervention effect, ensures that the causal atlas and the intervention scheme are optimized according to the real-time change state of the patient, and realizes a real dynamic prescription.

The instant invention relates to a process for the preparation of a pharmaceutical composition in sustained-release tablet form comprising from 600 milligrams to 2400 milligrams of Pirfenidone (PFD), in such a way that the drug is bioavailable during an extended period of time of 12 hours from its administration. In this way, the anti-fibrotic and anti-inflammatory action of the drug Pirfenidone is optimized. Moreover, the instant invention offers advantages and a higher therapeutic efficacy compared to other pharmaceutical forms of Pirfenidone for oral administration and its therapeutic application in the regression of chronic renal failure secondary to primary glomerulosclerosis; it shows a better activity with regard to the reduction and / or regression of deleterious effects in breast capsular contracture observed after the surgical implantation of breast implants in humans and has an important anti-TNF-α and anti-TGF-β1 action for the treatment of hepatic fibrosis.

The application discloses a traditional Chinese medicine composition for treating chronic renal failure and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 25-35 parts of radix astragali, 15-25 parts of radix salviae miltiorrhizae, 5-15 parts of raw radix et rhizoma rhei, 15-25 parts of fructus corni, 15-25 parts of radix paeoniae alba, 15-25 parts of poria cocos, 5-15 parts of rhizoma chuanxiong, 15-25 parts of radix atractylodis macrocephalae, 15-25 parts of radix codonopsis, 15-25 parts of radix alismatis, 15-25 parts of radix sophorae flavescentis and 15-25 parts of herba plantaginis. The traditional Chinese medicine composition for treating chronic renal failure is scientifically and reasonably formulated, and the traditional Chinese medicine composition has obvious and exact curative effects on chronic renal failure and has a shorter treatment cycle compared with the prior art.

To provide a jelly composition containing spherical adsorptive carbon for improving uremic symptoms and delaying initiation of dialysis of chronic renal failure patients, which has more improved medication compliance than existing therapeutic agents.SOLUTION: The jelly composition contains spherical adsorptive carbon as an active ingredient, a gelling agent, a thickener, and spherical adsorptive carbon containing distilled water.SELECTED DRAWING: Figure 2

This invention belongs to the field of pharmaceutical analysis, specifically relating to a method for constructing a fingerprint spectrum of Shenfushu granules. The method for constructing a fingerprint spectrum of Shenfushu granules provided by this invention features high accuracy, high stability, good repeatability, good specificity, and strong specificity. The fingerprint spectrum analysis method for Shenfushu granules, a traditional Chinese medicine preparation for treating chronic renal failure, established by this invention can not only qualitatively analyze and identify the seven chemical components contained in this preparation, but also simultaneously present the characteristic peaks of five traditional Chinese medicines in the prescription, achieving the goal of overall quality control of multiple medicinal ingredients.

Provided is a pharmaceutical composition and use thereof in treating a chronic kidney disease. In the pharmaceutical composition, Astragalus membranaceus is adopted for strengthening body resistance, and Radix et Rhizoma Rhei, Whitmania pigra (W. pigra), and Bombyx batryticatus (B. batryticatus) are adopted for eliminating pathogens, that is, the pharmaceutical composition can improve a kidney function through the combination of strengthening body resistance with eliminating pathogens. The above treatments all can significantly reduce creatinine, urea nitrogen, and urine protein / creatinine ratio indexes in rats with chronic renal failure (CRF), and improve pathological changes such as glomerular mesangial expansion, extracellular matrix deposition of mesangial cells, glomerulosclerosis, and renal interstitial fibrosis (RIF) in rats (a model) with CRF, thereby further improving a therapeutic effect of the TCM composition for CKD.

1. The name of the product under this design: hemodialysis machine. 2. Purpose of this design product: Hemodialysis treatment for patients with acute and chronic renal failure. 3. The key point of the design of this product lies in its shape. 4. The picture or photo that best illustrates the design points: three-dimensional picture.

The invention belongs to the field of traditional Chinese medicines, and provides a medicine for treating or adjunctively treating chronic renal failure, which is prepared from the following raw material medicines in parts by weight: 5-15 parts of ginseng; 5-20 parts by weight of bighead atractylodes rhizome; 10-30 parts by weight of wrinkled gianthyssop herb; 10-30 parts by weight of amomum tsao-ko; 5-20 parts by weight of Chinese angelica; 5-25 parts by weight of ligusticum wallichii; 5-20 parts by weight of rheum officinale; 5-20 parts by weight of curcuma zedoary; 5-20 parts by weight of rhizoma sparganii; and 10-30 parts by weight of Radix Astragali. The components in the medicine provided by the invention are reasonable in compatibility and synergistic in effect, can relieve progressive deterioration of renal function and improve biochemical indexes of patients, has an obvious treatment effect on chronic renal failure, does not have obvious toxic or side effects, and is very suitable for popularization and application.

The invention belongs to the technical field of biological medicines, and particularly discloses a liposome containing a natural extract composition as well as a preparation method and application of the liposome. The method for preparing the liposome containing the natural extract composition comprises the following steps: S1, adding the grape, poria cocos and apple extract, cholesterol and lecithin into an organic solvent, heating, stirring and dissolving to obtain an organic phase; adding the soybean extract and the ginseng extract into ultrapure water, heating and stirring to obtain a water phase; and S2, slowly adding the organic phase into the water phase while stirring, continuing stirring and emulsifying, and removing the organic solvent by reduced pressure distillation to obtain a liposome suspension. And S3, filtering the suspension, adding a freeze-drying protective additive, and freeze-drying to obtain the liposome. The invention also covers the application of the liposome in treating renal failure. In the invention, through the combination of natural extracts and the combination of a specific composition and liposome administration, the components generate a synergistic effect, and the pharmaceutical composition has a remarkable treatment effect on renal failure, especially chronic renal failure.

The invention relates to a feed for inducing a chronic renal failure animal model and a construction method of the model. The feed comprises maintenance feed, lard, soybean oil, sodium dihydrogen phosphate, casein and yeast extract. The construction method of the model comprises the following steps: selecting a 4-8-week-old mouse, and feeding the mouse with the feed for 3-6 weeks to obtain the chronic renal failure mouse model. According to the invention, high-fat, high-yeast and high-phosphorus diet is adopted, so that the actual pathological manifestation of the chronic renal failure is better simulated, and the animal model can be used as an animal model for screening or evaluating drugs for preventing and / or treating the chronic renal failure.

The present invention relates to novel pyrrolidine-fused myrtanol derivatives (or 4-azatricyclo[6.1.1.02,6]decanes) of the general formula (I) or pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compositions comprising such compounds as well as their use as medicaments, especially in methods for the prophylaxis or treatment of a disease and / or a disorder caused by and / or associated with indolamine 2,3-dioxygenase 1 (1001) selected from: an inflammatory condition, an infectious disease, a cancer, a central nervous system disease or disorder, a disease or disorder relating to female reproductive health, coronary heart disease, chronic renal failure, post anaesthesia cognitive dysfunction, and cataracts.

The application provides a traditional Chinese medicine composition for treating uremia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition for treating uremia is prepared from raw materials and is characterized by kidney-tonifying, spleen-strengthening, qi-benefiting, turbidity-removing, dampness-removing and blood-stasis-removing, and is an effective medicine for treating chronic renal failure and is worth popularization and application.

The invention discloses a traditional Chinese medicine composition for treating chronic kidney failure as well as a preparation method and application of the traditional Chinese medicine composition, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 35 parts of radix astragali seu hedysari, 15 to 25 parts of radix salviae miltiorrhizae, 5 to 15 parts of raw radix et rhizoma rhei, 15 to 25 parts of fructus corni, 15 to 25 parts of rhizoma dioscoreae, 15 to 25 parts of poria cocos, 5 to 15 parts of rhizoma chuanxiong, 15 to 25 parts of rhizoma atractylodis macrocephalae, 15 to 25 parts of radix codonopsis, 15 to 25 parts of rhizoma alismatis, 15 to 25 parts of radix sophorae flavescentis and 15 to 25 parts of herba plantaginis. The traditional Chinese medicine composition for treating the chronic kidney failure is scientific and reasonable in formula compatibility, and compared with the prior art, the traditional Chinese medicine composition has an obvious and exact curative effect on the chronic kidney failure and is shorter in treatment cycle.

The invention relates to the technical field of traditional Chinese medicine, and particularly discloses a traditional Chinese medicine monomer composition for chronic renal failure and application thereof. The traditional Chinese medicine monomer composition is prepared from the following raw materials in molar ratio: 9.5 to 40 mol of liquiritigenin, 3.5 to 9.5 mol of ginsenoside Rg2, 1 to 4 mol of quercetin, 0.5 to 3.5 mol of tanshinone IIA and 1 to 5 mol of baicalin. The invention further discloses application of the traditional Chinese medicine monomer composition in preparation of a preparation for chronic renal failure and application of the traditional Chinese medicine monomer composition in preparation of a medicine for chronic renal failure. The traditional Chinese medicine monomer composition has good in-vivo anti-inflammatory and anti-renal fibrosis activity, can significantly improve the renal function of chronic renal failure animals, and has a good application prospect.

The invention belongs to the technical field of adsorbents, and particularly relates to a carbon nanosphere, a preparation method of the carbon nanosphere and application of the carbon nanosphere in preparation of an organ / tissue toxin removal reagent. The nano carbon sphere provided by the invention is rich in micropore structure, large in specific surface area, smooth in surface and free of dust, and further can be used as or used for preparing an organ / tissue toxin removing reagent through a specific diameter, so that toxin and impurities in organs or tissues are directionally removed, specific toxin is accurately removed, the poisoning condition is corrected, and the toxic and side effects are reduced. The positive significance is realized on treating acute and chronic renal failure of animals. The carbon nanosphere provided by the invention can be used as or used for preparing an organ / tissue toxin removing reagent. When lipopolysaccharide in blood is removed, the removal rate is 80% or above, and the influence on other beneficial components in the blood is smaller than 10%.

The present invention provides a traditional Chinese medicine composition for treating chronic renal failure with poor appetite, as well as its preparation method and application, belonging to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition comprises the following raw materials in parts by mass: 24-36 parts of Atractylodes macrocephala, 16-24 parts of raw Astragalus membranaceus, 12-18 parts of Poria cocos, 12-18 parts of stir-fried chicken gizzard lining, 8-12 parts of Sophora flavescens, 6-10 parts of Ginseng, 4-6 parts of Licorice and 1-3 parts of Coptis chinensis. The various traditional Chinese medicine raw materials in the traditional Chinese medicine composition cooperate with each other, have good therapeutic effects on the symptoms of poor appetite associated with chronic renal failure, can significantly improve the condition of poor appetite, promote the body's absorption and utilization of nutrients in food, and improve small intestinal motility. The traditional Chinese medicine composition provided by the present invention can improve the symptoms of spleen and stomach deficiency and coldness in patients with chronic renal failure and poor appetite, and has excellent clinical application prospects.

The invention provides a traditional Chinese medicine composition for treating chronic renal failure and a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 25 to 35 parts of radix et rhizoma rhei, 25 to 35 parts of herba taraxaci, 25 to 35 parts of radix salviae miltiorrhizae, 25 to 35 parts of concha ostreae, 25 to 35 parts of caulis lonicerae, 25 to 35 parts of flos sophorae, 10 to 20 parts of radix aconiti lateralis preparata, 40 to 60 parts of rhizoma smilacis glabrae and 25 to 35 parts of rhizoma imperatae. The whole formula is clear in compatibility, the rheum officinale serves as a monarch drug, the dandelion, the rhizoma smilacis glabrae and the lalang grass rhizome serve as ministerial drugs, the salvia miltiorrhiza, the oysters, the honeysuckle stems, the sophora flowers and the black prepared common monarch herbs serve as adjuvant and conductant drugs, all the drugs act synergistically, the effects of descending turbid and expelling toxins and removing turbid and removing toxins are achieved, and through the multi-component and multi-target-point synergistic effect, the effects of removing turbid and toxins and giving consideration to both evil and positive pathogen are achieved; and a better choice is provided for clinical treatment of chronic renal failure.

The invention provides a combined dialysis nursing bed for the nephrology department, and relates to the technical field of chronic renal failure nursing. The left side and the right side of the top of the nursing bed body are each rotationally provided with an extension bed board. Four supporting sleeves in two groups are fixed on the inner wall of the top of the nursing bed main body, and an expansion bed board bracket is slidably mounted on each of the two groups of supporting sleeves; a double-head motor is further fixed on the inner wall of the top of the nursing bed main body; bracket adjusting screw rods are fixed on main shafts on the left side and the right side of the double-head motor; a heating block is fixed to the front side of the top of the upper heating bracket, and a dialysis tube limiting block is installed among the four guide rods in a sliding mode. When the nursing bed is not used, the expansion bed plates can be rotated downwards to be folded on the left side and the right side of the nursing bed body, the overall length of the nursing bed is shortened, therefore, the occupied space during folding is saved, dialysate about to flow into the abdominal cavity of a patient can be heated and subjected to heat preservation, and the comfort of the patient is improved.

The present invention belongs to the field of traditional Chinese medicine compositions, and specifically discloses a traditional Chinese medicine composition with the efficacy of preventing and treating chronic renal failure and its preparation method. The composition is made from four types of raw materials of monarch, minister, assistant and envoy drugs. The monarch drugs include polygonum cuspidatum and smilax glabra, which clear heat and detoxify, promote diuresis, disperse stasis and resolve turbidity. The minister drugs include cannabis seed, magnolia officinalis, rheum palmatum, trichosanthes kirilowii and excrementum bombycis, which assist the monarch drugs to purge turbidity in the way of promoting bowel movement. The assistant drugs include astragalus membranaceus, codonopsis pilosula, atractylodes macrocephala, pueraria lobata, angelica sinensis and polygonatum sibiricum, which replenish qi, strengthen the spleen, nourish blood and promote the ascending of lucid yang, and the promotion of the ascending of lucid yang facilitates the descending of turbidity. The envoy drugs include pinellia ternata and pericarpium citri reticulatae, which strengthen the stomach and regulate qi, and regulate the qi movement of the whole body. This formula focuses on strengthening the spleen for strengthening healthy qi, embodying the theory of "the spleen is the foundation of acquired constitution" in traditional Chinese medicine, and has good preventive and therapeutic effects on the type of chronic renal failure with deficiency of the spleen and kidney and internal accumulation of dampness and turbidity.

A Cs-4 fermentation mycelium heteropolysaccharide, a preparation method and use thereof, the polysaccharide structure is as shown below, n is selected from 6-104, the polysaccharide can be used for preventing or treating chronic renal failure, inhibiting immune rejection, preventing or treating hyperlipidemia, preventing or treating acute kidney injury.

This invention discloses a metal-coordinated iohexol nanoparticle, its preparation method, and its applications. The metal-coordinated iohexol nanoparticles of this invention are prepared by reacting a metal salt with iohexol in an organic medium; the particle size range of the metal-coordinated iohexol nanoparticles is 50-100 nm. This invention synthesizes metal-coordinated iohexol nanoparticles via a one-pot method, which is simple and does not require multiple reaction steps. The metal-coordinated iohexol nanoparticles prepared by this invention mainly accumulate in the liver, with only a small amount accumulating in the kidneys. They can significantly reduce the nephrotoxicity of chronic renal failure model mice after CT imaging, and exhibit good biocompatibility and almost no cytotoxicity in vitro.

Use of hydronidone in the preparation of a medicament for treating chronic renal failure patients such as by preventing and / or treating chronic renal failure.

As a compound that can be used as a therapeutic or preventative agent for diseases involving TRPC6, such as nephrotic syndrome, membranous nephropathy, acute renal failure, sepsis, chronic renal failure, diabetic nephropathy, pulmonary hypertension, acute lung injury, heart failure, malignant tumors, and muscular dystrophy, a compound of formula (I) or a pharmaceutically acceptable salt thereof is provided (where Ar... 1 Ar 2 X 1 ~X 3 R 1 R 3 R 7 R 8 and L 1 L 2 (As defined in the instruction manual).