2 results about "Blood creatinine" patented technology

This invention relates to the field of biomedical technology, and more particularly to a biomarker set, staging model, and their applications for chronic kidney disease. This invention utilizes metabolomics data analysis to obtain a biomarker set based on serum creatinine. Then, through methodological optimization, a staging model for chronic kidney disease is constructed. This staging model is also used for staging chronic kidney disease, and the results are accurate, specific, precise, and highly sensitive. It eliminates the false positive problem of traditional serum creatinine-based methods and removes the influence of gender factors. Staging chronic kidney disease based on this model is more consistent with the disease's progression characteristics.

The application discloses a preparation method and application of an autologous mitochondrion preparation, relates to the technical field of kidney protection and regeneration, and is characterized in that the mitochondrion is derived from heart tissue of a healthy C57 mouse of 8-10 weeks old, is obtained through a kit combined with a differential centrifugation method, and is characterized in that the obtained mitochondrion is continuous in outer membrane and clear in ridge structure under an electron microscope, and has good structural and functional integrity. In an in-vivo experiment, the mitochondrion is delivered to the renal cortex region of a recipient mouse through a subcapsular injection method 30 minutes before ischemia-reperfusion, and the result shows that the blood creatinine and urea nitrogen levels can be significantly reduced, the necrosis and oxidative stress damage of renal tubular epithelial cells can be reduced, and the renal tissue pathological score can be improved. The application provides a repeatable and standardizable organelle treatment strategy for intervention of kidney transplantation and acute kidney injury related IRI.