The invention relates to novel application of
betulin, in particular to application of
betulin in prevention and treatment of
cognitive impairment after
stroke, and belongs to the field of biological
pharmacy. The
betulin can obviously improve
cognitive impairment and neuronal impairment of post-
stroke cognitive impairment, obviously improve cognitive impairment and neuropathological change of post-
stroke cognitive impairment, and can play a role in improving post-stroke cognitive impairment. According to the invention, betulinol ester is creatively used for preventing and treating cognitive impairment after stroke; the betulin disclosed by the invention can be used as a
medicine for preventing and treating cognitive impairment after stroke, and also can be used as an
adjuvant therapy for preventing and treating cognitive impairment after stroke clinically. The
traditional Chinese medicine composition has good
social benefits and is worthy of clinical popularization and application.