128 results about "Hyperuricemia" patented technology

The invention provides a probiotics plant solid beverage for treating hyperuricemia and gout. The solid beverage is prepared by mixing freeze-dried probiotics powder and plant extract with the addition of proper auxiliary materials. The solid beverage comprises the following components: the plant extract, the auxiliary materials and the probiotics, with the sum of the mass percentage of each component being 100%. The plant extract comprises celery seed powder, sophora flower bud powder and platycodon root powder. The invention has an obvious effect on lowering uric acid and relieving gout.

The invention discloses a hexapeptide TE6 with xanthine oxidase inhibitory activity and a preparation method and application thereof, and belongs to the technical field of small molecule peptides. The amino acid sequence of the hexapeptide TE6 is TIATVE, and the hexapeptide TE6 can be prepared through a solid-phase synthesis method and an enzymolysis method. The hexapeptide TE6 is identified from a solieria cavaleriei proteolysis solution and has potential interaction with xanthine oxidase, under the concentration of 0.1 mg / mL, the xanthine oxidase inhibition rate is 44.74%, and compared with goose carnosine (the xanthine oxidase inhibition rate is 36.03%), the xanthine oxidase inhibition rate is remarkably increased (plt; 0.05), which is stronger in xanthine oxidase inhibitory activity, and can be used for preparing a preparation for inhibiting xanthine oxidase activity and relieving hyperuricemia.

The invention belongs to the technical field of microbial fermentation, and discloses lactobacillus mucilaginosus and application thereof in preparation of a uric acid reducing preparation. The survival rate of the fermented lactobacillus mucus in simulated gastric juice with the pH value of 2.0 for 3 hours is greater than 92%, the survival rate in simulated intestinal juice environment containing 0.5% of cholate is greater than 86%, and the viability of the fermented lactobacillus mucus is obviously higher than that of a conventional strain; and the tea has the effects of reducing uric acid, resisting oxidation and inhibiting pathogenic bacteria. The xanthine oxidase inhibition rate of the natural medicinal and edible compound potion obtained by mixing and co-fermenting the strain and existing bacterial powder is greater than 77% (45% or more higher than that of an unfermented group), and the oxidation resistance after fermentation can be improved by 50% at the same time. The beverage is suitable for being drunk as a daily functional food for a long time, and provides a natural and healthy collaborative diet relieving scheme for patients with hyperuricemia and gout.

The invention relates to the technical field of medical informatics, in particular to an AI-based intelligent early warning system for hyperuricemia male reproductive metabolism abnormality. The system comprises a memory and a processor, and the processor executes a computer program stored in the memory to realize the following steps: acquiring uric acid data, waistline data, glycosylated hemoglobin data and reproductive index data of a target male; combining the uric acid fluctuation abnormality degree, the multi-dimensional blood glucose abnormality expression degree and the movement rule expression degree of each stage to obtain the reproduction metabolism abnormality degree; according to the relative relationship between the reproductive index data and the corresponding standard range, obtaining the abnormal performance degree of the reproductive index; integrating the reproductive metabolism abnormality degree and the reproductive index abnormality expression degree to obtain a multi-dimensional feature linkage reproductive metabolism expression comprehensive evaluation degree of the target male; and according to the comprehensive evaluation degree of the multi-dimensional feature linkage reproductive metabolism performance, whether early warning is carried out is judged. According to the invention, the accuracy and credibility of intelligent early warning of the risk of abnormal male reproductive metabolism of hyperuricemia are improved.

The application discloses a composition for protecting liver and strengthening kidney and reducing uric acid, which is made of the following raw material components: Anoectochilus roxburghii, dried tangerine or orange peel, chicory, gardenia, turmeric, Hovenia dulcis Thunb, Cistanche deserticola Y.C.Ma, Rehmannia glutinosa, potassium citrate, sodium citrate and goose myo-peptide. The composition combines the immortal concept of TCM (Traditional Chinese Medicine) "treating disease from the root" and the uric acid control method of modern nutritional medicine as an organic whole, and achieves multiple effects of protecting liver and strengthening kidney, mutual benefit of yin and yang and reducing uric acid through multiple action targets. Animal experiment results show that the composition can effectively reduce the activities of transaminase ALT and AST, relieve liver damage, reduce serum creatinine level and improve urea ammonia excretion rate, improve kidney function, inhibit the activities of xanthine oxidase and adenosine dehydrogenase and reduce uric acid level. The composition is safe and has no toxic side effects, is suitable for people with insufficient liver and kidney functions and hyperuricemia and has a wide application prospect.

This invention discloses a benzofuran compound and its application in lowering uric acid activity. Compounds 1-3 were isolated from the fermentation products of the endophytic fungus *Septoriella phragmitis*, with compound 1 being a novel compound. The fermentation products were purified using mixed solvent extraction, normal silica gel column chromatography, and high-performance liquid chromatography to obtain compounds 1-3. The inhibitory activity of compounds 1-3 on xanthine oxidase, a target related to gout symptoms, was tested. Experimental results showed that the novel compound 1 exhibited good inhibitory activity against xanthine oxidase. Molecular docking experiments also demonstrated that compound 1 had a good binding energy to the target protein. Therefore, compound 1 can be used to prepare a natural lead compound for delaying or treating diseases caused by xanthine oxidase, providing a potential therapeutic agent for hyperuricemia and gout.

The application discloses a tetrapeptide IR4 with uric acid reducing activity, and a preparation method and application thereof, and belongs to the technical field of small molecular peptides. The amino acid sequence of the tetrapeptide IR4 is IDWR, and the tetrapeptide IR4 can be prepared by a solid-phase synthesis method and an enzymatic hydrolysis method. The tetrapeptide IR4 is identified from a porphyra haitanensis protease hydrolysate, has potential interaction with xanthine oxidase, and can reduce the uric acid content of zebrafish by 33.6% (to 5.93+ / -0.47 mu mol / g protein) at a concentration of 100 mu g / mL. Compared with an anserine (which can reduce the uric acid content of zebrafish by 25.7%), the tetrapeptide IR4 has better uric acid reducing activity. Compared with allopurinol (which can reduce the uric acid content of zebrafish to 4.61+ / -1.11 mu mol / g protein), the uric acid reducing ability of the tetrapeptide IR4 and the allopurinol has no significant difference. The tetrapeptide IR4 can be used for preparing uric acid reducing drugs and relieving hyperuricemia.

The present disclosure relates to RNAi agents, e.g., double stranded RNAi agents, able to inhibit xanthine dehydrogenase (XDH) gene expression. Also disclosed are pharmaceutical compositions that include XDH RNAi agents and methods of use thereof. The XDH RNAi agents disclosed herein may be conjugated to targeting ligands to facilitate the delivery to cells, including to hepatocytes. Delivery of the XDH RNAi agents in vivo provides for inhibition of XDH gene expression. The RNAi agents can be used in methods of treatment of diseases, disorders, or symptoms mediated in part by XDH gene expression, such as gout and hyperuricemia.

The invention relates to the technical field of preparation of deep-sea longevity fish precise active peptides, in particular to a deep-sea longevity fish precise active peptide with uric acid reducing and anti-inflammatory effects as well as a preparation method and application of the deep-sea longevity fish precise active peptide. The preparation method comprises the following steps: carrying out medium-temperature pretreatment, carrying out step-by-step enzymolysis with alkaline protease and acid protease, centrifuging, filtering, carrying out ultrafiltration interception and the like, and screening out 10 non-reported non-toxic active peptide fragments. The active peptide has a multi-target synergistic effect, inhibits the activity of xanthine oxidase, regulates and controls the expression of uric acid resorption protein, regulates and controls the expression of uric acid transporter protein, realizes bidirectional regulation of uric acid metabolism, efficiently removes hydroxyl radicals, activates superoxide dismutase and reduces the content of inflammation-related factors. The technology is simple and easy to control, low in equipment requirement and suitable for large-scale production, the active ingredients are natural, safety is high, the active ingredients can serve as functional factors to be applied to functional food, health care products and the like, and safe and diversified intervention schemes are provided for hyperuricemia and related inflammation problems.

The present application relates to the field of food processing technology, and provides a method and a device for purine reduction, and an equipment and an electronic equipment and a storage medium. The method for purine reduction includes the following steps: first cooling step: performing first cooling treatment on a food material to be treated at a first preset cooling rate to reduce a temperature of the food material to be treated to a temperature below a freezing point. By performing first cooling treatment on a food material to be treated at a first preset cooling rate to reduce a temperature of the food material to be treated to a temperature below a freezing point, the activity of ATP-degrading enzyme in the food material to be treated can be rapidly inhibited, which can quickly and effectively inhibit the generation of hypoxanthine, thereby reducing the generation of hypoxanthine, reducing the risk of hyperuricemia and gout, and having little effect on the taste and quality of the food material.

The application discloses a small molecule peptide AGGINLAR, and an amino acid sequence of the small molecule peptide is shown as SEQ ID NO. 3. The small molecule peptide is applied to preparation of a xanthine oxidase inhibitor and preparation of a drug for treating or preventing hyperuricemia. Through experimental research, six small molecule peptides with xanthine oxidase inhibiting activity are screened from enzymatic hydrolysate of Penaeus vannamei, and the small molecule peptides have the potential of serving as xanthine oxidase inhibitors, wherein AGGINLAR shows higher xanthine oxidase inhibiting activity, and has greater potential value in preventing hyperuricemia.

The invention belongs to the technical field of biological fermentation, and particularly relates to a preparation method and application of a fermented rhizoma smilacis glabrae extract. The invention relates to a fermented rhizoma smilacis glabrae extract, which is characterized in that a lactobacillus rhamnosus LR.M8 strain is utilized, the inhibition effect of the rhizoma smilacis glabrae extract on xanthine oxidase is improved through fermentation, and the treatment effect of the rhizoma smilacis glabrae extract on hyperuricemia is improved. The solution for improving the effect of the extract through biological fermentation is provided for solving the problems that the content of effective components in common medicinal and edible extracts is low, and the human body utilization rate is not high. The lactobacillus rhamnosus LR.M8 can effectively improve the adjusting effect of the rhizoma smilacis glabrae medicine and food homologous plant extract on uric acid balance, can reduce damage of inflammation to cells, and promotes in-vivo purine metabolism to recover balance. The fermentation method provided by the invention is simple and remarkable in effect, and has a wide application prospect.

The invention relates to the technical field of traditional Chinese medicine pharmacy, and discloses a traditional Chinese medicine composition for reducing uric acid and application thereof, and the traditional Chinese medicine composition comprises the following components in parts by mass: 15-20 parts of ash bark, 20-25 parts of clerodendranthus spicatus, 18-22 parts of astragalus membranaceus, 12-15 parts of prepared polygonum multiflorum, 15-18 parts of rhizoma smilacis glabrae, 8-10 parts of ligusticum wallichii, 10-12 parts of roasted rhizoma atractylodis macrocephalae and 10-15 parts of salt-fried semen plantaginis. The preparation method comprises the three steps of segmented extraction, sustained-release pellet forming and preparation forming. The traditional Chinese medicine composition disclosed by the invention has the high-efficiency performance of reducing uric acid, protecting healthy qi and achieving long-term effect, and can regulate and control a uric acid metabolic pathway in a multi-target manner; the product can be widely applied to the fields of products for treating primary hyperuricemia and gout in a sustained-release period, products for improving hyperuricemia metabolic syndrome, health-care tea for hyperuricemia and high-risk people, gel products for relieving red, swollen and heat pain of joints in an acute attack period of gout and the like, and the preparation process is controllable and easy to industrialize.

The application discloses a yak milk casein peptide with uric acid reducing activity and application thereof, and belongs to the technical field of protein peptide development. The yak milk casein peptide with clear uric acid reducing activity is prepared by taking yak milk casein as raw material, and the yak milk casein peptide can inhibit xanthine oxidase activity, reduce uric acid generation, and has good anti-inflammatory activity. The yak milk casein peptide is rich in small molecule active peptides, can be directly absorbed and utilized by the body, has excellent bioavailability, and has good application potential in improving hyperuricemia and related inflammatory damage. The application provides a new raw material source for developing hyperuricemia conditioning functional food and auxiliary intervention.

The invention belongs to the technical field of biological medicines and bioactive peptides, and relates to a xanthine oxidase inhibitory peptide derived from goat milk protein and application thereof. The amino acid sequence of the xanthine oxidase inhibitory peptide is as shown in SEQ ID NO. 1. The xanthine oxidase inhibitory peptide can be used for preparing a product for inhibiting xanthine oxidase or a product for regulating and controlling the uric acid level in a human body. The XOD regulation active peptide provided by the invention is safe in source and clear in structure, can be applied to the field of functional food or nutrition intervention, and provides a safe and natural active substance basis for diet regulation of hyperuricemia and related metabolic diseases.

The application discloses a pentapeptide IK5 with uric acid reducing activity as well as a preparation method and application thereof, and belongs to the technical field of small molecular peptides. The amino acid sequence of the pentapeptide IK5 is ITGYK, and the pentapeptide IK5 can be prepared by a solid-phase synthesis method and an enzymolysis method. The pentapeptide IK5 is identified from a protease enzymolysis liquid of a fine weak red winged seaweed, has potential interaction with xanthine oxidase, and can reduce the uric acid content of zebrafish by 44.4% (to 5.93+ / -0.47 mu mol / g protein) at a concentration of 100 mu g / mL. Compared with ananeine (which can reduce the uric acid content of zebrafish by 25.7%), the pentapeptide IK5 has better uric acid reducing activity. Compared with allopurinol (which can reduce the uric acid content of zebrafish to 4.61+ / -1.11 mu mol / g protein), the uric acid reducing ability of the pentapeptide IK5 and the allopurinol has no significant difference. The pentapeptide IK5 can be used for preparing uric acid reducing drugs and relieving hyperuricemia.

This invention relates to *Lactobacillus paracasei* NEFU-5 and its applications, belonging to the field of biotechnology. To address the problems of limited functionality and poor direct degradation of metabolites in existing probiotic strains, this invention provides *Lactobacillus paracasei* NEFU-5 (accession number CCTCC NO: M 2026147). This *Lactobacillus paracasei* NEFU-5 can simultaneously and efficiently degrade uric acid, triglycerides, and cholesterol, and possesses excellent probiotic properties and safety. The *Lactobacillus paracasei* NEFU-5 provided by this invention can be used to prepare fermented products and can be used to prevent or improve hyperuricemia, hyperlipidemia, and other concurrent metabolic diseases, showing significant application prospects.

The present invention relates to: a novel method for preparing a heterocyclic derivative compound of chemical formula I below; a novel intermediate compound used in the preparation method; a composition for treatment or prevention of hyperuricacidemia, gout, nephritis, chronic renal insufficiency, nephrolith, uremia, urolithiasis, or a uric acid-related disease, the composition containing the compound of chemical formula I at a dose of more than 2 mg and equal to or less than 10 mg and being orally administered once a day; and a hydrochloride 1.5 hydrate of the novel compound of chemical formula I.

This invention belongs to the field of pharmaceutical technology, and relates to the use of a combination of sour cherry powder and celery seed powder, and complexes containing this composition. Specifically, the sour cherry powder and celery seed powder composition is used in the preparation of drugs for treating or regulating intestinal flora imbalance caused by hyperuricemia. The preparation method of this composition is as follows: pitting sour cherries, freezing them separately with liquid nitrogen, grinding them into powder using a pulverizer, and sieving them separately to obtain sour cherry powder and celery seed powder; mixing the obtained sour cherry powder and celery seed powder at a ratio of (0.5~3):1. This invention discusses the diversity, richness, and evenness of intestinal flora through diversity analysis, community bar chart analysis, and Venn diagram analysis. The results show that this composition can increase beneficial bacteria (Prevotella, Mulliez, Lactobacillus, etc.), reduce harmful bacteria (Alternaria), improve the structure of intestinal flora, and maintain the balance of intestinal flora.

The present invention belongs to the field of medicine, and specifically relates to a phenyl ether compound containing a hexahydrofuro[3,2-b]furan structure and use thereof. The compound is a phenyl ether compound containing a hexahydrofuro[3,2-b]furan structure represented by general formula I or a pharmaceutically acceptable salt thereof, wherein substituents R1, R2, and R3 have the meanings given in the description. The compound disclosed in the present invention has significant inhibitory activity against xanthine oxidase, and the phenyl ether compound containing a hexahydrofuro[3,2-b]furan structure and the pharmaceutically acceptable salt thereof can be used for preparing a drug for treating hyperuricemia or gout.

The application discloses a pediococcus acidilactici, a bacterial agent, a microbial composition and application and products thereof for reducing uric acid, and belongs to the technical field of microorganisms. The application provides a pediococcus acidilactici with a preservation number of GDMCC No: 67942, and a 16S rDNA sequence of the pediococcus acidilactici is shown as SEQ ID NO. 1. The strain can degrade purine nucleosides, inhibit xanthine oxidase, and has strong antioxidant activity; can be efficiently fermented in a plantago major plant base to prepare a live / inactivated bacterial agent and a microbial composition. Animal experiments prove that the strain and the plantago major fermentation product can significantly reduce blood uric acid of a hyperuricemia model mouse, improve liver, kidney and intestinal injury, reduce inflammation, increase short-chain fatty acid level and regulate intestinal flora, and the inactivated fermentation product has better effect. The product can be prepared into food, health products or drugs, and is used for reducing uric acid and assisting in reducing uric acid, is safe and effective, and is suitable for long-term intervention.

The invention discloses a traditional Chinese medicine formula for treating cerebral infarction, three highs and hyperuricemia and a preparation method thereof. The composition comprises 48 medicinal materials such as radix astragali and radix salviae miltiorrhizae, and combined treatment of multiple diseases is achieved through the synergistic effect of tonifying qi, activating blood, dredging collaterals and descending turbidity. The preparation method adopts ceramic membrane filtration and low-temperature spray drying processes, and the retention rate of active ingredients is increased by 30%. An embodiment verifies that the traditional Chinese medicine composition can be prepared into tablets, granules and other dosage forms, can synchronously improve neurological functions and metabolic indexes through clinical verification, and has high efficiency and safety.

The invention discloses a pentapeptide VE5 with xanthine oxidase inhibitory activity and a preparation method and application thereof, and belongs to the technical field of small molecule peptides. The amino acid sequence of the pentapeptide VE5 is VSIVE, and the pentapeptide VE5 can be prepared through a solid-phase synthesis method and an enzymolysis method. The pentapeptide VE5 is identified from porphyra haitanensis proteolysis liquid and has potential interaction with xanthine oxidase, under the concentration of 0.1 mg / mL, the xanthine oxidase inhibition rate is 67.88%, and compared with goose carnosine (the xanthine oxidase inhibition rate is 36.03%), the xanthine oxidase inhibition rate is remarkably increased (plt; and the compound has higher xanthine oxidase inhibitory activity, and can be used for preparing a preparation for inhibiting xanthine oxidase activity and relieving hyperuricemia.

The invention discloses a plant beverage with a function of reducing uric acid and blood sugar, and relates to the technical field of health-care food, in particular to a plant beverage with a function of reducing uric acid and blood sugar, the formula of the beverage comprises chicory, cape jasmine, lophatherum gracile, pericarpium citri reticulatae, dendrobium officinale, lotus leaf, hawthorn, poria cocos, liquorice, corn stigma, lalang grass rhizome and stevioside. The dosage range of the raw materials is 1-2g, and the chicory and the corn stigma are dominant to enhance the diuresis and uric acid excretion effects. The uric acid reducing function is mainly realized through the compatibility of the chicory, the corn stigma and the lalang grass rhizome; the blood sugar reducing function is achieved through combination of lophatherum gracile, lotus leaves and liquorice. The preparation method comprises the following steps: mixing and decocting the raw materials, controlling the temperature to be 80-100 DEG C and the time to be not less than 1 hour, and performing high-temperature sterilization. The product is suitable for people with hyperuricemia or prediabetes, and is drunk 1-2 times a day, 100-200 ml each time. The finished product is bottled or bagged liquid and needs to be stored in a shady and cool manner in a dark place, and the shelf life is not less than 12 months.

The invention relates to the technical field of biomedicine, in particular to application of hydrated electrons or a hydrated electron preparation in preparation of products for reducing uric acid and resisting inflammation or oxidation. The hydrated electron and the preparation thereof are found to be capable of effectively reducing the uric acid level, have antioxidant and anti-inflammatory effects, have obvious improvement and treatment effects on hyperuricemia, gout and inflammation and lesion of kidneys and joints caused by hyperuricemia and gout, do not have toxic or side effects and adverse reactions on animals, and are suitable for clinical application. The compound has a good application prospect in treatment of hyperuricemia and gout, and a new treatment means is provided for hyperuricemia and gout.

This invention discloses an abalone-derived xanthine oxidase inhibitory peptide and its application, belonging to the field of biopeptides. Using abalone as raw material, this invention employs a mild blanching-ultra-high pressure-ultrasound synergistic pretreatment process, followed by enzymatic hydrolysis, separation and purification, and bioinformatics screening combined with molecular docking technology to obtain four polypeptides with amino acid sequences as shown in SEQ ID NO. 1-4. Experimental results show that the abalone-derived polypeptides provided by this invention have outstanding XOD inhibitory activity, with a half-maximal inhibitory concentration as low as 0.53 mg / mL, superior to existing shellfish peptides. They are non-toxic or non-sensitizing and can effectively reduce uric acid and pro-inflammatory factor levels in a hyperuricemia cell model, and can be applied to the preparation of uric acid-lowering drugs. This invention effectively overcomes the shortcomings of low activity and limited sources of natural peptides, promotes the high-quality utilization of abalone protein resources, improves the level of deep processing in the abalone industry, and provides novel natural candidate substances and technical solutions for the prevention and treatment of hyperuricemia.

The application discloses a kind of medicine food homologous soup base suitable for gout crowd and preparation method thereof, belong to functional food technical field.Soup base includes physically independent A bag (relieve gout conditioning bag) and B bag (seasoning package).A bag is composed of twelve medicine food homologous raw materials such as radix puerariae, hawthorn, clove, liquorice, polygonatum, wolfberry etc.according to specific ratio, for auxiliary regulation uric acid metabolism;B bag is compounded by Chinese yam, poria cocos, yiyi ren, dried ginger, ginseng, salt and natural spice, provides natural salty flavor, no adverse additives.The application adopts split design to realize the separation of function and flavor, supporting standardized preparation process and eating method, product can be directly integrated into daily soup, without professional knowledge, palatability is good, safe and healthy, convenient to use, can significantly improve the compliance of gout and hyperuricemia crowd diet conditioning, suitable for long-term daily consumption.

This invention belongs to the field of functional marine food processing technology, specifically involving a method for producing a composite sausage made from Antarctic krill, tuna, and collagen, comprising the following steps: (1) preparation of Antarctic krill meat, (2) preparation of tuna blood-infused meat, (3) preparation of low-temperature raw pork skin collagen paste, (4) preparation of krill-derived composite enzyme solution, (5) mixing of meat materials and low-temperature enzymatic hydrolysis, (6) low-temperature chopping, (7) sausage filling and quick-freezing, and (8) thawing and maturation of the product. This invention uses Antarctic krill meat, tuna blood-infused meat, and low-temperature raw pork skin collagen paste as core raw materials, and utilizes krill endogenous composite enzymes for low-temperature enzymatic hydrolysis to produce a composite sausage with uric acid-lowering function, high protein content, and high unsaturated fatty acid content, providing a safe, convenient, and daily-consumable functional marine food for people with hyperuricemia.