The invention relates to the field of microorganisms, and particularly relates to Lactobacillus gasseri LG08 with a uric acid degradation effect and application thereof. The Lactobacillus gasseri LG08is preserved in the China General Microbiological Culture Collection Center (CGMCC) in July 18, 2018, with the preservation number being CGMCC No. 16131, and is classified and named as Lactobacillusgasseri, with the preservation address being the Institute of Microbiology, Chinese Academy of Sciences, No.3, Academy No.1, Beichen West Road, Chaoyang District, Beijing. The Lactobacillus gasseri LG08 has an excellent nucleoside and nucleotide degradation capability, can decompose most precursors for uric acid synthesis, reduce the body absorption of precursors for uric acid synthesis and directly and efficiently decompose uric acid in intestinal tracts, and can further inhibit the generation of uric acid and relieve inflammation and other side reactions by reducing the serum endotoxin leveland inhibiting the xanthine oxidase activity.