381 results about "Tetrapeptide" patented technology

Pharmaceutical, personal care and cosmetic compositions containing a tripeptide and a tetrapeptide are useful for treating visible signs of aging including wrinkles, stretch marks and dark circles.

Peptides and peptidomimetics capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The peptides and mimetics are based on the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these peptides and peptidomimetics for therapeutic purposes and for rational drug design.

Molecular mimics of Smac are capable of modulating apoptosis through their interaction with cellular IAPs (inhibitor of apoptosis proteins). The mimetics are based on a monomer or dimer of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABLO, Hid, Grim and Reaper, which interact with a specific surface groove of LAP. Also disclosed are methods of using these peptidomimetics for therapeutic purposes. In various embodiments of the invention the Smac mimetics of the invention are combined with chemotherapeutic agents, including, but not limited to topoisomerase inhibitors, kinase inbhibitors, NSAIDs, taxanes and platinum containing compounds use broader language

The invention relates to the technical field of cosmetics, and discloses a nona-oligopeptide composition for skin repairing and application thereof. The nona-oligopeptide composition is prepared from, by weight, 1-30 parts of palmitoyl-tripeptide-1, 1-30 parts of tripeptide-1 copper, 1-50 parts of palmitoyl-tripeptide, 1-30 parts of carnosine, 1-30 parts of acetyl tetrapeptide-5, 1-30 parts of palmitoyl-tetrapeptide-7, 0.1-30 parts of acetyl hexapeptide-8, 0.1-30 parts of nonapeptide-1, and 1-30 parts of nisin. The nona-oligopeptide composition has the effect of a cell factor sample, affects the growth of skin flora, is applied to dermatology and skin beautifying, and has the effects of repairing skin lesion, adjusting metabolism and inhibiting skin condition conditioned pathogen growth.

The present invention relates to the synthesis of beta-tetrahydro carboline carboxylic acid and its nanoparticle preparation; liquid phase process of gradually grafting peptide to obtain protected tetrapeptide intermediate, which, after eliminating its Boc, is condensated with N-Boc-beta-tetrahydro carboline carboxylic acid and further HF treated to eliminate its protection to obtain the said compound; the nanoparticle of tetrahydro carboline carboxylic acid and the in-vitro and in-vivo activity of said compound in-vitro and in-vivo experiments show that the compound of the present invention has excellent activity of resisting blood platelet aggregation, effect of resisting cell adhesion and effect of resisting thrombus.

Disclosed is a multi-beneficial topical skin care composition, and methods for its use, that can hydrate skin, increase the firmness of skin, reduce the appearance of fine lines or wrinkles on skin, and reduce the appearance of age spots on skin. The composition can include a combination of skin active ingredients comprising euterpe oleracea fruit extract, punica granatum sterols, caprooyl tetrapeptide-3, tocopherol or tocopherol acetate, and niacinamide, a combination of skin moisturizing agents comprising glycerin and butyrospermum parkii, a photo stable combination of sunscreen agents providing the composition with a sun protection factor (SPF) of at least about 15, and a dermatologically acceptable vehicle which imparts a non-greasy feel when applied to skin.

The invention discloses a polypeptide composition for repairing, whitening and removing wrinkles. The polypeptide composition for repairing, whitening and removing the wrinkles is prepared from the following components is percentage by weight: a repairing polypeptide composition, a collagen supplementing polypeptide composition, a wrinkle removing polypeptide composition, a skin-brightening polypeptide composition, a small molecular active substance, a skin-care activating agent, a pH (Potential of Hydrogen) regulator, a plurality of auxiliary agents and the balance of water, wherein the repairing polypeptide composition comprises palmitoyl tetrapeptide-7 and tripeptide-1-copper; the collagen supplementing polypeptide composition comprises palmitoyl tripeptide-1, palmitoyl tripeptide-5 andpalmitoyl pentapeptide-4; the wrinkle removing polypeptide composition comprises acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and melittin; the skin-brightening polypeptide composition comprises nonapeptide-1, carnosine and tetrapeptide-30. According to the polypeptide composition disclosed by the invention, a novel formula is formed through adjusting ratios of differentpolypeptide components, so that polypeptide effects with different focuses and different applicable ranges; the monarch, minister, assistant and guide thought in traditional Chinese medical science isapplied to the polypeptide composition, so that the formula is diversified and the maximum applicability and applicable range are realized.

The invention relates to a method for preparing Semaglutide through solid and liquid combination, and solves the technical problems that in the process for synthesizing long-sequence polypeptide by the existing technology, the synthesis period is long; the purification difficulty is high; the yield is low. The method for preparing Semaglutide through solid and liquid combination provided by the invention is characterized in that firstly, Lys and resin are condensed in an Alloc-Lys(Fmoc)-OH form by adopting a solid phase synthesis method; Fmoc protecting groups on epsilon-NH2 are removed; sidechain connection is performed; cracking is performed to obtain Alloc-Lys(PEG-PEG-gamma-Glu(OtBu)-Monobutyl octadecanate)-OH; meanwhile, 10 dipeptide or tripeptide or tetrapeptide fragments are simultaneously synthesized by a liquid phase synthesis method; then, the condensation reaction of the synthesized peptide fragments and single amino acid is performed by using the resin as a carrier; the 15-step solid phase condensation reaction is reduced in the process; the generation of lacked peptide impurities is reduced; the product purity and the yield are improved; meanwhile, the generation of the impurities of [+Gly]-Semaglutide and [+Ala]-Semaglutide is effectively avoided; the purification difficulty is greatly reduced. The method is widely applied to the technical field of polypeptide medicine preparation.

The invention discloses RGD peptide-modified carbolino-hexahydropyrazine-1,4-diketones, which are three novel conjugates of carbolino-hexahydropyrazine-1,4-diketone and RGD tetrapeptide and are shown in the general formula I. In the general formula I, R represents Arg-Gly-Asp-Val, Arg-Gly-Asp-Phe or Arg-Gly-Asp-Ser. The invention also discloses heterocyclic nucleuses of the novel conjugates, wherein R represents OH. The invention also discloses a preparation method and in-vitro anti-platelet aggregation effects of the novel conjugates, and also discloses an antithrombotic use of the novel conjugates in a rat thrombus formation model. A result shows that the three novel conjugates of carbolino-hexahydropyrazine-1,4-diketone and RGD tetrapeptide (wherein R represents Arg-Gly-Asp-Val, Arg-Gly-Asp-Phe or Arg-Gly-Asp-Ser) and their heterocyclic nucleuses (wherein R represents OH) have good antithrombotic activity and clear application prospects in antithrombotic agent preparation.

The present invention relates to a proteinaceous extract derived from tortoise spleen and to a tetrapeptide FTGN, which have stimulatory activity on hematopoietic cells. In particular, this tetrapeptide enhances hemopoietic reconstruction, and bone marrow re-population, reduced as a consequence of a high dose of radiation or chemotherapy exposure. The invention further provides pharmaceutical compositions comprising as an effective ingredient the proteinaceous extract or the FTGN tetrapeptide and ex vivo and in vivo methods of treatment employing them.

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C₂-C₁₈ alkyl, branched C₃-C₁₈ alkyl, linear C₂-C₁₈ alkenyl, branched C₃-C₁₈ alkenyl, aryl, aryl-C₁-C₁₈ alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described, for example, for administration via subcutaneous or intravenous infusion to a patient in need of pulmonary hypertension treatment. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom.

The invention provides skin care composition with effects of realizing repairing and regenerating, supplementing water, preserving moisture and delaying aging. The composition contains a component A,a component B and a component C, wherein the component A contains herba dendrodii officinalis extract, aloe extract, fructus citri sarcodactylis extract, herba centellae extract and herba selaginellaeextract; the component B is oligopeptide which is one or more selected from oligopeptide-1, oligopeptide-2, oligopeptide-3, oligopeptide-4, oligopeptide-5, oligopeptide-6, oligopeptide-10, palmitoylpentapeptide-3, palmitoyl tripeptide-1, palmitoyl tripeptide-5, palmitoyl tetrapeptide-3, nutmeg pentapeptide-11, acetyl tetrapeptide-5, acetyl pentapeptide-1, acetyl hexapeptide-8 and acetyl dipeptide-1; the component C contains cosmetic auxiliary materials and a cosmetic matrix.

The invention discloses a preparing method and application of a human mesenchymal stem cell-sourced exosome beautifying preparation. The beautifying preparation comprises 92-108 parts of human umbilical cord mesenchymal stem cell exosome, 8-13 parts of mannitol, 0.42-0.55 part of oligopeptide-32, 1.3-2.5 parts of tetrapeptide-4, 0.7-1.3 parts of palmitoyl tripeptide-1 and 0.8-1.2 parts of palmitoyl pentapeptide-4. The preparation method includes: evenly mixing and stirring the human mesenchymal stem cell exosome, the mannitol, the oligopeptide-32, the tetrapeptide-4, the palmitoyl tripeptide-1and the palmitoyl pentapeptide-4 according to the weight, filtering through a filter membrane, performing split charging, and performing freeze drying to obtain the human mesenchymal stem cell-sourced exosome beautifying preparation. The exosome beautifying preparation can be externally applied to the epidermal layer or guided into an epidermis deep layer and the corium layer through a microneedle, a rolling needle or a hydro-lifting needle. The ImmuReg technology is utilized to bring the optimal repairing effect of freeze-dried powder into play, the skin immune state can be precisely adjusted, and accordingly aged cells can be removed, and skin cells can be rejuvenated.

The invention discloses an affinity chromatography medium employing tetrapeptide as a functional ligand and a preparation method of the affinity chromatography medium. The method comprises the following steps: adding dry matrix and allyl bromide to a dimethyl sulfoxide solution, activating, and reacting activating matrix with N-bromo succinimide; enabling bromo alcoholized matrix to react with hexamethylendiamine to obtain amino activating matrix; sequentially washing with deionized water, absolute ethyl alcohol and anhydrous N,N-dimethyl formamide, adding an N,N-dimethyl formamide solution containing tetrapeptide, 2-(7-azobenzotriazole)-N,N,N',N'-te-tramethyluronium hexafluorophosphate and N,N-diisopropylethylamine, and coupling a tetrapeptide ligand; and putting a medium coupled to tetrapeptide in a mixed liquid of sodium acetate and acetic anhydride to obtain the affinity chromatography medium employing tetrapeptide as the functional ligand. According to the novel chromatography medium developed by the method, a functional group is tetrapeptide composed of tyrosine, phenylalanine, arginine and histidine, and is designed on the basis of a protein A binding site of an antibody Fc segment; the antibody binding selectivity is greatly improved; and the affinity chromatography medium can be applied to efficient separation of an antibody.

Defects in a cartilaginous tissue are filled by: (a) mixing (i) a first reagent composition preferably comprising an amine-free hydroxyalkyl (preferably hydroxymethyl) phosphine crosslinking agent with (ii) a second reagent composition comprising a bioelastic polymer, the bioelastic polymer preferably comprising elastomeric units, the elastomeric units preferably selected from the group consisting of bioelastic pentapeptides, tetrapeptides, and nonapeptides; to produce a therapeutic composition; and then (b) administering the therapeutic composition to the cargilagenous tissue. Compositions and kits for carrying out the method are also described.

The invention discloses a polypeptide composition for facial care. The polypeptide composition comprises the following components in percentage by mass: 0.0001-0.0005% of acetyl hexapeptide-8, 0.01-0.1% of acetyl tetrapeptide-5, 0.02-0.1% of tripeptide-1 copper, 0.0005-0.1% of glutathione, 0.0001-0.0005% of oligopeptide-1, 0.0001-0.0005% of oligopeptide-2, 0.0001-0.0005% of oligopeptide-3, 0.0001-0.0005% of oligopeptide-4, 0.0001-0.0005% of oligopeptide-5, 1.0-5.0% of polyethylene glycol, 84.697-97.9689% of mannitol and 1.0-10.0% of deionized water. The polypeptide composition disclosed by the invention comprises 9 polypeptide active matters, has the advantages of remedying and whitening skin and preventing aging, and is capable of permeating into skin for improving blood circulation of the face, supplying sufficient nutrients and energy to cells and promoting metabolism of the skin, and thus the purposes of remedying and caring skin can be achieved; and a freeze-drying technique is adopted in a production process, so that various active substances can be retained to the maximum extent, original properties of various active substances can be maintained, conversion of active matters can be prevented, and the stability of a product can be improved.

Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.

The invention discloses an anti-wrinkle moisture-retention skin care product containing a bioactive peptide ingredient. The anti-wrinkle moisture-retention skin care product is prepared form following raw materials, by weight, 30 to 70 parts of an anti-wrinkle moisture-retention factor, 1 to 7 parts of a vitamin C derivative, 2 to 5 parts of hibiscus rosa-sinensis extract, 1 to 4 parts of blue-green algae, 4 to 12 parts of rhodiola rosea extract, 2 to 7 parts of glycerin, and 1 to 5 parts of rose oil; the anti-wrinkle moisture-retention factor is composed of tripeptide-3, tetrapeptide-4, pentapeptide-3, hexapeptide-11, and ceramide 1. The bioactive peptide ingredient is taken as a main raw material; the anti-wrinkle moisture-retention skin care product is prepared via adding of plant extracts with wrinkle prevention and moisture retention performance; and additives such as essences, pigments, mineral oil, and antiseptics are not added. The anti-wrinkle moisture-retention factor is capable of improving face skin rapidly; effects are longlasting; wrinkle prevention effects are excellent; the anti-wrinkle moisture-retention factor also possesses moisture retention performance, and is capable of removing microgrooves and wrinkles; and wrinkle removing effect is excellent.

The invention belongs to the field of medicament synthesis, in particular to a new method for synthesizing buserelin by using a pure liquid-phase segment method. In the synthesizing method of the buserelin, the buserelin Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-NHEt is formed by condensing a pentapeptide segment Pyr-His-Trp-Ser-Tyr-OH and a tetrapeptide segment D-Ser(Tbu)-Leu-Arg-Pro-NHEt in the existence of a condensing agent. In the invention, the buserelin is formed by directly condensing the pentapeptide segment Pyr-His-Trp-Ser-Tyr-OH and the tetrapeptide segment D-Ser(Tbu)-Leu-Arg-Pro-NHEt in the existence of the condensing agent by adopting a 5+4 segment synthesizing method. The method not only shortens the synthesis period and avoids the severe reaction condition of a traditional method, but also has high yield, good product purity, low cost and mild reaction condition and is suitable for industrialized production.

The invention discloses a chlorella silk mask for eliminating the turbid, beautifying skin and repairing radiation damage. The mask is manufactured by soaking non-woven fabric in mask essence. The mask essence comprises, by weight, 50-80 parts of water, 2-10 parts of 1,3-butanediol, 5-10 parts of chlorella extracts, 5-10 parts of rose extracts, 1-5 parts of betaine, 1-5 parts of 1,2-propylene glycol, 0.5-2 parts of acetyl hexapeptide-1, 0.25-0.5 part of xanthan gum, 0.2-1 part of acetyl tetrapeptide-2, 0.3-0.5 part of sodium hyaluronate, 0.8-1.5 parts of serine, 0.8-1.5 parts of citrulline, 0.5-1 part of nicotinamide, 0.5-1 part of methylisothiazolinone, 0.1-0.5 part of PEG-40 hydrogenated castor oil and 0.005-0.01 part of essence. The mask can deeply purify pores, clean away abundant grease, and promote water and grease balance of the skin, enables the skin cool, comfortable and vigorous and meanwhile has an anti-radiation function.

The invention relates to a preparation method of a donkey-hide gelatin small molecular peptide. Donkey-hide gelatin is adopted as a main raw material, and the donkey-hide gelatin small molecular peptide is prepared by adopting the technologies such as raw material pretreatment, enzymolysis, filtration, decolorization and drying, wherein an enzymolysis process is characterized in that enzymolysis is carried out for multiple times by adopting multiple proteases, and collagen in the donkey-hide gelatin is treated by enzymolysis to obtain a small molecular peptide easy to be digested and absorbed by a human body. The preparation method of the donkey-hide gelatin small molecular peptide has the beneficial effects that a compound biological enzyme enzymolysis technology is utilized, enzymolysis is carried out by sequentially adopting alkaline protease, neutral protease and pepsin for enzymolyzing macromolecular protein contained in the donkey-hide gelatin into the donkey-hide gelatin small molecular peptide, the molecular weight of the obtained donkey-hide gelatin small molecular peptide is mainly distributed within 100-1000D, and the obtained donkey-hide gelatin small molecular peptide is mostly a small molecular peptide such as dipeptide, tripeptide and tetrapeptide, belongs to a small molecular structure and is extremely easily absorbed and utilized by the human body.

The invention belongs to the field of the synthesis of medicines, which particularly relates to a novel method for synthesizing goserelin by a pure liquid-phase fragment method. In the method for synthesizing the goserelin, the goserelin Pyr-His-Trp-Ser-Tyr-D-Ser(Tbu)-Leu-Arg-Pro-AZgly-NH2 is formed by condensing a pentapeptide fragment Pyr-His-Trp-Ser-Tyr-OH and a tetrapeptide fragment D-Ser(Tbu)-Leu-Arg-Pro-AZgly-NH2 under the existence of a condensing agent. The invention adopts a 5+4 fragment synthesis method and can directly condense the pentapeptide fragment Pyr-His-Trp-Ser-Tyr-OH and the tetrapeptide fragment D-Ser(Tbu)-Leu-Arg-Pro-AZgly-NH2 into the goserelin under the existence of the condensing agent. The method shortens the synthesis period, avoids rigorous reaction conditions in the traditional method, has high yield, good product purity, low cost and mild reaction condition and is suitable for industrialized production.

The invention discloses hyaluronic acid anti-wrinkle essence. The hyaluronic acid anti-wrinkle essence is prepared from a group A, a group B and a group C; the group A includes solvent and a first wetstorage agent; the group B includes a first skin conditioning agent, a first antioxidant agent and a second wet storage agent; the group C includes a second skin conditioning agent, a third skin conditioning agent, a second antioxidant agent, a third antioxidant agent and a third wet storage agent; the first wet storage agent is composed of multiple kinds of sodium hyaluronate; the second skin conditioning agent includes glycerol and dipeptide diaminobutyroyl benzylamide diacetate; the third skin conditioning agent includes water for the third skin conditioning agent, glycoprotein, multiple amino acids, phenoxyethanol, ethylhexylglycerin and sodium metabisulfite; the second antioxidant agent comprises palmitoyl tripeptide-5; the third antioxidant agent comprises acetyl hexapeptide-8; thethird wet storage agent includes acetyl tetrapeptide-4. The hyaluronic acid anti-wrinkle essence can improve skin metabolism, bring elasticity to the skin, reduce the shrinkage degree of the skin, andachieve good effects of removing wrinkles, moisturizing and nursing the skin and delaying aging.

The invention provides composition for moisturizing and nourishing eye serum. The composition comprises effective components in parts by weight as follows: jojoba seed oil, squalene, avocado tree fruit ester, a xanthan gum/glucose/chondrus crispus extract, mycose, acetyl tetrapeptide, a rhodiola extraction solution, tocopheryl acetate, sodium hyaluronate, decarboxy carnosine HCL, a kudzuvine root extract and a glycyrrhiza glabra root extract. The composition is applied to the eye serum, can nurse the delicate skin around eyes, can realize lasting moisturizing and water supplement effects, and can activate blood around the eyes, obviously improve black eyes and smooth dry lines of the eyes after being used for a long time.

The invention discloses an eye-care composition. The eye-care composition comprises, by weight, 0.1-2 parts of tuberose extract, 0.1-2 parts of aesculus hippocastanum seed extract, 0.1-4 parts of coffee cherry extract, 0.1-2 parts of sodium tocopheryl phosphate and 0.001-0.01 part of acetyl tetrapeptide. The eye-care composition has the advantages that the components of the eye-care composition has a synergic effect on causes of problems such as black eye, eye bags and eye wrinkles affecting eye attractiveness, can stimulate a skin blood circulation system and skin collagen synthesizing again, can allow the eye contour to recover the original shape and color and can allow a user to have even, smooth, bright and young facial appearance. The invention further discloses medicine or eye-care product containing the eye-care composition, and the medicine or eye-care product can aim at different use purposes to improve and reduce the problems such as black eye, eye bags and eye wrinkles affecting eye attractiveness.