165 results about "Active center" patented technology

The application discloses a P and O co-doped FeNiRuOx nano catalyst and a preparation method and application thereof, relates to the technical field of electrocatalytic materials, and the catalyst takes Fe, Ni and Ru as metal active centers, reconstructs a surface electronic structure through P and O double anion co-doping, and forms a polygonal nano structure, wherein the mass fraction ranges of Fe, Ni, Ru and P are 5.0-6.0%, 75-78%, 11-12% and 6.5-7.0% respectively. The preparation method comprises the following steps: taking iron acetylacetone, nickel acetylacetone and ruthenium chloride trihydrate as metal sources, synthesizing a precursor through a solvothermal reaction, and realizing P and O co-doping through a sodium hypophosphite assisted solid-phase phosphorization process, and the preparation process is mild. The synthesized catalyst has unique structural advantages, the formed polygonal nano structure has a large specific surface area and rich grain boundary defects, more active sites are exposed, and convenient channels are provided for the mass transfer of reactants and products. The synergistic effect among the polymetals further enhances the catalytic performance.

This invention relates to the field of catalyst technology, specifically to a latent epoxy resin curing catalyst with precisely controllable activity and its preparation method. The catalyst is 1-(2-(N-tert-butyl-N'-phenylurea)ethyl)-3-(2-(phenyldithio)ethyl)imidazolium, which simultaneously possesses an imidazolium ring catalytic active center, a thermally hindered urea bond, a temperature-responsive dynamic disulfide bond, and an intramolecular hydrogen bond unit. Precise control of catalytic activity is achieved through the synergistic effect of these triple dynamic bonds. The catalyst exhibits excellent storage stability at room temperature, rapid curing at activation temperature, and is free of metal ions. The cured epoxy resin exhibits good dielectric properties. This invention's catalyst achieves a balance between excellent latency and rapid curing performance through the synergistic control of these triple dynamic bonds. It possesses excellent dielectric and mechanical properties, can be compounded with various curing agents, and its preparation method is simple and easy for industrial production.

The application relates to the technical field of organic silicon synthesis, and particularly discloses a high-selectivity platinum catalyst and a vinyl double-seal head synthesis method. The high-selectivity platinum catalyst comprises a carrier and a platinum active component loaded on the carrier, the platinum active component is obtained by reducing and activating a platinum precursor and a ligand under a hydrogen atmosphere at 250-350 DEG C after coordination modification, and the molar ratio of the ligand to the platinum element in the platinum precursor is 2-3:1. In the application, the platinum active component is obtained by reducing and activating the platinum precursor and the ligand after coordination modification, and the ligand and the platinum element form a specific coordination structure of the platinum active center, guide the direct silicon-hydrogen addition reaction of acetylene and a hydrogen-containing double-seal head, thus the dimethyl chlorosilane intermediate is not needed, the process flow is simplified, and the effects of improving the reaction yield, environmental protection and process economy are achieved.

This application discloses a cyclic GMP-AMP synthase mutant. Compared to the wild-type cyclic GMP-AMP synthase shown in SEQ ID NO.1, the amino acid sequence of the cyclic GMP-AMP synthase mutant has any one of the following mutations: L377M or H437T / S434T. Specifically, the amino acid sequence of the L377M mutated cyclic GMP-AMP synthase mutant is shown in SEQ ID NO.4, and the amino acid sequence of the H437T / S434T mutated cyclic GMP-AMP synthase mutant is shown in SEQ ID NO.9. The cGAS mutant of this application exhibits four times the activity of the wild-type. The preparation method uses readily available and economical raw materials, is simple to operate, environmentally friendly, and pollution-free, with high synthesis efficiency, making it suitable for industrial development.

The application discloses a chlorine axial coordination copper monatomic catalyst, a preparation method and application, and belongs to the technical field of catalytic materials. In the preparation, dicyandiamide is first calcined and treated by thermal stripping for several times to prepare a layered carbon carrier rich in nitrogen defects and anchoring sites; then, the carrier is mixed with copper salt, lithium salt and potassium salt, and a molten salt thermal reaction is carried out under an inert atmosphere; with the high-temperature fluidity and space confinement effect of the molten salt, copper atoms are stably anchored in a monodispersed manner, and a Cu-N x -Cl chlorine axial coordination active center is formed, so that the target catalyst is prepared. When the catalyst is used in a CO2 electrocatalytic reduction reaction, the methane faradaic efficiency reaches 73% under an industrial-grade current density, and the catalyst has good catalytic stability and structural durability in a wide current density range. ‑2 The application provides a new way for controllable preparation of a high-performance monatomic catalyst and utilization of CO2 resources.

This invention discloses a method for preparing and applying a class of highly efficient catalytic materials for activating persulfate. The preparation method includes: dispersing g-C3N4 in nitric acid at room temperature, stirring, washing, and drying to obtain g-C3N4-H; placing it in an inert atmosphere and treating it at high temperature to obtain a g-C3N4 substrate; mixing it with iron salt, cobalt salt, water, and 1,10-phenanthroline to obtain a suspension; evaporating to dryness, grinding, drying, treating at high temperature, dispersing in nitric acid, washing, drying again, treating at high temperature in an inert atmosphere, and naturally cooling to obtain FeCo-g-C3N4 catalytic material. The method of this invention constructs structurally stable and highly dispersed FeCo bimetallic-nitrogen-carbon active centers on the g-C3N4 substrate; it can achieve efficient degradation of pollutants with low dosage, while the metal leaching rate is extremely low, avoiding secondary pollution; this catalytic material combines high activity, high stability, environmental friendliness, and operational economy, showing outstanding application potential in the field of advanced oxidation water treatment.

The application discloses a preparation method and application of a composite catalyst for preparing carbon dioxide-based polycarbonate polyols, and belongs to the technical field of catalysts. The composite catalyst is prepared by compounding a double metal cyanide catalyst and a zinc gallate catalyst in a certain proportion. In the presence of a chain transfer agent, the two kinds of catalysts produce a synergistic effect in a polymerization process: the double metal cyanide catalyst serves as a main active center, initiates and promotes chain growth; and the zinc gallate catalyst serves as a selective regulation center, promotes carbon dioxide insertion and inhibits side reactions, so that the catalysts have high activity and high selectivity. The polycarbonate polyols prepared by using the composite catalyst have high carbon dioxide insertion rates and low number average molecular weights. Moreover, the composite catalyst has simple preparation process, is wide in raw material and low in cost, and is suitable for industrialized scale preparation.

This invention relates to the field of flue gas treatment technology, specifically to a sulfur dioxide gas absorbent, comprising the following raw materials by weight: 90-100 parts of an aqueous amine solution and 2-6 parts of additives. In this invention, the nitrogen-zinc ion-sulfur active center of the catalyst acts as a molecular key, efficiently and reversibly coordinating and activating sulfur dioxide molecules, significantly reducing the reaction energy barrier and fundamentally improving the intrinsic absorption rate. The enhancer, with its high specific surface area, provides a large interface for the reaction. Its surface sulfonic acid groups not only buffer the decrease in system pH, maintaining the optimal acid-base environment for the reaction, but also catalyze the conversion of absorption intermediates into more stable products, thereby shifting the reaction equilibrium to the right. Under the combined effect of these two factors, the catalyst accelerates the reaction towards equilibrium, while the enhancer continuously shifts the equilibrium point, resulting in a higher absorption capacity for the absorbent.

The present application provides a kind of carbon fiber material and its preparation method and application in CO2 capture and electrocatalytic conversion.The present application creatively combines macro-scale hierarchical porous structure for enhanced mass transfer, atomic-level carbon vacancy defects for enhanced CO2 adsorption and activation, and molecular-level Ni-N X S Y Asymmetric active sites are integrated in one. This multiscale synergistic design enables the catalyst to simultaneously address both low CO2 concentration (mass transfer limitation) and oxygen-containing (competing reactions) challenges.

This invention relates to the field of catalyst technology, and in particular to a MgO nanocluster catalyst, its preparation method, and its application. The preparation method of the MgO nanocluster catalyst involves adding magnesium salt and long-chain diol to a solvent, and then adding a surfactant dropwise. Under heating conditions, the MgO nanocluster catalyst forms a catalyst. Due to its size-driven surface effect, the MgO nanocluster catalyst possesses a large number of oxygen vacancies and low-coordination sites, forming strongly basic catalytic active centers. The MgO nanocluster catalyst is applied to the preparation of dipropylene glycol ethers. Using propylene oxide and alcohol as raw materials, a two-stage series reactor packed with the MgO nanocluster catalyst is used for the reaction. The use of the MgO nanocluster catalyst effectively improves the conversion rate of propylene oxide and the selectivity of primary ethers. Its nanocluster structure makes it easy to separate from the product by physical methods, overcoming the difficulties of traditional heterogeneous catalysts and product separation, significantly improving production efficiency, and showing good industrial application prospects.

The application discloses a key type specificity changed alpha-glucosyltransferase mutant, and belongs to the technical field of enzyme engineering and starch modification. The method is characterized in that, by analyzing the combination of Lf2970GtfB 4,3-alpha-glucosyltransferase in the active center donor / acceptor sub-site and the substrate, part of key amino acids of Lf2970GtfB are mutated into different types of amino acids, the mutant is prepared by changing the enzyme and substrate interaction force, space steric hindrance and other factors affecting the orientation of the substrate in the active center, the transglycosylation is changed, and the bond type composition of the product is changed. The application changes the bond type specificity of Lf2970GtfB 4,3-alpha-glucosyltransferase by mutation, the obtained mutant has novel 4,3 / 6-alpha-glucosyltransferase activity, and is helpful to synthesizing unique structure and more valuable alpha-glucan by using starch substrates.

The application belongs to the technical field of catalytic chemistry and porous materials, and specifically discloses a kind of vacancy anchoring full-silicon core-shell monatomic catalyst and its preparation method, the application makes Fe highly dispersed in the form of monatomic through the synergistic anchoring effect of silicon vacancy and ligand, avoids the metal oxide cluster produced by traditional impregnation method, inhibits excessive pyrolysis caused by local overheating, reduces the generation of gas impurities such as low-carbon alkane, the crystalline shell layer of the catalyst shortens the diffusion path of the product dimethyl ethylene ketone, DMK molecules can be quickly desorbed and leave the active center after generation, the content of by-product dimers is reduced, the structure of the catalyst improves the feed rate and accelerates the product diffusion, prevents the secondary reaction of reaction intermediates in the pore, greatly reduces the carbon deposition rate, forms a hydrophobic gradient layer by MTES modification, effectively repels the associated by-products isobutyric acid generated in the reaction, blocks the DMK polymerization reaction, thereby maintaining the yield of the target product DMK.

This invention discloses a nitrogen-based, fully flowable amination method for molybdenum-based materials, comprising the following steps: S1, pretreating the molybdenum-based material in a reducing atmosphere; S2, subjecting the pretreated molybdenum-based material to high-temperature nitridation at a first temperature in a nitrogen-containing gas atmosphere to form a molybdenum nitride catalyst with a core-shell structure, wherein the core layer is metallic molybdenum and the shell layer is molybdenum nitride; S3, after lowering the ambient temperature to a second temperature, introducing alcohol vapor to contact the molybdenum nitride catalyst for an amination reaction to generate amine products; S4, continuously collecting the amine products using an acidic absorbent; S5, repeating steps S2-S4 to achieve continuous production. This invention uses molybdenum as the catalytic active center, first nitriding and cracking nitrogen gas at high temperature to generate active nitrogen species, which then react with alcohols to generate corresponding amine substances.

The application discloses a carbon dioxide assisted dehydrogenation catalyst and a preparation method thereof. The catalyst comprises a honeycomb matrix, a modified silicon-aluminum coating on the surface of the honeycomb matrix and a first active component Pt, and the coating contains a group VIB metal carbide. Characteristic peaks representing the group VIB metal carbide appear at positions of 36°, 42°, 61° and 74° in an XRD spectrum, and lattice shift occurs. The preparation method comprises the following steps: (1) dissolving a group VIB metal precursor and / or an auxiliary metal salt in water to obtain solution A; (2) mixing alumina powder, pseudo-boehmite, a surfactant, a silicon source and the solution A to obtain a slurry; (3) loading the slurry on the honeycomb matrix, drying and roasting to obtain a carrier; and (4) loading Pt on the carrier to obtain the catalyst. The catalyst has a double active center synergistic cooperation function, has a double function of activating carbon dioxide and alkane dissociation adsorption, and has a wide application prospect in the fields of selective oxidation, oxidative dehydrogenation and the like.

The application discloses a preparation method of a single-center catalyst system and application thereof, and the preparation method comprises the following steps: (1) performing vacuum distillation on a modified methylaluminoxane solution, separating out a solvent and aluminum alkyl to obtain a solid product; (2) dissolving the solid product obtained in step (1) with a pentane solution to obtain a homogeneous solution with different aluminum contents; and (3) combining the homogeneous solution obtained in step (2) with a single-active-center catalyst to form a catalyst system. When the single-active-center catalyst system is used for preparing polyethylene wax, different solvents can be avoided from being introduced into a polymerization system, a process flow of the polyethylene wax is simplified, and energy consumption for solvent separation is reduced; reduction of active aluminum helps to improve polymerization activity, the obtained polyethylene wax has lower metal content and narrower molecular weight distribution, the devolatilization efficiency of the polyethylene wax is improved, and the obtained polymer has a VOCs content lower than 20 ppm.

The present application relates to the technical field of ore dressing, discloses a kind of activator N,N-bis phosphonamidic sulfonates, its structural formula is as shown in formula 1, N,N-bis phosphonamidic sulfonates contain phosphonic acid group (-PO3H2) and sulfonic acid group (-SO3H) two functional groups, with the molecular architecture of double active center synergistic effect;And the preparation method of N,N-bis phosphonamidic sulfonates, with the application of N,N-bis phosphonamidic sulfonates in the field of sulfide ore flotation.The present application first proposes a new type of sulfide ore activator N,N-bis phosphonamidic sulfonates, can effectively destroy the hydrophilic film on the surface of sulfide ore, restores mineral surface activity, both can enhance the adsorption firmness of reagent molecule on the surface of mineral, and also can inhibit secondary adsorption of impurity ions, realizes the efficient enrichment of sulfide ore in raw ore, and it is relatively mild, and the degree of pollution is low.

This invention provides a solid acid catalyst comprising a divinylbiphenyl polymer as a backbone and a sulfonate group as an active center; wherein the divinylbiphenyl polymer comprises substituted or unsubstituted divinylbiphenyl monomer structural units and optionally substituted or unsubstituted divinylbenzene monomer structural units; in both the substituted or unsubstituted divinylbiphenyl monomer structural units and the substituted or unsubstituted divinylbenzene monomer structural units, the substituents are each independently C1-C5 alkyl groups. This invention selects suitable polymeric monomers and polymerizes them to obtain a polymer backbone with a stable backbone structure and a large specific surface area; after sulfonation, the backbone structure is maintained, and the resulting catalyst has a stable acid active center.

The application provides a preparation method and application of a metallocene polypropylene catalyst. The first aspect of the application provides a preparation method of a metallocene polypropylene catalyst, comprising the following steps: subjecting a carrier to a thermal activation treatment to obtain a thermally activated carrier; loading a first cocatalyst on the thermally activated carrier to obtain a thermally activated carrier after loading of the first cocatalyst; preparing a catalyst precursor by using a second cocatalyst, a metallocene compound and an indole compound; and reacting the thermally activated carrier after loading of the first cocatalyst with the catalyst precursor to obtain the metallocene polypropylene catalyst. The preparation method of the metallocene polypropylene catalyst can effectively improve the activity and stereoregularity of the metallocene polypropylene catalyst by adding an electron donor of the indole compound to modify an active center in the preparation process of the metallocene polypropylene catalyst; and meanwhile, the preparation process is simple, and the types of chemical reagents used are few.

The application discloses an atomic transition metal modified nitrogen-carbon catalyst and a preparation method and application thereof, and relates to the technical field of environmental functional materials.The atomic transition metal modified nitrogen-carbon catalyst is composed of edge-sharp wrinkle nanosheets, and the wrinkle nanosheets comprise an N3C carrier and transition metals uniformly distributed on the N3C carrier in the form of single atoms and atomic clusters.The atomic transition metal modified nitrogen-carbon catalyst is obtained by modifying transition metal atoms on the basis of nitrogen-carbon, constructing a metal active center, increasing the light-heat absorption capacity of the material, and not damaging the inherent morphology of the catalyst, so that the atomic transition metal modified nitrogen-carbon catalyst has high light-heat conversion capacity, can activate active oxygen species by activating molecular oxygen, and can realize efficient light-heat catalytic inactivation of pathogenic microorganisms by combining the physical and chemical synergistic effects of the sharp edges of the material.

The application belongs to the technical field of organic chemical synthesis and heterogeneous catalysis, and particularly relates to a catalyst for preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride and a preparation method thereof. The application overcomes key technical bottlenecks in the existing gas-phase ketonization reaction, such as serious cracking side reactions, quick deactivation of the catalyst due to carbon deposition, and low selectivity of the target product. The application provides a method for efficiently preparing 2,4-dimethyl-3-pentanone from isobutyric acid or isobutyric anhydride. The method innovatively constructs a modified HZSM-5 molecular sieve catalyst with a micropore-mesopore multi-level pore structure, and introduces specific metal oxide active components to construct acid-base synergistic active centers, thereby realizing directional regulation of the reaction path. The method not only significantly inhibits the competitive monomolecular cracking reaction, greatly improves the selectivity of the bimolecular coupling ketonization reaction for generating 2,4-dimethyl-3-pentanone, but also effectively eliminates the diffusion resistance of macromolecular products by using mesoporous channels, thereby fundamentally solving the problem of easy carbon deposition and deactivation of the catalyst, and having excellent industrial application prospects and technical progress.

This invention discloses a nanozyme for the detection of phenolic compounds and a quantitative detection method for phenolic compounds. The nanozyme comprises an organometallic framework material and copper loaded on the surface of the organometallic framework material, possessing a core-shell structure. The active metal catalytic center is loaded on the material surface, which helps to improve the utilization efficiency and catalytic activity of the active center, thereby enhancing the detection capability of large molecular weight phenolic compounds. Based on the standard addition method, the nanozyme of this invention can be used for the quantitative analysis of BPA in environmental water and thermal paper, exhibiting high accuracy and sensitivity, and strong anti-interference ability. The quantitative detection method of this invention can be used in conjunction with an image acquisition device for quantitative calculation of phenolic compounds, further simplifying the detection of phenolic compounds.

This invention provides a method and apparatus for preparing sodium ferrochlorophyllin using green organic acid-assisted membrane separation, relating to the fields of chemical separation and pharmaceutical raw material refining. The method first utilizes a green organic acid to construct a supramolecular micelle system, inducing high monomer-level dispersion of chlorophyllin molecules through a hydrogen bond network, thus solving the problem of hydrophobic aggregation in an aqueous environment. Then, an electrocoupled ceramic membrane reactor is employed, utilizing the physical confinement effect of nanopores to force microscopic deformation of the porphyrin ring, combined with a transmembrane alternating pulsed electric field to achieve targeted complexation of iron ions, overcoming the high energy barrier of steric hindrance in central ion replacement. Finally, based on a constant-volume cross-current dialysis and reverse osmosis coupling mechanism, macromolecular products are distinguished from small-molecule impurities, achieving closed-loop circulation of the organic acid solvent and precise product purification. This invention effectively solves the bottlenecks of active site masking and membrane fouling, significantly improving preparation efficiency, product purity, and the greening level of the production process.

This invention discloses a bimodal styrene-acrylic resin, its preparation method, and its applications, belonging to the field of polymer materials. The method for preparing the bimodal styrene-acrylic resin provided by this invention first generates a prepolymer with a certain molecular weight (as a precursor for high molecular weight segments) through semi-continuous bulk polymerization; subsequently, a chain transfer agent is added during the suspension polymerization stage, and the growing polymer chains are quantitatively broken by chain transfer reaction to form low molecular weight segments and generate new active centers; by adjusting the concentration of the chain transfer agent, the short chain length can be controlled, and the bimodal molecular weight distribution of the styrene-acrylic resin can be precisely regulated. This allows for the simultaneous construction of high molecular weight and low molecular weight segments in the same resin system.

This invention discloses an R-type α-fluoroimine reductase mutant, its preparation method, and its applications. The wild-type imine reductase is derived from *Xanthomonas aeruginosa*. Luteolibacter luteus By using directed evolution to modify its active site, an imine reductase mutant with high activity, stereoselectivity, and high yield of 4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline was obtained. The mutation is at least one of S237T, I241L, or R248L. This invention achieves efficient synthesis of (R)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline from inexpensive (Z)-2,2,2-trifluoro-N-(4-methoxyphenyl)-1-phenylethylimine, which is beneficial for the industrial synthesis and application of (R)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline.

This invention belongs to the field of catalysis technology, specifically relating to a method for preparing cyclopentane derivatives from furan compounds. The method includes the following steps: mixing a furan compound, a copper-based catalyst, a halogen modifier, and a first solvent, and reacting them under a hydrogen atmosphere; the halogen modifier is at least one selected from sodium chloride, sodium bromide, potassium chloride, potassium bromide, chlorobenzene, and bromobenzene. This invention, by adding a halogen modifier to the catalytic system, introduces halogen components onto the surface of the copper-based catalyst to construct Cu-halogen active centers, achieving highly selective rearrangement of furan compounds into cyclopentane derivatives under relatively mild conditions, while significantly suppressing condensation side reactions, improving carbon utilization efficiency, and reducing dependence on the type of support.

This invention relates to the field of gaseous decarbonylation of iron and nickel, specifically to a gaseous decarbonylation protective agent, its preparation method, application, and a method for removing decarbonylation of iron and nickel from methanol synthesis gas. The protective agent comprises an active component, a support, and an auxiliary agent. The active component comprises elemental copper and elemental zinc, and the support comprises kaolin. In this system, the active component is distributed between the kaolin support and adheres to the support. The copper-zinc active system protective agent exhibits good activity and a higher decarbonylation capacity, better protecting the long-term operation of the methanol synthesis catalyst. Kaolin has a large specific surface area and numerous micropores, enabling it to fully physically adsorb carbonylation of iron and nickel, which then catalytically dissociates and deposits afterward at the copper-zinc active centers.

This invention belongs to the field of catalytic chemical technology and discloses a method for preparing a Ni2P / SAPO-11 catalyst and its application. Ni(NO3)2·6H2O and (NH4)2HPO4 are dissolved in deionized water to obtain a mixed solution A. Citric acid is dissolved in mixed solution A and ultrasonically treated until completely dissolved to obtain an impregnation solution B. Impregnation solution B is added dropwise to a SAPO-11 support, and after aging, drying, and calcination, a catalyst precursor is obtained. The precursor is reduced under a hydrogen atmosphere to prepare the active phase, thus obtaining a CA-modified CA(x)-Ni2P / SAPO-11 catalyst, where x is the CA / Ni molar ratio. This invention, by regulating the metal-acid active center balance with citric acid, promotes the synergistic effect of bifunctional active centers, significantly improving the catalyst's ability to simultaneously perform hydrodesulfurization and hydroxyl skeletal isomerization. This invention provides a new method for preparing bifunctional catalysts with deep desulfurization and olefin skeletal isomerization activities.

The application belongs to the technical field of organic synthesis, and particularly relates to a kind of bromine-containing isoindoline-1-ketone compound and preparation method thereof.The preparation method of the bromine-containing isoindoline-1-ketone compound uses commercially available aldehyde-derived imine as raw material, is reacted with aryl bromide oxazoline compound under butyl lithium condition, and then is subjected to acid-mediated cascade cyclization process, to efficiently construct isoindoline-1-ketone skeleton.The isoindoline-1-ketone compound can be directly used as an organic catalyst, the N-H functional group remaining in the structure of the isoindoline-1-ketone compound has reactivity, can be coupled with other bioactive molecules as a key connection site, to construct functional derivatives, the amide carbonyl group thereof can be further reduced, to be converted into pyrrolidine structural unit, and the structure itself can be used as a catalytically active center, to expand its application in the field of catalysis.

The application discloses a COF-based nanoscale enzyme and a preparation method thereof, a COF-based nanoscale enzyme sensor and a detection method of phoxim residues, and relates to the technical field of pesticide detection. The technical scheme in the application designs a COF-based nanoscale enzyme sensor and a method for detecting phoxim residues by using the sensor. The COF-based nanoscale enzyme sensor in the application is synergistically designed by valine functionalization and MnO2 nanoscale enzyme loading, provides rich recognition sites and catalytic active centers, significantly promotes interface electron transfer, and thus amplifies the detection signal. In addition, a machine learning module is introduced in the detection method, which can accurately analyze complex electrochemical signals, effectively distinguish target signals from interference noise, significantly improve the accuracy, reproducibility and anti-interference ability of detection, and provide a universal solution for rapid detection of various samples and multiple targets.