701results about How to "Few synthetic steps" patented technology

The invention provides a prodrug of an antiviral drug for use in liver of cyclic phosphate of a general formula (I) and isomers, pharmaceutical salts, hydrates, solvates and pharmaceutical compositions of the same. The invention provides uses of the compounds singly or together with other antiviral drugs in the treatment of viruses, in particular of hepatitis B viruses (HBV), hepatitis C virus (HCV), HIV viruses and/or human cytomegaloviruses (HCMV).

The invention provides a method for preparing a Salen-metal complex. The method comprises the following steps of: under the argon atmosphere, adding ligands(II), sodium methoxide, absolute methanol soluble ligands(II) and sodium methoxide into a reactor in sequence; stirring the mixture for 2 minutes, and adding 1mol/L cobalt acetate anhydrous/ methanol solution dropwise, wherein the molar ratio of the ligands(II) to sodium methoxide to cobalt acetate is 1:1:1; and making the mixture reacted at the room temperature for 24 hours, adding anionic salt which has the same molar weight as the cobalt acetate, stirring the mixture for three days in the air, stopping the reaction, concentrating the mixture, performing dissolution and filtration by adding methylene chloride, drying the filtrate by anhydrous sodium sulfate overnight, filtering the mixture, concentrating under reduced pressure, and drying the mixture under the vacuum condition to obtain the Salen-metal complex. The Salen-metal complex prepared by the method has the advantages of simple method, low cost and high catalytic efficiency.

The invention relates to a quinoline nitrile derivative. A method comprises the following steps of: reacting 2-methylquinoline serving as an initial raw material with the corresponding alkyl halide to obtain quaternary ammonium salt, performing Michael addition-elimination reaction on the quaternary ammonium salt and malononitrile, and performing Knoevenagel condensation reaction on the obtained compound and the corresponding aromatic aldehyde to obtain a target product. The aggregate or solid substance of the derivative has strong fluorescence and large wavelength, is a good aggregation-induced emission material, and has considerable application prospects in the fields of electroluminescent devices, fluorescent probes, intelligent materials, organism imaging and the like.

Disclosed is a Sofalcone preparation method which mainly comprises, (1) subjecting p-hydroxybenzaldehyde and 2,4-ihydroxyacetophenone to condensation reaction under alkaline condition, obtaining 2,4,4-Trihydro-xychalcone, (2) subjecting 2,4,4-trihydro-xychalcone and 1-bromo-3-methyl-2-butene to condensation reaction, obtaining 2-hydroxyl-4,4-bis (3-methyl-2-butenyloxy) chalcone, (3) subjecting the 2-hydroxyl-4,4-bis (3-methyl-2-butenyloxy) chalcone and ethyl bromoacetate to condensation under the action of potasium carbonate, thus obtaining sofalcone. The mol ratio of p-hydroxybenzaldehyde, 2.4-dihydroxyacetophenone, 1-bromo-3-methyl-2-butene, and ethyl bromoacetate can be 1 : (0.90-1.50) : (1.60-2.55) : (0.60-1.25).

The invention discloses a synthesis method of metaraminol bitartrate, and in particular provides a method for synthesizing metaraminol bitartrate by using a chiral catalysis method. The synthesis method comprises the steps: catalyzing a chiral addition reaction of hydroxybenzaldehyde and nitroethane by using a chiral catalyst system consisting of cinchona alkaloid, copper acetate hydrate and less imidazole to obtain an addition product with a dominant required spatial configuration, and then reducing nitro by using hydrogen in the presence of Pd-C to obtain amine to obtain aramine, and salifying the aramine with L(+)-tartaric acid to obtain a final product metaraminol bitartrate. According to the synthesis method, an enzyme catalyst is prevented from being used, a raw material of the synthesis reaction is easily available, the chiral catalyst is easily purchased or prepared self, the synthesis steps are relatively less, the chiral control efficiency is higher, the enantioselectivity is high, the yield is good, the reaction operation is easily controlled, and is safe and reliable, and the foundation is laid for the later industrialized amplification production.

The invention provides a method for preparing chlorinated-2-acetyl-1,10-phenanthroline amine iron (II) complex with the structural formula of formula (I) and an application of the obtained complex as an ethylene oligomerization catalyst, wherein variables in the formula (I) are defined in the specification. According to the method, triethyl aluminum which is adopted as an initial raw material in the process of the preparation of 2-acetyl-1,10-phenanthroline from 1,10-phenanthroline is hydrolyzed and undergoes an oxidation reaction with nitrobenzene to obtain 2-acetyl-1,10-phenanthroline, 2-acetyl-1,10-phenanthroline is condensed with substituted aniline to obtain a 2-acetyl-1,10-phenanthroline amine ligand, and the ligand is reacted with iron dichloride to obtain the complex. The synthetic method of the invention, which has the advantages of less step, simple technology, and catalyst preparation cost reduction, and adopts nontoxic triethyl aluminum to replace potassium cyanide used in routine preparation methods, has a wide industrialization prospect.

The invention relates to the field of medicinal chemistry, and discloses a method for preparing mangiferin aglycone. The method comprises that: step 1, 2-halogenate-4,5-dimethoxy benzoic acid and 1,3,5-trimethoxy benzene are subjected to Friedel-Crafts reaction, so a compound which has a structure in a formula IV is generated; step 2, the compound in the formula IV is selectively demethylated, and a compound which has the structure in the formula V is generated; step 3, the compound in the formula V is cyclized, and a compound which has the structure in the formula VI is generated; and step 4, the compound in the formula VI is completely demethylated, and mangiferin aglycone is generated. The method for preparing mangiferin aglycone improves the synthetic yield of the mangiferin aglycone, has the characteristics of cheap and easily-obtained raw materials, less synthetic steps, convenience in operation, easiness in control and high product purity, and can be widely applied in industrial production.

The invention relates to an edging cube-shaped cobalt-iron prussian blue nanometer material and a preparation method thereof. The preparation method comprises the following steps of firstly, stirring and dissolving a surfactant into water under the magnetic action; after dissolving, sequentially adding sodium citrate and cobalt salt to prepare a solution A; then, dissolving potassium ferricyanide solid into water to prepare a solution B; gradually dripping the solution A into the solution B while stirring; after dripping, continuing to stir for a period of time; standing and aging the reaction liquid for a period of time, naturally cooling, centrifuging, washing, and drying, so as to obtain the edging cube-shaped cobalt-iron prussian blue nanometer material. Compared with the prior art, the synthesizing method has the advantages that by changing the conditions, the edging cube-shaped cobalt-iron prussian blue nanometer material is prepared; the morphology and structure of the material are not reported in the literature; the preparation is simple, the implementing is easy, and the large-batch preparation effect is realized.

The invention discloses a method for preparing (Z)-5-amino-alpha-(ethoxy imino group)-1, 2, 4-thiadiazole-3-acetic acid. The method comprises steps of firstly, carrying out oximation reaction on malononitrile and sodium nitrite under the action of acetic acid so as to obtain a compound A, then carrying out Williamson synthesis on the compound A and bromoethane or diethyl sulfate under alkaline condition, so as to obtain a compound B, then carrying out amidine reaction on the compound B and ammonia water, so as to obtain a compound C, carrying out cyclization reaction on the compound C and potassium rhodanide for ring closing so as to obtain a compound D, and finally, hydrolyzing the compound D under the action of a strong base, so as to obtain (Z)-5-amino-alpha-(ethoxy imino group)-1, 2, 4-thiadiazole-3-acetic acid. The method has few synthesis steps, has low cost, uses the materials which are cheap and easy to obtain, is beneficial to industrial production, and has light contamination; the purity of the product can reach 99%, so that synthesis of high-purity ceftaroline fosamil in the subsequent step is guaranteed.

The invention discloses a preparation method 2,4,5-trifluorophenylacetic acid. The method is characterized by consisting of four reaction steps of: A, reaction of 2,4,5-trifluoronitrobenzene (I) and diethyl malonate which are condensed to prepare 2,5-difloro-4-nitrobenzophenone diethyl malonate; B, hydrolysis, acidification and decarboxylic reaction of dibasic ester; C, reduction reaction of nitryl; and D, diazotization fluoridation of amino. The four reaction steps can be sequentially carried out according to A, B, C and D, or A, C, B and D, or A, C, D and B. According to the preparation method provided by the invention, condensation of 2,4,5-trifluoronitrobenzene (I) and diethyl malonate is easy to realize by means of high substituting activity of nitryl p-fluorine, and the raw material 2,4,5-trifluoronitrobenzene (I) is low in cost and easy to obtain and can be easily prepared by nitration and fluorination of 2,4-dichlor fluorbenzene. Compared with the prior art, the preparation method provided by the invention has the characteristics of low-cost and easily obtained raw materials, mild reaction condition, high total yield, low production cost and the like, and is comparatively suitable for industrialized production.

The invention discloses a zinc catalyst applicable to controllable depolymerization of a polyester material and a catalytic method thereof, and belongs to the technical field of polyester depolymerization. The problems that an existing zinc catalyst used for alcoholysis of waste polyester materials needs to synthesize complex ligands, and the number of synthesis steps is increased are solved. Thecatalyst adopted by the invention is a bis(hexaalkyldisilazane)zinc catalyst with a simple structure, and under the participation of an alcohol compound, the polyester material can be depolymerized into small organic molecules under mild conditions through the transesterification reaction catalyzed by the catalyst, so that the reutilization of waste polyester is realized. The zinc catalyst is adopted to catalyze polyester depolymerization, metal zinc is non-toxic, colorless, cheap and easy to obtain and serves as one of the microelements of a human body, biocompatibility is good, and the production process is more environmentally friendly; the catalyst is simple in structure, few in synthesis steps and more economical in production cost. The catalyst has very good universality, and has a very good depolymerization effect on various polyester materials with different structures.

The invention provides a method of preparing a complex represented by formula (I) of 2-n-butyryl-1,10-phenanthroline condensation amine ferric chloride (II) and application of the prepared complex as a catalyst for ethylene oligomerization, wherein variables in formula (I) are defined in the specification. According to the method, in the process of preparing 2-n-butyryl-1,10-phenanthroline from 1,10-phenanthroline, tri-n-butylaluminum is used as a starting material, then hydrolysis and an oxidation reaction with nitrobenzene are sequentially carried out so as to obtain 2-n-butyryl-1,10-phenanthroline, 2-n-butyryl-1,10-phenanthroline and substituted aniline undergo a condensation reaction so as to prepare 2-n-butyryl-1,10-phenanthroline condensation amine ligand, and the ligand reacts with ferrous chloride so as to obtain a target product. The synthetic method comprises a few procedures, is a simple process, enables preparation cost for the catalyst to be reduced and uses nontoxic tri-n-butylaluminium to substitute potassium cyanide used in normal preparation methods, thereby having a wide industrial prospect.

The invention discloses a semi-aromatic polyamide PA11T and a synthetic method thereof and belongs to the technical field of high polymer material synthesis. The structure formula is shown in the description, wherein n is 10-200. The 1, 11-undecanedioic diamide and the terephthalic acid are taken as the raw materials and the synthetic process is finished in a drum type reaction kettle through a one-pot method. By adopting the method, the reaction devices and the synthetic steps are few, the reaction time is short, the polymerization temperature is low, and the method is pollution-free and suitable for the large-scale industrial production. The PA11T produced by the process is excellent in performance and has a good market prospect in the industries such as the electric products and the automobiles.

A cyclodextrin derivative for preventing and treating cardiovascular and cerebrovascular diseases, diabetes, liver injury, diseases in respiratory system, rheumatic and rheumatoid diseases, dermatopathy and tumor is disclosed. It is an artificial analogue enzyme with the activity of glutathion peroxidase.

The invention relates to a perfluoropolyether group-containing silane compound represented by a formula (1): Rf-X1-X2-NQkT2-k(1), and a preparation method therefor. The invention also relates to a perfluoropolyether group-containing silane compound shown in the description, and a preparation method therefor. The invention also relates to a perfluoropolyether group-containing silane compound represented by a formula (3) shown in the description, and a preparation method therefor. The perfluoropolyether group-containing silane compound can be used for a surface treatment agent so that the glassand other base materials processed by the surface treatment agent are excellent in anti-pollution, anti-fingerprint, scrape-resistant and wear-resistant performances, and the preparation methods for the compounds are simple in process, and are easy to operate and implement.

The invention discloses a (+)-(3R,4R)-[[2S-[[4-(3-hydroxyphenyl-3,4- dimethyl-1-nipecotic)-methyl]-1-oxo-3-phenylpropyl]amido]benzyl cetate compound and its process for preparing and a new technology for preparation of Mope by the said compound. The new technique of this invention changes the íŒone chainíŒ synthesis of the original patent method to the separate í‹two chainsíŒ preparation, by which the total compound steps are dramatically shortened, the compound cost is reduced to about one-half of the original patent method, and the method is more competitive on the market in price. Furthermore,the reaction condition is moderate, the operating procedure is simple, each reaction step is no need of given condition such as low temperature and absolute water-free, so it is more suitable for industrial production.

The invention provides a method for preparing a chlorinated 2-benzoyl-1,10-phenanthroline condensed amine iron (II) complex shown in formula I, and its catalytic application in ethylene oligomerization. The preparation method comprises the following steps: orderly performing hydrolysis and an oxidation reaction with nitrobenzene of initial reaction raw materials of 1,10-phenanthroline and benzyl lithium to obtain 2-benzoyl-1,10-phenanthroline, then performing condensation of 2-benzoyl-1,10-phenanthroline with substituted aniline to obtain 2-benzoyl-1,10-phenanthroline condensed amine ligand, and reacting the ligand with ferrous chloride to obtain a target product I. The synthetic method provided by the invention is few in steps, and simple in process, substitutes nitrobenzene for selenium dioxide in the prior art for the oxidation reaction, substitutes nontoxic benzyl lithium for hypertoxic potassium cyanide in the prior art, reduces the preparation cost of the catalyst, and has wide industrialization prospects.

The invention relates to a nano stannic oxide-graphene composite as well as a preparation method and an application thereof. Firstly, a SnCl4*5H2O solution is added to a graphene oxide aqueous solution and stirred, graphene oxide sheets adsorb Sn<4+>,the graphene oxide sheets adsorbing Sn<4+> are dissolved in deionized water and subjected to ultrasonic treatment after being separated, and an obtained dispersing solution is used as a seed crystal adsorbing solution; a SnCl4*5H2O aqueous solution, a NaOH aqueous solution and a surfactant aqueous solution are prepared respectively; the seed crystal adsorbing solution and the SnCl4*5H2O aqueous solution are mixed, then the NaOH aqueous solution and the surfactant aqueous solution are dropwise added to the solution sequentially, the mixture is stirred, mixed evenly and ultrasonically and then transferred to a closed reaction kettle to be subjected to a hydrothermal reaction, and the nano stannic oxide-graphene composite is obtained after natural cooling, centrifugation, washing and drying. The nano stannic oxide-graphene composite is applied to specific response to ammonia gas under the room temperature condition. Compared with the prior art, the composite has the advantages that the synthesis method is simple and easy to implement, and the shape of a product is controlled.

The invention relates to a preparation method and application of a cobalt disulfide and carbon nano fiber composite material. The preparation method comprises the following steps: firstly, preparing carbon nano fiber by using an electrostatic spinning method; by taking N-N dimethyl formamide (DMF) as a solvent, preparing a polyacrylonitrile spinning solution, uniformly stirring, sucking into an injector, and performing electrostatic spinning; cutting a white film obtained after spinning into long strips, and performing thermal treatment in a tubular furnace so as to obtain a black carbon fiber film; activating with concentrated nitric acid, adding cobalt nitrate hexahydrate and thioacetamide so as to obtain a solution, performing ultrasonic treatment, further transferring the solution into a reaction kettle, and performing hydrothermal reaction; after the reaction kettle is cooled after reaction, taking out the carbon fiber, respectively washing the carbon fiber with distilled water and ethanol for multiple times, and performing vacuum drying, thereby obtaining the cobalt disulfide and carbon nano fiber composite material. The cobalt disulfide and carbon nano fiber composite material is used as an electrode material of a supercapacitor, and properties of the supercapacitor can be tested.

The invention provides a new method for preparing single-ended double-hydroxyl alkyl polydimethylsiloxane and the preparation method of the invention is different from prior synthetic methods. The preparation method takes D3 (Hexamethylcyclotrisiloxane), allyl glycidyl ether and methylaminoethanol as starting raw materials which go through three-step reactions of anion ring-opening polymerization, hydrosilylation and epoxy ring-opening to synthesize the target product of the single-ended double-hydroxyl alkyl polydimethylsiloxane of which the product purity is over 98 percent. The invention has the advantages of simple and convenient reaction steps, easily accessible raw materials, low production cost, high product yield, high purity, etc.

The invention discloses a one-step synthesis method for a B-EU-1/ZSM-5 composite molecular sieve. The one-step synthesis method comprises the following steps: adding sodium hydroxide, a silicon source, an aluminum source, a boron-containing compound and a template agent into water at a molar ratio of Na2O:SiO2: Al2O3:B2O3: a template agent:H2O being 1.5 to (0.1-7) to (0.001-0.2) to (0.001-0.3) to (0.01-2.25) to (1-10), and uniformly stirring to obtain mixed gel; crystallizing the mixed gel at a constant temperature of 130-200 DEG C, roasting at 350-650 DEG C to remove the template agent, performing ion exchange by an acid solution, washing and keeping for 4 hours at 350-650 DEG C to obtain a B-EU-1/ZSM-5 hydrogen composite molecular sieve, wherein the template agent consists of tetrapropylammonium bromide and hexamethonium bromide by mixing. The one-step synthesis method disclosed by the invention can be used for quickly and simply synthesizing a composite molecular sieve which simultaneously contains a EUO structure and an MFI structure, and is doped with a nonmetal element B, wherein the composite molecular sieve is used as a catalyst for preparing dimethylbenzene by methanol aromatization.

The invention relates to an alpha-diimine nickel metal organic compound and a preparation method thereof. The preparation method comprises the following steps: adding NiBr2 (DME) and alpha-diimine into a dichloromethane solution for reaction under the protection of an inert atmosphere, reducing an obtained product in a diethyl ether or n-hexane solution by using metallic sodium, and then reacting with 1,5-cyclooctadiene to obtain a mononuclear nickel metal organic compound of alpha-diimine. The preparation method provided by the invention is simple, is high in product yield and good in purity and can be used as an olefin polymerization catalyst.

The invention discloses a method for preparing scutellarin. The method comprises the following steps: taking phenol as a starting material, preparing a chalcone intermediate compound 6 through bromination, methoxy substitution, friedel-crafts acylation and the like, performing oxidative cyclisation on the chalcone intermediate compound 6 to obtain a key flavone intermediate 4',6-dihydroxy-5,7-dimethoxy flavone-compound 7, and preparing high-purity scutellarin through benzoylation, selective demethylation, glycosylation and hydrolysis reaction of the key intermediate. According to the method, the adopted raw material reagents are all low in price and easy to obtain, the synthesis steps are less, the operation is simple and convenient, production control is easy, the product yield and purity are high, and the method is suitable for scutellarin production.