863results about How to "High synthetic yield" patented technology

Non-hydroxyalkylated cyclodextrins are disclosed wherein at least one primary alcohol function (CH2OH) is substituted, the -OH portion being replaced by a substituent with formula -O-CO-R or -NR1R2, where:R, R1 and R2 independently represent a linear or cyclic, saturated or unsaturated, hydroxylated or non-hydroxylated alkyl group containing 1 to 30 carbon atoms, preferably 1 to 22 carbon atoms, more preferably a fatty chain containing 2 to 22 carbon atoms. These cyclodextrins are used as vectors for at least one active ingredient, in particular to encourage tissue penetration, in a cosmetic application, or for the production of pharmaceutical compositions, in particular dermopharmaceuticals.

The invention relates to the hydropyridine derivatives of 2-acetoxy-5- (Alpha-cyclopropyl carbonyl-2-fluorobenzyl) -4, 5, 6, 7-tetrahydrothiophene plus [3, 2-C] pyridine and salts of the hydropyridine derivative as well as the preparation method. The invention comprises following steps: preparing two main intermediates: Alpha-cyclopropyl carbonyl-2 fluorobenzyl halogen 2 (wherein, X=F, CL, Br, I) and 2-oxygen-2, 4, 5, 6, 7, 7 Alpha-hexahydrothiophene plus [3, 2-C] pyridinium salt 3 (wherein, HA=HCL, H2SO4, HBr, HI); esterifying the product obtained through condension of the two main intermediates using acetic anhydride to get target product. The target product and the needed acid are combined to be salts via addition reaction; during the process of crystallization, necessary crystal seed is added to achieve single-morphic crystals.

The invention discloses a solid-phase synthesis method for liraglutide. The solid-phase synthesis method for liraglutide comprises the following steps: 1) firstly synthesizing first to tenth amino acid segments 3, eleventh to nineteenth amino acid segments 2, and twentieth to thirty-first amino acid segments 1, wherein the twentieth lysine adopts Fmoc-Lys(Mtt)-OH, and the first histidine adopts Boc-His(Trt)-OH; 2) synthesizing pal-Glu(OH)-Otbu by adopting a liquid phase synthesis method; 3) selectively removing the Mtt protecting group on the twentieth lysine by use of 5% TFA (Trifluoroacetic Acid), connecting pal-Glu(OH)-Otbu with the side chain of the twentieth lysine to obtain a segment 4; 4) sequentially connecting the segments 2, the segments 3 and the segments 4 to obtain peptide resin completely protected by liraglutide; 5) cracking, purifying, and lyophilizing to obtain the liraglutide product.

The invention provides an organic dye which uses five-membered heterocyclic ring, derivatives thereof and a dye-sensitized solar cell prepared by the organic dye. The dye uses the five-membered heterocyclic ring or the derivatives thereof as a Pi unit, uses substituted triarylamine as an electron donor, uses cyanoacetic acid structure as an electron acceptor, and belongs to molecule of D-Pi-A structure. The dye molecule belongs to pure organic compounds, the structure of the materials is simple and is easy to be obtained; expensive materials of metal of Ru and purifying agent of polydextrose do not need to use, the compound yield is higher, so the total yield is between 40 percent and 70 percent; besides, the performance of spectral absorption and molar extinction coefficient and the like of the dye are excellent; and the peak value of the spectral absorption is over 550nm at the most, the molar extinction coefficient is over 48000M<-1>cm<-1>, the peak value and the coefficient are more than the Ru dye, therefore, the dye has wider absorption range to the sunlight. The dye-sensitized solar cell prepared by the organic dye has the maximum of quantum conversion efficiency of 97 percent and the highest photoelectric conversion efficiency of more than 8.0 percent.

The present invention provides a preparation method of SiBN(C) ceramic fiber. In the preparation method, silicon haloganide, boron halide and disilazane of small molecules are used as starting materials and are mixed according to a certain ratio; the temperature is raised to be between 150 and 500 DEG C and is maintained for a certain period; after the temperature is lowered, the mixture is processed through vacuum distillation and is cooled to be at the room temperature; thus the precursory of solid boron-containing polysilazane can be prepared and is then used for fusing filature to prepare precursor fiber of SiBN(C) ceramic fiber. Compared with the existing method, the preparation method has the advantages of low costs in raw materials, reliable source, higher synthetic yield, simple process and one-step preparation of the precursor; the fiber of the precursor is treated through chemical crosslinking that has high efficiency and is conducive to the integrative operation of spinning, non-melting treatment and sintering.

The invention relates to a preparation method of a fluorescent molecular probe for detecting sulfite ions through naked eyes and fluorescence ratio as well as the application of the fluorescent molecular probe in detecting sulfite ions. The fluorescent molecular probe is prepared by condensing 4-hydroxy naphthalimide serving as raw material and acetylpropionic acid in refluent methylene dichloride. The synthesis is simple and convenient, and the reaction conditions are mild. The probe molecule provided by the invention has higher sensitivity, stable fluorescence performance, higher synthesis yield and good selectivity, and furthermore, the response range of the probe is 0-1500 mu m, the detection limit is 6 mu m; the detection range is wide, the lower detection limit is low, and the probe is suitable for naked eye detection. Meanwhile, the florescence-ratio detection is adopted to avoid errors caused by exciting light intensity, probe concentration and environment factors of an off-on type probe which detects ions only depending on the change of fluorescence intensity and the probe disclosed by the invention is not influenced by anions such as F<->, Cl<->, Br<->, I<->, HPO4<2->, SO4<2->, NO<3->, AcO<->, ClO<4->, N<3-> and HCO<3->. Even interfering ions exist, the probe has very good response to sulfite ions. Therefore, the fluorescent molecular probe has practical application value in the fields of biochemistry, environmental science and the like.

The invention discloses synthesis of nitrogen-doped graphene quantum dot/similar-graphene phase carbon nitride composite material and research and application of photocatalytic decomposition of aquatic hydrogen performance. A catalyst is composed of a nitrogen-doped graphene quantum dot and similar-graphene phase carbon nitride. Under simulated sunlight, the catalyst can efficiently and stably achieve water photolysis to produce hydrogen. The synthesis and application have the advantages that the catalyst is completely composed of nonmetal elements and has the advantages of being environmentally friendly and low in cost; the light response range of the similar-graphene phase carbon nitride is enlarged due to the doping of the nitrogen-doped graphene quantum dot, and absorption under the visible light is increased; the photosensitization effect and the ultrastrong electron conduction capacity of the nitrogen-doped graphene quantum dot are utilized at the same time, photo-induced electron and hole composition is restrained, and meanwhile the light utilization rate is improved; the raw materials are low in cost and easy to obtain, the synthesis method is simple, the synthesis yield and purity are high, and experimental repeatability is good.

The invention relates to an intermediate iodide in the synthesis of Tazobactam, and a preparation method and the application thereof in preparing Tazobactam, and discloses the structural formula (I) of 2Beta-iodomethyl penicillanic acid ester. The invention has unique technique, stable product quality, mild technique condition and high yield, is easy to be controlled, requires relatively low production cost, reduces environmental pollution, needs no special equipment and is suitable for industrialized mass production.

The invention relates to a preparation method of a fluorescence enhanced fluorescent molecular probe for detecting mercapto-containing amino acids, and an application of the probe, and concretely relates to a preparation method of a 7-hydroxyquinoline derivative and an application of the 7-hydroxyquinoline derivative in the mercaptoamino acid detection. The fluorescent probe is a pure probe synthesized through directly reacting the 7-hydroxyquinoline derivative with dimethyl sulfate. The largest absorption wavelength of the molecule of the probe is 315nm; and the absorption wavelength of the probe molecule redshifts to 406nm from 315nm with the addition of the mercapto-containing amino acids, the intensity of a fluorescent spectrum at 505nm is continuously enhanced, and very strong green fluorescence is emitted. The probe molecule has the advantages of high detection sensitivity, strong identification capability on the mercapto-containing amino acids, and fast response speed, and has detection limits of Cys, GSH and Hcy mercaptoamino acids being 23nM, 52nM and 5.3nM respectively, and like probes have important application values in the biochemical field and the like.

The invention relates to a Si/C/Zr ceramic precursor and a preparation method thereof, and belongs to the technical field of a ceramic material. The Si/C/Zr ceramic precursor is prepared by adopting a Grignard coupling reaction method; Si and Zr elements can be simultaneously introduced to a main polymer chain at an atomic level so as to obtain a silicon-zirconium integrated polymer; a synthetic technology is simple and practicable; and the synthetic yield and the purity of the product are relatively high. A reaction raw material, namely polycarbosilane used in the preparation method contains Si-H bonds and C is equivalent to C bonds, has good thermosetting property and is small in curing heat release, low in curing weight loss and good in manufacturability; the polycarbosilane self is cross-linked and cured at a certain temperature; and the ceramic yield is high and can reach 60-70%. The Si/C/Zr ceramic precursor can be applied to a superhigh temperature ceramic matrix composite steeping matrix, can also be used for preparation of high performance materials such as Si/C/Zr ceramic coatings and fibers and has wide application.

The invention discloses a organic silicon compound containing silicon-silicon bond, silicon-carbon bond, silicon-halogen bond and ceramics precursor poly carbon silicon alky synthesized under high pressure and with medium in supercritical fluid status which uses mixture of the aforementioned compound as raw material, uses solvent soluble of poly carbon silicon alky as supercritical fluid medium. Ceramics precursor poly carbon silicon alky with different molecular weight and different softening point can be obtained by controlling reaction condition of synthesis. The inventive method effectively improves uniformity of heat transfer and reaction, with short reaction time, high synthesis efficiency, high synthesis yield. The produced poly carbon silicon has a high molecular weight, high content of bonds of silicon and hydrogen and uniform distribution of molecular weight. The inventive method can be widely used in preparation of SiC fibre, SiC composite, heat resistant alloy with high strength, ceramic binder, SiC membrane, nano-wire, nano-pipe and nano-powder and so on.

The invention relates to a preparation method and application of a fluorescence enhancement type mercury ion probe, and particularly relates to preparation based on 2-(2-ethyleneoxy-4-dialkyl amino-benzylidene)-malononitrile and high-sensitivity detection applied to mercury ions. The fluorescent probe disclosed by the invention has the advantages of easiness and convenience for synthesis, moderate reaction condition, easiness for purification, high synthesis yield, better water solubility, higher selectivity and stability in optical property. According to the invention, the maximum absorption wavelength of a probe molecule in a PBS (Phosphate Buffer Solution) (pH=7.4) and DMSO (Dimethylsulfoxide) mixed solution (with the volume ratio of 95:5) is 446 nanometers, and the fluorescent light is very weak; the absorption wavelength is removed from 446 nanometers to 437 nanometers with the addition of the mercury ions; and the intensity of a fluorescence spectrum is continuously enhanced on a position with the wavelength of 486 nanometers, and the maximum enhancement is 90 times. The fluorescent probe molecule is very suitable for being applied to an organism and has important practical application value in the fields of biology, medical chemistry, environmental science, and the like.

The invention relates to a rhodamine fluorescent probe for detecting Fe <2+>, and a preparation method thereof. The preparation method comprises the following steps: enabling rhodamine 6G and hydrazine hydrate to perform reflux reaction in alcohol to generate rhodamine hydrazide, then enabling rhodamine hydrazide and 2,6-diacetylpyridine to perform reflux reaction in alcohol, and through neutral aluminium trioxide column chromatography purification, obtaining the rhodamine acylhydrazone and acetyl pyridine fluorescent probe. The fluorescent probe is high in synthesis productivity, quick in reaction and high in selectivity, has high specificity to Fe <2+>, can work under the physiological environmental condition with the pH value of 7.4, and has a prospect of being applied to bioluminescence imaging.

The invention relates to the field of medicinal chemistry, and discloses a method for preparing mangiferin aglycone. The method comprises that: step 1, 2-halogenate-4,5-dimethoxy benzoic acid and 1,3,5-trimethoxy benzene are subjected to Friedel-Crafts reaction, so a compound which has a structure in a formula IV is generated; step 2, the compound in the formula IV is selectively demethylated, and a compound which has the structure in the formula V is generated; step 3, the compound in the formula V is cyclized, and a compound which has the structure in the formula VI is generated; and step 4, the compound in the formula VI is completely demethylated, and mangiferin aglycone is generated. The method for preparing mangiferin aglycone improves the synthetic yield of the mangiferin aglycone, has the characteristics of cheap and easily-obtained raw materials, less synthetic steps, convenience in operation, easiness in control and high product purity, and can be widely applied in industrial production.

The invention discloses a water-soluble polymer oil displacement agent and a synthesis method thereof. The synthesis method comprises the following steps of: placing hydrophobic monomers, namely N-allyl morpholinium (AMPL) and alkylphenol ethoxylate (OP-10) into a beaker, adding a small amount of distilled water, stirring till a solution is transparent, and transferring into a three-mouth flask; mounting a nitrogen tube and a stirring device in the three-mouth flask, and adding the distilled water; adding acrylamide (AM) and acrylic acid (AA), and stirring till complete dissolution; regulating the pH value to 7 with 20% by weight of NaOH solution; and introducing N2, performing constant-temperature reaction for a period of time, adding ammonium persulfate ((NH4)2S2O8) and sodium hydrogen sulfite (NaHSO3), and reacting for 8h to obtain a corresponding polymer. The polymer oil displacement agent shows good viscosity-increasing property, temperature resistance, anti-salt property and anti-shearing property, and can effectively improve the simulation crude oil recovery rate by 10.4%.

The invention discloses a controllable synthesis method of a monoatomic catalyst with low cost and high loading capacity, the monoatomic catalyst prepared by a method takes graphite-phase carbon nitride as a substrate, has the characteristics of low cost, high metal element loading capacity, controllable content and adjustable variety, and meanwhile, the method can be used for preparing the single-metal single-atom catalyst and a multi-metal single-atom catalyst, the single-atom catalyst has excellent catalytic activity and stability, and by taking the silver single-atom catalyst as an example, the visible light hydrogen production rate of the silver single-atom catalyst is 6.2 times that of silver nanoparticle-loaded graphite-phase carbon nitride, and after 60-hour continuous photocatalytic hydrogen production test, the hydrogen production rate is almost unchanged.

Polypeptide linkers with defined tertiary structures, usually of defined alpha helical structure, are used to join two domains in a fusion protein. In one embodiment of the invention, a method is provided for the cell-free synthesis of the fusion protein.

The invention discloses an N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound of which the general formula is TDCA. The N-trisubstituted-1,2,3-thiadiazoles-5-formamidine target compound is obtained from an M compound through a cyclization reaction. The new synthetizing method is high in yield, catalysts are easy to prepare, the catalysts are low in cost, phosphoric waste water is less, and the multi-nitrogen heterocycle thiadiazoles-5-formamidine compound is environment-friendly. (As shown in the Description).

The present invention relates to a novel solid phase peptide synthesis method for Bivalirudin. This method contains following steps: serving Trityl Chloride Resin, 4-Methyltrityl Chloride Resin, 4-Methoxytrityl Chloride Resin, or 2-Cl Trityl Chloride Resin, or attaching of Wang Resin as a start raw material); according to general solid phase peptide synthesis rules, coupling protected amino acids after deprotection of Fmoc-protection group and then deprotecting side chain protection group; cleaving peptides from resin; and then obtaining crude Bivalirudin product. C18 high pressure liquid chromatography (HPLC) column is applied to purify the product of Bivalirudin. This method is suitable and effective for mass production, in addition to its features of high quality, low production cost, high synthetic yield, avoidance of usage of fatal toxic chemical such as HF, and less environmental pollution. The high yield rate of 99% is achieved for each synthetic step and total yield rate is 14%.

The invention relates to a method for preparing nano flyash zeolite. Flyash is used as a raw material in the method, and the method comprises the following steps of: firstly melting the flyash and sodium hydroxide at high temperature; mixing the molten flyash with concentrated seawater used as a solvent, stirring and aging to obtain silica-alumina gel; crystallizing the silica-alumina gel hydrothermally, and then washing with water to be neutral; and finally drying to obtain a powdery product. Based on the special aperture structure of zeolite, the synthesized zeolite can be applied to catalysis, adsorption, ion exchange and soil improvement. By using the flyash and the concentrated seawater which are both wastes, the method realizes the recycling of the flyash and the concentrated seawater and is a new environment-friendly production method which meets the requirement of sustainable development.