67results about How to "High synthetic yield" patented technology

The invention discloses a UDP-glycosyl transferase mutant, and belongs to the technical field of enzyme engineering and microbial engineering. Isoleucine at the 83th site and / or phenylalanine at the 285th site of UDP-glycosyltransferase with the amino acid sequence shown as SEQ ID NO: 1 is mutated, parallel mutant screening is performed, a mutant I83A / F285M with the highest yield of generated ginsenoside Rh1 is obtained, the yield is 92% and is increased by 5.1 times compared with WT, and the mutant has a great application prospect in industrial production of ginsenoside Rh1.

The invention provides hydroxyl silica gel and a preparation method thereof. The preparation method comprises the following steps: carrying out pre-drying treatment on hydroxyl-terminated polydimethylsiloxane; then adding a catalyst and a dialkoxy coupling agent into the treated raw material, heating under the protection of nitrogen, controlling the reaction temperature, and removing the temperature until a certain viscosity is reached; secondly, discharging nitrogen to vacuum, adding special amino silane, heating after adding the materials, preserving heat, stirring and reacting for several hours; and adding a reaction terminator after the reaction is finished, keeping the temperature for a certain time, and cooling to obtain the product. The hydrophilic amino silicon oil has the advantages of easily available synthesis raw materials, extremely low ring content and no solvent reaction, the response to low ring product requirements and low VOC (volatile organic compound) limitation of the current organic silicon material and the urgent demand of hydrophilic functional silicon oil is very matched, the synthesis process route is easy for industrial production, and the hydrophilic amino silicon oil product synthesized by the method is particularly smooth in hand feeling, fine and elastic, and has a good market prospect. The anti-yellowing agent is extremely low in yellowing property and can be commonly used in the fields of textile after-finishing auxiliaries, daily chemical care additives and the like.

The invention discloses epigallocatechin gallate starch nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicinal chemistry. According to the method, high-proportion branched-chain cassava starch is used as a raw material, ultrasonic microwave assistance is adopted, in the nanometer starch alcohol precipitation process, epigallocatechin gallate is synchronously packaged to form nanometer-level epigallocatechin gallate starch nanometer particles, and embedding of epigallocatechin gallate is completed. The embedding rate of the epigallocatechin gallate starch nanoparticles can reach 50.20%, the drug loading capacity can reach 311mg / g, the drug slow release performance is obvious in the process of simulating gastrointestinal digestion, the sustained release time can be 20 hours, the drug release capacity can reach 72.33% and 90.10% respectively, and the preparation process is simple, easy to operate, low in preparation cost and suitable for large-scale production and application.

The invention discloses a preparation method and application of a reactive flame retardant containing double DOPO groups and nitrogen heterocycles, and the preparation method of the reactive flame retardant comprises the following steps: adding an amino compound R-NH2 and terephthalaldehyde into a reactor with a stirring device, adding a solvent, adding an acid to adjust the pH value to 6, then heating until the solvent is refluxed, keeping the refluxing temperature to react for a period of time, and cooling to room temperature to obtain the reactive flame retardant containing double DOPO groups and nitrogen heterocycles. Reaction liquid containing an imine intermediate product is obtained; then adding DOPO, controlling the reaction temperature to be the solvent reflux temperature, and keeping the reflux temperature to react for a period of time; after the reaction is finished, cooling, carrying out suction filtration, washing and drying to obtain a reaction type flame retardant containing double DOPO groups and nitrogen heterocyclic rings; the reaction formula is as follows: # imgabs0 # amino compound R-NH2 is 4-aminopyridine or 3-aminopyrazole, namely R is pyridyl or pyrazolyl. The synthesis and purification method of the flame retardant is simple, the reaction yield is high, and the flame retardant effect of epoxy resin can be remarkably improved by adding the flame retardant into bisphenol A epoxy resin through modification.

The invention provides a phenazine-quinoxaline organic electrode material, and belongs to the technical field of aqueous zinc ion battery electrode materials, and the phenazine-quinoxaline organic electrode material is synthesized from 2, 3-diaminophenazine and 2, 5-dihydroxy-1, 4-benzophenone through a dehydration condensation reaction. The organic electrode material can be used for manufacturing a positive electrode of an aqueous zinc ion battery, and shows relatively high reversible specific capacity, relatively long cycle life, relatively good rate capability and relatively good wide temperature range performance. The invention also provides an application of the phenazine-quinoxaline organic electrode material in preparation of an aqueous zinc ion battery.

The invention is suitable for the technical field of organic chemical synthesis, and provides a novel condensed ring group macrocyclic aromatic hydrocarbon and a synthesis method thereof. The fused-ring-based macrocyclic aromatic hydrocarbon has the advantages of simple synthesis, easy purification and high synthesis yield, and different fused rings are hybridized in the same macrocyclic aromatic hydrocarbon skeleton at high yield through classic Friedel-Crafts acylation and Friedel-Crafts alkylation reactions. The condensed ring group macrocyclic aromatic hydrocarbon with diversified structures, good host-guest properties and high quantum yield luminescence is successfully obtained. In addition, the novel condensed ring group macrocyclic aromatic hydrocarbon and an electron-deficient object are co-crystallized in a solution or ground in a solid state to prepare a corresponding light-emitting charge transfer assembly, a new construction element is provided for developing supramolecular charge transfer co-crystals, and development of the field is promoted.

The invention provides a method for synthesizing semaglutide, wherein Fmoc-N(FMPB)-Gly-OtBu and HBTU react with a swollen AM Resin in the presence of an activator to obtain Fmoc-N(FMPB-AM Resin)-Gly-OtBu; Fmoc-Arg(Pbf)-OH and HOBT are added to a reaction system of a resin and a PIP / DMF solution, and reacted under DIC activation conditions until the ninhydrin test is negative; the above steps of removing Fmoc protection and coupling the corresponding amino acid or polypeptide fragment are repeated, and the peptide resin coupling is completed sequentially from the C-terminus to the N-terminus according to the semaglutide sequence, and the crude semaglutide is obtained by cleavage, filtration, precipitation, and drying. The method adopts the condensation of the modified Gly with the amino resin to obtain the resin, which can be successfully completed at a higher temperature, and the synthesis efficiency and synthesis yield are higher.

The invention relates to the field of preparation of molecular sieves, and discloses a preparation method of an all-silicon molecular sieve with an MFI topology structure, the all-silicon molecular sieve with the MFI topology structure and application of the all-silicon molecular sieve with the MFI topology structure, the method comprises the following steps: (1) mixing molecular sieve mother liquor, organic silicate ester, an organic template agent and alcohol to obtain a colloid mixture; the mass ratio of SiO2 in the molecular sieve mother liquor to the organic silicate ester based on SiO2 is (0.01-0.2): 1; the molar ratio of the alcohol to SiO2 in the molecular sieve mother liquor is (10-100): 1; (2) carrying out crystallization reaction on the colloid mixture; (3) carrying out solid-liquid separation on the crystallization product obtained in the step (2) to obtain a molecular sieve wet material and crystallization mother liquor; drying and roasting the molecular sieve wet material; and (4) optionally concentrating the crystallized mother liquor, and then returning to the step (1). The preparation method can effectively utilize the molecular sieve mother liquor, saves the cost, is beneficial to environmental protection, and is easy to operate.

The invention belongs to the technical field of catalysts, and particularly relates to a Cu-POM type catalyst and a preparation method and application thereof. The Cu-POM type catalyst provided by the invention is Anderson type polyoxometallate taking Cu as the center, and the Cu-POM type catalyst is prepared by connecting metal element copper with the polyoxometallate through the steps of oil bath, filtration, crystallization and the like. The Cu-POM prepared by the invention is used as a catalyst for esterification reaction, and has the advantages of low cost, simple synthesis conditions, low toxicity and the like; the catalyst is used for catalyzing ester synthesis, the yield is high, high catalytic efficiency can be achieved, the green and environment-friendly principle is met, meanwhile, Cu-POM has high stability and high activity, and multi-batch recycling can be achieved.

The present invention provides a method for synthesizing semaglutide. It includes coupling amino acids or peptides from the C-terminus to the N-terminus in sequence according to the amino acid sequence of semaglutide by a solid phase synthesis method to obtain a fully protected semaglutide resin, and semaglutide is obtained by cracking and purification; the peptide includes a dipeptide S20-S21 formed by the 20-21 amino acids, and the S20-S21 is R1-Lys(Fmoc)-Glu(OtBu)-OH, wherein R1 is Dde or ivDde, Fmoc is a side chain protecting group, and R1 is a main chain protecting group. The total yield of the crude semaglutide produced by the present invention reaches 57.07%, and the HPLC purity reaches 77.71%, which reduces the production of impurities, and the synthesis and purification process is simple, the selected materials are cheap and easy to obtain, the comprehensive production cost is low, and it is more conducive to industrial production.

The invention provides a synthetic method of semeglutide. The synthetic method comprises the following steps: reacting Fmoc-N (FMPB)-Gly-OtBu and HBTU with swelling AM Resin in the presence of an activating agent to prepare Fmoc-N (FMPB-AM Resin)-Gly-OtBu; adding Fmoc-Arg (Pbf)-OH and HOBT into a reaction system of the resin and the PIP / DMF solution, and reacting under the condition of DIC activation until ninhydrin is detected to be negative; and repeating the steps of removing Fmoc protection and coupling the corresponding amino acid or polypeptide fragment coupling, sequentially finishing peptide resin coupling from the C terminal to the N terminal according to the sequence of the semeglutide, and cracking, filtering, precipitating and drying to obtain a crude product of the semeglutide. According to the method, the modified Gly and the amino resin are condensed to obtain the resin, the method can be smoothly completed at a relatively high temperature, and the synthesis efficiency and the synthesis yield are relatively high.

The invention provides a synthetic method of methyl ethyl ketazine. According to the synthetic method, a nonionic surfactant is introduced into a traditional hydrogen peroxide method reaction system; the specific reaction system comprises raw materials, a catalyst, an oxidizing agent and an auxiliary agent, wherein the raw materials comprise butanone and ammonia water, the oxidizing agent is hydrogen peroxide, the catalyst is an amide compound, the auxiliary agent is a nonionic surfactant, and preferably, EDTA disodium can be introduced into the hydrogen peroxide. By introducing the auxiliary agent to modulate the reaction system environment, the effective contact area between the reaction materials can be greatly increased, the synthesis reaction is ensured to be more uniform and rapid, the reaction temperature for synthesizing the methyl ethyl ketazine can be reduced, the energy consumption is reduced, and the effects of improving the reaction efficiency and the yield of the methyl ethyl ketazine are also achieved.

The application provides a method for synthesizing N,N-diethyl-2-hydroxyphenylacetamide and analogues thereof, and a reaction route of the method is as follows: the method comprises the following steps: 1) reacting a compound of formula (III) with a compound of formula (IV) in a solvent A under the action of a condensing agent and a base for a certain time to obtain a reaction solution containing a compound of formula (II); 2) adding a reducing agent to the reaction solution containing the compound of formula (II) obtained in step 1), and reacting for a certain time; the reaction is monitored, and after the reaction is completed, the solvent is spun dry, separated and dried to obtain a crude product of the compound of formula (I); 3) purifying the crude product obtained in step 2) to obtain a pure product of the compound of formula (I); wherein R1 and R2 are independently hydrogen, an alkyl group or an aryl group; and A is a substituted or unsubstituted aryl group or a heteroaryl group.

The invention discloses a method for constructing a C (sp3)-C (sp3) bond in a light-mediated non-catalytic manner, and belongs to the technical field of organic photosynthesis. The method comprises the following steps: under the protection of inert gas, irradiating a reaction tube under a 427 nm light source for 4-20 hours by taking a p-toluenesulfonyl hydrazone derivative 1 and non-activated alkane or ether 2 as raw materials in the presence of alkali and an organic solvent, and separating and purifying to obtain a C (sp3)-C (sp3) bond coupling compound 3; the key of the reaction is that a singlet carbene intermediate is generated through photolysis by slowly releasing a donor / donor heavy nitrogen compound, and then the singlet carbene intermediate is selectively inserted into a C-H bond of alkane or ether through a transition state of a three-membered ring; the reaction system has the advantages of cheap and easily available raw materials, simple operation, greenness and environmental protection, and provides a green, efficient and easily operated synthesis strategy for realizing the construction of the C (sp3)-C (sp3) bond. Meanwhile, the method can also be applied to gram-level synthesis and later modification of drug molecules, and shows good practicability.

The present invention provides a production method and a germanium hydride preparation system for germanium hydride. The method of the present invention is used to prepare germanium hydride, which can improve the yield of germanium hydride and is suitable for large-scale industrial production of germanium hydride. The production method comprises the following steps: (1) grinding a first portion of ammonium halide in a first grinder and purging it with hot nitrogen, then adding the magnesium germanide into the first grinder, continuing grinding and mixing to obtain material A; grinding a second portion of ammonium halide in a second grinder and purging it with hot nitrogen to obtain material B; (2) adding the material B into a reactor and mixing it with the solvent, then adding the material A into the reactor, and reacting to obtain a crude germanium hydride product; (3) refining the crude germanium hydride product to obtain a germanium hydride product.

The invention discloses a synthesis method of a trifluoromethanesulfonate radical promoted amidino nickel complex. The preparation method comprises the following steps: reacting N, N '-dialkyl substituted amidino alkali metal salt with a nickel precursor, adding trifluoromethanesulfonate as an accelerant, and regulating the reaction rate and selectivity by utilizing the coordination effect of trifluoromethanesulfonate so as to efficiently prepare the amidino nickel complex. In the process, an ether compound is used as a solvent, the reaction is carried out at 0-70 DEG C for 1-48 hours, the reaction yield can reach 90% at most, and the product purity is gt; and 98%. The method has the characteristics of easily available raw materials, simplicity and convenience in operation, mild reaction conditions, good target product selectivity, high synthesis efficiency, convenience in post-treatment and the like, and has industrial application prospects.

The invention provides a bimetallic particle modified g-C3N4 photocatalyst and a preparation method thereof, and application in photocatalytic cellulose-based biomass reforming hydrogen production. The photocatalyst comprises a g-C3N4 carrier and bimetallic particles loaded on the g-C3N4 carrier, the bimetallic particles are one of Au-Pt, Ag-Pt or Au-Pd, and the bimetallic particles are of a core-shell structure, with Au or Ag crystals as cores and Pt or Pd atomic clusters as shells. The invention first prepares g-C3N4, and uses a one-step photodeposition method in a lignocellulose-based biomass alkaline solution to prepare bimetallic nanoparticles of the core-shell structure, the bimetallic nanoparticles are modified on the g-C3N4, the active metals are highly dispersed on the core surface, the exposed active area is larger, the activity is higher, the bimetallic synergistic effect is more significant, the capture efficiency of photogenerated electrons and the intrinsic catalytic activity of hydrogen production are greatly improved, and the efficiency of photocatalytic cellulose-based biomass reforming hydrogen production can be greatly improved.

The invention discloses a polypeptide compound as well as a preparation method and application thereof. The amino acid sequences of the polypeptide compound are as shown in SEQ ID NO.1-9. The polypeptide GN and the analogue GN11 thereof show a remarkable renal fibrosis resisting effect at in-vivo and in-vitro levels. The analogue disclosed by the invention is low in dosage, free from obvious toxic and side effects, low in production cost and relatively high in generalizability, and can be used for preventing or treating chronic kidney diseases and related inflammation and fibrosis diseases induced by the chronic kidney diseases.

The invention provides a 4-methylpyridine diterminated benzene diimide and hexafluorosilicate eutectic supramolecule as well as a preparation method and application thereof, and belongs to the technical field of p-phenylenediamine fluorescence detection. The preparation method comprises the following steps: mixing 4-methylpyridine diterminated benzene diimide and hexafluorosilicate in a mixed solvent, and then carrying out solvothermal reaction to obtain the 4-methylpyridine diterminated benzene diimide and hexafluorosilicate eutectic supramolecule. The 4-methylpyridine two-end group benzene diimide and hexafluorosilicate eutectic supramolecule encounters p-phenylenediamine molecules, p-phenylenediamine and benzene diimide generate hydrogen-bond interaction under the synergistic effect of hexafluorosilicate, the characteristic of quenching benzene diimide fluorescence is achieved, and the eutectic supramolecule can be used as a fluorescence detection p-phenylenediamine reagent, can be used for fluorescence detection of p-phenylenediamine, can be used for fluorescence detection of p-phenylenediamine, and can be used for fluorescence detection of p-phenylenediamine. The operation is simple and the detection effect is good.

The invention provides a homogeneous metallocene catalyst preparation system and method. The system comprises a homogeneous metallocene catalyst synthesis unit, a solvent condensation and collection unit and a gas purification unit, the homogeneous metallocene catalyst synthesis unit comprises a fluidized bed reactor; the solvent condensation and collection unit comprises a condenser; and the gas purification unit comprises a fluidized bed gas purifier. The method comprises the following steps: adding a solid metallocene ligand and a solvent into a fluidized bed reactor, introducing protective gas, and spraying a metal ion solution to generate a homogeneous metallocene catalyst; the protective gas entraining the solvent enters a condenser for condensation; and then the protective gas enters a fluidized bed gas purifier to be purified. The synthesis of the homogeneous metallocene catalyst and the purification of the gas are completed by adopting the double fluidized beds, the content of water and oxygen in the atmosphere in the reaction process of the metallocene ligand and the metal ions is reduced, and the conversion rate of the active center in the reaction process is improved.

The invention relates to the technical field of catalytic organic synthesis, in particular to calix [4] arene cyclohexanediamine derivatives and a method for green catalysis of asymmetric Aldol reaction by the calix [4] arene cyclohexanediamine derivatives. The method comprises the following steps: by taking aromatic aldehyde and cyclic ketone as raw materials, calix [4] arene cyclohexanediamine derivative as a phase transfer catalyst, p-nitrobenzoic acid as an additive and water as a solvent, reacting at 25 DEG C for 24-48 hours, adding dichloromethane after the reaction is finished, extracting and separating to obtain an organic phase, drying by using anhydrous Na2SO4, and separating and purifying by column chromatography to obtain an Aldol product. The calix [4] arene cyclohexanediamine derivative is mild in synthesis process condition and high in catalytic reaction efficiency, asymmetric Aldol reaction catalyzed by the calix [4] arene cyclohexanediamine derivative takes water as a solvent, the calix [4] arene cyclohexanediamine derivative is green and environment-friendly, good dr value and ee value can be obtained through catalytic reaction at room temperature, and the calix [4] arene cyclohexanediamine derivative has a wide application prospect.

According to the high-quality geranyl acetone composition provided by the invention, when the geranyl acetone composition provided by the invention is used as a raw material for synthesizing nerolidol, the yield of a product can be improved, and the composition has high-quality aroma and antibacterial characteristics. The composition mainly comprises two isomers of (E) and (Z)-geranyl acetone, four main components of hydrogenated geranyl acetone and alpha, gamma-unsaturated dienone and other impurities, the sum of the mass contents of the isomers of (E) and (Z)-geranyl acetone is larger than 98%, and the mass content ratio of (E)-geranyl acetone to (Z)-geranyl acetone meets the condition that (E) / (Z) is larger than or equal to 1.15 and smaller than or equal to 1.75. The mass content of hydrogenated geranyl acetone is less than 0.5%, and the mass content of alpha, gamma-unsaturated dienone is less than 0.1%. The fragrance characteristic of the composition is purer, and the composition has higher application value.

The application discloses a green preparation method of 4,4'-difluorobenzophenone. The method uses 4,4'-difluorobenzene as raw material, potassium bromide as catalyst, acetic acid as solvent, and oxygen as oxidant, and 4,4'-difluorobenzophenone is generated in high selectivity through one-step oxidation under mild conditions. The application surprisingly finds that in the presence of potassium bromide, a new non-metallic catalytic oxidation system of potassium bromide / acetic acid / oxygen is used to realize high-efficiency and high-selectivity conversion of the C-H bond at the benzyl position. Compared with the traditional method, the application does not need to use a transition metal catalyst, does not need to use carbon tetrachloride and other materials damaging the ozone layer, and does not need to involve a dangerous intermediate such as a diazonium salt, the process route is short, the atomic economy is high, the product yield is high, the product purity is high, the catalyst is cheap and easy to obtain, and the application has excellent industrial application prospect and green chemistry characteristics.

The invention belongs to the technical field of organic chemical synthesis, and relates to a method for recycling a compound, in particular to a method for recycling 2, 6-dichloroacetophenone. The invention relates to a method for recycling 2, 6-dichloroacetophenone, which comprises the following steps: taking waste containing 2, 6-dichloroacetophenone as a raw material, and reacting in the presence of a catalyst and inorganic alkali to generate m-dichlorobenzene. According to the method, the dichloroacetophenone waste is used as the raw material to recover the m-dichlorobenzene serving as the dichloroacetophenone synthesis raw material, equipment required by the process is conventional equipment, other solvents are not involved in the reaction, normal-pressure reaction is adopted in the process, the reaction temperature is lower, the process path is shorter, the operation is simple, the safety is high, waste resources are recycled, and the method is suitable for industrial production. The environmental pollution is effectively reduced, and the raw material consumption of the dichloroacetophenone production process is remarkably reduced.

This invention discloses a floating catalyst and its application in the synthesis of p-hydroxyphenylhydantoin. Copper and manganese co-doped nano-TiO2 hydrosol is loaded onto fly ash cenospheres to form a gel. The dried gel is sintered at 600-700℃ to obtain a floating catalyst with fly ash cenospheres as the support. Its chemical composition is: SO42- 2‑ / TiO2-CuO-Mn2O3 / fly ash cenospheres; its mass composition is: TiO2-CuO-Mn2O3 / 2 25%‑30%, CuO3%‑10%, Mn2O 3 6%–20%, S 0.02%–0.1%, fly ash cenospheres 50%–60%; its specific gravity is 0.6–0.90 g / cm³. 3 Specific surface area is 10-50 m² 2 / g; possesses solid superacid properties with an acid strength H0 ≤ -14.5; dissolves in acidic solvents to generate trace amounts of copper and manganese ions. The catalyst of this invention can float on the surface of aqueous solutions, solving the problem of separating solid catalysts from insoluble p-hydroxybenzylhydantoin products; it catalyzes the synthesis of p-hydroxybenzylhydantoin via two pathways, achieving a product molar yield of 68%-72%; it possesses photocatalytic functionality, allowing for the regeneration of catalysts that have lost surface catalytic activity; and it reduces the generation of organic pollutants at the source.

This invention discloses a one-pot method for preparing amidine-lanthanum complexes. Specifically, the lanthanum salt first reacts with an ether compound; the product, without separation, is then directly reacted with an N,N'-dialkyl-substituted amidine alkali metal salt to prepare the amidine-lanthanum complex in a one-pot process. The reaction yield can reach up to 90%, and the product purity is >98%. This invention features readily available raw materials, simple operation, mild reaction conditions, good selectivity for the target product, high synthesis efficiency, and convenient post-processing, making it promising for industrial applications.

The invention discloses a Standberg type polyoxometallate-based organic-inorganic compound for catalytic oxidation desulfurization as well as a synthesis method and application of the Standberg type polyoxometallate-based organic-inorganic compound. The molecular formula of the Standberg type polyoxometallate-based organic-inorganic compound is [Zn (H2datrz) 2 (P2Mo5O23) (H2O) 2]. 11H2O. The synthesis method comprises the following steps: step 1, mixing zinc acetate, 3, 5-diamino-1, 2, 4-triazole, sodium molybdate and deionized water to a homogeneous phase; the molar ratio of the zinc acetate to the deionized water is 1: 173, the molar ratio of the 3, 5-diamino-1, 2, 4-triazole to the sodium molybdate is 1: 1, and the molar ratio of the 3, 5-diamino-1, 2, 4-triazole to the zinc acetate is 4: 3; 2, adjusting the pH value to 2.5-3, stirring, heating, and carrying out hot filtration; and 3, standing the filtrate at room temperature for one week to obtain a product. The method has the characteristics of low cost, high yield and high catalytic efficiency.

This invention belongs to the field of enzymatic synthesis technology, specifically relating to a method for enzymatically synthesizing fucosylated novo-LNO series human milk oligosaccharide chains, comprising the following steps: using sialic acid-protected asymmetric branched oligosaccharide I as a substrate, firstly, fucosylation modification of the C3 branch site of the glycan chain is achieved through a fucosylation enzyme module; subsequently, galactose is introduced at the C6 branch end using a galactosylation enzyme module; finally, the sialic acid protecting group is removed by sialyl glycosidase to obtain the monofucosylated target product. By introducing sialic acid as a temporary protecting group into the asymmetric branched oligosaccharide I, the recognition of the reducing lactose and the internal LacNAc unit by fucosyltransferase is blocked, thereby selectively introducing fucose onto the non-reducing LacNAc / LNB unit, accurately constructing the branched structure.

The invention discloses a grinding aid for producing a regenerated composite admixture by using construction wastes and a preparation method of the grinding aid. The grinding aid is prepared from the following raw materials in percentage by mass: 10%-20% of modified triethanolamine mother liquor, 1%-5% of diethylene glycol, 1%-5% of sodium chlorate sulfate, 1%-5% of diethanolisopropanolamine, 1%-5% of calcium lignosulphonate and the balance of water. According to the scheme, the regenerated composite admixture has the advantages of simple preparation, reliable performance and the like, and has very high practical value and popularization value in the technical field of regenerated composite admixture production.

The invention relates to a monomer for a thermal crosslinking type high-temperature-resistant polyimide film material, the polyimide film material and a preparation method of the polyimide film material. The diamine monomer is 6-(2, 3, 5, 6-tetrafluoro-4-vinyl phenoxy) pyrimidine-2, 4-diamine, and the solvent is a solvent. The preparation method comprises the following steps: copolymerizing a monomer with other diamine monomers and dianhydride monomers to prepare polyimide, introducing a tetrafluorostyrene structure on a polyimide main chain, and thus preparing the thermal crosslinking type high-temperature-resistant polyimide film. Through thermal crosslinking of vinyl and large-volume side groups, polyimide is endowed with the advantage of high temperature resistance and improvement of mechanical properties. According to the polyimide film material prepared by the invention, the temperature of 5% of mass loss at high temperature obtained by a thermogravimetric analyzer is 500-524 DEG C, the glass-transition temperature obtained by testing of a differential scanning calorimeter is 274-295 DEG C, and the technical requirements of a flexible substrate on a high-temperature-resistant PI material can be met.