2 results about "Bivalirudin" patented technology

The invention belongs to the technical field of biological medicine, and particularly relates to a preparation method and application of ginseng polypeptide. The ginseng active polypeptide is prepared by carrying out enzymolysis reaction on ginseng protein. The ginseng active polypeptide can effectively inhibit the activity of thrombin, so that the ginseng active polypeptide can be used as a thrombosis inhibitor to treat cardiovascular and cerebrovascular diseases such as myocardial infarction and ischemic stroke. The plant extract disclosed by the invention not only has an antithrombotic effect, but also has the advantages of no toxicity, no side effect, simplicity in preparation, easiness in absorption and the like, and the adverse effects of side effects of traditional chemical medicines such as bivalirudin and other thrombus inhibitors on human bodies are avoided.

This invention discloses a method for preparing a bioprosthetic valve with synergistic anticoagulant and antioxidant functions, comprising: Step 1, immersing a decellularized bioprosthetic valve matrix in a buffer solution containing carbodiimide, N-hydroxysuccinimide, and tyramine; Step 2, immersing the tyramine-grafted bioprosthetic valve matrix obtained in Step 1 in a solution containing the direct thrombin inhibitor bivalirudin; subsequently adding tyrosine oxidase for catalytic reaction; Step 3, immersing the bivalirudin-immobilized bioprosthetic valve obtained in Step 2 in a cerium nitrate solution for reaction; adjusting the pH to an alkaline environment to form cerium oxide nanoparticles in situ. This invention also provides a bioprosthetic valve with synergistic anticoagulant and antioxidant functions. This invention simultaneously enhances the mechanical properties of the matrix and constructs a bioactive interface in a single reaction step. The method is simple and efficient. It also exhibits synergistic anticoagulant effects, multifunctional integration, and long-term stability.