97results about How to "Reaction temperature" patented technology

The invention provides a synthetic method of rosuvastatin calcium, which is characterized in that a compound 6 and branched chain react under the action of 2,2,6,6,-tetramethylpiperidine and n-butyl lithium to generate a compound 7, the reaction temperature is increased to minus 30 DEG C and the aspects such as reaction solvent and reaction reagent are improved so that the total reaction route has the advantages of mild condition, low device requirement and suitability for industrial production. Meanwhile, another improved synthetic route of rosuvastatin calcium comprises the following steps: converting esters into acids, synthesizing esters again, and synthesizing the rosuvastatin calcium. The rosuvastatin calcium purity is as high as 99.8%.

The invention relates to a motor temperature detection technique and discloses a method of detecting the temperature of the winding of a motor. The objective of the invention is to solve the problem of low temperature accuracy of a method in the prior art according to which a temperature sensor is adopted detect the temperature of a motor in an apparatus comprising the motor. The method of the invention includes the following steps that: at least one change rate in an apparatus comprising the motor is determined, wherein the at least one change rate includes a magnetic flux change rate and / or a resistance change rate corresponding to the motor; and the operating temperature of the motor is determined based on the at least one change rate. In addition, the present invention is provided with an apparatus comprising a motor. According to the method for detecting the temperature of the winding of the motor and the apparatus comprising the motor of the invention, the temperature of the interior of the motor is determined according to the magnetic flux change rate and the resistance change rate, and a test result is more accurate relative to a test result obtained through the temperature sensor; and since the temperature sensor is not required to be adopted, the cost of the apparatus comprising the motor is decreased.

The invention belongs to the technical field of polypeptide medicament preparation methods, and in particular relates to a preparation method for bivalirudin. The preparation method for the bivalirudin comprises solid phase polypeptide synthesis for preparing bivalirudin resin, acid hydrolysis of the bivalirudin resin to obtain a crude bivalirudin product, and purification of the crude bivalirudin product to obtain a purified bivalirudin product, wherein the solid phase polypeptide synthesis for preparing the bivalirudin resin comprises the following steps of: sequentially connecting corresponding Fmoc- protected amino acids in the following sequences to Fmoc-Leu-carrier resin by a solid phase coupling synthesis method: R1-D-Phe-Pro-Arg(Pbf)-Pro-X-Asn(R2)-Gly-Asp(OtBu)-, Phe-Glu(OtBu)-Glu(OtBu)-Ile-Pro-Glu(OtBu)-Glu(OtBu)- and Tyr(tBu)-Leu-resin, and thus obtaining the bivalirudin resin; and when the X fragment is connected, only one times of solid phase coupling synthesis reaction is used, and the corresponding Fmoc- protected amino acid is Fmoc-Gly-Gly-Gly-Gly-OH. The purity of the bivalirudin is more than 99.5 percent, and the single impurity is less than 0.2 percent.

The invention belongs to the technical field of preparation methods for polypeptide medicines, and particularly relates to a method for preparing bivalirudin. The method for preparing the bivalirudin comprises the following steps of: preparing a bivalirudin resin by a solid phase polypeptide synthesis method, performing acidolysis on the bivalirudin resin to obtain a bivalirudin crude product, and purifying the bivalirudin crude product to obtain a bivalirudin pure product, wherein the step of preparing the bivalirudin resin by the solid phase polypeptide synthesis method comprises the following substeps of: sequentially accessing the corresponding protection amino acid or fragments on an Fmoc-Leu-carrier resin by a solid phase coupling and synthesis method to obtain the bivalirudin resin, wherein the corresponding protection amino acid or fragments have the following sequences: R1-D-Phe-Pro-X-Y-Phe-Glu(OtBu)-Glu(OtBu)-Ile-Pro-Glu(OtBu)-Glu(OtBu)-Tyr(tBu)-Leu-resin, R1 is Fmoc, Boc or H; X is Arg(Pbf)-Pro; Y is Gly-Gly-Gly-Asn(R2)-Gly-Asp-(OtBu); and R2 is Trt or H. The purity of the product can reach above 99.5 percent.

The invention relates to a preparation method for a Fe3O4 / SiO2 nanometer particle containing multiple magnetism cores, which comprises (1) dissolving Fe3O4, cetyltrimethyl ammonium (CTAB) and tetraethyl orthosilicate (TEOS) in solvent, obtaining mixed solution after ultrasonic processing, then adding polyvinylpyrrolidone powder, and evenly stirring to achieve spinning solution; (2) using the spinning osolution to perform electrostatic spinning to obtain nanometer fiber; and (3) placing the nanometer fiber in ethanol water, and forcefully stirring at the temperature of 20 DEG C to 40 DEG C to achieve the Fe3O4 / SiO2 nanometer particle containing the multiple magnetism core. The preparation method is convenient in operation, moderate in reaction condition, low in cost of raw materials, easy in obtaining the raw materials, free of poison and pollution and good in biocompatibility. The Fe3O4 / SiO2 nanometer particle contains multiple magnetism cores, has excellent magnetic property, is uniform in particle diameter, regular in shape, high in chemical stability and has the advantages of a general nanometer particle.

The invention discloses an organic silicon polymer super-hydrophobic textile finishing agent. The organic silicon polymer super-hydrophobic textile finishing agent is prepared by adding organic silicon and organic silane into an alkaline alcohol-water solution and carrying out hydrolytic condensation. The organic silicon polymer super-hydrophobic textile finishing agent contains a hydrophobic group and a coupling group; and in dip-coating and high-temperature curing processes, the coupling group can be chemically bonded with fibers of a textile and the hydrophobic group has a super-hydrophobiceffect. The textile is dipped and coated in an organic silicon textile finishing agent solution which is diluted for 5 to 10 times for 2 to 10min and then is cured at 80 to 180 DEG C for 2 to 10min to obtain the super-hydrophobic textile. The super-hydrophobic textile disclosed by the invention has the advantages of excellent super-hydrophobic performance, washing resistance and the like and canbe used for constructing various super-hydrophobic textiles; and the textile does not need to be pre-treated, so that a preparation technology is extremely simplified, and properties including intrinsic mechanical strength, flexibility, luster, hand feeling and the like are kept.

The invention provides a production process for preparing dichloropropanol by reactive distillation of glycerol. The production process comprises the following steps: the raw material glycerol containing a homogeneous catalyst is sent to a reactive rectification tower from the top after heat exchange, hydrogen chloride gas enters from the lower part of a rectification section of the tubular reactive rectification tower, and the raw material glycerol and countercurrent flow of the hydrogen chloride gas are subject to absorption and chlorination reaction by a packing layer at the temperature of 90-120 DEG C and the temperature of 0.001-0.1MPa (absolute pressure) and are rectified; omonochloropropylene glycol at the bottom of the tubular reactive rectification tower, glycerol and glycerol oligomer are sent to a heavy constituent separation tower for decompressing and recovering the monochloropropylene glycol and the glycerol is returned to the raw material glycerol; and product gas on the top of tubular reactive rectification tower is cooled by a heat exchanger to obtain the dichloropropanol which is sent to a cyclization working procedure, and tail gas is further washed with lye, and is discharged from by a vacuum pump.

The invention relates to a method for catalytically synthesizing paraethyl phenol, which is characterized by taking diethyl carbonate and phenol as the raw materials and taking the modified microporous molecular sieve MCM-22, ZSM-5 or HY as a catalyst to carry out catalytic reaction under the following conditions: the reaction temperature is 200-350 DEG C, the mole ratio of diethyl carbonate to phenol is 1:2-2:1 and the mass space velocity is 1-12h<-1>. By the method, good raw material conversion rate and target product selectivity can be obtained. Under the best conditions, the conversion rate of phenol can reach 100% and the selectivity of paraethyl phenol can reach 82.2%. The method in which the modified microporous molecular sieve MCM-22, ZSM-5 or HY is taken as the catalyst and diethyl carbonate is taken as the alkylating agent to react with phenol to catalytically synthesize paraethyl phenol has the advantages of high raw material activity, mild reaction conditions, simple process, convenient product separation, good selectivity of the target product paraethyl phenol, etc.

The invention provides a method for treating dye waste water. The dye waste water subjected to catalytic oxidation in advance is subjected to anaerobic-aerobic treatment, and then the waste water subjected to anaerobic-aerobic treatment is subjected to activated carbon adsorption and then drained out. Due to the fact that the dye waste water has the characteristics of being high in salt content and COD concentration, part of COD loads are reduced by carrying out catalytic oxidation at the front end in advance, sanitary sewage diluting and anaerobic-aerobic treatment are carried in the middle to reduce COD of the waste water, meanwhile, the salt content is reduced, the anaerobic-aerobic biochemical process can be carried out, activated carbon adsorption is conducted, and sewage water treatment is completed. The method is simple, moderate in reaction condition, high in speed and easy to operate, and a catalyst adopted during pretreatment can be recycled. During the reaction, acidic conditions are not needed, the pH value does not need to be adjusted, and consumption of a large amount of acid is avoided. The treatment process is short, and treatment efficiency is high.

The invention belongs to the field of environmental water pollution abatement, and discloses a ZnIn2S4 nanosheet coated beta-Bi2O3 core-shell heterogeneous compound photocatalyst, as well as a preparation method and application thereof. According to the method, the ZnIn2S4 nanosheet coated beta-Bi2O3 core-shell heterogeneous compound photocatalyst is prepared by using ZnIn2S4 and synthetic beta-Bi2O3 monomer as raw materials through a simple self-aggregation effect. The binary ZnIn2S4 / beta-Bi2O3 compound nano-photocatalyst can be applied to catalytic degradation of tetracycline hydrochloride and methyl orange under visible light, shows excellent photo-induced electron separation efficiency, and can be used for improving the visible light utilization and integral photocatalytic activity. The ZnIn2S4 nanosheet coated beta-Bi2O3 core-shell heterogeneous compound photocatalyst is prepared from nontoxic raw materials, has simple operation and mild reaction condition, accords with the concept of environment-friendly chemistry, and has a wide application prospect in the aspect of solving water environmental pollution.

The invention discloses an octahedral metal oxide composite material and preparation and application thereof. The octahedral metal oxide composite material is formed by roasting a ZnSn(OH)6 octahedron of 1-6 micrometers and composed of a Zn2SnO4 / SnO2 octahedron. The preparation method comprises the steps that, a mixed aqueous solution of zinc salt and citric acid is added to an aqueous solution of tin tetrachloride, stirring and mixing are conducted to be uniform, a NaOH solution with appropriate concentration is added, a vigorous stirring reaction is conducted for 4-6 h at 10-90 DEG C, centrifugating, washing and drying are conducted, and the ZnSn(OH)6 octahedron with the size ranging from 1 micrometer to 6 micrometers is obtained; the octahedron is put in an air atmosphere at the temperature of 550-750 DEG C, roasting treatment is conducted for 2-6 h, and white solid powder is obtained. According to the octahedral metal oxide composite material and preparation and application thereof, the ZnSn(OH)6 octahedron material is prepared through a coprecipitation method, the reaction condition is mild, operation is easy, the cost is low, environmental friendliness is achieved, the obtained product is uniform in size, dispersion is good, the yield is high, and excellent selectivity on VOCs gases of methanal and the like is achieved.

The invention provides a method for whole-cell catalytic synthesis of 1-hydroxy-2-butanone and belongs to the technical field of bioengineering. A mutant library is constructed by fixed-point saturated mutation of formaldehyde lyase 482 amino acid, and an engineering strain containing formaldehyde lyase (FLS) is obtained by screening. Whole-cell catalytic synthesis of the 1-hydroxy-2-butanone is realized with the strain as whole cells and formaldehyde and n-propanal as raw materials. The strain can produce the 1-hydroxy-2-butanone from one molecule of formaldehyde and one molecule of propionaldehyde under the action of the FLS. The method can finish synthesis of the 1-hydroxy-2-butanone in only one step, the reaction condition is mild, the raw materials are wide and easy to obtain, and thecost is low.

The invention relates to an application of prussian blue nanoparticles in preparation of drugs for preventing, delaying or treating nervous system degenerative diseases. Researches find that the prussian blue nanoparticles have remarkable effects in the aspects of preventing, delaying or treating nervous system degenerative diseases. Cell level test results show that the prussian blue nanoparticles can reduce the ROS level in nerve cells stimulated by hydrogen peroxide and increase the proportion of living cells in the nerve cells stimulated by hydrogen peroxide; and animal level test resultsshow that the prussian blue nanoparticles can significantly reduce the expression level of oxidative stress markers in hippocampus of nervous system degenerative disease model mice, significantly improve the learning and memory ability of nervous system degenerative disease model mice, and improve dyskinesia. The preparation process of the prussian blue nanoparticles is simple, the macro production is easy, the reaction condition is mild, and the surface modification is easy.

The invention relates to a preparation method of 2,4-diethyl thioxanthone. The preparation method of the 2,4-diethyl thioxanthone is characterized by finally obtaining a product, i.e. the 2,4-diethyl thioxanthone, through the processes of condensation, extraction, washing, caustic washing, distillation, dissolution and crystallization, centrifugation, drying, and the like by taking o-diethylbenzene and dithio-salicylic acid as main raw materials and sulphuric acid, toluene, sodium carbonate, methanol, and the like as auxiliary raw materials. The preparation method of the 2,4-diethyl thioxanthone, which is disclosed by the invention, has the advantages of higher yield reaching 85 percent through experimental determination, little acid pollution, easy aftertreatment, moderate reaction condition and capability of reducing the energy consumption because the distillation is not needed by the aftertreatment of the product.

The invention belongs to the field of preparation of inorganic nano composite materials and environment governance, and particularly discloses a preparation method of binary 2D / 2D CdIn2S4 / BiOCl nano composite photocatalyst with visible light activity. The preparation method adopts BiOCl nanosheets as a precursor and uses cadmium nitrate tetrahydrate, indium nitrate hydrate and thioacetamide as rawmaterials to prepare the BiOCl nanosheet-loaded CdIn2S4 nanosheet composite photocatalyst of different ratios by adopting a single one-step hydrothermal method. The 2D / 2D CdIn2S4 / BiOCl nano compositephotocatalyst with a unique structure can be used for degrading the dye methyl orange under the visible light, and has the advantages that the preparation raw material is environment-friendly, the method is simple, the hybridization reaction condition is mild, the period is short, the cost is low and the like. The CdIn2S4 / BiOCl nano photocatalyst is a novel composite visible photocatalyst; and due to the unique surface-surface heterogeneous structure, the photocatalytic degradation activity is excellent, and the application prospect in the aspect of treating the dye waste water is important.

The invention discloses a preparation method of cis-hexahydroisoindoline, which comprises the following steps: enabling maleic anhydride and 1,3-butadiene, which are used as raw materials, to be subjected to Diels-Alder reaction to obtain cis-1,2,3,6-tetrahydrophthalic anhydride (I); carrying out Pb / C hydrogenation on the product I to obtain cis-cyclohexanedicarboxylic anhydride (II); reacting the product II with carbamide to obtain cis-hexahydrophthalimide (III); and reducing the product III with lithium aluminum hydride in anhydrous tetrahydrofuran to obtain the target product cis-hexahydroisoindoline. The Mitiglinide calcium preparation method disclosed by the invention can save the raw material cis-hexahydroisoindoline, and has high chiral degree of separation.

The invention discloses titanium dioxide / baffeta with super-hydrophobic and self-cleaning functions. The titanium dioxide / baffeta is prepared by the steps of in-situ generating nanometer TiO2 particles in the baffeta, and cladding the TiO2 particles in the middle of BSA to obtain BSA / TiO2 / BSA modified baffeta; then soaking the BSA / TiO2 / BSA modified baffeta into a fluoroalkyl silane ethanol solution with the volume fraction being 1 to 10 percent for 1 to 24h, and after finishing reaction, repeatedly cleaning through deionized water, and vacuum drying to obtain the titanium dioxide / baffeta withthe super-hydrophobic and self-cleaning functions. A preparation method provided by the invention has the advantages of simplicity in operation, moderate reaction conditions and the like; the baffetahas an excellent super-hydrophobic performance, an excellent self-cleaning performance, an excellent anti-microbial performance, an excellent uvioresistant performance, an excellent photocatalysis performance, an excellent anti-wrinkle performance and excellent washing resistance.

The present invention discloses a difluoropropargyl-containing compound, a preparation method and applications. The preparation method comprises that in the presence of an organic solvent, a catalyst, a ligand and an alkali, a compound A and a compound B are subjected to a coupling reaction to obtain a compound C, wherein the catalyst is one or a plurality of materials selected from palladium acetate, palladium trifluoroacetate, tetrakis(triphenylphosphine)palladium, tris(dibenzylideneacetone)dipalladium chloroform adduct, and tris(dibenzylideneacetone)dipalladium, and the ligand is one or a plurality of materials selected from triphenylphosphine, tris(o-methoxyphenyl)phosphine, tris(o-methylphenyl)phosphine, tri-tert-butylphosphine fluoroborate, 2-(dicyclohexylphosphino)-2'-methylbiphenyl, 2-(di-tert-butylphosphino)biphenyl, and 4,5-bisdiphenylphosphino-9,9-dimethyl xanthene. According to the present invention, the method has characteristics of low catalyst consumption, mild reaction condition, high region selectivity, wide application range, and high reaction yield, and is suitable for industrial production. The compounds A, B and C are defined in the specification.

The invention provides optical fiber sensing equipment detecting oil-water interface of a storage pot and relates to the technical field of oil field measuring. Oil-water liquid surface can be monitored in real-time and with accuracy by monitoring of various temperatures of different medium layers such as air, an oil layer, an emulsion layer and a water layer of the oil storage pot. The optical fiber sensing equipment detecting oil-water interface of the storage pot comprises a ripple pipe vertically disposed in the oil storage pot. The bottom of the ripple pipe is provided with a horizontal base seat; an armored temperature measuring optical fiber winds the ripple pipe; the armored temperature measuring optical fiber at least comprises two multi-mode temperature-sensing optical fibers backing up for each other; the optical fiber sensing equipment further comprises a temperature sensor and a distributing optical fiber host; and the temperature sensor is connected with the distributing optical fiber host via the multi-mode temperature-sensing optical fibers.

The invention discloses a organic small molecule containing a boron-nitrogen coordination bond, and a preparation method and sensing application thereof to a fluorine ion, and belongs to the technicalfield of preparation of fluorescent compounds and preparation of fluorescent probes. According to the invention, 2-(3-bromobenzothiophen-2-yl)benzothiazole reacts with n-butyl lithium to form a lithium reagent, and then the lithium reagent reacts with triphenylboron to prepare the small molecule containing the boron-nitrogen coordination bond. Experiments verify that the small molecule containingthe boron-nitrogen (BN) coordination bond prepared by the invention can successfully realize selective recognition of the fluorine ion. The preparation method of the fluorescent compound containing the boron-nitrogen (BN) coordination bond of the invention is simple and convenient, the reaction condition is mild, and a prepared fluorescent probe has the characteristics of photochemical stabilityand good selectivity.

The invention provides cooling agent spice menthyl formate for a cigarette. A chemical formula of the cooling agent spice is as shown in the specification. The invention further provides a preparation method and an application of the cooling agent spice for the cigarette. The preparation method comprises the steps of mixing menthyl-3-carboxylic acid and thionyl chloride, conducting a backflow reaction till menthyl-3-carboxylic acid reacts completely, removing excessive thionyl chloride, adding anhydrous pyridine and menthol, reacting for 1-4h at 40-80 DEG C, separating and purifying after the reaction, and obtaining cooling agent spice menthyl formate for the cigarette. The cooling agent spice for the cigarette has obvious effects on improving the harmony and the softness of smoke of the cigarette, and reducing the irritation of an oral cavity and a throat, and is good in taste; the fragrance is similar to that of L-menthol, but is lasting; in addition, the cooling agent spice for the cigarette is simple in preparation process, mild and safe in reaction condition, and high in practicability; industrial production is facilitated; and the production cost of the cigarette cannot be increased.

The invention relates to field of organic synthesis, and aims to provide a method preparing N-aryl and N-alkyl aromatic amine type compound from phenol type compound. The method includes that the phenol type compound and ammoniation reagents are solved in organic solvent or mixed solvent of the organic solvent and cosolvent, alkali is added, reaction is conducted for 2-4 hours under 50-80 DEG C, temperature rises to 100-160 DEG C, stirring reaction is conducted for 2-24 hours, and aromatic primary amine type compound is obtained after postprocessing. Alternatively, part of alkali is added, reaction is conducted for 2-24 hours under 50-80 DEG C, another part of alkali is additionally added, temperature rises to 100-160 DEG C, stirring reaction is conducted for 2-24 hours, and the N-aryl and N-alkyl aromatic amine type compound is obtained after postprocessing. The method is wide in application range, strong in generality, high in yield, and simple and convenient to operate.

The invention relates to a phosphonic acid-terminated hyperbranched dendritic polymer for heavy metal treatment and a preparation method for the phosphonic acid-terminated hyperbranched dendritic polymer. Aminotriphenylamine is adopted as a hyperbranched structural raw material, and the phosphonic acid-terminated hyperbranched dendritic polymer with 30 phosphonic acid radicals, far more than phosphonic acid radicals in an existing soil passivator molecule, is designed by virtue of the characteristic of strong chelating action of a phosphonic acid radical over heavy metal ions, so that the phosphonic acid-terminated hyperbranched dendritic polymer is strong in chelating action, large in molecule space volume, low in migration rate, mild in reaction condition and favorable for large-scale preparation, and has high stabilization performance for heavy metals in soil and high acid and alkali resistance, a long-term safety requirement of the soil is met, and the preparation method has broad application prospect in the fields of soil with industrial and mining heavy metals, paddy field remediation and the like.

The invention discloses a preparation method for eptifibatide. The method includes the steps of sequentially coupling and connecting Fmoc-protected amino acid and a protected amino acid tripeptide section with Fmoc-Cys(Trt) resin as a coupling resin carrier, splitting eptifibatide resin through a split agent, oxidizing reduced type eptifibatide in an acetonitrile aqueous solution, conducting condensation after oxidation, and conducting purification, salt transfer and freeze drying on crude eptifibatide product concentrated liquor to obtain a fine eptifibatide product. By means of the preparation method, production cost can be effectively reduced, yield is increased, and the content of impurities in the finished product is reduced.

A preparation method of an azamethiphos intermediate 3H-oxazolo[4,5-b]pyridin-2-one includes the technological steps that 1, 2-amino-3-pyridinol is dissolved in a solvent; 2, alkali is added; 3, a triphosgene organic solution is dripped at -5-30 DEG C; 4, a reaction is carried out for 2-20 h at 40-90 DEG C; 5, solid-liquid separation is carried out after the temperature is cooled to 0-20 DEG C; 6, drying is carried out, and the azamethiphos intermediate 6-chloro-3H-oxazolo[4,5-b]pyridin-2-one is obtained. Compared with the prior art, according to the method, reaction steps are short, operation is easy, and reaction conditions are mild; besides, as triphosgene with low toxicity is used for replacing high-toxicity phosgene, the reaction yield reaches up to 85%, the organic solvent can be recycled and reused, and the method is suitable for industrial production.

The invention relates to a method for preparing polypyrrole doped molybdate, which comprises the following steps: 1) using an inert electrode as an anode, an inert electrode as a cathode, mixed aqueous solution containing sodium molybdate and pyrrole as an anolyte, acid solution, alkaline solution or salt solution as the catholyte, in the double-chamber electrolyzer with cationic membrane as diaphragm, controlling the temperature from the room temperature to 90 DEG C, and using constant-current electrolysis or constant-voltage electrolysis to electrolyze; 2) after electrolysis, drying the solution obtained in the anode chamber at 80 DEG C to 120 DEG C; filtering and cleaning the resulting powder and drying at 80 DEG C to 120 DEG C and then cooling to room temperature to obtain a sample of polypyrrole doped molybdate. The prepared polypyrrole doped molybdate sample is pure, free of impurities, and evenly distributed, and the follow-up treatment is simple, the investment is small and the synthesis amount is large, which solves the problems of product heterogeneity, low stability, high cost, complex operation, and others in the process of preparing polypyrrole doped molybdate.

The invention relates to a method for recovering a carbon-fiber enhanced epoxy resin composite material. In the existing method, the requirement for equipment is high and the recovery cost is large. The method comprises the following steps of: cutting materials needing to be decomposed into blocks with the volume being 5cm<3>, putting the blocks in a backflow device containing acid liquor, heating for 5-20 minutes at the temperature of boiling point, cleaning and carrying out vacuum drying; then putting the obtained mixture into a reaction kettle, adding an organic solvent and an oxidizing agent, firstly heating, then cooling to normal temperature, and obtaining a primary product; and after cleaning, putting a solid product in the primary product into industrial acetone solution for dipping, obtaining recovered carbon fiber and carrying out pressure-reduced distillation on a liquid product to obtain phenol and derivatives thereof. In the method, reaction under low temperature and low pressure is realized and has the advantages of moderate reaction condition, easy control of reaction, fewer side products, no pollution basically and no corrosion to equipment and the like, so that the method is a green recovering method.

The invention discloses a method for synthesizing a polysubstituted aminoisoquinoline compound by cyclizing pyridine and alkyne under the catalysis of rhodium, which comprises the following steps: byusing a pentamethylcyclopentadienyl rhodium complex as a catalyst and a 2-aminopyridine derivative and an internal alkyne compound as raw materials, reacting in an organic solvent at 30-150 DEG C for1-24 hours, cooling the reaction solution after the reaction is finished, removing the organic solvent under reduced pressure; purifying the crude product through a silicon dioxide column, and elutingwith petroleum ether / ethyl acetate to obtain the pure polysubstituted aminoisoquinoline derivative. According to the method, a guide group (carbonyl) or a steric hindrance group (methyl) is introduced into the reaction to realize C-H bond activation and avoid the coordination effect of pyridine on the metal catalyst, and the regulation and control of the reaction activity and selectivity are efficiently realized through the regulation and control of the group with large steric hindrance. The obtained generation target products are high in selectivity, and the selectivity is 90% or above, byproducts are few, and the product separation cost is reduced, and the method is simple in synthesis process, mild in reaction condition and convenient for industrial production.

The invention discloses 5-alkyl guanidine ionic liquid, and preparation and application thereof. After tetramethyl guanidine and alkyl halide are adopted to be ionized, ion exchange with metal salt is performed to prepare 5-alkyl guanidine acid radical ionic liquid, and the ionic liquid is used as a catalyst to synthesize quinazoline-2,4(1H,3H)-ketone and derivatives thereof in the carboxylation and cyclization reaction of carbon dioxide and anthranilonitrile. Compared with the prior art, the 5-alkyl guanidine ionic liquid is simple in synthetic process, low in costs and has excellent performance in a homogeneous catalysis carbon dioxide reaction process; particularly, when the 5-alkyl guanidine ionic liquid is used in the carboxylation and cyclization reaction synthesis of the carbon dioxide and the anthranilonitrile, quinazoline-2,4(1H,3H)-diketone and derivatives thereof can be obtained in a relatively mild condition; the catalytic performance is good; the reaction condition is mild; and the postprocessing is easy. Meanwhile, the 5-alkyl guanidine ionic liquid can be used as a solvent and a catalyst; the use of a large quantity of organic solvent is avoided; and the 5-alkyl guanidine ionic liquid has important significance on researching medicinal chemistry and compounds of medical intermediates.