96 results about "Propionaldehyde" patented technology

[Problem] To provide a means capable of more efficiently exerting an antibacterial effect against bacteria. [Solution] An antibacterial agent containing at least two compounds selected from the group consisting of trans-2-methyl-2-pentenal, 2-methylbutanal, trans-2-hexenal, propionaldehyde, 3-methylpentanol, and 2,5-dimethylfuran.

The invention relates to the technical field of pesticide production, and particularly discloses a preparation process of glufosinate-ammonium intermediate 3-(methyl hydroxyl phosphonyl) propionaldehyde. The preparation method comprises the following steps: 1, carrying out addition reaction on diethyl methylphosphonite and acrylic acid in absolute ethyl alcohol to generate 3-[ethyoxyl (methyl) phosphonyl] propionate; in the second step, 3-[ethyoxyl (methyl) phosphonyl] propionate is subjected to a hydrosilylation reaction in an oriented mode, and 3-triethyl siloxy-3-ethyoxyl propyl methyl ethyl phosphonate is generated; and 3, carrying out a simple dilute acid hydrolysis reaction to obtain the 3-(methyl hydroxyl phosphonyl) propionaldehyde. According to the method, a three-step reaction route of addition-hydrosilylation-hydrolysis is adopted, and the acrylic acid is used for replacing the traditional high-toxicity raw material acrolein, so that the toxicity risk is avoided from the source, the yield of the target glufosinate-ammonium intermediate is remarkably improved, the total yield of the three-step reaction can reach 95% or above, and the method is suitable for industrial production. And an efficient and green brand-new technical scheme is provided for large-scale production of glufosinate-ammonium.

The application relates to a high-efficiency molecular sieve adsorbent for deep purification of oxygenates and preparation and application of the adsorbent, and the preparation process comprises the following steps: 1) molecular sieve synthesis: uniformly mixing an aluminum source, a silicon source, alkali, a template agent and water to obtain a crystallization liquid, aging, then carrying out microwave hydrothermal crystallization and traditional hydrothermal crystallization to obtain EMT / 13X mixed crystal molecular sieve, and then carrying out pressure filtration to obtain a wet filter cake; 2) granulation: drying the wet filter cake, uniformly mixing inorganic additives and pore-forming agents, rolling and granulating, and then drying; and 3) calcination: placing the granulated product in an oxygen-containing atmosphere for calcination, so that the EMT / 13X composite molecular sieve adsorbent is obtained. The application breaks through the double-template method for synthesizing the EMT / 13X mixed crystal molecular sieve with an EMT molecular sieve as the main component, complete structure and high crystallinity, the specific surface area of the molecular sieve is greater than or equal to 450 m 2 / g, ethylene adsorption heat is less than or equal to 70 DEG C, the oxygenate adsorption capacity is increased by more than 30%, the purification depth can reach below 1 ppb, and the molecular sieve is suitable for efficient removal of trace nonpolar or polar oxygenates such as dimethyl ether, methanol and propyl aldehyde in low-carbon olefins.

A method for controlling a chemical process, by preparing methanol, hydrogen sulfide, methyl mercaptan, hydrocyanic acid, acrolein, 3-methylthiopropionaldehyde, 5-(2-methylmercaptoethyl)-hydantoin, methionine, a salt of methionine, and a derivative of methionine. The method includes providing a training set TS1, wherein TS1 is process values PV1 and process values PV2 being correlated to one another, and / or laboratory values LV1 and process values PV2 being correlated to one another. The method includes training a processing unit on the training set TS1 to identify a pattern of correlation between one or more measured process variables and at least one process variable. The method includes developing a calibration function CF1 for a calibrated soft sensor from the identified pattern of correlation and predicting at least one operating parameter for the chemical process as an approximation to LV1 and / or PV1. A system for controlling a chemical process.

This invention provides a 1,3,5-triarylbenzene compound and its preparation method, which involves uniformly mixing α,β-unsaturated ketones, 2-phenylpropanal, and elemental iodine, followed by heating to react, thereby obtaining the compound. Compared with existing technologies, this invention has the following advantages: the reaction conditions are mild, the method is simple and rapid, and the substrate applicability is wide, which is beneficial for industrial production. Furthermore, the structure of the prepared 1,3,5-triarylbenzene compound is more complex and diverse.

This invention belongs to the field of organic synthesis technology and relates to a precursor of an obisec key intermediate and a method for preparing the key intermediate. The method involves a [4+2] cycloaddition reaction of 4-trifluoromethylaniline, propionaldehyde, and N-vinylformamide under the catalysis of chiral phosphoric acid, yielding the obisec key intermediate precursor with high enantioselectivity. N -((2) R 4 S )-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-4-yl)formamide; subsequently, the key intermediate of obisetri can be obtained through a deprotection reaction under acidic conditions. The method provided by this invention uses a small amount of chiral catalyst and commercially available reagents to efficiently obtain the key intermediate of obisetri in just two steps. R 4 S )-2-ethyl-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-4-amine; under mild conditions without the need for chiral resolution, the utilization of starting materials is greatly improved, thereby significantly increasing the yield of the target product and the economic efficiency of the process.

The invention discloses an exhaled gas VOC (volatile organic compound) marker for detecting inflammatory bowel diseases and a detection system thereof. The marker is a combination of one or more of the following components: methyl propyl sulfide, propionaldehyde, cyclohexanone, allyl methyl sulfide, octanal, 2-pentanone, phenol, butyric acid, propionic acid and 3-methylheptane. The detection system comprises an exhaled air sampling module, a sample preprocessing module, a detection analysis module and a data analysis module. The marker provided by the invention has the advantages of high specificity and good stability, can realize accurate noninvasive diagnosis of IBD, and can assist in realizing early screening and dynamic monitoring in a clinical environment.

The invention belongs to the technical field of medicine preparation, and particularly relates to a fenoprofen calcium preparation method which comprises the following steps: 1) m-hydroxyacetophenone and bromobenzene generate an intermediate 1, namely m-phenoxyacetophenone under the action of alkali and cuprous iodide; 2) reacting the intermediate 1 with ethyl chloroacetate under the action of strong base, and then performing hydrolysis and decarboxylation reaction to generate an intermediate 2, namely 2-(3-phenoxy phenyl) propionaldehyde; the invention discloses a preparation method of fenoprofen calcium, which comprises the following steps: (1) preparing fenoprofen, (2) preparing fenoprofen, (3) carrying out oxidation reaction on an intermediate 2 to obtain fenoprofen, (4) reacting fenoprofen with a sodium hydroxide solution to obtain fenoprofen sodium, and (5) salifying fenoprofen sodium with a calcium chloride solution to obtain fenoprofen calcium.

The application provides a preparation method and product of 1,3-propanediol. The preparation method comprises the following steps: subjecting 3-hydroxypropionaldehyde aqueous solution to a first-stage hydrogenation reaction under the action of a first-stage hydrogenation catalyst to obtain a first-stage hydrogenation reaction product; and subjecting the first-stage hydrogenation reaction product to a second-stage reaction under the action of a second-stage hydrogenation catalyst to obtain a 1,3-propanediol product. The preparation method adopts two-stage hydrogenation, effectively improves the economy of the propenal hydration hydrogenation process, and solves the problems that the impurities generated in the 1,3-propanediol preparation route of the propenal hydration process are difficult to treat and resource utilization.

This invention provides the application of compounds in attracting or controlling midges, relating to the field of midge control technology. Through screening and identification, this invention has obtained five compounds (butyric acid, butyraldehyde, propionaldehyde, 2-hexanone, and acetophenone) with significant attractant activity against Formosan midge. These compounds can be used alone or in combination, are environmentally friendly and have a high affinity for non-target organisms, greatly enriching the candidate resource of midge attractants. They can be directly applied to the monitoring and large-scale trapping of midges, effectively reducing midge population density, thereby reducing midge bites and the spread of midge-borne diseases, which has significant public health implications.

The application provides a black fungus provenance characteristic molecular marker and application thereof, and the molecular marker comprises the following: the molecular marker 2-acetyl furan, beta-pinene and 2-pinene of Shaanxi black fungus; the molecular marker 2-propanol and 2, 6-dimethyl pyrazine of Heilongjiang black fungus; the molecular marker pentanal and 2-butanone of Jilin black fungus; the molecular marker n-hexanal and acetic acid of Zhejiang black fungus; and the molecular marker 2-methyl propionaldehyde and hexanoic acid of Fujian black fungus. The molecular marker can be used for identifying the provenance of black fungus. The application first provides the provenance characteristic molecular marker of black fungus, the molecular marker can replace all chemical components of black fungus and serve as a detection basis of the provenance of black fungus; compared with existing black fungus physical and chemical indexes and artificial sensory recognition analysis, the provenance characteristic molecular marker of black fungus provided by the application improves the accuracy and recognition rate of detection, and provides a simple, rapid and effective scheme for provenance identification of black fungus.

The present invention provides a method for producing liquid methionine or methionine, and particularly provides a method for producing liquid methionine or methionine by condensation reaction of 3-hydroxypropionaldehyde and formyl-CoA derived from a C1 substrate. The present invention also provides a genetically engineered microorganism for the production of liquid methionine or methionine.

The application discloses a preparation method of butanediamine, which comprises the following steps: synthesizing cyanopropyl aldehyde by adopting synthesis gas and acrylonitrile, and then performing ammoniation hydrogenation on the cyanopropyl aldehyde to produce 1,3-butanediamine and 1,4-butanediamine in a combined manner. According to the synthesis route, the total yield of the product butanediamine is greater than or equal to 95%, and compared with the hydrocyanic acid method, the ammoniation hydrogenation catalyst has the advantages of low single consumption and low total production cost of the product.

The invention discloses a method for preparing 1, 3-propylene glycol based on catalysis of a copper complex, and relates to the technical field of catalytic hydrogenation of aldehyde. According to the method, the problems of high reaction temperature and poor selectivity in the prior art are solved, the reaction process is simple, the yield of 1, 3-propylene glycol is high, and the selectivity is good; a cheap copper catalyst phosphine ligand is used, so that the cost is relatively low; the reaction conditions are mild, the temperature and the pressure are relatively low, and the requirement on production equipment is not high; the reaction system is wide in application range; the 1, 3-propylene glycol is prepared by hydrogenation of the 3-hydroxypropionaldehyde, the method is milder and quicker, and the method is also suitable for hydrogenation reaction of other aldehyde substances.

The present invention discloses a method for preparing beer having an ethanol content of 0-1.0 vol. %, comprising providing a medium having an ethanol content of 0-20 vol. %, which medium comprises restricted-fermentation beer; subjecting said medium to a distillation step, thereby reducing the quantity of one or more aldehydes selected from the group consisting of 2-methyl-propanal, 2-methylbutanal, 3-methylbutanal, 3-methylthiopropionaldehyde, phenylacetaldehyde, hexanal, trans-2-nonenal, benzaldehyde and furfural in the medium, and thereby also reducing the ethanol content, if present, to a content in the range of 0-1.0 vol. %. The invention furthermore discloses beer obtained with the said process.

The invention relates to a preparation method of a hydrogenation catalyst suitable for preparing n-propyl alcohol through liquid-phase hydrogenation of propionaldehyde, which comprises the following steps: S1, preparing a precursor solution: dissolving sodium carbonate in deionized water to prepare a mixed nitrate solution with the total metal ion concentration of 0.8-1.2 mol / L, and dissolving sodium carbonate in desalted water to prepare a sodium carbonate solution as a precipitator; s2, co-precipitation reaction: under a stirring condition, adding the mixed nitrate solution and a precipitant into a reaction kettle at the same time to obtain a precipitate, and after the precipitate is fully aged, removing foreign ions in the precipitate; s3, drying and roasting: drying the precipitate, and roasting in an air atmosphere to obtain composite oxide powder; s4, molding: preparing the composite oxide powder into cylindrical catalyst particles; and S5, secondary drying and roasting: carrying out drying treatment and roasting treatment on the cylindrical catalyst particles to obtain a final catalyst product.

A filtration device for propionaldehyde industrial wastewater, relating to the field of industrial wastewater treatment, includes a filter box, a filter screen, and a liquid suction mechanism. The filter screen is located inside the filter box, and the liquid suction mechanism is located on top of the filter box. The liquid suction mechanism includes a guide rod, a float plate, and a discharge pump. A top plate is provided on the top of the filter box, the guide rod slides through the top plate, the float plate is located at the bottom of the guide rod, and a suction nozzle is located at the bottom of the float plate. The discharge pump is located on the top plate, and the suction nozzle is connected to the discharge pump via an outlet pipe. This invention discharges propionaldehyde wastewater into the filter box, where it passes through the filter screen under its own gravity, resulting in more stable filtration pressure. The filtered propionaldehyde liquid is transferred through the suction nozzle to the outlet pipe and finally discharged, achieving stable pressure filtration of the propionaldehyde wastewater and resulting in a more uniform filtration degree.

A corrosion inhibitor composition and a method of inhibiting corrosion on a surface (e.g., steel surface) are disclosed. The corrosion inhibitor composition includes a precursor that is a reaction product of 3-hydroxypropion aldehyde and at least one aliphatic component.

The present invention specifies an unpleasant odor, which is a semi-dry odor generated by a fibrous product such as clothing, towels, bedding, and the like, and provides a perfume composition, a common consumer product, and the like, which are capable of reducing the unpleasant odor. The perfume composition according to the present invention can exert a deodorizing (masking) effect on unpleasant odors, which are half-dry odors, by containing, as a masking active ingredient, one or more compounds selected from the group consisting of 3-(4-tert-butylphenyl) propionaldehyde, 3-tricyclo [5.2. 1.02, 6] deca-3-alkenyl acetate, 3-(4-ethylphenyl)-2, 2-dimethylpropionaldehyde, ethyl 2-cyclohexyl propionate, and the like.

The invention discloses a high-efficiency rotigotine preparation process which comprises the following steps: dissolving sodium triacetoxyborohydride in a reaction solvent, adding 2-thiopheneethylamine while stirring, dropwise adding a dichloromethane solution of 5-methoxy-2-tetralone, continuously reacting, and carrying out post-treatment to obtain N-(1, 2, 3, 4-tetramethyl-4-piperidine)-1, 2, 3, 4-tetramethyl-4-piperidine. The preparation method comprises the following steps: adding 2, 2, 4-tetrahydro-5-methoxy-2-naphthyl)-2-thiophene ethylamine; dissolving L-DTTA and L-DBTA in ethanol and a water solvent, adding into the product, carrying out a reflux reaction, and recrystallizing to obtain a single-configuration resolution salt; the preparation method comprises the following steps: adding sodium triacetoxyborohydride into a reaction kettle, carrying out product alkalization, carrying out methyl tertiary ether extraction, concentrating an organic layer until the organic layer is dry, dissolving with dichloromethane, adding sodium triacetoxyborohydride, dropwise adding propionaldehyde, continuously carrying out stirring reaction after dropwise adding, after the reaction is finished, concentrating until no liquid drop exists, and carrying out post-treatment to obtain (S)-5-methoxyrotigotine; and dropwise adding HBr, and recrystallizing with n-hexane to obtain rotigotine. According to the present invention, the STAB-mediated continuous reductive amination is adopted to replace the high pressure hydrogenation, and the L-DTTA / L-DBTA composite resolution system is designed to improve the chiral selectivity, such that the process is simplified, and the cost is reduced.

The invention relates to the technical field of chemical synthesis, in particular to a synthesis method of matrichthrin, which comprises the following steps: S1, under an alkaline condition, carrying out aldol condensation reaction on propionaldehyde to obtain a first reaction mixture containing 2-methyl-2-pentenal; s2, in the presence of a hydrogenation catalyst, 2-methyl-2-pentenal in the first reaction mixture obtained in the step S1 is subjected to a hydrogenation reaction, and a second reaction mixture containing 2-methylvaleraldehyde is obtained; s3, in the presence of an oxidation catalyst, 2-methylvaleraldehyde in the second reaction mixture obtained in the step S2 and oxygen or oxygen-containing gas are subjected to an oxidation reaction, and a third reaction mixture containing 2-methylvaleric acid is obtained; and S4, in the presence of an esterification catalyst and a water-carrying agent, carrying out esterification reaction on the 2-methylvaleric acid in the third reaction mixture obtained in the step S3 and ethanol to obtain matrichthrin. The requirement for supplementing manganese acetate is remarkably reduced, and the production cost is reduced.

The invention discloses an aldolase mutant and application thereof in production of 3-hydroxypropionaldehyde, and relates to the technical field of enzymes. The invention provides an aldolase mutant. The amino acid sequence of the aldolase mutant is as shown in SEQ ID NO: 1. The enzyme activity of the aldolase mutant constructed by the invention is 79 times that of a wild type, and the yield of 3-hydroxypropionaldehyde produced by aldolase is greatly increased. The aldolase mutant has improved comprehensive catalytic efficiency on substrates formaldehyde and acetaldehyde after modification. On the basis of the mutant, yqhD gene knockout is carried out on an expression host, the substrate conversion rate is obviously increased, the formaldehyde conversion rate is increased by 28.20%, the acetaldehyde conversion rate is increased by 30.41%, and the mutant has wide application prospects and high industrial value in biosynthesis of 3-hydroxypropionaldehyde.

The invention belongs to the field of catalytic reaction equipment, and particularly relates to heterogeneous catalytic reaction equipment for low-temperature and low-pressure propionaldehyde production, which comprises a reaction kettle, the kettle body of the reaction kettle is of a two-section type, a connecting column is fixedly connected between the upper section and the lower section of the kettle body of the reaction kettle, and the middle section of the column body of the connecting column is rotatably connected with a rotating seat; a mounting locking mechanism is jointly arranged between the rotating seat and the connecting column, a ring sleeve is fixedly connected to the rotating seat, the ring sleeve is slidably connected between the upper section and the lower section of a kettle body of the reaction kettle, and two catalytic carriers are fixedly connected to the inner ring wall of the ring sleeve. Through the design of the rotatable ring sleeve and the double catalytic carriers and the combination of a material backflow system driven by a circulating pump, reactants can circularly pass through the catalytic carriers for multiple times, the reaction contact efficiency is remarkably improved, meanwhile, a rotating seat is arranged on the ring sleeve and is rotationally connected to a connecting column outside the reaction kettle, and the reaction kettle is convenient to use. And a locking mechanism is arranged in the rotating seat, so that the catalytic carrier can be quickly disassembled, assembled and maintained.

The present application relates to the technical field of catalyst, and discloses a method for preparing a supported catalyst by using alkaline gas, the supported catalyst and application thereof, which comprises the following steps: (1) contacting a solution containing active component precursor and inorganic alkaline substance with a carrier to obtain a solid-liquid mixture; the active component precursor comprises a noble metal precursor; (2) drying the solid-liquid mixture in the presence of a first alkaline substance to obtain a solid product; (3) then activating the solid product in the presence of a second alkaline substance; wherein the first alkaline substance and the second alkaline substance are independently nitrogen-containing alkaline substances. The catalyst has a low acid amount and a B acid / L acid acid amount ratio, and when used in a propylene epoxidation reaction, can significantly reduce the selectivity of by-products propyl aldehyde and acetone, while obtaining a higher propylene conversion rate and propylene oxide selectivity.

The invention relates to the technical field of production of a chemical reagent dipentaerythritol, and discloses a method for improving the yield of dipentaerythritol, which comprises the step of adding monopentaerythritol which accounts for 50-150% of the molar mass of acetaldehyde when the condensation reaction of formaldehyde and acetaldehyde begins. Under the catalysis of strong base, formaldehyde and acetaldehyde firstly generate 3-hydroxypropionaldehyde, and the intermediate is dehydrated to form acrolein. According to the invention, the mono-pentaerythritol is added at the initial stage of the reaction, so that the acraldehyde and the mono-pentaerythritol are subjected to addition reaction to directly form a skeleton structure of the dipentaerythritol, thereby bypassing part of competitive reaction, and greatly improving the generation efficiency of the dipentaerythritol. Specifically, the yield of the dipentaerythritol in the scheme can be increased from 10% to 23%.

The application discloses a carboxylic resin catalyst for preparing 3-hydroxypropionaldehyde by hydrating propenal and a preparation method and application thereof, and relates to the technical field of catalysts. The resin is first swelled, then a cage cavity structure organic matter is added for pore filling and reconstruction, then a Friedel-Crafts acylation and amination are carried out to graft an amino carboxylic acid group, and finally an H type resin catalyst is obtained through acidification. The resin catalyst has stable pore structure and high active site abundance, and when used for a propenal hydration reaction, the space velocity can reach 5h ‑1 , the propenal conversion rate is greater than or equal to 75%, the 3-hydroxypropionaldehyde selectivity is greater than 93%, and after a tubular fixed bed reaction continuous evaluation for 100 hours, the decrease ranges of the propenal conversion rate and the 3-hydroxypropionaldehyde selectivity are less than 2%, and the catalytic performance and stability are significantly improved.

The invention relates to the field of chemical synthesis of insect sex pheromones, in particular to a preparation method of codling moth sex pheromones. The method comprises the following steps: in N2 atmosphere, taking anhydrous THF as a solvent, reacting 7-chloroheptyltrimethylsilyl ether with sodium acetylene to prepare an intermediate (I), and reacting the intermediate (I) with halide salt and propionaldehyde to generate an intermediate (II); and reducing the intermediate (II) by using LiAlH4 / anhydrous AlCl3, and carrying out acid hydrolysis to obtain the codling moth sex pheromone (8E, 10E)-dodecadiene-1-alcohol. The method disclosed by the invention is mild in reaction condition, simple in post-treatment, environment-friendly, high in product yield and purity and suitable for industrial production.

1. A process for the simultaneous production of methacrylic acid and methyl methacrylate, comprising: a) producing methacrolein from propionaldehyde and formaldehyde; b) dividing the methacrolein into a first methacrolein stream and a second methacrolein stream; c) producing methacrylic acid from water and the first methacrolein stream in an oxidation reaction; and d) producing methyl methacrylate from methanol and the second methacrolein stream in an oxidative esterification reaction.

The invention discloses design and application of an ionic liquid catalyst based on an internal electric field effect. The design mainly comprises design of the ionic liquid catalyst and application of the ionic liquid catalyst for catalyzing aldol condensation reaction of formaldehyde and propionaldehyde to produce methylacrolein. The internal electric field intensity of the ionic liquid can be regulated and controlled through the interaction of ionic bonds and hydrogen bonds of the ionic liquid, so that efficient activation of reactant formaldehyde is promoted, and the self-condensation side reaction of propionaldehyde is inhibited. The method can increase the generation rate of methylacrolein to 2-6 times, has the characteristics of simple catalyst preparation method, mild reaction conditions and the like, and is suitable for industrial application.

The present application relates to the recombinant microorganism for producing 3-amino propanol by fermentation method and its construction method and application. Specifically, the present application provides a construction method of the recombinant microorganism for producing 3-amino propanol, which is introducing the coding gene of omega-transaminase into the microorganism producing 3-hydroxy propionaldehyde, wherein the omega-transaminase can catalyze the conversion of 3-hydroxy propionaldehyde into 3-amino propanol in the presence of amino donor. The present application introduces the omega-transaminase capable of catalyzing the synthesis of 3-amino propanol with 3-hydroxy propionaldehyde as the substrate into the microorganism producing 3-hydroxy propionaldehyde based on gene editing, molecular cloning and other technologies, which first creates a brand new full-path biosynthesis process route of 3-amino propanol.