91 results about "Sodium cyanide" patented technology

The invention provides a sulphide ore alkaline desulfurization and cyanidation gold leaching agent system and a method for extracting gold through the sulphide ore alkaline desulfurization and cyanidation gold leaching agent system, and belongs to the technical field of hydrometallurgy. According to the method, a ternary agent system consisting of potassium ferricyanide, low-concentration sodium cyanide and thioguanosine is constructed. An efficient'oxidation-inhibition 'synergistic system is formed between the auxiliary desulfurization agent potassium ferricyanide and the thioguanosine. The rapid and selective oxidation of potassium ferricyanide is smoothly carried out under the synergistic effect of thioguanosine, minerals are thoroughly decomposed, and the surface keeps high activity; meanwhile, due to the existence of the thioguanosine, the local microcell passivation risk and catalytic electron transfer can be eliminated more directionally. The sodium cyanide and the sodium cyanide complement each other, it is jointly guaranteed that the exposed gold can be smoothly and efficiently leached through follow-up low-concentration sodium cyanide, finally, the total consumption of reagents is reduced, environmental pollution is reduced, and meanwhile high-recovery-rate extraction of the gold in the sulfide ore difficult to treat is achieved.

The invention relates to the field of metallurgy and chemical engineering, in particular to a heap leaching gold extraction method for low-grade gold sulfide ore. Comprising the following steps that an anti-seepage bottom mat is laid on a dump leaching site; pre-treating the sulfide gold ore by using quick lime; ore crushing; ore is poured and piled on the upper portion of the bottom pad; spraying is conducted on the top of the ore heap and a side slope frame pipe, the gold-containing pregnant solution is collected, and the spraying solution is a sodium cyanide solution; and recovering gold from the gold-containing pregnant solution. According to the heap leaching gold extraction method provided by the invention, the quicklime is adopted to carry out pretreatment (iron removal, desulfurization and arsenic removal) on the sulfide gold ore, and then processes of subsequent ore crushing, heap building, spraying, adsorption and the like are carried out, so that the difficult problems of heap leaching utilization and popularization of low-grade sulfide ore resources are solved.

This invention discloses a method for recycling and reusing cyanide silver plating wastewater. The method includes four steps: separation of silver ions and cyanide, concentration of the silver-containing solution, cyanide concentration, electrolysis and residual liquid recycling, and reuse of reclaimed water. This method achieves the separate recycling and reuse of silver, cyanide, and water. The silver-containing solution is electrolyzed to obtain metallic silver, the cyanide concentrate's main component is sodium cyanide or potassium cyanide solution, and the reclaimed water with a conductivity below 20 μS / cm is reused in the production line. This method not only maximizes resource utilization and reduces wastewater discharge, but also separates most of the cyanide from the silver-containing solution during electrolysis, making the electrolysis process safer. Furthermore, the residual liquid after electrolysis can be recycled multiple times for the separation and concentration of silver ions and cyanide.

The utility model discloses a high-concentration sodium cyanide wastewater treatment system, which is characterized in that the whole system is in an under-pressure closed state, no waste gas is generated in the process, the safety can be ensured, cyanogen breaking is carried out through alkaline hydrolysis and hydrogen peroxide oxidation in the reaction process, the cyanogen breaking effect is obvious, the concentration of sodium cyanide in wastewater can be reduced from 20000 mg / L to 0.5 mg / L, and the concentration of sodium cyanide in wastewater can be reduced from 20000 mg / L to 0.5 mg / L. And through two-stage under-pressure heat exchange and one-stage normal-temperature heat exchange in the heat recovery device, waste heat energy is utilized to the maximum extent, and the energy-saving effect is obvious.

The invention belongs to the technical field of sodium ion batteries, and particularly relates to a Prussian blue sodium battery positive electrode material and a preparation method thereof.The preparation method comprises the steps that anhydrous sodium ferrocyanide, anhydrous manganese sulfate and a NaA molecular sieve are mixed and preliminarily ground, and a precursor mixture is obtained; placing the precursor mixture in a planetary ball mill for ball milling to obtain a primary reaction product; and washing the preliminary reaction product, and carrying out vacuum drying to obtain the Prussian blue sodium battery positive electrode material. The method is low in material loss and short in generation period, and the prepared Prussian blue sodium battery positive electrode material is low in crystal water content and has good cycle stability.

The invention relates to an environment-friendly gold leaching agent and a gold leaching method, and belongs to the technical field of gold leaching. The environment-friendly gold leaching agent comprises sodium cyanurate and guanidine salt. The gold leaching agent provided by the invention has a good gold leaching effect, is high in gold selectivity, does not contain traditional highly toxic sodium cyanide, is small in environmental pollution, and is green and environment-friendly.

The invention belongs to the technical field of medicine synthesis, and discloses a preparation method of a sodium nitroprusside raw material medicine. According to the method, weak acid is adopted for catalysis, the effect of remarkably reducing generation of toxic substances such as cyanide and nitrogen dioxide is achieved by controlling the material dripping speed and the dripping pH, the reaction is mild, the technological operation is safe and controllable, and industrial production of the sodium nitroprusside raw material medicine is facilitated. According to the preparation method of some examples, silica gel filtration is used for post-treatment, the residual risk of impurities such as sodium ferricyanide, ferric ferrocyanide and ferric ferricyanide is reduced, and the purity of the raw material medicine is larger than or equal to 99.9% and is far superior to the requirements of pharmacopoeia of various countries.

The invention discloses a lanthanide-doped Prussian blue positive electrode material and a preparation method and application thereof, and the preparation method comprises the following steps: mixing and dissolving sodium ferrocyanide and lanthanide metal salt to obtain a mixed solution; and under a protective atmosphere, dropwise adding the mixed solution into a mixed chelating agent salt solution through a peristaltic pump, and reacting to obtain the lanthanide-doped Prussian blue positive electrode material. The lanthanide metal in the lanthanide-doped Prussian blue positive electrode material occupies the Na site, the single iron source coprecipitation method is adopted for synthesis, the process concentration is uniform, the synthesized positive electrode material has fewer defects, the material structure is stable, the rate capability is excellent, the specific capacity is high, and the application prospect is very good.

The present application relates to a process for producing synthetic ammonia by using hydrogen-containing tail gas, comprising the following steps: S1: sodium cyanide tail gas is pressurized, then heated and water-cooled. S2: the impurity-removed tail gas is desulfurized. S3: the desulfurized tail gas is mixed with chlor-alkali tail gas, the mixed gas is heated and deoxidized. S4: the deoxidized tail gas is pressurized and enters a PSA (pressure swing adsorption) device for pressure swing adsorption treatment, obtaining high-purity hydrogen. In the PSA device, dehydrating, carbon dioxide, methane, carbon monoxide and nitrogen adsorbents are sequentially arranged. The carbon dioxide adsorbent is activated carbon modified by carbonate and strong alkali, and the nitrogen adsorbent is 13X zeolite molecular sieve modified by Na + and Ba 2+ and Ca 2+ ion exchange. S5: nitrogen reacts with the high-purity hydrogen obtained in step S4 to generate ammonia. The present application can improve the adsorption capacity of the adsorbent for impurity gas, thereby reducing the replacement frequency of the adsorbent, prolonging the service period and service life of the adsorbent, and improving the production efficiency.

The invention provides a method for synthesizing ethyl 4-cyano-3-hydroxybutyrate by a pure hydrocyanic acid method, which is characterized in that ethyl 4-chloro-3-hydroxybutyrate and hydrocyanic acid are used as raw materials, a biological enzyme is used as a catalyst, the pH value of a reaction solution is controlled to be 6.5-7.5, and the ethyl 4-cyano-3-hydroxybutyrate is synthesized; the hydrogen cyanide is used as a raw material, so that the cost of a sodium cyanide preparation process can be reduced, the consumption of sodium hydroxide can be reduced, and the treatment cost of pollutants (sodium salt) can be reduced. The method has the advantages of being high in reasonability, low in material loss and high in production efficiency. The ethyl 4-cyano-3-hydroxybutyrate prepared by the method has the yield of 80%, the content of more than or equal to 98.5% and the single impurity content of less than 0.5%.

The application provides a synthesis method of 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid, comprising the following steps: a) mixing acryloyl chloride, a first solvent, a polymerization inhibitor, a catalyst and sodium cyanide, performing a substitution reaction, and obtaining an acryloyl cyanide intermediate after reduced pressure distillation; b) mixing the acryloyl cyanide intermediate obtained in the step a) with hydrochloric acid and a polymerization inhibitor, performing a hydrolysis reaction, and obtaining 2-carbonyl-3-butenoic acid crude product after purification treatment; c) mixing the 2-carbonyl-3-butenoic acid crude product obtained in the step b) with a second solvent and methyl phosphinite, performing an addition reaction, recovering the solvent after water separation and extraction, and obtaining a ketonic acid ester solution; and d) adding hydrochloric acid to the ketonic acid ester solution obtained in the step c) to adjust the pH to be less than or equal to 3, performing a hydrolysis reaction, and obtaining 4-(hydroxymethyl phosphine) 2-carbonyl butyric acid after purification. The synthesis method selects inexpensive acryloyl chloride as a raw material, has mild reaction conditions, is simple to operate, has low production cost, is easy to realize industrialization, and has high yield.

The application provides a method for detecting the titer of vitamin B12 in a fermentation liquor. The method comprises the following steps: preparing a potassium dichromate solution, a hydrochloric acid solution and a potassium dihydrogen phosphate solution, mixing the three solutions with the vitamin B12 fermentation liquor under certain conditions to generate cyanocobalamin, and then testing the titer of the cyanocobalamin by using a high performance liquid chromatography. The titer of the vitamin B12 detected by using the method is consistent with the titer detected by using a sodium cyanide method. The operation method greatly reduces the safety risk of an analyst caused by using the sodium cyanide, and the operation method is simple, easy to manage in a laboratory and can save the testing cost.

The invention belongs to the technical field of energy materials, and particularly relates to preparation and application of a high-crystallinity long-life Prussian blue and analogue positive electrode material thereof. Aiming at the defects in the prior art, the invention provides the preparation method of the high-crystallinity long-life Prussian blue and the analogue thereof, which comprises the following steps: 1) mixing soluble transition metal M salt and a solvent to obtain a solution A; 2) mixing sodium ferrocyanide salt, sodium salt and a solvent to obtain a solution B; adding a complexing agent or / and an acid for regulating and controlling the chelating ability into the solution A, adding a complexing agent or / and an acid for regulating and controlling the chelating ability into the solution B, and controlling the total molar ratio of the complexing agent to the acid for regulating and controlling the chelating ability in the solution A and the solution B to be (20-1): 1; and 3) dropwise adding the solution A into the solution B, reacting, aging, centrifuging, washing and drying to obtain the Prussian blue and the analogue thereof. The method disclosed by the invention greatly widens the selection range of the chelating agent in the production process of the Prussian blue analogue positive electrode.

The application discloses a kind of low-defect manganese-based prussian blue under solid-liquid dynamic balance fast preparation method, comprising the following steps: S1, sodium citrate is dissolved in deionized water, then add manganese acetate and ascorbic acid, form the solution A containing manganese complex;Wherein, the molar ratio of sodium citrate, manganese acetate and ascorbic acid is (4.5-5.5): 1:(0.3-0.4);S2, sodium ferrocyanide is added to deionized water, stirring is formed at a set temperature containing unsolved sodium ferrocyanide solid supersaturated suspension B;Wherein, the addition amount of sodium ferrocyanide is far more than its saturated solubility at the temperature, so that the system maintains solid-liquid two-phase equilibrium state;Crystalline integrity is higher: thanks to "whole process dynamic saturation" environment, the manganese-based prussian blue prepared by the application has more obvious monoclinic phase characteristics (corresponding XRD double peak is obvious, intensity is obvious, signal-to-noise ratio is good) compared with comparative document, lattice vacancy and coordination water content are significantly lower than comparative document scheme, and electronic conductivity is increased by nearly 50%.

The invention relates to the field of compound preparation, and discloses a method for preparing alkali metal ferrocyanide by using iron powder as an iron source through a mechanochemical method, and the method comprises the following steps: mixing the iron powder with a solution containing alkali metal cyanide to obtain a mixture, and enabling the water content of the mixture to be not more than 50wt%, the alkali metal cyanide comprises sodium cyanide or potassium cyanide, the reaction time is short, the reaction temperature is low, the process of treating the raw materials in advance is omitted, hydrolysis of the sodium cyanide is reduced, side reactions are reduced, a small amount of NH3 is released in the complexing reaction process, and the method is suitable for industrial production. The yield is high, sulfate containing ferrocyanide is not produced as a byproduct, and unreacted metal residues are recycled. Compared with a traditional method, the method disclosed by the invention is low in production cost and high in added value of products, and has a relatively good industrial prospect.

The invention discloses a vacancy content controllable Prussian blue crystal as well as a preparation method and application thereof, and belongs to the technical field of material synthesis. In order to solve the technical problems that the vacancy content of a prussian blue material is difficult to accurately control and a vacancy-free material is difficult to prepare, the invention provides a series of prussian blue crystals with controllable vacancy content, and the preparation method comprises the following steps: mixing sodium ferrocyanide, a complexing agent, a sodium salt and water to obtain a solution A; mixing soluble manganese salt, soluble ferrous salt, a complexing agent, sodium salt and water to obtain a solution B; and controlling the sodium ion concentration and the reaction atmosphere and temperature, adding the solution A into the solution B, reacting, and aging to obtain the Prussian blue crystal. According to the method, the sodium ion concentration, the reaction atmosphere and the temperature are regulated and controlled by changing the addition amount of the sodium salt and the like, and the crystal growth speed and the ion transmission speed in the coprecipitation reaction are controlled, so that the purpose of accurately controlling the vacancy content is achieved, and a material without vacancy and first-stage crystal water can be prepared.

The application provides a single crystal type high-entropy Prussian blue positive electrode material and a preparation method and application thereof, and the preparation method comprises the following steps: mixing a transition metal salt solution, a sodium ferrocyanide solution, a complexing agent solution, a base solution and a precipitant, performing a co-precipitation reaction under the condition that the pH value is 10-13, then performing standing and aging, and sequentially performing filtration, washing and drying to obtain the single crystal type high-entropy Prussian blue positive electrode material. The single crystal type high-entropy Prussian blue positive electrode material obtained by the application has a high material thermal decomposition temperature and excellent thermal stability; vacancies in the positive electrode material and a small amount of water content can inhibit the dissolution of metals; in addition, the single crystal type high-entropy Prussian blue positive electrode material obtained by the application has excellent morphology.

The application provides a preparation method of a sodium-rich and low-water-content Prussian blue positive electrode material, which comprises the following steps: dissolving sodium ferrocyanide or a hydrate thereof and a complexing agent in deoxygenated water under an inert gas atmosphere and at a certain temperature to obtain a mixed solution A; dissolving a transition metal salt or a hydrate thereof, a sodium supplementing agent, a complexing agent and an auxiliary complexing agent in deoxygenated water under an inert gas atmosphere and at a certain temperature to obtain a mixed solution B; continuously stirring solution A and solution B by dropwise adding them into a container with a positive pressure inert gas atmosphere and at a certain temperature, continuing to stir for a period of time after the dropwise adding is completed, and then standing, centrifuging and vacuum drying to obtain the Prussian blue positive electrode material. The Prussian blue positive electrode material comprises a mixed phase structure of rhombic phases and cubic phases, has the characteristics of high sodium content and low water content. The battery assembled by using the positive electrode material obtained by the method has a theoretical specific capacity close to the theoretical specific capacity under a small current density and still has a high specific capacity under a large current density.

This invention relates to a method for reducing decomposition of an aqueous sodium cyanide solution by passing an inert gas through the aqueous sodium cyanide solution to remove carbon dioxide from the solution, and / or storing the aqueous sodium cyanide solution under an inert gas or under a vacuum. This invention also relates to a method for reducing decomposition of a sodium cyanide slurry, a sodium cyanide paste, or a solid sodium cyanide composition by storing the sodium cyanide paste, the sodium cyanide slurry, or the solid sodium cyanide under an inert gas or under a vacuum.

The utility model discloses a sodium cyanide hydrogen-containing tail gas liquid ammonia device, which relates to the technical field of tail gas treatment, and comprises a first filter tank and a second filter tank, an input pipeline is arranged above the first filter tank and the second filter tank, a first electric control valve is arranged between the input pipeline and the first filter tank, and a second electric control valve is arranged above the first electric control valve. An input pipeline is arranged below the first filtering tank, a second electric control valve is arranged between the input pipeline and the second filtering tank, an output pipeline is arranged below the first filtering tank and the second filtering tank, a third electric control valve is arranged between the output pipeline and the first filtering tank, and a fourth electric control valve is arranged between the output pipeline and the second filtering tank; filtering sections are arranged in the middles of the interiors of the first filtering tank and the second filtering tank, a first-layer filtering plate and a second-layer filtering plate are arranged at the upper end and the lower end of the interior of each filtering section respectively, by improving the technology, recycling of by-products can be achieved, for example, hydrogen-containing tail gas is converted into liquid ammonia, and therefore resource waste is reduced.

The present invention relates to a process for producing a composite ferrocyanide adsorbent of a transition metal in the silica gel matrix comprising the following steps: (i) the preparation of a first aqueous composition comprising at least a mixture of a sodium or potassium ferrocyanide with a sodium silicate solution so as to obtain the dissolution of salts; (ii) the preparation of a second composition comprising a mixture of at least: a transition metal salt selected from one or more of the following compounds: nickel, copper, zinc, cobalt, and an inorganic acid; (iii) the mixing of the first aqueous composition with the second composition until a suspension is obtained; (iv) the addition of an inorganic acid or base so that the suspension obtained at the end of step (iii) has a pH ranging from 4 to 9;(v) the separation of the suspension obtained at the end of step (iv) so as to obtain a precipitate within a liquid phase; (vi) the separation of said precipitate, the rinsing and drying of the precipitate, so as to obtain a solid precipitate, characterized in that the first aqueous composition comprises a soluble salt of rubidium or cesium, and the second composition further comprises a soluble salt of metal selected from one or more of the following compounds: aluminium, titanium, zirconium.;

The application provides a continuous production device and method of methyl cyanoacetate, which comprises a feeding unit, a reaction unit and a post-treatment unit connected in sequence, the reaction unit comprises a tubular reactor, the lower part of the tubular reactor is provided with a methanol feeding port and a sodium cyanide feeding port, the top of the tubular reactor is provided with a methyl chloroacetate feeding port, and the bottom of the tubular reactor is provided with a methyl cyanoacetate crude product discharging port; the feeding unit comprises a methanol feeding device, a sodium cyanide feeding device and a methyl chloroacetate feeding device, and the methanol feeding device, the sodium cyanide feeding device and the methyl chloroacetate feeding device are connected with the methanol feeding port, the sodium cyanide feeding port and the methyl chloroacetate feeding port respectively. The tubular reactor is used for continuous production, compared with the traditional batch production mode of the reaction kettle, the problem of sodium cyanide solid feeding is solved, the occurrence of the reverse reaction is effectively inhibited, and the yield of methyl cyanoacetate is greatly improved.

The application provides a sulfide ore alkaline desulfurization cyanide leaching gold reagent system and a gold extraction method thereof, and belongs to the technical field of hydrometallurgy. The method constructs a ternary reagent system composed of potassium ferricyanide, low-concentration sodium cyanide and thioguanosine. An efficient "oxidation-inhibition" synergistic system is formed between the auxiliary desulfurization reagent potassium ferricyanide and thioguanosine. The rapid and selective oxidation of potassium ferricyanide is smoothly carried out under the synergistic action of thioguanosine, the mineral is completely decomposed, and the surface remains high activity; at the same time, the presence of thioguanosine can more directly eliminate the risk of local micro-area passivation and catalyze electron transfer. The two complement each other, and together guarantee that the subsequent low-concentration sodium cyanide can smoothly and unobstructedly leach the exposed gold with high efficiency, finally realizing the high recovery rate extraction of gold in the refractory sulfide ore while reducing the total consumption of reagents and environmental pollution.

A method for preparing a Prussian blue-based sodium-ion battery cathode material with both high capacity and long cycle performance, belonging to the field of sodium-ion batteries, includes the following steps: Step 1, preparing a sodium ferrocyanide solution, denoted as solution A; Step 2, dissolving a transition metal divalent ferric salt, a doped metal salt, ascorbic acid, and a complexing agent in deionized water, denoted as solution B; Step 3, preparing an aqueous solution of the complexing agent, denoted as solution C; Step 4, simultaneously adding solutions A and B in equal molar amounts to solution C for a co-precipitation reaction, aging the solution to obtain a suspension, separating the suspension to obtain the Prussian blue-based sodium-ion battery cathode material with both high capacity and long cycle performance. This invention proposes a synthesis method that only requires co-precipitation through a combination of slow crystallization and ion doping to obtain a low-cost, non-toxic, harmless, simple preparation process, short production cycle, and Prussian blue-based sodium-ion cathode material with both high capacity and long cycle performance.

The utility model discloses alkali liquor absorbing and spraying equipment of sodium cyanide production equipment, which relates to the technical field of alkali liquor spraying equipment and comprises a main pipeline, four auxiliary pipelines are arranged on two sides of the side wall of the main pipeline, spraying ends are arranged at the outer side ends of the four auxiliary pipelines, and the spraying ends are communicated with the main pipeline. A connecting end head is arranged at the upper end of the spraying end head, an adjusting rod is connected to the middle position of the connecting end head in a penetrating mode through threads, an adjusting end head is arranged at the lower end of the adjusting rod, and the adjusting end head extends into the lower end of the interior of the spraying end head; an adjusting seat is arranged at the position, corresponding to the adjusting end, of the lower end of the interior of the spraying end, a nozzle is formed in the lower end of the adjusting seat, a spraying end structure is reset, and an adjustable adjusting end structure is designed, so that water mist sprayed by the spraying end can be adjusted, fine liquid drops are easily formed, the gas-liquid contact area is increased, and the spraying effect is improved. Therefore, the absorption efficiency meets the production requirement.

The invention discloses a rapid preparation method of low-defect manganese-based Prussian blue under solid-liquid dynamic equilibrium, which comprises the following steps: S1, dissolving sodium citrate in deionized water, and then adding manganese acetate and ascorbic acid to form a solution A containing a manganese complex; wherein the molar ratio of the sodium citrate to the manganese acetate to the ascorbic acid is (4.5-5.5): 1: (0.3-0.4); s2, adding sodium ferrocyanide into deionized water, and stirring at a set temperature to form a supersaturated turbid liquid B containing an undissolved sodium ferrocyanide solid; wherein the addition amount of the sodium ferrocyanide far exceeds the saturation solubility of the sodium ferrocyanide at the temperature, so that the system is kept in a solid-liquid two-phase equilibrium state; benefited from the whole-process dynamic saturation environment, compared with a comparison file, the manganese-based Prussian blue prepared by the method has more obvious monoclinic phase characteristics (corresponding to obvious XRD double peaks, obvious strength and good signal-to-noise ratio), the lattice vacancy and coordinated water content are obviously lower than those of a comparison file scheme, and the electronic conductivity is increased by nearly 50%.

The invention discloses an anode catalyst as well as a rapid Joule heat preparation method and application thereof. Mixing the nickel ion solution with the iron ion solution to obtain a mixed metal ion solution; dropwise adding the mixed metal ion solution into a sodium ferrocyanide solution, mixing and dispersing, and carrying out centrifugal separation and drying to obtain a precursor material; the foamed nickel is sequentially subjected to ethanol ultrasonic treatment and then immersed in nitric acid for ultrasonic cleaning; and mixing the pretreated foamed nickel with the precursor material obtained in the step 1, carrying out rapid Joule heat treatment under the protection of inert gas, and cooling to obtain the anode catalyst. The anode catalyst material prepared through rapid Joule heat treatment shows excellent electrochemical (OER) oxygen evolution reaction catalytic performance, the overpotential reaches 220 mV under the current density of 10 mA cm <-2 >, and compared with a commercial anode catalyst material prepared through a traditional method, the overpotential is reduced by about 30-100 mV.

The invention relates to a novel process for synthesizing ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, which adopts 3-oxygen-glutaric acid monoethyl ester as a raw material and comprises the following steps of: 1, reacting the 3-oxygen-glutaric acid monoethyl ester as a raw material with a chlorination reagent to generate 4-formyl chloride ethyl acetoacetate; 2, enabling the 4-formyl chloride ethyl acetoacetate to react with an amination reagent to generate 4-formyl amino ethyl acetoacetate; 3, the 4-formamido ethyl acetoacetate and a dehydrating agent are subjected to a reaction, and 4-cyano ethyl acetoacetate is generated; and 4, reacting the 4-cyanoacetoacetic acid ethyl ester with hydrogen under the action of a hydrogenation catalyst to generate (R)-(-)-4-cyano-3-hydroxybutyric acid ethyl ester. According to the method, ethyl 3-oxoglutarate is innovatively adopted as a raw material, and the (R)-4-cyano-3-hydroxybutyrate meeting the quality standard is finally obtained through chlorination, amination, dehydration and chiral hydrogenation reaction. Sodium cyanide is not used as a cyaniding reagent, the amount of three wastes is small, reaction conditions are mild, and the method is suitable for industrial production.

The application provides a preparation method of 4-(hydroxymethyl phosphono)-2-carbonyl butyric acid, comprising the following steps: a) mixing methyl phosphonate diester, carboxylic acid and acryloyl cyanide to perform an addition reaction, and obtaining (3-cyano-3-carbonyl propyl) methyl phosphonate liquor after reduced pressure distillation; b) uniformly mixing the (3-cyano-3-carbonyl propyl) methyl phosphonate liquor obtained in step a) with water, cooling to 10-40 DEG C, then adding hydrochloric acid dropwise to perform acidification, continuing to stir for 0.1-1 h after the dropwise addition is completed, then performing a hydrolysis reaction, and finally performing purification treatment to obtain 4-(hydroxymethyl phosphono)-2-carbonyl butyric acid. Compared with the prior art, the preparation method provided by the application does not need to perform a cyanation reaction, avoids the use of high-cost, hard-to-obtain cyclic phosphonic anhydride and the highly toxic sodium cyanide; and the preparation method has short process steps, the raw materials are widely sourced and low in cost, the reaction conditions are mild, and the element comprehensive utilization rate is high.