817 results about "Hydantoin" patented technology

The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

The present invention relates to diarylthiohydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.

The present invention relates to novel compounds useful in the treatment of androgen receptor associated conditions, such as age-related diseases, pharmaceutical compositions containing at least one of the compounds of the present invention and methods of treating a patient in need of therapy for an androgen receptor associated condition by administering a therapeutically effective amount of at least compound of the present invention.

This invention is directed to an extrudable compound, an extrusion method using a polymer, a cellulosic fiber, and at least one lubricant selected from the group consisting of ethoxylated esters of hydantoins, ethoxylated esters of sorbitol and sorbitan, and ethylene bisamides made from fatty acids containing 6-10 carbons and composites manufactured through such processes which simulate conventional wood products. Another embodiment of the invention is directed to a composition containing polymer, a cellulosic fiber from an agricultural waste product and a lubricant containing a mixture of an alkylene bisamide derived from a C10-C18 is fatty acid and an alkaline earth salt of a fatty acid.

The present invention provides an optoelectronic device comprising a light emitting semiconductor and an encapsulant. The encapsulant is made from an encapsulant formulation comprising an epoxy hydantoin, an epoxy isocyanurate, and a curing agent. The present invention also provides a method of preparing such optoelectronic device.

The invention discloses a method for preparing methionine. The method for preparing the methionine concretely comprises the steps that cyanohydrins, carbon dioxide and ammonia or sodium cyanide, 3-(Methylthio)propionaldehyde, carbon dioxide and ammonia serve as raw materials to prepare hydantoin; alkaline hydrolysis is conducted on the hydantoin and then the hydantoin is acidized to pH 3.0-6.0 to obtain a compound of the methionine and salts; crystallization is conducted under the condition of temperature ranges from 8 DEG C to 45 DEG C, then the compound is separated to obtain a methionine crystal and salt mother liquor, the methionine crystal is washed by water and dried, and washing liquor is standby; finally, the salt mother liquor is concentrated under the condition of temperature which is lower than 60 DEG C, and then the salt mother liquor passes through a chromatographic column to obtain an inorganic salt and the methionine; the preparation method can efficiently separate the methionine and the salts, the recovery rate of the methionine can reach 99%, and the method is green and protects the environment, no methionine is resolved, no large number of acid and stink wastewater is discharged, and the purity of the inorganic salt is high and can be sold as a commodity.

This invention is directed to a class of compounds (Formula I) including succinoyl amino pyrazoles, succinoyl amino thiadiazoles, succinoyl amino acid esters, succinoyl amino acid amides, succinoyl amino alcohols, succinoyl amino ketones, succinoyl amino hydantoins, succinoyl anilines, and succinoyl derivatives of privileged structures. The invention is also directed to a pharmaceutical formation comprising such compound in a pharmaceutically acceptable salt form or prodrug thereof. The invention is further directed to a method for inhibiting β-amyloid peptide release and/or synthesis, a method for inhibiting γ-secretase activity and a method for treating neurological disorders associated with β-amyloid peptide production. The method comprises administering to a host a pharmaceutical formulation comprising an effective amount of a compound of Formula I. The compounds of Formula I are useful in the prevention and treatment of Alzheimer's disease.

Processes for preparing sulfoxides useful as drugs such as acid secretion inhibitors or antiulcer drugs or intermediates for the preparation of drugs in high yields, at high purities, and with safety. Specifically, a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with a peroxoborate salt in the presence of an acid anhydride or a metal catalyst; and a process for the preparation of sulfoxides (II) by oxidizing a thio ether (I) with an N-halosuccinimide, 1,3-dihalo-5,5-dimethyl-hydantoin or dichloroisocyanuric acid salt in the presence of a base. In said formulae R1 is hydrogen, methoxy or difluoromethoxy; R2 is methyl or methoxy; R3 is 3-methoxypropoxy, methoxy or 2,2,2-trifluoroethoxy; and R4 is hydrogen or methyl

The invention discloses a composite for preventing and controlling an agricultural bacterial disease, and belongs to the technical field of plant protection pesticides. The composite comprises an active component A and an active component B, wherein the active component A is benziothiazolinone; the active component B is one or two of cymoxanil, qingkuling, yekuzuo, bismerthiazol, ethylicin, thiram, dioctyl divinyltriamino glycine, active ester, metalaxyl, chlorothalonil, dithiocyano-methane, bromine chlorine hydantoin, 2-bromine-2-nitryl-1,3-propylene glycol and moroxydine hydrochloride; the weight ratio of the active component A to the active component B is 1:100 to 100:1. The composite disclosed by the invention obtains the synergetic effect through the mixing of the benziothiazolinone and other bacterial medications and is used for agricultural production.

A personal care composition comprising leghemoglobin and at least one preservative selected from the group consisting of alcohols, glycols, parabens, hydantoins, quaternary nitrogen-containing compounds, isothiazolinones, aldehyde-releasing agents, and halogenated compounds. Preferably, the leghemoglobin is a nitrogen fixation root nodule extract providing a leghemoglobin concentration in the composition of between 0.0001% and about 10% based upon the total weight of the composition. Also disclosed is a method for preparing the personal care composition.

A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.

A method for environment-friendly clean production of D,L-methionine includes: performing alkaline hydrolysis of 5-(2-methylmercaptoethyl)-hydantoin to obtain carbonate-containing methionine alkali metal saponified solution; then feeding carbon dioxide, crystallizing, and separating to respectively obtain methionine and hydrocarbonate water solution of methionine; subjecting the hydrocarbonate water solution of methionine to chromatographic separation. The method has advantages that loss of D,L-methionine due to pyrolysis can be reduced, simplicity in operation, low cost and high utilization rate of raw materials are realized, high efficiency in acquisition of high-purity methionine crystals is achieved, the purity of the obtained methionine is up to 99.4%, the methionine recovery rate reaches 97%, and the desalinization rate reaches 98% or above. In addition, accumulation of a great quantity of impurities of methionine-containing potassium bicarbonate mother liquor and emission of the potassium bicarbonate mother liquor are avoided, discharge of saline wastewater is avoided, and accordingly environment friendliness and clean production are realized. In a whole process, potassium carbonate serving as a hydrolysis agent is recycled without loss, and replenishment of alkaline potassium compounds is avoided.

The present invention relates to naturally degradable environment friendly halogen-containing disinfectant, and is especially disinfectant of halogeno dialkyl hydantoin aqua and its application. In room temperature, halogeno dialkyl hydantoin, stabilizer, solubilizer and and/or synergist in certain weight proportion are mixed and dissolved in water to form the liquid preparation. The liquid preparation has raised water solubility of halogeno dialkyl hydantoin and excellent disinfecting effect. The liquid preparation may be used in industrial cooling water, industry waste water, air conditioner cooling water and swimming pool water, especially oil field refilling water, as well as daily life.

This invention relates to a crosslinking composition comprising a compound having the structure of Formula I:

A′-NR^A—R^D

where A′ is a moiety derived from the group consisting of linear or cyclic ureas, cyanuric acid, substituted cyanuric acids, linear or cyclic amides, glycolurils, hydantoins, linear or cyclic carbamates and mixtures thereof, or a moiety comprising the structure:

where R^A is R^D, hydrogen, an alkyl of 1 to 20 carbon atoms, or taken together with A′ forms a cyclic compound; R^D is —CHR^C OR^B, wherein R^B is hydrogen, alkyl, aryl, aralkyl or an alkaryl having from 1 to about 24 carbon atoms and R^C is an alkyl, halogenated alkyl, aryl, aralkyl, halogenated aralkyl, alkoxyalkyl or an alkaryl having from 1 to about 24 carbon atoms; A is a moiety derived from the group consisting of linear or cyclic ureas, cyanuric acid, substituted cyanuric acids, linear or cyclic amides, glycolurils, hydantoins, linear or cyclic carbamates and mixtures thereof; B is a residue of a poly(alkylaldehyde) with n aldehyde groups; n is an integer of 2 to about 8; R_a is R_d, hydrogen, an alkyl of 1 to about 20 carbon atoms, or taken together with A forms a cyclic compound; where R_d is CHR_cOR_b or

where R_b is hydrogen, alkyl, aryl, aralkyl or an alkaryl having from 1 to about 24 carbon atoms and R_c is an alkyl, halogenated alkyl, aryl, aralkyl, halogenated aralkyl, alkoxyalkyl or an alkaryl having from 1 to about 24 carbon atoms; and where the alkyl or aryl groups in each radical may optionally have heteroatoms in their structure. This invention also relates to a process for producing the crosslinking composition by reacting an amino compound containing amino groups; a mono(alkylaldehyde) and/or a poly(alkylaldehyde), and an alcohol; where said amino compound is selected from the group consisting of: linear or cyclic ureas, cyanuric acid, substituted cyanuric acids, linear or cyclic amides, glycolurils, hydantoins, linear or cyclic carbamates and mixtures thereof.

The invention discloses a pyridine quaternary ammonium salt type halamine antibacterial agent with a structure represented by a general formula I, wherein n is an integer of 1-10. The preparation method comprises the following steps: a, 5,5-dimethyl hydantoin is placed in an acetone solution doped with anhydrous potassium carbonate; refluxing is carried out for 30min, and dibromoalkane is added; refluxing is continued for 4h, such that a bromo-alkyl hydantoin compound is obtained; b, the obtained bromo-alkyl hydantoin compound is dissolved in acetonitrile; excessive pyridine is added; heating and refluxing are carried out overnight; concentration is carried out, such that a pyridine bromide quaternary ammonium salt type halamine precursor is obtained; the precursor is delivered through chlorine-type anion exchange resin, such that a pyridine chloride quaternary ammonium salt type halamine precursor is obtained; and c, the obtained pyridine chloride quaternary ammonium salt type halamine precursor is dissolved in a mixed solution composed of deionized water and tert-butanol; tert-butyl hypochlorite is added, and stirring is carried out for 2-4h while protected from light, such that the pyridine quaternary ammonium salt type halamine is obtained. The method has the advantages of easy-to-obtain raw materials, and relatively simple synthesis method. The method has a prospect of industrialized application.

The present invention relates to an ozone-stressed yeast lysate, and a personal care composition including an ozone-stressed yeast lysate and at least one preservative selected from the group consisting of alcohols, glycols, parabens, hydantoins, quaternary nitrogen-containing compounds, isothiazolinones, aldehyde-releasing agents, and halogenated compounds. The present invention also relates to a method for preparing and using the ozone-stressed yeast lysate and the personal care composition.

The invention discloses a cyanide-free electrosilvering solution applicable to high-speed electroplating and an electroplating process, which belong to the technical field of electrosilvering. The electrosilvering solution is prepared from hydantoin derivatives, an auxiliary complexing agent, potassium hydroxide, potassium carbonate, silver nitrate and ultrapure water. The electrosilvering process comprises the following steps of: firstly, pre-plating an intermediate silver-plating layer and performing quick silver-plating; secondly, after the electroplating, taking a sample out of the electroplating solution, cleaning the surface of the sample through distilled water, and performing cold air drying. The obtained electroplating solution of an electrosilvering system does not contain extremely toxic substances and is extremely high in stability; the phenomena of precipitation, color changing and the like of a newly-prepared plating solution and a plating solution subjected to repeated constant-current plating, which are placed for over two months, are avoided; the plating effect of all plating solutions, which are placed for a long time or work for a long time, is the same as that of a newly prepared plating solution; a silver-plating layer with good appearance can be obtained in a wide temperature range and a wide current density range.

The invention provides a compound as shown in a Formula I or salts, solvent compounds, pre-drugs, stereoisomers, tautomers, polymorphic forms or metabolites thereof that are acceptable pharmaceutically, a medicine composition containing the same and an application thereof in preparation of medicines for treating male hormone receptor relevant diseases.

A fabric for use in chemical and biological (CB) protective garments includes at least one felt layer having from 25% to 100% carbon nanotube (CNT) fibers as a breathable physical barrier against toxic chemical droplets and/or pathogens. The felt layers are cleaned and consolidated into a mechanically competent sheet which can form adhesive seams having lapshear greater than the sheet itself. An additional supporting layer can be included. The supporting layer can be a wicking layer which is permeable with a chlorinated or otherwise chemically active solution to establish a reactive chemical barrier, the solution being dispensed on demand from a portable container. Embodiments include a second layer of CNT or of another backing fabric, sandwiching the wicking layer therebetween. Impermeable fluoropolymer seams can divide the fabric into a plurality of CNT/wicking cells. A layer of activated charcoal and/or halamine-forming hydantoin can be included for persistent reactive chemical protection.

The invention relates to a preparation method of flurbiprofen axetil. The method comprises the following steps of: preparing 4-bromine-2-fluoroanili from fluoroaniline under the action of 1,3- dibromo-5,5-dimethyl hydantoin; condensing 4-bromine-2-fluoroanili with benzene under the action of a catalyst and sodium nitrite to synthesize 4-bromine-2-fluorobiphenyl; carrying out grignard reaction and acidity reaction on the 4-bromine-2-fluorobiphenyl and 2-bromine sodium propionate under the action of a catalyst to generate 2-(2- fluorine-4-biphenylyl) propionic acid; condensing the 2-(2- fluorine-4-biphenylyl) propionic acid with 1-chloroacetic ethyl acetate to generate a target compound flurbiprofen axetil; and carrying out molecular distillation on the flurbiprofen axetil crude product to obtain a flurbiprofen axetil final product.

A process is provided for preparing spiro-hydantoin compounds of the formula II

wherein Z is N or CR_4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A₂ is a linker, G′ is a linker; Q is a linker; and R₂, R_4a, R_4c, and R_h are defined in the specification. The process optionally includes the enantiomeric separation of intermediates to allow preparation of enantiomers of the spiro-hydantoin compounds of formula II. Substituted spiro-hydantoin compounds may be prepared from the spiro-hydantoin compounds of formula II. The spiro-hydantoin compound of formula II and the substituted spiro-hydantoin compounds are useful in the treatment of immune or inflammatory diseases. Also, provided are products made by the instant inventive process and crystalline forms (prepared by any process) of the substituted spiro-hydantoin compound, 5-[(5S, 9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-ylmethyl]-thiophene-3-carboxylic acid, including solvates and salts thereof, as well as methods of use thereof. Crystalline forms of certain intermediates are provided.