163 results about "Hydantoin" patented technology

Oligomers that contain an ethylenically unsaturated group, a silane group, and an aspartate group and / or hydantoin group are described. Also disclosed are methods for producing and using such compounds, such as their use in coating compositions, such as coating compositions suitable for application to optical glass fiber substrates.

The invention discloses a medical washable high-temperature-resistant modified polyester fiber fabric and a preparation method thereof, and relates to the technical field of fabrics. The medical washable high-temperature-resistant modified polyester fiber fabric prepared by the invention is obtained by blending, spinning and weaving modified polyester and modified mica and activating with sodium hypochlorite; the modified polyester is obtained by grafting organic silicon modified polyester with n-dodecanethiol and then reacting with bromooctylhydantoin; the modified mica is prepared by polymerizing diethyl phosphite and bisphenol S on the surface of the pretreated mica, grafting a vinyl monomer and then reducing; the vinyl monomer is obtained by carrying out a reaction on 1-allyl-3-cyano-6-hydroxy-4-methyl-2-pyridone and an azo salt, and the vinyl monomer is obtained by carrying out a reaction on 1-allyl-3-cyano-6-hydroxy-4-methyl-2-pyridone and an azo salt; the medical washable high-temperature-resistant modified polyester fiber fabric prepared by the invention has good antibacterial, anti-aging and flame-retardant properties.

The invention relates to hydantoinase and application thereof in hydrolysis or preparation of chiral monomeric compounds. Compared with an amino acid sequence as shown in SEQ ID NO: 1, the amino acid sequence of the hydantoin enzyme is different in one or more positions selected from the 63 site, the 64 site, the 70 site, the 92 site, the 94 site, the 123 site, the 318 site, the 319 site and the 345 site. The invention also relates to a nucleic acid molecule, a nucleic acid construct, a recombinant vector and a host cell encoding the hydantoin enzyme, and an enzyme preparation containing the hydantoin enzyme. The invention also relates to a method for hydrolyzing or preparing a chiral monomeric compound by using the hydantoinase. The hydantoinase provided by the invention has better selectivity on substrate configuration and higher hydrolase activity, can catalyze various racemate hydantoin analogues, and selectively hydrolyzes R configuration with high reaction efficiency to obtain a compound chiral monomer with S configuration.

The invention discloses a gold leaching process using a high-safety bromine-containing substance, and belongs to the technical field of gold extraction. According to the method, the dibromo dimethyl hydantoin and the calcium bromide are prepared into the leaching solution according to a certain proportion, efficient gold leaching is achieved by adjusting parameters such as the pH value and the leaching time under the condition of the metal ion catalyst, and the gold can be effectively adsorbed, analyzed and recycled through the leached pregnant solution. Meanwhile, bromine in the leachate is recycled through an electrochemical method, bromine is prevented from permeating into the environment, the dosage of chemicals is reduced, a complete gold leaching and chemical circulating system is constructed, the gold leaching efficiency is improved, the environmental risk is reduced, the technical applicability is expanded, and the defects that traditional liquid bromine gold leaching is large in toxicity, low in leaching rate and leaching efficiency and the like are overcome.

The invention relates to the field of carbon fiber epoxy resin modification and preparation, in particular to a pultrusion epoxy resin composition and application thereof, an epoxy resin material and a preparation method and application of the epoxy resin material. Wherein the component A comprises an epoxy resin mixture, a diluent, a coupling agent, a modified carbon nanotube and a release agent; the epoxy resin mixture comprises at least two of polyfunctional epoxy resin, rigid particle modified bisphenol epoxy resin, hydantoin epoxy resin and alicyclic epoxy resin; the component B comprises a curing agent, a toughening agent, a composite accelerant and a catalyst; the composite accelerant is selected from at least two of modified imidazole, chromium acetylacetonate and triphenyl ethyl phosphonium bromide; the composition overcomes the defects that the viscosity of an epoxy resin system is relatively high and all the components need to be mixed at relatively high temperature, and the heat resistance and the strength retention rate are high while the toughness is improved.

The present invention belongs to the technical field of mechanochromic materials, and specifically relates to a mechanochromic material containing rhodamine with a hydantoin structure, and its preparation method and application. The rhodamine mechanochromic material containing a hydantoin structure is shown in structure (I), with rhodamine B as the matrix, reduced to rhodamine alcohol, oxidized to generate rhodamine aldehyde, and reacted with hydantoin to prepare a six-membered spirocyclic rhodamine containing a hydantoin structure. The rhodamine compound containing a hydantoin structure involved in the present invention has good ion interference resistance, exhibits photochromic properties in a dichloromethane solvent, and has the properties of mechanical stress discoloration and solvent mixing stress discoloration with high contrast and good repeatability. The solid powder of the rhodamine mechanochromic material containing a hydantoin structure has the characteristic of changing color upon grinding. After the action of mechanical force, the color of the powder changes from yellow to pink, and a reversible color change is achieved during the grinding-heating process.

The invention discloses a modified graphene antistatic fiber and a preparation method thereof, and relates to the technical field of chemical fibers. When the modified graphene antistatic fiber is prepared, polyethylene glycol terephthalate, an ultraviolet absorption monomer and dimethyl (vinyl) silane react to prepare modified polyester; the preparation method comprises the following steps: polymerizing thiophene, hydantoin thiophene and 3-vinyl thiophene, and coating the phase change microcapsule with the polymerized thiophene, hydantoin thiophene and 3-vinyl thiophene to prepare a pre-modified phase change microcapsule; reacting the pre-modified phase change microcapsule with sodium hypochlorite to obtain a modified phase change microcapsule; the pre-modified graphene and 5-chloro-1-pentene are subjected to a reaction, and modified graphene is prepared; preparing a spinning solution from the modified polyester, the modified phase change microcapsules, the modified graphene, chloroplatinic acid and N, N-dimethylformamide, and performing wet spinning to obtain the modified graphene antistatic fiber. The modified graphene antistatic fiber prepared by the invention has excellent anti-aging, antibacterial, flame-retardant, antistatic, warm-keeping and mechanical properties.

The invention discloses a sewage treatment membrane and a preparation method thereof, and relates to the field of sewage treatment. When the sewage treatment membrane is prepared, porous nano titanium dioxide, 3, 5-diaminopyrazole and benzo [1, 2-B: 3, 4-B ': 5, 6-B'] trithiophene-2, 5, 8-trialdehyde are uniformly mixed to prepare modified nano titanium dioxide; the preparation method comprises the following steps: reacting 1, 3, 5, 7-tetramethylcyclotetrasiloxane, 1, 3-bis (3-aminopropyl) tetramethyldisiloxane, 2-vinyl imidazole and 1-allylhydantoin to prepare functionalized amino siloxane; and uniformly mixing p-phenylenediamine, functionalized amino siloxane, pyromellitic dianhydride, modified nano titanium dioxide and zinc nitrate hexahydrate, and treating with a sodium hypochlorite solution to obtain the sewage treatment membrane. The sewage treatment membrane prepared by the invention has excellent heavy metal ion complexing property, antibacterial property and photocatalytic degradability.

The invention relates to the technical field of plastic waste recovery, in particular to automatic recovery equipment for hydantoin epoxy resin waste. Comprising a shell, the shell is fixedly connected with a first guide plate and a second guide plate, the shell is fixedly connected with a baffle, the shell is provided with a first electromagnetic sliding rail, a first electromagnetic sliding block is slidably connected into the first electromagnetic sliding rail of the shell, the first electromagnetic sliding block is fixedly connected with an extrusion plate, and the shell is provided with a second electromagnetic sliding rail. The second electromagnetic sliding rail of the shell is in sliding connection with a second electromagnetic sliding block, and the second electromagnetic sliding block is fixedly connected with an extrusion frame. The extrusion plate and the extrusion frame drive one side of waste to reciprocate, so that the waste is continuously bent, epoxy resin on the waste is continuously crushed and falls off, the epoxy resin recycling efficiency is improved, the waste is not directly crushed, the content of waste impurities in the recycled epoxy resin is reduced, and the epoxy resin recycling quality is improved.

The application relates to substituted hydantoinamides of formula (I) as ADAMTS7 antagonists, to processes for their preparation, their use alone or in combination for the treatment or prophylaxis of diseases, in particular of cardiovascular diseases, including atherosclerosis, coronary artery disease (CAD), peripheral vascular disease (PAD), arterial occlusive disease or restenosis after angioplasty. R1 is hydrogen, alkyl, cycloalkyl, heterocycloalkyl, heteroaryl or phenyl; R2 is hydrogen, cyano, halogen, alkylsulfonyl, alkyl, cycloalkyl or alkoxy; R3, R4, R5, R6, R7 and R8 are independently hydrogen, halogen, alkyl or alkoxy; most groups being optionally substituted; with the proviso that at least one of R2, R3, R4 is H; X1, X2, X3, X4, X5 and X6 are independently N or C; with the proviso that in each ring maximal one X is N.

Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

A method for controlling a chemical process, by preparing methanol, hydrogen sulfide, methyl mercaptan, hydrocyanic acid, acrolein, 3-methylthiopropionaldehyde, 5-(2-methylmercaptoethyl)-hydantoin, methionine, a salt of methionine, and a derivative of methionine. The method includes providing a training set TS1, wherein TS1 is process values PV1 and process values PV2 being correlated to one another, and / or laboratory values LV1 and process values PV2 being correlated to one another. The method includes training a processing unit on the training set TS1 to identify a pattern of correlation between one or more measured process variables and at least one process variable. The method includes developing a calibration function CF1 for a calibrated soft sensor from the identified pattern of correlation and predicting at least one operating parameter for the chemical process as an approximation to LV1 and / or PV1. A system for controlling a chemical process.

The invention discloses a preparation method of 1-(3-chloropyrazolo [1, 5a]-4, 5, 6, 7-tetrahydropyridine-2-yl)-5-amino-1H-pyrazole-4-formonitrile, which comprises the following steps: taking 1-(3-pyrazolo [1, 5a]-4, 5, 6, 7-tetrahydropyridine-2-yl)-5-amino-1H-pyrazole-4-formonitrile as an initial raw material, and reacting with dichlorohydantoin in an organic solvent to prepare the 1-(3-chloropyrazolo [1, 5a]-4, 5, 6, 7-tetrahydropyridine-2-yl)-5-amino-1H-pyrazole-4-formonitrile. The preparation method comprises the following steps: adding 2-(4-(4-(4-(4-(4-(4-(4-(4-(4-(4-(4-(4- According to the preparation method disclosed by the invention, the raw materials are green and environment-friendly, and the prepared 1-(3-chloropyrazolo [1, 5a]-4, 5, 6, 7-tetrahydropyridine-2-yl)-5-amino-1H-pyrazole-4-formonitrile is environment-friendly in process, high in yield, high in purity and low in cost.

The subject matter described herein is directed to myelin-promoting compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for the treatment of disorders, such as myelin-related disorders.

A method for separation of cis and trans isomers of hydantoin-containing spiro- compound from an isomeric mixture, including contacting the isomeric mixture with a medium comprising a polar aprotic solvent, and separating the cis isomer and / or trans isomer.

The co-production and recovery process comprises the following steps: dissolving alpha-aminobutyric acid and potassium cyanate in water, and carrying out heating reaction to obtain an intermediate water solution; directly dropwise adding hydrochloric acid into the intermediate water solution, heating for reaction, cooling and filtering to obtain a main product filter cake and mother liquor; and drying the obtained main product filter cake to obtain the 5-ethyl hydantoin. Adding potassium hydroxide into the mother liquor to adjust the pH value, carrying out reduced pressure distillation until no distillate exists, adding ethanol, heating and filtering to obtain a potassium chloride filter cake and ethanol filtrate; concentrating and drying the ethanol filtrate, and recovering to obtain 5-ethyl hydantoin; washing the potassium chloride filter cake with ice water; drying the washed potassium chloride filter cake to obtain potassium chloride; and concentrating and drying the washing water after washing the potassium chloride filter cake to obtain the potassium chloride / ammonium chloride composite salt. According to the method, the product yield is increased, the waste liquid amount is reduced, and the production cost is further reduced, so that the method is very suitable for industrial large-scale environment-friendly production.

The invention belongs to the technical field of biological medicine, and particularly relates to application of a metabolic marker in preparation of a product for diagnosing abdominal aortic aneurysm. The metabolic marker comprises one or more than two of 5-delta-hydroxybutyl hydantoin, I-alpha-amino acid, PGF2 alpha, D-pyroglutamic acid, nicotine glucuronide, cysteine glutathione disulfide or Trp-P-1. Experiments prove that the metabolic marker has the advantages that the metabolic marker can be applied to the field of biomarkers, and the metabolic marker can be applied to the field of biomarkers; the seven metabolites are independently or jointly used as metabolic markers for diagnosing the abdominal aortic aneurysm and have good specificity and sensitivity.

The invention discloses a preparation method of super-weather-resistant polyester modified hydantoin epoxy acrylate, which comprises the following steps: reacting pentaerythritol triacrylate, hexahydrophthalic anhydride and cyclohexene oxide serving as main raw materials in the presence of triphenylphosphine serving as a catalyst, p-hydroxyanisole serving as a polymerization inhibitor and hypophosphorous acid serving as an antioxidant to obtain polyester resin containing monocarboxylic acid; and modifying hydantoin epoxy resin by using the prepared polyester resin to obtain the six-functionality polyester modified hydantoin epoxy acrylate. The main body structure of the resin is a saturated six-membered ring structure, a five-membered ring structure and a polyester structure, the phenomena of yellowing, pulverization and the like are not prone to occurring outdoors, and the resin has the outstanding advantages of being high in UV curing efficiency, resistant to abrasion and good in adhesion.

The invention discloses a hydantoin thiourea compound with dual inhibition effects of an androgen receptor and histone deacetylase 6, and further discloses a pharmaceutically acceptable salt of the hydantoin thiourea compound with the dual inhibition effects of the androgen receptor and the histone deacetylase 6. The invention further discloses application of the compound in preparation of a dual inhibitor serving as an androsinesin receptor and histone deacetylase 6. The invention also discloses application of the compound in preparation of drugs for treating tumors related to androgen receptors and histone deacetylase 6. The medicine prepared from the compound has an anti-prostatic cancer effect, provides a new direction for the research of the anti-prostatic cancer medicine, and is of great significance to the development of the anti-prostatic cancer medicine.

The invention relates to the technical field of cyanide-free silver plating solutions and preparation, and discloses a cyanide-free silver plating solution based on composite coordination and double-pulse fine regulation and a preparation method thereof.The cyanide-free silver plating solution comprises silver salt, a composite coordination agent, supporting electrolyte, a pH regulator and a composite functional additive, the silver salt provides silver ions with the concentration being 15-50 g / L, and the composite coordination agent provides silver ions with the concentration being 15-50 g / L; the composite coordination agent is composed of 80-140 g / L of a hydantoin main coordination agent and 15-30 g / L of a nitrogen heterocyclic amide auxiliary coordination agent, the concentration of the supporting electrolyte is 75-130 g / L, the supporting electrolyte is used for enhancing the conductivity of the plating solution, and the pH regulator is used for maintaining the pH value of the plating solution within the alkaline range of 9.0-11.5; the composite functional additive comprises 0.5-4 g / L of a main brightener, 0.1-1.5 g / L of an auxiliary brightener and 5-25 g / L of a grain refiner, and is used for improving the glossiness and compactness of a plating layer; through the preparation method, the difficulty and cost of wastewater treatment during solution plating can be reduced, the environmental protection effect is improved, and the stability of the plating solution during long-term use is improved.

This invention discloses a method for preparing sodium ketovaline, belonging to the field of chemical synthesis technology, including the following steps: using hydantoin and acetone as raw materials, and using a solid base catalyst K / MgAlO x Using sodium hydroxide as the main catalyst and a solvent as the co-catalyst, a condensation reaction is carried out in the presence of a solvent. After the condensation reaction is completed, a certain amount of sodium hydroxide is added, and the hydrolysis reaction is continued under the catalysis of a solid base catalyst to prepare sodium ketovaline. This invention can effectively improve the yield of sodium ketovaline, and the catalyst can be recycled.

The application discloses a crosslinking agent for degradable hydrogel and a preparation method of degradable polyacrylamide hydrogel based on the crosslinking agent; the crosslinking agent for degradable hydrogel is composed of hydantoin epoxy resin, N, N-dimethyl benzylamine and acrylamide; the degradable polyacrylamide hydrogel prepared by using the crosslinking agent comprises acrylamide, 1.8-4.6 parts of water, potassium persulfate and the crosslinking agent; the crosslinking agent for degradable hydrogel can realize the preparation of the degradable hydrogel by chemical crosslinking method, and by adjusting the crosslinking agent, the degradable hydrogel prepared based on the crosslinking agent is applicable in the temperature environment range of normal temperature to 150 DEG C, the degradable hydrogel has selectivity to gel breaking liquid, and can realize gel breaking only by adding alkaline gel breaking liquid, and the gel breaking time is adjustable in the range of 90 min to 72 h; in addition, the crosslinking agent and the preparation method of the hydrogel are simple, the conditions are easy to control, and have good market application and promotion prospect.

The invention discloses immobilized hydantoin enzyme. The immobilized hydantoin enzyme comprises an immobilized carrier, a cross-linking agent and recombinant hydantoin enzyme, wherein the recombinant hydantoin enzyme is connected with the immobilized carrier through the cross-linking agent by a chemical bond. In addition, the immobilized hydantoin enzyme is cross-linked again through a bifunctional cross-linking agent, and the 3-isobutyl glutarimide can be converted into the (R)-(-)-3-(carbamyl methyl)-5-methylhexanoic acid by the re-cross-linked immobilized enzyme with higher stability.

The present invention relates to the field of chemical technology, and more particularly to a method for synthesizing a hydantoin epoxy resin. Specifically: (1) 5,5-dimethylhydantoin, sodium hydroxide and water are mixed as a standby solution; (2) 1,2,3,4-diepoxybutane, isopropyl alcohol and benzene are sequentially added to a reaction tank and heated to 50-150°C, and kept under reflux for 4h; (3) the standby solution is added dropwise to the reaction tank, and the reaction is continued after the addition is completed, the viscosity of the solution is tested, and the reaction is stopped when it reaches 5-30cp; (4) isopropyl alcohol and benzene are distilled off under reduced pressure to obtain a crude hydantoin epoxy resin; (5) the crude product is refined, and a fine product is obtained after removing sodium hydroxide. The hydantoin epoxy resin obtained by the method has two hydroxyls, is more water-soluble, and has no ether bond and benzene ring, so it has excellent UV resistance and heat resistance, and can be used to produce a water-based epoxy resin coating with good weather resistance, low toxicity and high thermal stability.

The invention discloses a whitening facial cleanser and a preparation method thereof, and relates to the field of skin care products. The whitening facial cleanser is prepared from 35 to 42 weight percent of a cleaning agent, 1 to 2 weight percent of a whitening and freckle-removing agent, 0.8 to 1.2 weight percent of a skin conditioner, 4 to 8 weight percent of an emollient, 4 to 6 weight percent of a humectant, 0.3 to 0.5 weight percent of a preservative, 0.05 to 0.1 weight percent of a chelating agent, 4 to 4.5 weight percent of a thickening agent, 0.2 to 0.5 weight percent of an aromatic, 0.8 to 1.0 weight percent of a pH regulator and the balance of a solvent. The cleaning agent is prepared from sodium lauroyl isethionate, sodium cocoyl aminopropionate, cocamidopropyl betaine and sodium lauroyl sarcosinate according to the weight ratio of (3.5 to 4.5) to 1 to 1 to 1; the preservative comprises DMDM hydantoin and methylparaben in a weight ratio of (3-4): 1. The whitening facial cleanser provided by the invention has both cleaning power and mildness, and also has a whitening effect.

17-Beta-hydroxysteroid dehydrogenase type 13 (17β-HSD13) plays an important role in the pathogenesis and progression of Non-alcoholic fatty liver disease (NAFLD), also known as Metabolic dysfunction-associated steatotic liver disease (MASLD), and Alcohol-related liver disease (ARLD). Loss-of-function variant of 17β-HSD13 has been associated with a significantly reduced risk of NAFLD (MASLD), cirrhosis associated with nonalcoholic steatohepatitis (NASH (MASH)), alcoholic-related liver disease, alcoholic cirrhosis, hepatocellular carcinoma (HCC), hepatitis C chronic liver disease, pediatric liver disease, NASH (MASH) disease severity, ballooning degeneration, lobular inflammation, and fibrosis. The present invention relates to hydantoin compounds useful as inhibitors of 17β-HSD13 and methods for their preparation and use for treatment and prevention of above mentioned liver diseases.

Embodiments of the present application provide an electroplating solution for a gold-silver alloy and a use thereof. The electroplating solution comprises a gold ion source, a silver ion source, a first complexing agent, and a second complexing agent, wherein the first complexing agent comprises a hydantoin-based substance, and the second complexing agent comprises an organic sulfonic acid or a salt thereof. By means of a synergistic effect of the two types of complexing agents, the electroplating solution exhibits relatively high stability and can specifically inhibit electrodeposition of silver without affecting deposition of gold, thereby reducing the influence of current density fluctuations on the gold content in an alloy coating. Thus, an alloy coating having a gold content stably maintained within a range of 30-50 wt% can be produced over a relatively wide current density range having an interval width of at least 0.3 ASD.

Compounds that contain an ethylenically unsaturated group, an active-hydrogen group, and an aspartate group and / or hydantoin group are described. Also disclosed are methods for producing and using such compounds, such as their use in coating compositions, such as coating compositions suitable for application to optical glass fiber substrates.

The invention relates to a guanidino hydantoin methanesulfonate nonlinear optical crystal as well as a preparation method and application thereof. The molecular formula of the crystal is C3N3OH < 6 > (CH3SO3), the molecular weight is 195.2, the crystal belongs to an orthorhombic system, the space group is P212121, and the cell parameters are as follows: a = 5.5142 (5), b = 8.6892 (7), c = 17.4413 (16), alpha = 90.00 degrees, beta = 90.00 degrees, gamma = 90.00 degrees, Z = 4 and V = 820.5 (3) 3. Under the irradiation of 1064nm laser, the powder frequency-doubled effect of the crystal is about 3-5 times that of KH2PO4 (KDP), the ultraviolet absorption edge of the crystal is about 217nm, and the experimental birefringence is about 0.08-546nm. And growing crystals with the size of more than centimeter by adopting an evaporation method, an aqueous solution cooling method or a solvothermal method. The crystal is simple in preparation method and low in cost, has a relatively large nonlinear optical effect, a relatively large birefringence and a wide transmission range, is easy to grow and process, and can be used as an ultraviolet nonlinear optical crystal and a birefringence crystal.

A polyoxymethylene polymer composition containing a formaldehyde stabilizer package is disclosed. In one embodiment, the formaldehyde stabilizer comprises a substituted hydantoin, it has been found that the substituted hydantoin alone or a combination of a substituted hydantoin with another emission control agent significantly reduces formaldehyde emissions. When the polymer composition does not contain calcium stearate, the formaldehyde emission is low.