10 results about "Neurofibrillary tangle" patented technology

The present invention relates to a novel fluorescent marker that selectively binds to tau protein, its use, a method for imaging neurofibrillary tangles of tau protein in the retina of a subject, as well as an apparatus allowing said method to be carried out.

Novel and useful compounds, such as 2,4-dihydropyrazolo[3',4':4,5]pyrano[2,3-b]pyridines, are disclosed herein. Such compounds may be employed in various treatments, alleviation, or prevention of a group of disorders, such as disorders associated with Tau (tubulin associated unit) protein aggregates, such as neurofibrillary tangles (NFTs), such as Alzheimer's disease (AD).

The invention relates to generation, optimization and characterisation of VHH targeted against Tau MTBD (microtubule-binding domain) with high affinity, obtained by screening from a naïve synthetic library. The inventors optimized version of a lead VHH which is able to inhibit Tau aggregation in vitro and in HEK 293 aggregation-reporting cellular model, providing a new tool in Tau immunotherapies. Accordingly the invention relates to new VHH antibody that specifically binds with high affinity Tau species, especially the epitope region involved in Tau aggregation. Moreover, the inventors found that immunization with the optimized version of this lead VHH prevented the formation of neurofibrillary tangles induced by injection of extracellular h-AD in mouse model. Thus, these specific antibodies can be used for the therapy of tauopathy disorders such as Progressive supranuclear palsy (PSP).

The present disclosure provides novel approaches to the treatment of Alzheimer's disease, and other neurodegenerative disorders such as chronic traumatic encephalopathy (CTE) using novel therapeutics comprising agents that reduce the interaction of a tau seed interactor with intracellular tau proteins and thus reduce or inhibit the production of tau-associated neurofibrillary tangles.

Disclosed are substituted heterocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in Alzheimer's patients. More specifically, this invention relates to a method of using the compounds of formula (I) as tracers in positron emission tomography (PET) imaging to study tau deposits in brain in vivo to allow diagnosis of Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology. The disclosure further relates to a method of measuring clinical efficacy of therapeutic agents for Alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

Provided herein is a method of identifying a pre-stage neurofibrillary tangle (NFT) in a patient sample, including obtaining a sample from a patient suspected of having or at risk of developing a tauopathy, incubating the sample with a composition comprising a first binding reagent, wherein the first binding reagent is specific to Ser262 and / or Ser356 of a tau protein, and detecting binding between the first binding reagent and the tau protein, wherein detecting binding between the first binding reagent and the tau protein indicates the presence of a pre-stage NFT in the patient sample.

Provided herein arc methods of administering BIIB080 for treating Alzheimer's disease, reducing Tau RNA, Tau protein and / or reducing Tau neurofibrillary tangles (NFTs) in a human subject in need thereof that has been treated with an anti-beta amyloid antibody prior to initiation of treatment with BIIB080. The Alzheimer's disease can be, for example, early Alzheimer's disease, mild cognitive impairment due to Alzheimer's disease, and / or Alzheimer's disease dementia (e.g., mild Alzheimer's disease dementia).

Compounds comprising a triazole scaffold, compositions comprising same, and the use of such compounds and compositions to inhibit tubulin-associated unit (tau) protein and alpha-synuclein (α-syn) protein aggregation, including neurofibrillary tangles (NFTs) and Lewy bodies.

A method of treating a neurodegenerative disease or condition comprising administering to a subject in need thereof a GLP-1 receptor agonist or a composition thereof, a medicament or composition using the GLP-1 receptor agonist, or a method of treatment, the traditional Chinese medicine composition can significantly improve the behavioral abilities, such as learning memory, life self-care, movement and emotion, related to neurodegenerative diseases or symptoms of a subject, and also improve the pathological states, such as brain A beta plaque deposition, nerve fiber entanglement and nerve cell inflammation, of the subject.

Provided herein arc methods of administering BIIB080 for treating Alzheimer's disease, reducing Tan RNA, Tan protein and / or reducing Tau neurofibrillary tangles (NFTs) in a human subject in need thereof that has been treated with an anti-beta amyloid antibody prior to initiation of treatment with BIIB080. The Alzheimer's disease can be, for example, early Alzheimer's disease, mild cognitive impairment due to Alzheimer's disease, and / or Alzheimer's disease dementia (e.g., mild Alzheimer's disease dementia).