1571 results about "Amino radical" patented technology

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

This application provides a method for preparing compound I-b or a pharmaceutically acceptable salt thereof, wherein (S)-N-methylamino-1-(2-thiophene)-1-propanol reacts with 4-fluorobenzo[1,3]dioxolane in a system containing sodium hydride and potassium benzoate to obtain compound I-b. This method has short steps, mild reaction conditions, and is simple to operate, making it suitable for industrial scale-up; moreover, the obtained product has high purity and low isomer content.

This invention provides an amino-modified copper-silicon catalyst, its preparation method, and its application, belonging to the field of catalyst technology. The copper oxide particles in the copper-silicon catalyst provided by this invention have a small particle size and high dispersibility on the silica surface, which can significantly improve the catalytic activity of the copper-silicon catalyst, thereby improving the selectivity of ethanol in the hydrogenation of diethyl oxalate. Example results show that, at 180℃ and a hydrogen-to-ester ratio of 25, the copper-silicon catalyst provided by this invention achieves a diethyl oxalate conversion rate of 96.66% and an ethanol selectivity of 84.72% for diethyl oxalate. Furthermore, after 270 hours of stable reaction, the diethyl oxalate conversion rate still reaches 94.7%, and the ethanol selectivity still reaches 66.29%, indicating that the copper-silicon catalyst does not show significant deactivation.

This invention relates to the field of polymer materials, and specifically discloses a waterborne polyurethane, its neutralization preparation method, and its applications. This waterborne polyurethane is prepared by mixing the following raw materials in parts by weight: 10-30 parts by weight of a polyurethane prepolymer containing carboxyl functional groups, 5-25 parts by weight of a polyurethane prepolymer containing amino functional groups, 0.6-2.0 parts by weight of an organic amine chain extender, and 50-80 parts by weight of deionized water; wherein the polyurethane solid content accounts for 20-50% of the total weight of the raw materials. The preparation process of this invention is simple, the product is stable during storage, and it does not contain volatile or migrating amine neutralizing agents such as triethylamine or dimethylethanolamine, thus meeting the stringent regulatory requirements for applications such as food contact materials.

The present application relates to a kind of five-ring thiazole indole ketone piperazine amide derivatives and purposes thereof.The derivatives take ethyl cyanoacetate as starting material, generate hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid;Obtain 2-amino ethyl cyanoacetate (B) by reduction, in turn with acetic anhydride, lawson reagent is reacted, and 5-amino-4-carboxylate thiazole compound (D) is obtained;After bromination by NBS, under the catalysis of phosphorus oxychloride, react with tetrahydropyridine indole ketone, generate 2-bromo-6,7-dihydrothiazolo [5'',4'':4',5'] pyrimido [1',2':1,2] pyrindo [3,4-b] indole-4 (12H) -ketone (F), again under alkaline condition, first with Boc piperazine, then by Boc treatment and obtain compound (H);Finally, react with acyl chloride, and 28 different substitution structures of five-ring thiazole indole ketone piperazine amide compound (I1-I28) are synthesized.The 28 compounds are tested on three kinds of cancer cells, and the results show that: 28 compounds have significant inhibitory activity on Hela cervical cancer cells, HT-29 human colon cancer cells and HGC-27 human gastric cancer cells.

The application discloses a pinacine alkyl tetrahydrocarbazole fluorescent probe capable of detecting cell lysosome polarity and a preparation method and application thereof. 9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-formaldehyde is used as raw material, and condensation reaction is carried out with 1,3-indan dione to obtain compound 2-(2-(9-(3-(dimethylamino)propyl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-2,4-bridged methylene carbazole-6-yl)vinyl)-1-indene-1,3(2H)-dione (TC-AP-ID), and the probe can specifically detect the polarity of cell lysosomes. In a mixed system of 1,4-dioxane and water, with the increase of the polarity of the system, the fluorescence color of the probe gradually changes from orange to red, and the fluorescence intensity significantly decreases. The probe has the advantages of simple synthesis, good selectivity, high sensitivity, good biocompatibility, low toxicity and the like, can be applied to targeted detection of the polarity of cell lysosomes, and has a good application prospect.

The present application provides a kind of 3-aminoisobutyric acid derivatives and preparation method thereof.The 3-aminoisobutyric acid derivatives of the present application are formed by 3-aminoisobutyric acid and arginine, and the preparation method comprises: step A: Boc-L-BAIBA is condensed with guanidyl-protected L-arginine under the action of condensing agent to obtain fully-protected dipeptide;Step B: the fully-protected dipeptide is reacted under the action of deprotecting agent to obtain 3-aminoisobutyric acid derivative.

A polishing liquid for CMP, the polishing liquid containing abrasive grains, a nitrogen-containing compound, and water, in which the abrasive grains include cerium-based particles, and the nitrogen-containing compound includes a compound A1 having a fused ring (a fused ring having an aromatic five-membered ring with one nitrogen atom), a compound A2 having a quinoline ring and one hydroxy group bonded to the quinoline ring, a compound A3 having an aromatic ring and a hydroxy group bonded to a nitrogen atom, or a compound A4 having a nitrogen-containing aromatic ring to which at least one selected from the group consisting of a hydroxy group and an amino group is bonded.

The technology herein provides various embodiments that relate to a method of treating pulmonary hypertension in a subject in need thereof, comprising administering to the subject an effective amount of BX-912 (N-[3-[[5-bromo-4-[2-(1H-imidazol-5-yl)ethylamino]-2-pyrimidinyl]amino]phenyl]pyrrolidine-1-carboxamide).

The application discloses a kind of composite super-hydrophobic paper based on alkyl ketene dimer and metal polyphenol network and preparation method thereof, belong to functional paper-based material field.The method is first immersed in 0.25%~5% alkyl ketene dimer emulsion in cellulose paper, is dried at 90~110 DEG C and is cured 48-96h to prepare modified paper;Then, the pH is 8.0-9.0 of tris-hydroxymethyl aminomethane hydrochloride buffer solution, hydrochloric acid dopamine is dissolved in the buffer solution to form dopamine solution, and the concentration is 0.25~20mg / mL of metal ion solution;Finally, the modified paper is immersed in dopamine solution and metal ion solution in turn, and is dried to obtain composite super-hydrophobic paper.The obtained composite super-hydrophobic paper uses cellulose paper-based material as substrate, and hydrophobic layer and metal polyphenol network layer are formed on the surface in turn, the composite paper has super-hydrophobic performance, water barrier performance and photo-thermal response performance, the preparation process is simple, and is suitable for waterproof packaging, self-cleaning surface, anti-icing and deicing and photo-thermal antibacterial and other fields.

The application discloses a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative and a synthesis method and application thereof, and relates to a 3-(5-(aminomethyl)-1-oxoisoindoline-2-yl)piperidine-2,6-dione derivative which is a compound with the following general formula (I): wherein R1 is selected from,,,,,,,,, and R2 is selected from,,, and. The compound can significantly inhibit the proliferation of leukemia, multiple myeloma, lymphoma, breast cancer, liver cancer and the like at a low dose (nanomole), can effectively degrade IKZF1, IKZF3, BRD4, GSPT1 and CK1 alpha, and has the prospect of being developed into an anti-tumor drug. The application solves the problem that the existing malignant hematological disease treatment drugs have a high safety risk.

The invention relates to novel herbicidal active compound combinations which comprise substituted isoxazolincarboxamides or agrochemical acceptable salts thereof and substituted aminopyridines and aminopyrimidines. They can be used with particularly good results for the control of weeds in various crops of useful plants.

The present invention relates to a polymer electrolyte membrane, a method for manufacturing same, and a membrane-electrode assembly, a water electrolysis cell, and a fuel cell each comprising same. The polymer electrolyte membrane comprises, as an electrolyte, a reaction product of a cation conductor and an amine compound, wherein the cation conductor includes at least one sulfonic acid group as a side chain, and the amine compound includes at least one sulfonic acid group as a side chain and at least one amino group as a side chain, a terminal, or a combination thereof.

The present disclosure relates to solid state forms of Compound (1) freebase. The present disclosure also relates to processes for the preparation of the solid state forms, the pharmaceutical compositions comprising the forms, and the use thereof, e.g., in the treatment and prevention of disorders in which NLRP3 activity is implicated.

Provided herein are methods for preparing crystalline forms of (R)-5-carbamoylpyridin-3-yl-2-methyl-4-(3-(trifluoromethoxy)benzyl)piperazine-1-carboxylate.

The application relates to a composite type corrosion and scale inhibition water treatment agent, which is obtained by in-situ copolymerization of phosphono carboxylic acid copolymer after modification of nitrogen-doped carbon quantum dots on the surface of attapulgite as a carrier. The application has the beneficial effects that: the attapulgite is used as the carrier, can be used as a grafting bridge to load the carbon quantum dots on the surface and in-situ generate the phosphono carboxylic acid copolymer, and has a synergistic effect; the nitrogen-doped carbon quantum dots have rich amino, carboxyl and hydroxyl functional groups on the surface, make it difficult for calcium carbonate microcrystals to gather or interfere with the normal growth of the crystals to inhibit scale crystal generation, have high stability, are coated with zinc ions, improve the antibacterial property of the material, are modified on the surface of the attapulgite, have excellent adsorption performance, and can effectively remove organic matters, heavy metals and the like in water; the phosphono carboxylic acid copolymer is in-situ generated on the surface of the attapulgite, has a good compounding effect, has a good effect on corrosion inhibition, and has good corrosion inhibition performance.

The invention relates to a curable composition comprising (I) at least one silane-modified polymer and / or at least one organopolysiloxane polymer; (II) at least one aminosilane or aminosilane oligomer; (III) at least one guanidine catalyst of Formula (G1) wherein R1 is hydrogen; R2 is selected from the group consisting of optionally substituted alkyls comprising at least 3 carbon atoms, optionally substituted cycloalkyls comprising at least 3 carbon atoms, and optionally substituted C6-C18 aryl; preferably from the group consisting of optionally substituted C3-C8 alkyls, optionally substituted C3-C10 cycloalkyls, and optionally substituted C6-C18 aryl; more preferably R2 is selected from C3-C10 cycloalkyls; R3 is selected from optionally substituted alkyls comprising at least 2 carbon atoms; preferably from optionally substituted C2-C8 alkyls; R4 is selected from optionally substituted alkyls comprising at least 2 carbon atoms; preferably from optionally substituted C2-C8 alkyls; wherein R3 and R4 can be linked so as to form a 3-, 4-, 5-, 6- or 7-membered aliphatic ring, preferably a 5- or 6-membered aliphatic ring, optionally substituted with one or more substituents; and R5 is selected from the group consisting of optionally substituted alkyls comprising at least 3 carbon atoms, optionally substituted cycloalkyls comprising at least 3 carbon atoms, and optionally substituted C6-C18 aryl; preferably from the group consisting of optionally substituted C3-C8 alkyls, optionally substituted C3-C10 cycloalkyls, and optionally substituted C6-C18 aryl; more preferably R5 is selected from C3-C10 cycloalkyls; (IV) optionally, surface treated calcium carbonate; (V) optionally, surface treated silica; and (VI) optionally, at least one plasticizer. The invention also relates to adhesive, sealant, and / or coating materials comprising said composition, the use of at least one guanidine catalyst of Formula (G1) and the use of said composition.

The application discloses an anticoagulant biomaterial for blood purification and a preparation method and application thereof, and comprises the following steps: providing an amphiphilic copolymer P(AA-MMA); blending polyethersulfone, P(AA-MMA) and a solvent, stirring at a set temperature to obtain a casting solution, and preparing a blending membrane from the casting solution; soaking the blending membrane in a 2-morpholine-4-yl ethanesulfonic acid buffer solution containing argatroban, 1-ethyl-(3-dimethylaminopropyl) carbonyl diimide and hydroxy succinimide, and reacting at room temperature to obtain an argatroban grafted blending membrane, namely the anticoagulant biomaterial. The method improves the hydrophilicity of the membrane, reduces the albumin adsorption of the membrane, reduces the adhesion of platelets on the membrane, prolongs the coagulation time APTT, PT and TT of the membrane, and is better in biocompatibility and enhanced in anticoagulation performance.

This invention relates to the field of functional materials technology, and particularly to a floating defective g-C3N4 / PDI composite thin-film photocatalyst, its preparation method, and its application. The preparation method of the floating defective g-C3N4 / PDI composite thin-film photocatalyst provided by this invention includes the following steps: mixing defective graphene carbon nitride, N,N'-bis(3-aminopropyl)perylene-3,4,9,10-tetracarboxylic acid diimide (PDI), an organic base, and water to obtain a first suspension; mixing the first suspension with a monohaloacetic acid to undergo a protonation reaction, followed by solid-liquid separation to obtain a protonated composite material; mixing the protonated composite material with a thermoplastic resin solution to obtain a second suspension; and forming the second suspension into a film and then drying it to obtain the floating defective g-C3N4 / PDI composite thin-film photocatalyst. This photocatalyst is recyclable after use, does not cause secondary pollution to the environment, and exhibits excellent photocatalytic performance.

This invention discloses a transparent silica aerogel, an aerogel film, its preparation method, and its applications. The transparent silica aerogel comprises the following components: silica aerogel powder, an alcohol-based organosilicon-modified nanoresin sol, and a silane coupling agent; the silane coupling agent is selected from (3-aminopropyl)triethoxysilane, or a combination of (3-aminopropyl)triethoxysilane and long-chain alkylsilane coupling agents; the silica aerogel powder has a particle size of 5.8-6.2 nm. This invention achieves a breakthrough in the comprehensive performance of transparent silica aerogel, including high transparency, strong adhesion, and tunable hydrophobicity, by compounding silica aerogel powder, alcohol-based organosilicon-modified nanoresin sol, and a specific silane coupling agent.

The present invention encompasses compounds of formula (I), the compounds of formula (I) for use as inhibitors of KRAS mutated in position 12, preferrably G12D, pharmaceutical compositions and preparations containing such compounds and the compounds of formula (I) for use as medicaments / medical uses, especially as agents for treatment and / or prevention of oncological diseases.

This invention relates to the use of at least one organic dialkyl dicarbonate ester for reducing the nitrogen content in an aqueous polyurethane-polyurea dispersion containing at least one polyurethane-polyurea and at least one nitrogen compound, wherein the nitrogen compound is selected from hydrazine, amines, and mixtures thereof, wherein the amine has at least one primary and / or secondary amino group, is free of carbonyl groups, and has a molecular weight of 31 to 1000 g / mol. The invention also relates to a method for producing an aqueous polyurethane-polyurea dispersion with reduced nitrogen content, to aqueous polyurethane-polyurea dispersions obtained or obtainable by the method according to the invention, and to articles, cosmetics, coatings, adhesive layers, coating formulations, adhesive formulations, and / or cosmetic formulations thus obtainable.

This invention belongs to the field of analytical detection technology and relates to a method for detecting estradiol using a combination of organometallic framework enrichment and enzyme-linked immunosorbent assay (ELISA). A magnetic organometallic framework solid-phase extractant is used to enrich estradiol in the sample, followed by detection of the enriched estradiol using ELISA. The magnetic organometallic framework solid-phase extractant is prepared by subjecting mercaptoacetic acid-modified Fe3O4 particles, zirconium salt, and 2-amino-terephthalic acid to a solvothermal reaction at 110–130°C for 22–26 hours. The detection method provided by this invention has advantages such as short detection time, high sensitivity, good specificity, and high accuracy, thereby enabling the detection of trace amounts of estradiol in environmental water samples.

The present invention encompasses compounds of formula (I) wherein POI is a moiety of formula (IV) as degraders of KRAS for use in the treatment and / or prevention of oncological diseases.

Vapor phase methods of depositing a metal or a semimetal—comprising materials on a substrate are provided. In the methods, various metal or semimetal precursors may be used together with reactants that may generate hydrogen radical or amino radical to react with the metal or semimetal precursor to deposit the metal or semimetal—comprising material on the substrate. Further provided are materials and structures deposited by the disclosed methods, as well as deposition assemblies.

The application discloses a kind of process methods for optimizing control production 5-aminovaleric acid, step one, amino acid fermentation seed is inoculated in culture medium, and aerobic fermentation culture is carried out;During fermentation culture process, fermentation temperature is controlled at 30-35 DEG C, pH value is maintained at 6.5-7.5, and by controlling aeration and stirring, dissolved oxygen level is controlled at 20%-30%;After fermentation, fermentation broth is separated, and 5-aminovaleric acid crude product is obtained;5-aminovaleric acid crude product is sequentially subjected to decolorization, crystallization and refining, and finally 5-aminovaleric acid finished product is obtained.The application uses optimized fermentation conditions, by accurately controlling fermentation temperature, pH value and dissolved oxygen level, to ensure the stability and efficiency of fermentation process, improve product quality and yield.

The application relates to a salt type of a new cell cycle regulatory kinase inhibitor and a crystal form and a preparation method thereof, and relates to a succinate salt of a compound (6-((4-(2-(diethylamino)benzo[d]thiazol-6-yl)-5-fluoropyrimidin-2-yl)amino)pyridin-3-yl)(4-isopropylpiperazin-1-yl)methanone and a crystal form thereof, wherein two crystal forms II and III of the succinate salt are good in stability, high in solubility, and the preparation method is simple and suitable for industrial production.

The present invention provides a pharmaceutical composition comprising a radiolabeled complex comprising a radionuclide and a targeting moiety linked to a chelating moiety, and a stabilizer against radiolytic degradation of a radiolabeled complex comprising para-aminohippuric acid or a pharmaceutically acceptable salt or carboxylic derivative thereof. The pharmaceutical composition of the present invention is characterized by high stability of its radiolabeled complex against radiolytic degradation. The present invention also provides a method for preparing such a pharmaceutical composition, and use of para-aminohippuric acid or a pharmaceutically acceptable salt or carboxylic derivative thereof for the stabilization of the radiolabeled complex of such a pharmaceutical composition.

The application provides a preparation method of a polyamide reverse osmosis membrane, comprising the following steps: (1) immersing a non-woven fabric supported ultrafiltration membrane into an aqueous phase solution, and removing the excess aqueous phase solution on the surface of the ultrafiltration membrane after taking out; (2) immersing the ultrafiltration membrane obtained in the step (1) into an oil phase solution to perform interfacial polymerization, and then removing the excess oil phase solution on the surface of the ultrafiltration membrane; (3) coating an alcohol solution containing dansyl on the surface of the membrane obtained in the step (2), performing heat treatment, cleaning with hot water after the reaction is completed, and obtaining the reverse osmosis membrane. The amino group in dansyl reacts with acyl chloride and is grafted in the polyamide network. The tertiary amine in dansyl accepts protons in an acidic solution and shows hydrophilicity, which improves the hydration water content of the polyamide and the stability of the polyamide structure. The naphthalene group in dansyl occurs hydrophobic aggregation in an alkaline solution, which reduces the size and polarity of the polyamide hole, so that the polyamide reverse osmosis membrane with acid and alkali resistance and high boron removal is prepared.