22306 results about "Amino radical" patented technology

The present invention encompasses compounds of formula (I), wherein R1a, R1b, R2a, R2b, Z, R3 to R5, ring A, ring B, p, q, V and W have the meanings given in the claims and specification, their use as inhibitors of KRAS, pharmaceutical compositions and preparations containing such compounds and their use as medicaments / medical uses, especially as agents for treatment and / or prevention of oncological diseases.

The present invention discloses substituted 2-amino-9-(3,3-difluoropiperidin-4-yl)-7,9-dihydro-8H-purin-8-one compounds compounds having the structural formula represented by formula (I)： The substituted 2-amino-9-(3,3-difluoropiperidin-4-yl)-7,9-dihydro-8H-purin-8-one compounds, derivatives and pharmaceutically acceptable salts thereof of the present invention are capable of acting as a drug characteristic of a protein kinase inhibitor, in particular for the expression of a protein through a DNA-dependent protein kinase (DNA-PK) and can be used to treat or prevent disorders associated with abnormal protein kinase activity, such as cancer, cancer with brain metastases, cancer with meningeal metastases, glioma, glioblastoma, DIPG, and the like either as monotherapy or combination with other treatments, such as radiation therapy or chemotherapy.

The invention relates to a pharmaceutically acceptable salt of a benzothiophene substituted fused ring compound, and a crystal form and application thereof. Specifically, the present disclosure provides a pharmaceutically acceptable salt of 2-amino-7-fluoro-4-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxyl)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptano-2-yl) benzo [b] thiophene-3-formonitrile, a crystal form and a preparation method thereof, and a preparation method of the pharmaceutically acceptable salt, the crystal form and the preparation method thereof. Corresponding salts have good stability and can be better used for clinical treatment. # imgabs0 #

The invention relates to a crystal form of a benzothiophene substituted fused ring compound and a preparation method thereof. Specifically, the invention provides a crystal form A and a crystal form D of 2-amino-7-fluoro-4-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxyl)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptano-2-yl) benzo [b] thiophene-3-formonitrile, and the crystal form A and the crystal form D have the advantages that the crystal form A and the crystal form D are good in stability; and the medicine can be better used for clinical treatment. # imgabs0 #

The invention relates to a crystal form of a benzothiophene substituted fused ring compound and a preparation method thereof. Specifically, the invention provides a crystal form E, a crystal form G and a crystal form H of 2-amino-7-fluoro-4-((5S, 5aS, 6S, 9R)-1-fluoro-12-((1-((4-(fluoromethylsubunit) piperidine-1-yl) methyl) cyclopropyl) methoxyl)-5-methyl-5a, 6, 7, 8, 9, 10-hexahydro-5H-4-oxa-3, 10a, 11, 13, 14-pentaaza-6, 9-methylbridged naphtho [1, 8-ab] heptano-2-yl) benzo [b] thiophene-3-formonitrile, and the crystal form E, the crystal form G and the crystal form H have the advantages that the stability is good; and the medicine can be better used for clinical treatment. # imgabs0 #

The present disclosure relates to a pharmaceutically acceptable salt of a G12D inhibitor compound and a crystal form thereof. Specifically, provided in the present disclosure are a salt of 2-amino-4-((5S,5aS,6S,9R)-12-((1-((4-(difluoromethylene)piperidin-1-yl)methyl)cyclopropyl)methoxy)-1-fluoro-5-methyl-5a,6,7,8,9,10-hexahydro-5H-4-oxa-3,10a,11,13,14-pentaaza-6,9-methanonaphtho[1,8-ab]cyclohepten-2-yl)-7-fluorobenzo[b]thiophene-3-carbonitrile and a crystal form thereof.

The invention discloses a thiapyran molecule modified solar cell and a preparation method thereof. The cell sequentially comprises an ITO (Indium Tin Oxide) conductive glass layer, a 4-aminotetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] phosphonic acid hole transport layer, a Cs0.05 (FA < 0.77 > MA < 0.23 >) < 0.95 > Pb < (I < 0.77 > Br < 0.23 >) 3 wide-band gap perovskite thin film, a phenethyl ammonium iodide passivation layer, an electron transport layer of [6, 6]-phenyl-C61-butyric acid isomethyl ester, a 2, 9-dimethyl-4, 6, 7-tetrahydro-2H-thiapyran-1, 1-dioxide hydrochloride modified [4-(3, 6-dimethoxy-9H-carbazole-9-yl) butyl] the hole barrier layer is made of 1, 7-biphenyl-1, 10-phenanthroline; the electrode layer is made of metal Ag; according to the scheme, the hole transport layer is modified through thiapyran molecules, agglomeration of the hole transport layer is relieved, and a more compact and more uniform self-assembled single layer is generated by inducing favorable crystal orientation. A good bottom interface is obtained based on thiapyran molecule modification, and ordered growth of high-quality perovskite crystal grains is promoted. In addition, the energy level of the hole transport layer is effectively adjusted through thiapyran molecule treatment, and the extraction and transmission of carriers by the hole transport layer are enhanced.

An advantageous isolated morphic form of trilaciclib which is 2′-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7′,8′-dihydro-6′H-spiro[cyclohexane-1,9′-pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyrimidin]-6′-one, for example in the form of a di-hydrochloride salt or a dihydrochloride, dihydrate.

The invention discloses a novel synthetic method for 5-phenyl tetrazole, which includes the following steps: firstly performing acid neutralization to hydrazine hydrate; then adding mixing solution formed by cyanobenzene, water and ethyl alcohol to generate phenyl aminoguanidine salt; adopting sodium nitrite for diazotization to obtain nitrine amidine under the acidic condition; obtaining 5-phenyl tetrazole crude product through closed loop under the alkaline condition; obtaining 5-phenyl tetrazole acceptable product through adopting ethyl alcohol for refining. The method has the advantages of simple technology, simplicity in operation and high product yield.

The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (GnRH) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethylaminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like.

The invention belongs to the technical field of flame retardants, and particularly relates to a high-thermal-stability polyphosphate flame retardant and a preparation method thereof. The DOPO is modified through the polyethylene glycol acrylate, methyl methacrylate and dicumyl peroxide composite solution, double bonds of the polyethylene glycol acrylate and P-H bonds of the DOPO can be subjected to nucleophilic addition to form stable C-P bonds, and thermal migration of the DOPO is hindered; dOPO has polymerization double bonds of methyl methacrylate and long carbon chains of polyethylene glycol acrylate, so that the compatibility of the polyphosphate flame retardant and a polymer substrate is improved, and phase separation is avoided; maleic anhydride grafted silicone oil is connected to the surface of an amino modified gamma-cyclodextrin-modified DOPO inclusion compound, so that the polyphosphate flame retardant has high thermal stability and high compatibility after long-chain alkyl modification; amino groups in the modified gamma-cyclodextrin react with maleic anhydride grafted silicone oil to generate an amido bond cross-linked network, so that the thermal migration of DOPO is reduced together, and the high thermal stability of the polyphosphate flame retardant is improved.

A water-soluble automatic dishwashing detergent pouch includes an automatic dishwashing detergent composition that is enclosed by a water-soluble film, wherein the automatic dishwashing detergent composition includes from 0.001 g to 5.0 g alkyl aminocarboxylate and greater than about 2.0 g methylglycinediacetic acid and / or salt thereof (MGDA). The weight ratio of MGDA to alkyl aminocarboxylate is greater than about 1:1, and the automatic dishwashing detergent composition, upon dilution in deionized water to a concentration of about 1.0 g / 100 ml and at a temperature of about 20° C., has a pH of greater than about 9.5

The invention relates to the technical field of chemical synthesis, in particular to a preparation method of 3, 4 '-diaminodiphenyl ether.The preparation method comprises the steps that m-dinitrobenzene is dissolved with alcohol, and selective hydrogenation is conducted in a high-temperature and high-pressure reaction kettle with a palladium catalyst; and co-heating and refluxing the product after selective hydrogenation, a strong alkali aqueous solution, a first solvent and a phase transfer catalyst to obtain the m-aminophenol salt. M-aminophenol salt, p-nitroiodobenzene, alkali and a second solvent are subjected to a co-heating reaction, and then 3-amino-4 '-nitrodiphenyl ether is obtained through post-treatment; the method comprises the following steps: dissolving 3-amino-4 '-nitrodiphenyl ether with alcohol, carrying out hydrogenation reduction with a palladium catalyst, and carrying out post-treatment purification to obtain 3, 4'-diaminodiphenyl ether. According to the method, common m-dinitrobenzene is used as a raw material, m-nitroaniline is obtained through selective hydrogenation, m-aminophenol salt is prepared through the m-nitroaniline, then etherification reaction is carried out, the reaction yield is higher, the purity is better, and side reactions are few.

The invention relates to the technical field of optical sensing, in particular to a copper-carbon quantum dot nano-enzyme and a preparation method and application thereof. Poria cocos and Cu < 2 + > are taken as raw materials, and the copper-carbon quantum dots with excellent peroxidase activity are prepared by adopting a one-pot hydrothermal method and can be used for sensitively, accurately and selectively detecting glyphosate. Cu < 2 + > is combined with oxygen-rich and nitrogen-rich components in poria cocos to generate an oxidation-reduction reaction, CuCDs with Cu < 2 + > / Cu < + > are obtained, Cu < 2 + > doping changes electron cloud distribution of the CDs, the electron transmission capability of the CuCDs is enhanced, and Cu < 2 + > and the CDs have a synergistic effect to generate three ROS (. OH,. O2 <-> and < 1 > O2), so that excellent peroxidase activity is exerted. The glyphosate is chelated with hydroxyl, amino, carbonyl, carboxyl and Cu on the surface of the CuCDs to occupy active sites, so that the active sites are poisoned, the peroxidase activity of the CuCDs is selectively inhibited, and a powerful choice is provided for simply, quickly, sensitively and selectively detecting the glyphosate.

The invention belongs to the technical field of pervaporation membrane preparation and application, and relates to a covalent organic framework pervaporation hybrid membrane with a combination sequence regulation interlayer structure, in particular to preparation of the pervaporation membrane and application of the pervaporation membrane in water / butanol separation. Adding the aldehyde monomer solution into the amino monomer solution, and standing for reaction; taking a water phase, and carrying out dialysis treatment; diluting the covalent organic framework nanosheet dispersion liquid to obtain dispersion liquid A; adjusting the pH of a polyelectrolyte aqueous solution to obtain a solution B; adjusting the pH value of the metal ion dispersion liquid to obtain a solution C; uniformly mixing the dispersion liquid A and the solution C at normal temperature, adding the solution B, and heating for reaction to obtain a membrane casting liquid; and carrying out suction filtration on the membrane casting solution to a base membrane, and carrying out vacuum drying to obtain the pervaporation membrane. At 70 DEG C, the separation flux of a 10wt% / 90wt% water / butanol mixture is 7.52 g / (m < 2 > h), and the separation factor reaches 13709.

The invention discloses a preparation method of injectable nano composite hydrogel for relieving osteoarthritis, which comprises the following steps: firstly, synthesizing nano rod-like hydroxyapatite with the length of 150-300 nm and the diameter of 10-15 nm, and the hydroxyapatite is hydrophilic hydroxyapatite doped with strontium and europium ions; the preparation method comprises the following steps: by taking Ca (NO3) 2, Sr (NO3) 2, Eu (NO3) 3 and soluble phosphate as main raw materials, carrying out hydrothermal reaction to prepare strontium and europium ion co-doped hydrophobic hydroxyapatite, dispersing the strontium and europium ion co-doped hydrophobic hydroxyapatite in a Tris-HCl buffer solution, adding tannic acid, stirring, centrifugally collecting precipitate, and drying to obtain strontium and europium ion doped hydrophilic hydroxyapatite; the preparation method comprises the following steps: taking chondroitin sulfate and adipic dihydrazide as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the chondroitin sulfate solution grafted with the hydrazide group; the preparation method comprises the following steps: taking hyaluronic acid, 3-aminophenylboronic acid and sodium periodate as main raw materials, stirring, dialyzing, freeze-drying, and dissolving in a buffer solution to obtain the phenylboronic acid group grafted oxidized hyaluronic acid solution; the preparation method comprises the following steps: blending hydrophilic hydroxyapatite doped with strontium and europium ions, a chondroitin sulfate solution grafted with a hydrazide group, an oxidized hyaluronic acid solution grafted with a phenylboronic acid group and a recombinant collagen solution, and stirring to obtain the injectable nano composite hydrogel. The injectable nano composite hydrogel obtained by the invention has good biocompatibility, and a favorable local immune microenvironment can be created to immunomodulate macrophages so as to relieve osteoarthritis and promote subchondral bone repair.

The invention discloses a wear-resistant and high-temperature-resistant synchronous belt and a preparation method thereof. The wear-resistant and high-temperature-resistant synchronous belt comprises a synchronous belt framework and a synchronous belt rubber sheet, the synchronous belt rubber sheet is prepared from the following raw materials: a fluorosilicone thermoplastic polyurethane elastomer containing a benzene ring structure, an amino-containing hyperbranched liquid crystal polymer, methyl vinyl phenyl silicone rubber, epoxidized natural rubber, molybdenum sulfide nanosheets, reinforced fibers, bis (1-vinyl imidazole-2-) ketone, 2-acrylamido-2-methylpropanesulfonic acid, 4, 4 '-difluoro-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1, 3, 4-trimethyl-1 The high-temperature-resistant rubber is prepared from 2, 6-hydroxy-2-cyanobenzothiazole, bis (3-aminophenyl) 3, 5-bis (trifluoromethyl) phenylphosphine oxide, a catalyst, a coupling agent, a vulcanizing agent, an anti-aging agent, a scorch retarder and a lubricating agent. The synchronous belt is good in mechanical property, sufficient in high-temperature resistance and cold resistance, good in wear resistance and excellent in aging resistance and flame retardance.

The invention discloses a colorimetric and fluorescent dual-mode nano-enzyme sensor. The colorimetric and fluorescent dual-mode nano-enzyme sensor comprises nano-enzyme, hydrogen peroxide and a colorimetric probe, wherein the nano-enzyme is prepared from ZrCl4, 2-aminobiphenyl dicarboxylic acid and Cu (NO3) 2 by a one-pot method; the colorimetric probe is TMB, can oxidize colorless TMB into blue oxTMB, generates an ultraviolet absorption peak at 652 nm, and has a strong fluorescence emission peak at 405 + / -5 nm. The zirconium-based metal organic framework UiO-67-NH2 with high stability is used as a carrier, Zr < 4 + > sites are replaced by part of Cu < 2 + >, the fluorescent nano-enzyme with peroxidase activity is formed, and the problems that free enzyme is difficult to recover, the stability is low and the like are solved.

The invention relates to a preparation method of an amino-functionalized metal organic framework material and application of the prepared material to separation of CO2 / N2 and CO2 / CH4. The preparation method comprises the following steps: dissolving adenine and copper nitrate trihydrate in N, N '-dimethylacetamide to obtain a first mixed solution; dissolving carboxylic acid and potassium carbonate in deionized water to obtain a second mixed solution; and adding the second mixed solution into the first mixed solution, carrying out stirring reaction, and carrying out vacuum drying on an obtained solid product to obtain the amino-functionalized metal organic framework material. The amino-functionalized metal organic framework material prepared by the invention has high CO2 adsorption selectivity and adsorption capacity, and also has good acid-resistant, alkali-resistant and water-resistant stability. The amino-functionalized metal organic framework material prepared by the preparation method disclosed by the invention is applied to industrial CO2 adsorption separation and has an excellent separation effect.

The present disclosure provides a carbon dioxide absorption composition, which includes a solution of an amino compound in a solvent comprising water and a glycol, as well as a method of using such composition to capture CO2. The present composition can be particularly advantageous for indoor use, with additional benefit for managing total volatile organic compounds and humidity to enhance overall indoor air quality.

The invention discloses an alkaline electrolytic water hydrogen production diaphragm for strengthening hydroxyl ion transfer and a preparation method of the alkaline electrolytic water hydrogen production diaphragm. The diaphragm comprises a supporting base net and a hydrophilic gas insulation coating which is arranged on the supporting base net and contains a hydroxyl ion transfer carrier, the method comprises the steps that a supporting base net is pretreated; the preparation method comprises the following steps: dissolving a polymer binder, a pore-foaming agent, a hydroxyl ion transfer carrier and a hydrophilic metal oxide in an organic solvent according to a mass ratio to obtain hydrophilic slurry; uniformly coating two sides of a supporting base net with the hydrophilic slurry, and then carrying out non-solvent induced phase conversion to obtain the alkaline electrolytic water hydrogen production diaphragm for strengthening hydroxyl ion transfer; polar groups such as hydroxyl, amino and carboxyl are introduced into a traditional composite diaphragm to construct a hydrogen bond network, so that hydroxyl ions can be transmitted in a jumping manner along the dynamic hydrogen bond network in the diaphragm to promote transmission of the hydroxyl ions, the performance of the diaphragm can be improved, the materials are cheap and easy to obtain, the preparation process is simple and convenient, and industrial expanded production is facilitated.

The invention relates to the technical field of coatings, and discloses an amino-terminated ether-containing hyperbranched polyamide modified epoxy resin coating, which comprises a component A: 100 parts of a water-borne epoxy resin emulsion, 5-20 parts of titanium dioxide, 1-2.5 parts of a dispersant, and 0.05-0.2 part of an antifoaming agent; the component B is prepared from 50 to 70 parts of amino-terminated ether-containing hyperbranched polyamide; the amino-terminated ether-containing hyperbranched polyamide contains an active amino-terminated group, so that the amino-terminated ether-containing hyperbranched polyamide is used as a curing agent and is subjected to a cross-linking curing reaction with epoxy resin, the hyperbranched polyamide has a three-dimensional branched network structure and forms a spatial cross-linked interpenetrating network system with the epoxy resin, and the hyperbranched polyamide contains a flexible ether-containing chain segment and an alkyl chain segment, so that the cross-linking property of the hyperbranched polyamide is improved. The epoxy resin coating has a good toughening effect, improves the impact resistance and impact strength of an epoxy resin coating layer and a casting body thereof, and keeps high hardness and tensile strength at the same time.

The invention relates to self-healing double-layer hydrogel for promoting healing of diabetic wounds as well as a preparation method and application of the self-healing double-layer hydrogel, and belongs to the technical field of medical materials of surgical supplies containing macromolecular materials. The hydrogel comprises an inner layer and an outer layer, the inner layer is self-healing hydrogel in which microalgae cells are uniformly distributed, and the outer layer is self-healing hydrogel in which metal ion-humic acid coordination nanoparticle compounds are uniformly distributed, the self-healing hydrogel is formed by self-crosslinking of a macromolecular polymer containing an aldehyde group and a macromolecular polymer containing an amino group. The hydrogel provided by the invention has excellent biocompatibility, adhesion and self-healing performance, can meet the requirements of actual production and application, and has a relatively great application prospect as a dressing for chronic diabetes wounds; and the preparation process has the characteristics of simplicity in operation, low cost and mild reaction conditions, and is suitable for large-scale popularization and application.

The disclosure relates to a particulate composition comprising ensifentrine, wherein the particulate composition further comprises: from greater than 0.00 wt % to 0.60 wt % of 1,3-bis(2-(2-(mesitylimino)-9,10-dimethoxy-4-oxo-6,7-dihydro-2H-pyrimido [6,1-a]isoquinolin-3(4H)-yl)ethyl)urea (BMIQU) relative to the total weight of ensifentrine; and from 0.00 wt % to 0.50 wt % of a biuret impurity of formula (A) relative to the total weight of ensifentrine. Further disclosed herein are liquid pharmaceutical compositions comprising the particulate composition, and a process for producing the particulate composition are also described.

The invention relates to a composite hydrogel dressing for promoting wound healing as well as preparation and application thereof, and belongs to the technical field of biological medicines. The hydrogel disclosed by the invention is prepared by mixing gelatin, oxidized dextran and metal ion modified metal-organic framework compounds (MOF-Ag and MOF-Cu). In the mixed solution, amino groups in the gelatin and aldehyde groups of the oxidized dextran are subjected to a Schiff base cross-linking reaction, and the composite hydrogel is formed after standing. The loaded MOF-Ag has antibacterial and anti-biofilm effects on staphylococcus aureus and escherichia coli, and the loaded MOF-Cu has similar superoxide dismutase activity and similar glutathione peroxidase activity, so that excessive active oxygen can be removed, and inflammatory response can be relieved. The obtained hydrogel has good biocompatibility, proper mechanical properties and biological adhesion, stable rheological properties, excellent antibacterial and anti-inflammatory functions and a certain hemostatic function.

The present invention belongs to the technical field of membrane-based water treatment and relates to a novel guanidine-based composite nanofiltration (NF) flat-sheet membrane, and a preparation method and application thereof. The present invention provides a method for preparing a guanidine-based composite NF flat-sheet membrane, where a dense separation layer is formed on the surface of a polyethersulfone ultrafiltration membrane through polymerization reaction between the amino group of 1,3-diaminoguanidine and the acyl chloride group of trimesoyl chloride. Under suitable reaction conditions, the guanidine-based composite NF membrane obtained according to the present invention enables effective separation of multivalent ions over a wide pH range, with a rejection rate of over 96% for 1000 ppm of MgSO4 solution, and can operate continuously and stably in a mixed ions solution with a wide pH.

The invention relates to the technical field of catalyst carriers, and relates to a modified alpha-alumina carrier, a preparation method thereof, a supported silver catalyst and application. The modified alpha-alumina carrier is an alpha-alumina carrier with a silane coupling structure on the surface, and silane is at least one of silane compounds containing 1-3-Si-O-C-structures and containing vinyl or amino. Preferably, the silane compound is selected from at least one of vinylmethoxysilane, 3-aminopropyltriethoxysilane and methylvinyldimethoxysilane. According to the modified alpha-alumina carrier, the silane solution is adopted to treat the alpha-alumina carrier, silane contains a-Si-O-C-structure, the group can form a relatively stable structure on the surface of the carrier after hydrolysis or dehydration condensation, and influence is generated for a long time in the use process of a silver catalyst, so that the performance of the catalyst is improved.

The invention relates to the technical field of environmental materials and water treatment, in particular to a graphene amino silica gel composite adsorbent for heavy metal wastewater treatment and a preparation method thereof.The graphene amino silica gel composite adsorbent is prepared from # imgabs0 nanoparticles, an amino-functionalized silicon dioxide coating layer, carboxylated reduced graphene oxide, a polydopamine modification layer and tetraethyl orthosilicate; the coating is prepared from the following raw materials: 3-aminopropyltriethoxysilane, 3-mercaptopropyltrimethoxysilane, N-((4-vinyl benzyl) amino) diacetic acid, chitosan, beta-cyclodextrin, hexadecyl trimethyl ammonium bromide, polyethylene glycol, L-ascorbic acid, 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide hydrochloride and N-hydroxysuccinimide. The composite adsorbent shows excellent adsorption performance on various heavy metal ions, and the adsorption performance is far higher than that of traditional adsorption materials and existing composite adsorbents.

The invention belongs to the field of electroplating, and particularly relates to a platinum electroplating solution, a preparation method thereof and application of the platinum electroplating solution in wafer electroplating. The platinum electroplating solution comprises the following components: a platinum salt which is 0.02 mol / L in terms of platinum (II); the platinum salt is ethylenediamine platinum chloride (II) or ethylenediamine platinum iodide (II); the concentration of the complexing agent is 0.16 to 0.46 mol / L; the complex is a linear molecule with amino groups at two ends or 1, 2-diaminocyclohexane; the carbon number n between two amino groups of a linear molecule with amino groups at two ends is selected from 2, 3 and 4; the concentration of the electrolytic salt is 0.13-0.53 mol / L, and the electrolytic salt comprises carboxylic acid ammonium salt or ammonium sulfate salt; the pH regulator is used for regulating the pH of the platinum electroplating solution to 7; the solvent is ultrapure water. The platinum plating layer formed by the method has excellent morphology, uniform distribution, high purity and excellent compactness, and the produced wafer electronic product has excellent corrosion resistance, high-precision conductivity and high-quality electronic signal transmission performance.

The invention discloses an immunoregulation hydrogel as well as a preparation method and application thereof, and relates to the technical field of medical materials, amino-derived cationic polysaccharide, carboxyl-derived anionic polysaccharide and dopa-modified protein biopolymer materials are used as biological matrix materials, spermidine is used as a bioactive functional component, and the immunoregulation hydrogel is prepared by a one-step method. The preparation method comprises the following steps: by taking a benzaldehyde-terminated high polymer material as a cross-linking agent, forming a first layer of dynamic reversible cross-linked network structure through Schiff base reaction; then calcium ions are introduced, and the calcium ions and carboxylate radicals are complexed and cross-linked to form a second layer of static irreversible cross-linked network structure which can be used for an ESD (Electro-Static Discharge) operation. By adopting a step-by-step cross-linking mode, the first-step cross-linked single-network hydrogel has injectability, self-repairability, tissue adhesiveness and an immune regulation function, and the second-step cross-linking further ensures stable and lasting performance, so that the problems that a submucosal injection material is easy to disperse, short in lasting time and poor in stability are solved. The immunoregulation function effect of the wound repair material is poor.