145results about How to "Rapid hydrolysis" patented technology

Compounds of the formulas LAn-Z-X-WwD and BZ-X-WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and / or excipient, and methods of delivery the drug D via the compounds.

An acid fracturing method is provided in which the acid is generated in the fracture by hydrolysis of a solid acid-precursor selected from one or more than one of lactide, glycolide, polylactic acid, polyglycolic acid, a copolymer of polylactic acid and polyglycolic acid, a copolymer of glycolic acid with other hydroxy-, carboxylic acid-, or hydroxycarboxylic acid-containing moieties, and a copolymer of lactic acid with other hydroxy-, carboxylic acid or hydroxycarboxylic acid-containing moieties. The solid acid-precursor may be mixed with a solid acid-reactive material to accelerate the hydrolysis and / or coated to slow the hydrolysis. Water-soluble liquid compounds are also given that accelerate the hydrolysis. The method ensures that the acid contacts fracture faces far from the wellbore.

Compounds of the formulaeLAn-Z-X—WwD and BZ-X—WwDwherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide residue; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and / or excipient, and methods of delivery the drug D via the compounds.

The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated as an aqueous eye drop solution.

The invention relates to polyaldimines which may be obtained from at least one polyamine (A) with aliphatic primary amino groups and at least one aldehyde (B). Said polyaldimines are odourless as are the aldehydes (B) produced by hydrolysis thereof. The invention further relates to methods for production of said polyaldimines and aldehyde (B) and methods for hydrolysis of the polyaldimine. The use of said polyaldimine in compositions as adhesive, sealant, coating or covering agents is disclosed. Said polyaldimines are characterised in being odourless, rapidly hydrolysed on contact with water, no detectable odours being generated after hydrolysis thereof and stable to storage with the exclusion of water in compositions which contain components reactive towards amines.

The composition and method for healing tissues is a medicinal composition for facilitating the growth, protection and healing of tissues and cells in animals and humans. The composition is formulated as a either a powder, gel, paste, film, fluid injectable, rehydratable freeze-dried paste or sponge, sprayable solution, topically applied patch with adhesive and reservoir system, an intermediate for coatables such as films and bandages, a matrix for membranes, or as a matrix of flexible polymer(s), or delivered as either an orally ingestible liquid, tablet or capsule. The main ingredient of the formulated compositions is hydrolyzed collagen, which can be combined with polysulfated glycosaminoglycans, hyaluronic acid or salts thereof, or a glucosamine salt, and mixtures thereof. The composition may be formulated with differing concentrations of PSGAG.

The present invention provides NO and, optionally, drug releasing macromers and oligomers wherein the drug molecule and NO releasing moiety are linked an absorbable macromer or oligomeric chain susceptible to hydrolytic degradation and wherein the macromer or oligomer comprises of repeat units derived from safe and biocompatible molecules such as glycolic acid, lactic acid, caprolactone and p-dioxanone. Furthermore, the present invention relates to controlled release of nitric oxide (NO) and / or drug molecule from a NO and drug releasing macromer or oligomer. Moreover, the present invention also relates to medical devices, medical device coatings and therapeutic formulations comprising of nitric oxide and drug releasing macromers and oligomers of the present invention.

The invention relates to a method for improving anaerobic digestion performance of sludge by utilizing microwave alkaline thermal hydrolysis, and the method belongs to the technical field of solid waste treatment. Alkaline solution is firstly added in the sludge with the solid concentration of 7 percent-10 percent for controlling the pH value of the sludge, the mixing is carried out after adding the alkaline solution, the alkalified sludge is placed in a pressure-bearing reactor, the heating is carried out in a microwave field with the frequency of 2450MHz, the sludge heated by microwave is cooled to the room temperature, and the anaerobic digestion treatment is carried out on the sludge after the cooling. More than 60 percent of organic matters in the sludge which is treated by the method are converted to liquid phase; during anaerobic digestion, the conversion efficiency of the organic matters of the sludge is improved, thereby being an effective means for realizing the whole process pollution control, the energy conservation and the emission reduction of sewage treatment.

The invention aims to provide an active oxygen free radical sensitive cyclodextrin material as a drug delivery carrier. The chemical structure of the cyclodextrin material is disclosed in the specification, wherein n is equal to 6, 7 or 8 which are respectively corresponding to active oxygen free radical sensitive alpha-cyclodextrin, beta-cyclodextrin or gamma-cyclodextrin material; R is -H or disclosed in the specification; and the glucose unit of each cyclodextrin molecule at least has one R group disclosed in the specification. The invention also provides a preparation method of the cyclodextrin material.

The invention relates to a rice protein polypeptide and also relates to a composite enzyme preparation method of the rice protein polypeptide. The preparation method comprises the following steps: size mixing, degreasing, centrifuging, homogenizing, enzymolysis reaction, sterilization and enzyme inactivation, centrifugal separation, concentration, drying and the like. The rice protein polypeptideprepared by using the preparation method has a protein content of 80% in percentage by weight and a fat content of 1% or below in percentage by weight, and has high bioactivity; the peptides of whichthe molecular weight distribution is 100-1000 Da account for more than 90% of the total protein content; and the product are completely soluble in water.

The invention discloses a fish scale processing method, which comprises the following steps of: washing fish scale raw materials and putting the fish scale raw materials into boiled water to obtain mixed liquid; transferring the mixed liquid to a sealed reaction container, heating the reaction container to improve the pressure inside and increase the temperature of the mixed liquid to hydrolyze the mixed liquid; then simmering the mixed liquid in the reaction container and relieving the pressure in the reaction container at a set time to obtain solution containing collagen; and later on, filtering the solution to separate a solid substance and collagen solution. Heating to pressurize and continuously simmering the fish scale raw materials in this way to fast hydrolyze the fish scale raw materials so as to obtain a large amount of food-grade collagen from the fish scale within a short time, speed up the manufacturing speed of the product and save the production cost.

Deep-frozen, unfermented raw dough pieces which can be directly baked into croissants and other similar bakery products without thawing or intermediate fermenting include a plurality of fat layers and a plurality of layers of yeast dough, the number of fat layers being greater than 50.

The invention relates to polyaldimines which may be obtained from at least one polyamine (A) with aliphatic primary amino groups and at least one aldehyde (B). Said polyaldimines are odorless as are the aldehydes (B) produced by hydrolysis thereof. The invention further relates to methods for production of said polyaldimines and aldehyde (B) and methods for hydrolysis of the polyaldimine. The use of said polyaldimine in compositions as adhesive, sealant, coating or covering agents is disclosed. Said polyaldimines are characterized in being odorless, rapidly hydrolyzed on contact with water, no detectable odors being generated after hydrolysis thereof and stable to storage with the exclusion of water in compositions which contain components reactive towards amines.

A continuous process for preparing a polyamide by reacting at least one aminonitrile with water comprises:(1) reacting at least one aminonitrile with water at a temperature from 90 to 400° C. and a pressure from 0.1 to 35x106 Pa in a flow tube containing a Brönsted acid catalyst selected from a beta-zeolite catalyst, a sheet-silicate catalyst or a titanium dioxide catalyst comprising from 70 to 100% by weight of anatase and from 0 to 30% by weight of rutile and in which up to 40% by weight of the titanium dioxide may be replaced by tungsten oxide to obtain a reaction mixture,(2) further reacting the reaction mixture at a temperature from 150 to 400° C. and a pressure which is lower than the pressure in step 1, in the presence of a Brönsted acid catalyst as in (1), the temperature and pressure being selected so as to obtain a first gas phase and a first liquid or a first solid phase or a mixture of first solid and first liquid phase, and the first gas phase is separated from the first liquid or the first solid phase or from the mixture of first liquid and first solid phase, and(3) admixing the first liquid or the first solid phase or the mixture of first liquid and first solid phase with a gaseous or liquid phase comprising water at a temperature from 150 to 370° C. and a pressure from 0.1 to 30x106 Pa to obtain a product mixture.

The invention discloses an efficient continuous crackless flattening method of bamboo. The method includes following process steps: (1), pre-treating fresh bamboo tubes; (2), enabling the bamboo tubes to enter a heating pipeline for heating treatment; (3), flattening the bamboo tubes in a heat-insulating space connected with the heating pipeline; (4), post-treating flattened bamboo chips. The method has the advantages that when the fresh bamboo tubes are placed in a high-temperature separated pipeline with temperature of 130-160 DEG C, quick heating and heat-moisture treatment of high-temperature overheated steam are utilized to enable temperature of the bamboo tubes to reach softening points of lignin, cellulose and hemicellulose, and in a subsequent section of the heat-insulating space for high-temperature heating, multiple bamboo tubes or bamboo chips with certain radian are sequentially flattened, cooled and set through flattening rollers which widens progressively. By using the method, treatment temperature for bamboo flattening and labor intensity of workers during operation are lowered, harsh environment for the workers during operation is improved, and production automation level is high; finished products do not need de-yellowing treatment, flattened bamboo is better in physical and mechanical performance, attractive in color and luster and suitable for being used for making artware and furniture and home decoration.

The invention belongs to disaster prevention and mitigation strategies in the field of water ecological safety, and further relates to the fields of control and treatment of red tide in offshore water areas, and specifically to modified clay capable of eliminating the red tide with high efficiency. The modified clay is a compound material prepared from inorganic aluminum salt, clay mineral and an oxidant in a ratio of 500: 0-1: 1-50 by weight. When in use, the modified clay is uniformly mixed with seawater into a uniform suspension which is sprayed on the surface of the red tide water according to a certain concentration, so the effect of rapid elimination of a large number of red tide organisms in water is achieved. The modified clay can solve the problems of harsh application conditions and difficult highly-efficient large-scale application of common PAC modified clay in treatment of the red tide.

The invention discloses a preparation method of an organic-Se nutrient solution for crops. According to the method, bacillus subtilis is adopted to perform fermentation treatment on Se-enriched yeast, the Se-enriched yeast is hydrolyzed by the aid of protease produced in the metabolic process of the bacillus subtilis, a Se-enriched hydrolysate is obtained, and the organic-Se nutrient solution for the crops is prepared. The invention further discloses the organic-Se nutrient solution applied to the crops and produced with the preparation method of the organic-Se nutrient solution for the crops as well as an application of the organic-Se nutrient solution for the crops. With the adoption of the preparation method, all raw materials are sufficiently and reasonably utilized, complete and sufficient utilization of the raw materials is realized, no residues and residual liquids are produced, and environmental pollution is avoided; the content of organic-Se in the prepared organic-Se nutrient solution for the crops is high, the organic-Se exists in modes of Se substituted amino acid and short peptide, plant absorption is facilitated, and the content of the organic-Se in agricultural products can be remarkably increased.

The invention relates to titanium dioxide photocatalysts, especially to a preparation method of an in-situ carbon doped hollow titanium dioxide photocatalyst and application of the photocatalyst in sewage treatment. In order to solve the disadvantage of needing to add a carbon precursor in existing preparation methods for carbon doped titanium dioxide, the invention provides a technology for in-situ preparation of the carbon doped hollow titanium dioxide visible light photocatalyst through carbonization of a cation template. The efficient carbon doped visible light photocatalyst is mainly obtained by control of monodispersion of the cation template, self-assembly of tetrabutyl titanate (TBT) on the template surface, catalytic hydrolysis of TBT and segmented programmed calcination to remove the template. Therefore, the method provided by the invention is continuation and further expansion of the titanium dioxide preparation technology, and is also invented directed at the disadvantages of slow reaction rate, low quantization yield, poor solar energy utilization ability and the like. And the research result can be widely applied to atmospheric pollution, wastewater treatment, solar cell development and other fields.

An aqueous curable imprintable medium having at least one curable compound according to Formula 1:wherein R1-R3 are hydrolysable alkoxy groups, and wherein R4 is selected from the group consisting of C1-C6 linear alkyl groups, hydrolysable alkoxy groups and a phenyl group; and a photo-acid generator or a photo-base generator. Such a medium may have an extended shelf-life and may facilitate the formation of highly reproducible patterned layers when used in an imprint lithography process.

The invention discloses a nano silver catalyst for catalyzing hydrolysis of amino borane and a preparation method thereof, and belongs to the field of hydrogen storage materials. The preparation method comprises the following steps: (1) adding graphene oxide, silicon dioxide, neutral aluminum sesquioxide, carbon black, calcium carbonate, cerium oxide or active carbon into a mixed solution of a soluble silver salt and a soluble M salt, and uniformly mixing to form a mixture; and (2) adding a reducing agent into the mixture under the condition of agitating, sufficiently reacting at 25-40 DEG C and purifying to obtain the nano silver catalyst for catalyzing hydrolysis of amino borane. The preparation method is simple, the preparation conditions are moderate and the production cost is low. The method can be used for preparing a bimetal, tri-metal or tetra-metal nano silver catalyst with a core-shell structure. The prepared nano silver catalyst is in the core-shell structure, and is large in specific surface area and good in catalytic performance.

The invention discloses an extraction method of a micromolecular sheep placenta extract and application of the micromolecular sheep placenta extract in the field of skin-care products, belonging to the technical field of biology. The extraction method disclosed by the invention comprises the following steps of obtaining a lot of sheep pregnant in the same period by adopting synchronization of estrus, taking out sheep fetus after 85-100 days through an operation method to obtain body homogenate, carrying out repetitive freeze-thawing and splitting cells, degenerating at high temperature, sterilizing, precipitating hybrid protein, carrying out 30 KD ultrafiltration after centrifuging at high speed so as to remove toxic and harmful components and impurities, such as macromolecular hybrid protein, bacteria and endogenous virus, so as to obtain a pure micromolecular sheep placenta extract product, and carrying out ultrafiltration and concentration of the micromolecular sheep placenta extract product by using a 1 KD ultrafiltration component. The micromolecular sheep placenta extract disclosed by the invention can be widely used in the fields of skin-care products, beauty products, wound healing products, health-care products, scientific searches and the like; the extraction method disclosed by the invention provides a novel important way for producing the sheep placenta extract; furthermore, the compositions of the micromolecular sheep placenta extract are authenticated for the first time, and thus, theoretical foundation is provided for scientifically using the sheep placenta extract.

The invention discloses a kitchen waste (food waste) treatment method which is used for fine treatment and anaerobic digestion of the kitchen waste (food waste). The method mainly comprises three major steps of: enzymolysis pretreatment, solid-solution separation and anaerobic fermentation, wherein the steps are connected through plate chain machines and helixes or pipelines. The major innovationpoint is that an enzymolysis process is added in a kitchen waste (food waste) pretreatment process, and the enzymolysis process can promote hydrolysis of proteins in the crushed kitchen waste (food waste), so that a utilization rate of organic substances and a biogas yield at an anaerobic digestion stage are increased; meanwhile, the method realizes efficient separation of dry and wet materials through a high-pressure extruding mode, and is complete in solid-liquid separation; and moreover, pressure is set for quickly separating out organic substance slurry from the kitchen waste (food waste),so that the separating effect is good, and therefore, the kitchen waste (food waste) treatment method can be widely applied to the kitchen waste (food waste) treatment field.

The invention discloses a titanium dioxide / graphene nanocomposite, and a normal-temperature preparation method and application thereof. According to the invention, a titanium source and graphite oxide are used as starting raw materials, an organic solvent is used as a reaction solvent, and the nanocomposite formed by compounding of titanium dioxide nanometer rods and graphene is obtained through normal temperature reduction and hydrolysis; and in the nanocomposite, graphene accounts for 1 to 30 wt%, with the rest being titanium dioxide. The preparation method provided by the invention has the advantages of simple process, easy preparation, mild reaction conditions, etc. In the prepared nanocomposite, titanium oxide is uniformly distributed on the surface of graphene, so the nanocomposite can be perfectly applied to the field of photocatalysis of photoelectric materials.

The invention discloses a method for completely dissolving and rapidly hydrolyzing cellulose and application thereof. Cellulose is put into an acid solution with the concentration of 10<-7> to 1M [H<+>] or in an alkaline solution with the concentration of 10<-7> to 1M [OH<->], and the volume ratio of solid to liquid is (0.003 to 1.05) to 1; the acid solution of 10-7 to 1M [H<+>] or the alkaline solution of 10<-7> to 1M [OH<->] is heated to be at the temperature of 261 to 352 DEG C; the products of the step 1 and the step 2 are mixed and put in a reactor; the concentration of the cellulose is 0.1 % to 35%; the concentration of the mixed material solution is regulated to be acid 10<-7> to 1M [H<+>] or alkaline 10<-7> to 1M [OH<->]; the water density is 587 to 997 kg / m<3>, the pressure is set to be 6 to 584MPa, heating rate is 7.8 to 14.8 DEG C / s, the mixture is rapidly heated to be at the temperature of 261 to 352 DEG C, and the cellulose can be completely dissolved in 0.8 to 2 seconds. The method first realizes the complete dissolution and rapid hydrolysis of cellulose at lower temperature, thereby greatly lowering production cost, improving production safety, prolonging service life of equipment, and thus having favorable application prospect.

The invention discloses a preparation method of a compound enzyme preparation for promoting production of methane from kitchen waste through anaerobic fermentation. The preparation method is characterized by comprising the following steps of: 1, preparing formula compositions which comprises liquifying enzyme, saccharifying enzyme, cellulase and lipase; 2, separation: classifying and recovering non-biomass parts in the kitchen waste through a manual or mechanical method, wherein a biomass part enters into a composite enzymatic hydrolysis process; 3, crushing and homogenating: crushing the biomass part obtained after the kitchen waste is separated into paste, and homogenating for later use; 4, composite enzymatic hydrolysis; and 5, anaerobic fermentation. According to the invention, from the aspects of methane anaerobic fermentation microbial metabolism and enzyme activity change rule, through using a compound enzyme preparation formula, the effects of promoting rapid and efficient hydrolysis of the kitchen waste and growth and metabolism of methane fermentation microorganism are achieved, and the purpose of efficient and stable operation of a system for producing methane by the kitchen waste through anaerobic fermentation is further realized.

The invention provides a titanium modified Fe3O4 magnetic nano-particle, a preparation method and the application thereof. The preparation method specifically comprises the following steps: in a eutecticevaporate solvent of choline chloride and urea, taking ferrite as an iron source, tetrabutyl titanate as a titanium source and air as an oxidizing agent, and using a precipitation oxidization process to synthesize the titanium modified Fe3O4 magnetic nano-particle in one step. According to the preparation method provided by the invention, the obtained material has excellent catalytic degradation capacity (for example, under the conditions of room temperature and neutral pH, the color removal rate for a 0.01 mmol / L methylene blue solution within 2h reaching 93.8%, and the removal rate for a20 mg / L Ciprofloxacin solution reaching 96.5%) for organic waste water, is easy for magnetic separation recycle and stable in reuse performance, and is a novel magnetic environmentally-friendly material with low cost, quick and convenient operation, obvious effect and wide application prospect.

A process for producing an acylated vinylamine-containing polymer is disclosed. The acylated vinylamine-containing polymer is produced by reacting a vinylamine-containing polymer with at least one acylating agent.

The present invention relates to a toothpaste composition for preventing calculus formation and removing plaque, more specifically to the toothpaste composition comprising soluble ultra phosphate with network structure and zeolite granule. The composition of the present invention has superior effect to prevent and remove calculus, and removing interdental plaque.