549 results about "Glycolipid" patented technology

The invention provides a preparation method of cereal fermentation broth postbiotics and application of the cereal fermentation broth postbiotics in improvement of systemic chronic inflammation and reduction of cholesterol and low-density lipoprotein, and belongs to the technical field of fermentation engineering. The invention provides a preparation method of cereal fermentation broth metabiotics, which is characterized in that mixed cereals are used as raw materials, anaerobic fermentation is carried out by using compound enzymes and various bacteria, and polysaccharides and proteins in the cereal raw materials can be quickly converted into functional small molecular substances, such as polypeptides, total phenols and total flavonoids. The cereal fermentation broth metagen can inhibit secretion of a macrophage proinflammatory medium, inhibit generation of inflammatory factors of liver, heart and intestinal tissues, and improve activation of adipose tissue macrophages related to body inflammation. After the cereal fermentation liquor is subjected to post-biogen treatment, glucose and lipid metabolism disorder can be effectively improved, liver function damage can be relieved, and the intestinal barrier function can be effectively improved.

The application belongs to the field of intestinal microbiology, and discloses a new mucinophilic Akkermansia with improved obesity and glycolipid metabolism, wherein the mucinophilic Akkermansia strain is Akk-101 and AMY001. The preservation number of Akk-101 is CGMCC No. 40786, and the preservation number of AMY001 is CGMCC No. 46141. The Akk-101 and AMY001 strains in the application are different from standard strains in nucleotide consistency and physiological and biochemical indexes, have better acid-base tolerance and colonization capacity than the standard strains, can more effectively inhibit the accumulation of liver cell lipids, reduce the fat deposition in nematodes, and have the effects of weight loss and improvement of glycolipid metabolism, so that related products can be effectively developed based on the strains.

The invention discloses a scylla paramamosain keep-alive and soft shell soft-keeping method, a low-temperature keep-alive mode refers to an on-ice keep-alive mode or a low-temperature acidification keep-alive mode, preferably, the low-temperature acidification keep-alive mode: cooling seawater to 16 DEG C or below by using a cooling-water machine, then adjusting the pH value of the seawater to be less than 8 to obtain low-temperature acidified seawater, and then cooling the low-temperature acidified seawater to obtain the scylla paramamosain soft shell soft-keeping method. And putting the soft-shell crabs which just molt into low-temperature acidified seawater for keeping alive and softness. The hardening of the soft shell can be obviously delayed by low-temperature acidified seawater and on-ice keep-alive; low-temperature acidified seawater and on-ice keep-alive soft-shell crabs can improve the delicate flavor and sweet taste of hepatopancreas of the soft-shell crabs, and the flavors of the two keep-alive soft-shell crabs are better than those of cold-stored dead soft-shell crabs; on-ice and low-temperature acidified seawater keep-alive interferes with glycolipid metabolism, oxidative stress and cell apoptosis of the soft-shell crabs, and compared with on-ice keep-alive, low-temperature acidified seawater keep-alive influences are milder than on-ice keep-alive.

The invention provides an amino acid frosted cleaning composition as well as a preparation method and application thereof. The amino acid frosted cleaning composition comprises a surfactant, an amino acid composition, a thickening agent, a humectant, an antioxidant, a pH regulator and water, the surfactant is a combination of cocoyl glycinate, cocamidopropyl hydroxy sulfobetaine, sodium cocoyl methyl taurine taurate, sulfonic acid hydroxypropyl ester lauryl glucoside cross-linked polymer sodium and glycolipid. According to the invention, a mild surfactant system with amino acid as a main component is adopted, so that the shampoo has rich and fine foam, quick foaming performance and easy washing performance, and the skin feeling is smooth and soft after washing. In addition, the system contains suspended crystal frosted particles formed by self-assembly of the amino acid composition, the appearance is novel, the better efficacy performance is achieved, and meanwhile the cleaning effect and the use comfort are improved.

The invention relates to pediococcus acidilactici XZ106, which is classified and named as pediococcus acidilactici, and is preserved in the China General Microbiological Culture Collection Center (CGMCC), the preservation number is CGMCC No.30094, the preservation date is March 22, 2024, and the preservation address is No.3, Yard 1, Beichen West Road, Chaoyang District, Beijing. The pediococcus acidilactici XZ106 can (1) relieve insulin resistance, regulate insulin and glucagon secretion and improve liver gluconeogenesis, so that diabetes hyperglycemia is improved; (2) weight gain, fat accumulation and liver lipid accumulation of obese mice are inhibited, glycolipid metabolism disorder of the mice is improved, and the composition has excellent effects of reducing fat and relieving obesity; (3) the level of IL-10 can be remarkably improved, and the anti-inflammatory ability of mice is improved; (4) vascular injury is reduced, so that diabetic complications and various cardiovascular diseases of atherosclerosis are prevented.

The invention discloses a medicinal and edible homologous compound based on probiotic fermentation synergy and application of the medicinal and edible homologous compound in blood sugar regulation and control, and belongs to the technical field of microorganisms and fermentation engineering. The preparation method comprises the following steps: respectively carrying out two-stage fermentation on aloe, mulberry leaves and liquorice by utilizing saccharomyces cerevisiae BLCC4-0032 and plant lactobacillus DFR-1, so as to obtain a fermentation mixture; the preparation method comprises the following steps: fermenting a fermentation mixture, adding balsam pear peptide into the fermentation mixture to obtain a medicinal and edible compound, forming a metabolic closed loop, and cooperatively regulating a'blood sugar-liver-intestinal flora axis', thereby providing a new solution for diabetes intervention, and opening up a new path for preventing non-alcoholic fatty liver and intestinal inflammation caused by glucose and lipid metabolism disorder.

The invention relates to an application of an Sdccag3 gene in preparation of a weight-reducing medicine for regulating glucose and lipid metabolism. The Sdccag3 gene is used as an action target to be applied to preparation or screening of the weight-reducing medicine for regulating glucose and lipid metabolism, and the nucleotide sequence of the Sdccag3 gene is as shown in SEQ ID No. 1. According to the application disclosed by the invention, the specific overexpressed Sdccag3 in adipose tissues in a mouse body can obviously inhibit the increase of the blood fat level, and the overexpressed Sdccag3 can also obviously improve the poor glucose tolerance, improve the insulin sensitivity, reduce the levels of serum triglyceride, cholesterol and low-density lipoprotein cholesterol of an obese mouse, improve the poor glucose tolerance and improve the insulin sensitivity. The insulin sensitivity is improved, obesity-related glycolipid metabolism is effectively regulated and controlled, the effect of reducing blood lipid and blood sugar is achieved, and the compound can be used for preparing weight-losing drugs for reducing blood lipid and blood sugar.

The invention relates to the technical field of microorganisms, in particular to enterococcus faecalis EF-1 capable of reducing blood lipid, a microbial preparation and application of the enterococcus faecalis EF-1. The enterococcus faecalis EF-1 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on September 27, 2024, and the preservation number is CGMCC No.32097. The enterococcus faecalis EF-1 is named as enterococcus faecalis EF-1. The enterococcus faecalis EF-1 has the functions of: (1) relieving the weight increase speed of animals, reducing body weight gain, and preventing, relieving or treating obesity; (2) the contents of triglyceride, cholesterol and low-density lipoprotein cholesterol in liver and serum are reduced; (3) the liver function is protected, and the contents of ALT and AST in serum and liver are reduced; (4) liver lipid deposition and lesion are relieved; (5) relieving adipose tissue hypertrophy; (6) preventing, relieving or treating metabolic syndrome; (7) reducing blood sugar, improving insulin resistance and relieving diabetes mellitus; 8, increasing the content of short-chain fatty acid; and (9) regulating intestinal flora.

The invention relates to a biological long-acting bactericide and a preparation method and application thereof.The biological long-acting bactericide can release a quaternary ammonium salt type sophorolipid sterilization unit with the sterilization effect according to needs, the sterilization time is effectively prolonged, the recycling performance of the bactericide is improved, and the biotoxicity of the bactericide is reduced; the excessive use of the bactericide is avoided to a great extent; in addition, the biological long-acting bactericide also has excellent substrate adhesion and washing resistance, and is beneficial to inhibition of adhesion of bacteria on the surface of a material, so that the surface of the material washed by water still keeps relatively high antibacterial ability.

The invention provides a glycolipid metabolism related gene-based endometrial cancer prognosis prediction model construction method, which comprises the following steps of 1, acquiring data containing gene expression and clinical information, and preprocessing the data; 2, differential expression and prognosis gene screening; 3, constructing a prognosis model; 4, analyzing model gene enrichment; 5, evaluating the immunocompetence of the two GLRG related dangerous groups; and step 6, statistical analysis. According to the technical scheme, more accurate and reliable prognosis evaluation is provided for endometrial cancer by comprehensively analyzing multi-dimensional information such as gene expression, immune characteristics, mutation characteristics and drug sensitivity.

The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition with a glycolipid metabolism regulating effect and a preparation method and application thereof. The traditional Chinese medicine composition with the glucolipid metabolism regulating effect is prepared from the following raw materials in parts by weight: 10 to 15 parts of herba cepbalanoplosis segeti, 7 to 12 parts of fructus phyllanthi, 10 to 15 parts of fructus citri sarcodactylis and 15 to 20 parts of semen cassiae. The traditional Chinese medicine composition disclosed by the invention can be used for carrying out comprehensive and integrated prevention and control and overall regulation on glycolipid metabolic diseases, is good in treatment effect, is natural medicines, and has few side effects.

The invention discloses emblic leafflower fruit polysaccharide with sugar-controlling and lipid-lowering activity as well as a preparation method and application of the emblic leafflower fruit polysaccharide. The polysaccharide is prepared by taking fresh phyllanthus emblica pulp as a raw material through hot water extraction, yeast fermentation, desorption after XAD-16 macroporous resin adsorption, alcohol precipitation, ultrafiltration and DEAE-52 cellulose column purification. The low-molecular-weight gulcomannan is separated from phyllanthus emblica for the first time, and monosaccharide composition of the gulcomannan mainly comprises glucose, mannose and galactose and contains trace rhamnose and xylose. The polysaccharide has sugar-controlling and lipid-lowering active action targets in the whole digestive tract (the upper digestive tract: glycolipid digestion and absorption enzymes alpha-amylase, alpha-glucosidase and pancreatic lipase inhibitory activity, starch hydrolysis delay, bile acid adsorption capacity and cholesterol micelle dissolution inhibition capacity; in the lower digestive tract, the multiplication promoting capacity of glycolipid metabolism-related probiotics) shows extremely high biological activity, and can be applied to food and health care products.

The present disclosure provides a polymetallic-ore beneficiation and separation reagent, a preparation method therefor and use thereof. The preparation method for a polymetallic-ore beneficiation and separation reagent, includes following steps: (1) mixing a substance A, caustic soda, soda ash and sodium polysulfide, and then heating the same and performing a catalytic reaction, to render an intermediate product B, wherein the substance A includes one or more of urea, glycine, urea peroxide, ammonium cyanate and isocyanic acid; and (2) mixing the intermediate product B with trichloroisocyanuric acid, dichloroisocyanuric acid and 2-amino-3-(4-imidazolyl)propanoic acid, to render the polymetallic-ore beneficiation and separation reagent.

The invention relates to the technical field of biological medicine, and discloses an intestinal insulinotropic analogue with multiple biological activities, a synthesis method, a pharmaceutical composition and application, the synthesized intestinal insulinotropic analogue has triple agonist activity of a GLP-1 receptor, a glucagon receptor and a CCK-1 receptor, not only has the treatment effect of GLP-1 on diabetes, but also has the treatment effect of GLP-1 on CCK-1, and also has the effect of GLP-1 on CCK-1 on CCK-1. The traditional Chinese medicine composition also has the regulating effect of glucagon on lipolysis and energy metabolism and the beneficial effect of CCK on appetite inhibition, so that a synergistic effect is generated on sugar, fat and energy metabolism; the application has great potential in preparation of drugs for treating metabolic syndromes, such as diabetes, obesity, non-alcoholic fatty liver diseases, dyslipidemia and other diseases.

The invention belongs to the technical field of biological medicine, and particularly relates to application of hUC-MSCs combined with Met in preparation of anti-diabetic drugs. The diabetes mellitus is particularly type 2 diabetes mellitus. Through construction of a T2DM rat model, paraffin tissue section detection, serum ELISA, cell experiments and the like, researches prove that T2DM can be effectively treated by HUC-MSCs combined with Met treatment, including reduction of body blood sugar and recovery of blood sugar regulation ability; liver injury caused by T2DM is relieved and repaired; the glycolipid metabolism of the liver of the T2DM rat is improved; the immune inflammation disorder caused by T2DM is relieved; and the apoptosis level of liver cells is improved. And compared with a single hUC-MSCs or Met treatment mode, the combined treatment mode has a better treatment effect. The invention provides a theoretical basis and a new treatment strategy for treatment of T2DM.

The disclosure provides methods for preparation of carbohydrate replacement therapies (CRT) that include nanocarriers of carbohydrates and glycolipids for pharmaceutical delivery to cell interior, endoplasmic reticulum, and Golgi for treating CDG type I and CDG type II diseases as well as other metabolic disorders.

The invention discloses a method for treating piglet damp-heat diarrhea through multi-omics combined analysis. According to the method, faeces metabonomics, intestinal transcriptomics and intestinal flora 16s analysis are adopted, transcriptome data, metabolome data and intestinal flora data are screened according to a prime difference standard, then transcriptomics of a model group and a control group, faeces metabonomics and intestinal flora are subjected to conjoint analysis, an intersection is taken, and the faeces metabonomics of the model group and the control group, the faeces metabonomics of the model group and the control group and the intestinal flora of the model group and the control group are subjected carrying out conjoint analysis on transcriptomics of the Model group and HQ-M, faeces metabonomics and intestinal flora, and then taking an intersection; the method comprises the following steps of: selecting a plurality of metabolites and florae from a plurality of intestinal florae, respectively obtaining intersections, screening related genes, searching gene FPKM expression quantity in transcriptomics, and screening corresponding metabolites and florae in metabonomics and intestinal florae to obtain a gene-flora-metabolite related network diagram. Multi-omics combined analysis shows that the piglet diarrhea due to damp-heat is mainly manifested by inflammation and glucose and lipid metabolism disorder.

The present invention relates to an immunoprophylactic and therapeutic vaccine comprising a peripheral blood mononuclear cell loaded with a natural killer T cell ligand and an antigen, and more particularly, to an immunotherapeutic vaccine comprising a peripheral blood mononuclear cell loaded with alpha-galactosylceramide, a natural killer T cell ligand and a glycolipid. The compositions of the present invention are readily available because there is no need to isolate specific cells from peripheral blood mononuclear cells. Besides, the immunization of the peripheral blood mononuclear cells loaded with the natural killer T cell ligands and antigens not only induces the obvious-level activation of the natural killer cells and the natural killer T cells and the response of cytotoxic T lymphocytes, but also has a synergistic treatment effect in the aspect of treating malignant tumors. Therefore, the compound can be beneficially used as an anti-cancer immunotherapeutic agent.

The present application relates to use of Ligilactobacillus salivarius in preparing a drug for preventing and / or treating diseases associated with overweight and / or obesity . The strain can inhibit the weight growth of a high-fat diet-induced obesity model mouse, reduce the blood lipid level of the high-fat diet-induced obesity model mouse, improve the liver injury index of the high-fat diet-induced obesity model mouse, reduce the area of white adipose cells of the high-fat diet-induced obesity model mouse, improve the colon GLP-1 level of the high-fat diet-induced obesity model mouse, improve the intestinal flora imbalance of the high-fat diet-induced obesity model mouse, and improve the liver glycolipid metabolism of the high-fat diet-induced obesity model mouse; and reduce the waist circumference, hip circumference, body fat mass, BMI, and weight of overweight and overweight and / or obesity volunteers, and maintain the muscle content, promoting overweight and overweight and / or obesity people to carry out safe, effective, and sustainable weight management.

The invention belongs to the field of intestinal microbiology, and discloses a novel ackermania muciniphila capable of improving obesity and glycolipid metabolism, and the ackermania muciniphila strains are Akk-101 and AMY001. The preservation number of the Akk-101 is CGMCC (China General Microbiological Culture Collection Center) No. 40786, and the preservation number of the AMY001 is CGMCC No. 46141. The Akk-101 and AMY001 strains are different from standard strains in nucleotide consistency and physiological and biochemical indexes, have acid-base tolerance and colonization ability superior to those of the standard strains, and have the effects of more effectively inhibiting lipid accumulation of liver cells, reducing fat deposition in nematode bodies, losing weight and improving glycolipid metabolism. Therefore, related products can be effectively developed based on the strain.

The invention relates to the technical field of medical information management, and discloses a method for constructing a model for predicting glycolipid metabolic disease based on artificial intelligence, which comprises the following steps: identifying the syndrome type and pathological product of a patient with glycolipid metabolic disease, and constructing a risk identification model of the patient with glycolipid metabolic disease according to the syndrome type and pathological product; identifying the disease site, syndrome and disease factors of the glycolipid metabolic disease patient, and analyzing the disease course distribution condition of the glycolipid metabolic disease patient; according to the disease course distribution condition, determining the distinguishing capability of the risk identification model, and executing model optimization processing of the risk identification model to obtain an optimization model; when the optimization processing result meets a preset effect, outputting a feedback result of the glycolipid metabolic disease patient, and setting a result paraphrase of the feedback result; and in combination with the risk identification model, the optimization model and the result paraphrasing, performing model construction processing of the glycolipid metabolic disease patient to obtain a model construction result. According to the invention, the accuracy and reliability of glycolipid metabolic disease prediction can be improved.

The invention provides a preparation method of a hydrolyzed collagen product with surface amphipathicity as well as the product and application thereof, and the preparation method comprises the following steps: (1) taking hydrolyzed collagen enzymatic hydrolysate as a substrate, then preparing a fermentation culture medium with vegetable oil and sugar, and fermenting by adopting candida bumblebee; (2) after fermentation, adding lysozyme into the fermentation liquor for activating treatment, and then sterilizing, centrifuging and filtering; and (3) carrying out freeze-drying treatment on the filtered fermentation liquor to obtain the hydrolyzed collagen product with surface amphipathicity. The hydrolyzed collagen product prepared by the invention not only has low molecular weight and high permeability to skin, but also has water locking and moistening effects on the skin surface due to the amphiphilic sophorolipid on the surface, so that the moisture retention of the skin is better improved, and the product has excellent product characteristics and has wide market prospects.

The invention belongs to the technical field of cosmetics, and particularly relates to a cosmetic delivery system based on a natural wall material, a preparation method and application. The cosmetic delivery system is of a core-shell structure, a core is a cosmetic active component, and a shell layer is a composite polymer gel network of sodium alginate, sophorolipid and cellulose. The natural polysaccharide composite wall material is green and safe, has good biocompatibility and strong compatibility with cosmetic formulas, and does not irritate the skin. The delivery system can effectively protect cosmetic active ingredients from being damaged by illumination and oxygen, and the storage stability of the active ingredients is remarkably improved; meanwhile, slow release and targeted transdermal absorption of active ingredients are realized, and the bioavailability is improved.

The invention discloses a mild oil-purifying acne-removing cleaning composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The cleaning composition is prepared from the following components in parts by weight: 15 to 35 parts of water / potassium cocoyl glycinate, 10 to 30 parts of water / potassium cocoate, 1 to 10 parts of water / potassium palmitate, 0.1 to 5 parts of water / sodium PEG-7 (Polyethylene Glycol) olive oil carboxylate, 0.1 to 10 parts of water / glycolipid and 0.01 to 1 part of water / glycosylglycerol / 1, 2-pentanediol. According to the cleaning composition disclosed by the invention, all the components are matched according to a specific proportion, so that the cleaning composition has mild and efficient oil-purifying and acne-removing effects. Various surfactants such as potassium cocoyl glycinate and the like have a synergistic effect, so that the skin irritation is reduced while the cleaning power is ensured; special functional components such as glycolipid further optimize the cleaning, moisturizing and acne removing effects. The preparation method comprises the following steps: firstly, mixing part of the components, heating to 70-90 DEG C, uniformly stirring, cooling to 40-45 DEG C, adding the rest of the components, and cooling to 30-35 DEG C to obtain a final product with the pH value of 7-8.5. The composition can be widely applied to various cleaning products such as facial cleanser, scrub cream, shower gel and the like, provides an innovative solution for the field of skin cleaning and nursing, meets the requirements of consumers on mild and effective oil-purifying and acne-removing cleaning products, and has a wide market application prospect.

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating glycolipid metabolic diseases and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 15-19 parts of coptis chinensis, 10-15 parts of rhodiola rosea, 10-20 parts of gynostemma pentaphylla, 9-12 parts of kapok, 10-15 parts of soapberry, 9-15 parts of salvia miltiorrhiza, 10-15 parts of rhizoma alismatis, 9-12 parts of oriental wormwood, 9-12 parts of radix bupleuri, 5-10 parts of semen cassiae, 10-15 parts of rhizoma anemarrhenae, 10-15 parts of hawthorn, 6-9 parts of polygonum cuspidatum and 5-10 parts of fructus aurantii. The traditional Chinese medicine composition disclosed by the invention has the effects of inhibiting hyperlipidemia, hyperglycemia and hepatic lipid accumulation and relieving insulin resistance, and has a remarkable curative effect on relieving and treating glycolipid metabolic diseases.

The invention provides a rhizoma polygonati extract as well as a preparation method and application thereof in prevention and control of glucose and lipid metabolism disorder. According to the invention, an effective component group consisting of effective parts of flavonoids and saponins is extracted from a traditional Chinese medicinal material polygonatum sibiricum, the sum of the actual contents accounts for more than 50% of the total weight of the polygonatum sibiricum extract, and meanwhile, the effective component group is used for preparing medicines for preventing and / or treating impaired glucose tolerance and glucose and lipid metabolism disorder. The traditional Chinese medicine composition is clear in curative effect, controllable in quality and easy to industrialize in preparation process, various proper dosage forms can be prepared according to clinical requirements, and a convenient, effective, stable and controllable modern traditional Chinese medicine is provided for clinical application.

The invention relates to the technical field of functional probiotic screening and application, and particularly provides a bifidobacterium animalis subsp. Lactis (Bifidobacterium animalis subsp. Lactis) capable of relieving liver injury and regulating glycolipid metabolism and application of the bifidobacterium animalis subsp. Lactis. The preservation number of the bifidobacterium animalis subsp. Lactis is CGMCC No.31656, and the bifidobacterium animalis subsp. Lactis can effectively reduce blood sugar and blood fat of diabetic mice and relieve insulin resistance and has the capacity of relieving diabetic cardiomyopathy. The strain has wide application prospects in preparation of drugs for treating diabetes mellitus, liver injury and glycolipid metabolism.

The present invention belongs to the technical field of cosmetics, and specifically relates to a skin care composition with repairing and anti-aging effects, wherein the skin care composition comprises the following components in parts by weight: 2.5-4 parts of common wheat extract, 0.1-1 parts of phospholipids, 1-2 parts of squalane, 2.5-4 parts of caprylic / capric triglycerides, 0.5-1.5 parts of glycolipids, 0.01-0.5 parts of phytosphingosine, 0.001-0.1 parts of ceramide NS / ceramide NG, 0.05-3 parts of gentian root extract, 0.1-2 parts of sea fennel extract, 0.01-0.5 parts of milo leaf / stem extract, 0.01-1.0 parts of rose extract, and 0.01-0.8 parts of schizonepeta extract. The skin care composition of the present invention has repairing and anti-aging effects, and can be used to prepare sebum biomimetic cosmetics.

The invention discloses a lactobacillus rhamnosus HX-4F3 strain and application thereof, and belongs to the technical field of biology. The lactobacillus rhamnosus HX-4F3 disclosed by the invention is preserved in the China Center for Type Culture Collection, and the preservation number of the lactobacillus rhamnosus HX-4F3 is CCTCC (China Center for Type Culture Collection) NO: M 20251454. The invention discloses an application of a strain HX-4F3 in preparation of drugs or food for lowering lipid or / and blood sugar. The invention also discloses application of the compound in preparation of functional food or / and medicines for preventing or / and treating metabolic diseases. The invention also discloses a composition for lowering lipid or / and blood sugar, which comprises a live bacterium of the strain HX-4F3 or freeze-dried powder, a spore preparation, a metabolic supernatant or an inactivated bacterium of the strain HX-4F3, and a pharmaceutically or food acceptable carrier. According to the lactobacillus rhamnosus HX-4F3 provided by the invention, the glucose and lipid metabolism disorder can be remarkably improved through a multiple synergistic mechanism, and the glucose and lipid metabolism disorder can be remarkably improved through the lactobacillus rhamnosus HX-4F3.