119 results about "Glycosphingolipid" patented technology

Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.

The invention provides a family of antibodies that specifically bind the human cell surface glycosphingolipid GD2. The antibodies comprise modified variable regions, more specially, modified framework regions, which reduce their immunogenicity when administered to a human. The antibodies may be coupled to a therapeutic agent and used in the treatment of cancer.

Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.

The invention herein encompasses methods effective to stimulate epithelial cell proliferation and/or enhance epithelial moisturization and lubrication in a mammalian subject utilizing a composition comprising one or more inhibitors of beta -glucosidase activity or beta -glucocerebrosidase activity. The composition of the method may alternatively comprise a glycosphingolipid, particularly glucocerebroside, or a combination of the above inhibitor(s) and a glycosphingolipid. The method is effective to enhance the cosmetic appearance of skin and promote healing of skin and mucous membranes damaged or deficient from aging, traumatic wounds, photo-aging and a variety of atrophic conditions. The method may be applied to cells in culture. Also included in the invention is a composition comprising one or more inhibitors of beta -glucosidase and a glycosphingolipid useful to stimulate cell proliferation and enhance tissue moisturization and lubrication.

The invention belongs to the technical field of cosmetics, and particularly discloses double-layer essence with repair and anti-aging functions. The double-layer essence comprises, by weight, 1.0%-2.0% of PEG-40 (polyethylene glycol-40) hydrogenated castor oil, 5%-19% of methyl trimethicone, 4%-6% of dicaprylyl carbonate, 0.5%-1.5% of cetyl dimethicone, 0.5%-1.5% of helianthus annuus seed oil, 3%-9% of glycerin, 0.1%-0.15% of sodium hyaluronate, 0.5%-1.5% of myrothamnus flabellifolia leaf/stem extract, 1%-3% of polypeptides with palmitoyl tripeptide-1 and palmitoyl tetrapeptide-7, 0.5%-1.5% of lactobacillus ferment lysate, 1%-3% of glycosphingolipid, 0.8%-1% of mixtures of glycerol caprylate, p-hydroxy phenyl ethyl ketone and glyceryl laurate and the balance water. The double-layer essence has the advantages that the double-layer essence which is a novel ultralow-viscosity double-layer system is unique in structure and convenient to use; formulas and structures of the double-layer essence are optimized, and accordingly the double-layer essence is free of potential irritation and allergy sources such as perfume and preservatives, is in mild and non-irritant formulas and has the excellent repair and anti-aging functions.

Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.

The invention belongs to the technical field of cosmetics, and discloses a skin care substrate with long acting moisturizing and whitening effects and preparation and application of skin care substrate. The skin care substrate is prepared from the following components in mass percent: 10%-20% of tremella polysaccharide, 5%-10% of glycosphingolipid, 10%-20% of saccharide isomerate, 5%-10% of nicotinamide, 3%-6% of alpha-arbutin, 3%-6% of tranexamic acid, 1%-3% of ADS-Oligonol and balance of water. The skin care substrate disclosed by the invention has obvious long acting moisturizing and skin whitening effects and can make the skin moisturized and bright white by persistent use.

The invention discloses a Bose factor polypeptide anti-wrinkle eye cream and a preparation method thereof. The eye cream provides a conditioner with main active ingredients, and the conditioner comprises tocopheryl acetate, hexapeptide-9, palmitoyl pentapeptide-4, tripeptide-1, palmitoyl palmitoyl tripeptide-5, palmitoyl tripeptide-1, palmitoyl tetrapeptide-7, hydroxypropyl tetrahydropyrantriol (Bose factor), carnosine, glycosphingolipid, illicium verum callus culture filtrate and rosa damascena flower oil. The eye cream can effectively promote the generation of eye skin collagen, increase theelasticity and compactness of the skin, prevent wrinkles from deepening and repair the damaged barrier of the eye skin, and has the effects of wrinkle resistance, whitening and oxidation resistance.

The invention discloses a making method of 2'-OH derivant of alpha-galactose sphislycolipid, which comprises the following steps: synthesizing intermediate of alpha--galactose sphislycolipid through 3-O-benzyl-4, 6-O-benzal-2-O-p-methoxybenzyl p-methyl bentiamine and plant sphingol under N-iodosuccinimide and catalyst; introducing C18 alkyl, methyl, prenyl or alpha/beta connected galactose radical into naked -OH derivant on the intermediate without 2' p-methoxybenzyl; reducing azido group into amino group; acylating with aliphatic acid acted by accelerator; hydrogenating through palladium agent or liquid amino-metal sodium to reduce.

The invention relates to the technical field of skin-care products, in particular to a composition containing a cryptomeria japonica bud extract for skin regeneration of a human face with steroid acnes and a preparation method of the composition. The composition comprises the following raw materials in parts by weight: 10-20 parts of the cryptomeria japonica bud extract, 20-40 parts of plant anti-sensitivity essence, 4-8 parts of glycosphingolipids, 20-30 parts of flowing spring factors, 5-15 parts of desert plant moisturizing factors, 15-25 parts of sodium hyaluronate and 4-8 parts of oat beta-glucan. The composition is good in antioxidant effect, awakens dormant cells, enables skin cells to slowly 'wake up', and has a rejuvenating effect; and furthermore, the skin can be safe against damage of an external environment, injury to sensitive skin by severe environment conditions can also be avoided, meanwhile, effects of astringing and controlling oil, and calming skin are achieved, andthus, the skin can be smooth and bright.

The invention discloses a roe essence cream and a preparation method thereof. The roe essence cream comprises a component A, a component B and a component C, wherein the component A mainly comprises 28.90-87.05 parts of purified water and 3-10 parts of butanediol according to the weight ratio; the component B mainly comprises 3-10 parts of hydrogenated vegetable oil and 0.2-2.0 parts of squalane according to the weight ratio; and the component C mainly comprises 3-10 parts of aloe barbadensis leaf juice, 0.3-3.0 parts of dendrobium stem extract, 0.3-3.0 parts of aloe barbadensis leaf extract,0.3-3.0 parts of sophora japonica root extract, 0.3-3.0 parts of lycium chinense fruit extract and 0.1-1.0 parts of sturgeon caviar extract according to the weight ratio. The roe essence cream disclosed by the invention has the advantages that moisturizing and nourishing effects are achieved by using polyols, moisturizing factors, such as glycosphingolipids, trehalose and glycine betaine, and compositions of squalane, vitamin E and the like; under coordination of active components such as high-content roe essences, dendrobium stem and wolfberry extract, the skin texture is comprehensively improved, the damaged skin is repaired, sufficient nutrient is provided, the repairing and anti-oxidant ability is developed, and the skin ageing process is relieved in a targeted manner.

The invention relates to an anti-human glycosphingolipid Globo-H monoclonal antibody and a preparation method and application thereof. The anti-human glycosphingolipid Globo-H monoclonal antibody can specifically bind glycosphingolipid Globo-H in tumor tissues of liver cancer patients. The anti-human glycosphingolipid Globo-H monoclonal antibody has strong specific binding ability with human glycosphingolipid Globo-H, and can be well used in preparation of diagnostic reagents for diagnosis of liver cancer and the like.

The invention relates to skin soothing and regenerating protein film cream and a preparation method of the skin soothing regenerating protein film cream, relating to the technical field of cosmetics. The skin soothing regenerating protein film cream is prepared from the following components: water, neopentyl glycol diheptanoate, butanediol, glycerol, an oat extract, fucogel-1, glycosphingolipids, wheat fine powder lipid, a plankton extract, a mirabilis jalapa extract, a hydrolyzed egg shell membrane and the like. The skin soothing regenerating protein film cream can permeate to the stratum corneum of skin and form a reticular protective film in the skin, so that the problems of ultraviolet ray invasion and skin dryness and ageing can be solved, meanwhile, the synthesis of collagens from fibroblasts is promoted, therefore, the formation of skin wrinkles is reduced, the skin aging is resisted, the skin elasticity is improved, the skin is enabled to be tender, fine and smooth, as well as full and plump, and is full of beautiful youth gloss, the outside contamination resistance of the skin is enhanced, the self-protection ability of the skin is enhanced, the cell ageing is prevented, and thus the skin ageing is delayed, the youthful vigor of the skin is recovered, the skin is tender and full, and the beautiful skin with the real lasting health is realized from inside to outside.

The invention discloses a probiotic mask, which comprises the following components by weight percentage: 1 to 5% of a fermentation product filtrate of bifida, 0.5 to 3% of a lactic acid bacteria fermentation lysate, 0.45 to 1.125% of alpha-glucan oligosaccharide, 0.5 to 5% of trehalose, 0.1 to 2% of a saccharide isomerate, and 0.1 to 2% of glycosphingolipid. The probiotic mask of the present invention is added with the fermentation product filtrate of bifida which is a probiotic product for repairing skin photoaging as well as a lactic acid bacteria fermentation lysate which is the probiotic product for promoting the exfoliation of the dead skin. The two probiotic products can repair damaged skin from the inside to outside; the addition of the moisturizing ingredients of alpha-glucan oligosaccharide, trehalose, the saccharide isomerate and glycosphingolipid can effectively moisturize the stratum corneum of the skin, and the combination of the probiotic product and the moisturizing ingredients enables the mask of the present invention to have a good skin repairing effect and a long-lasting moisturizing power.

There is provided a plant disease resistance-inducing composition comprising a filamentous fungus-derived glycosphingolipid. There is also provided a method for controlling a plant disease, comprising the step of treating a target plant with a composition comprising a filamentous fungus-derived glycosphingolipid.