1137 results about "Cell based" patented technology

The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal information about changes in physiological, biochemical and molecular activities. The present invention allows multiple types of cell interactions to be studied simultaneously by combining multicolor luminescence reading, microfluidic delivery, and environmental control of living cells in non-uniform micro-patterned arrays.

A two-way cable network offering high-speed broadband communications delivered via virtual private networks over a multi-channel shared media system. Bi-directional transmission of packet to ATM cell based communications is established between a head end communication controller and a number of subscriber terminal units, whereby individual cells are prioritized and routed according to a virtual connection. Virtual connections are organized to support multiple virtual private networks in a shared media CATV system. The virtual private network to which a particular STU belongs is user selectable and has the flexibility of handling multi up/downstream channels with different MAC domains. The present invention can also handle non-ATM MAC domains via the same common ATM switch. To overcome the limited number of addresses inherent to common ATM switches, a mapping/remapping function is implemented in the port cards. Furthermore, downstream as well as upstream traffic are filtered at each STU. In one embodiment, information pertaining to downstream traffic is used to implement predictive scheduling in order to improve the timing associated with the request/grant cycle. In another embodiment, a user has the ability to select a quality of service that best suits the needs of the current application. In a further embodiment, the scheduling function is associated with each of the receivers in order to provide improved scalability.

Timing synchronization between base stations of uncoordinated communication networks includes obtaining timing synchronization information from one base station, and adjusting a clock of the other station in response to the synchronization information. The timing synchronization information can be identified from a strongest synchronization signal from nearby uncoordinated base stations. The timing synchronization can accommodate clock offsets and frequency offsets.

This invention provides for a novel means for obtaining human idiologs for any non-human antibody to any target by epitope guided replacement of variable regions using competitive cell-based methods in which the competitor can be either the reference antibody or a ligand that binds to the same epitope on the target as the reference antibody.

The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.

A Fibre Channel switch is presented that tracks the congestion status of destination ports in an XOFF mask at each input. A mapping is maintained between virtual channels on an ISL and the destination ports to allow changes in the XOFF mask to trigger a primitive to an upstream port that provides virtual channel flow control. The XOFF mask is also used to avoid sending frames to a congested port. Instead, these frames are stored on a single deferred queue and later processed in a manner designed to maintain frame ordering. A routing system is provided that applies multiple routing rules in parallel to perform line speed routing. The preferred switch fabric is cell based, with techniques used to manage path maintenance for variable length frames and to adapt to varying transmission rates in the system. Finally, the switch allows data and microprocessor communication to share the same crossbar network.

A method and an apparatus for scheduling transmissions of a plurality of cells in a wireless communications system including one or more base stations is provided. The method comprises providing a set of virtual channels to enable an intra-cell transmission orthogonal to another transmission within each cell of the plurality of cells and inter-cell transmissions orthogonal to other transmissions across a cluster of cells associated with the one or more base stations. The method further comprises exchanging signaling messages between two or more base stations to coordinate scheduling of the intra-cell transmission with the inter-cell transmissions for the cluster of cells. For optimizing a parameter associated with scheduling of a plurality of users from a cluster of cells in a wireless communication system, an optimal power level for the parameter of each active user may be searched to maximize an indication of system capacity of the wireless communication system. This enables a coordinated jointly scheduling of the users active in the cluster of cells based on the optimal power levels such that the total interference within the cluster may be minimized to maximize the system throughput/capacity.

The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides or nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are T cells and NKT cells activated by the above compositions that can be administered for adoptive immunotherapy.

The invention provides a computer implemented, methods, systems, software program devices, and a Multi-Tier Graphical Interface level General User Interface (GUI) screen designed to support data integration processes for IT and Subject Matter Experts User access and use of structured data sources. The software enables create, extract, transform, programs, processes, and load data integration application Data Integration Application (Composite Object)s through an object based software design enabling efficient and rapid retrieval, processing, and positioning of structured data directly from one or multiple data sources to the required formats, processes, and application support at the skills set levels of the user. The software is a command and processes design for Data Integration Application (Composite Object) that can be transaction oriented, recurring process, as well as periodic The software is an open, data oriented system design for rapid generation and support of Data Integration Application (Composite Object)s using a Multi-Tier three dimensional graphical interface design for cell based data applications. The Data Integration Application (Composite Object) are compiled, independent object applications residing in an object library designated by the user/user IT organization. The compiled data application object are run on the organization's existing computing systems under standard compute processing procedures as either independent applications or in support of the organizations ongoing business/operational requirements for data use requirements.

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

A system and method for providing cell-based statistics for messages related to the same call. The system and method can receive messages into a message coverage area, link the messages with a call with which they are associated, determine a radio link associated with the messages, create a data record if the radio link has been added, and providing the cell-based statistics that are associated with the messages and the message coverage area to the data record.

Stem cells products having the potential to support cells of a soft tissue lineage, and methods of preparation and use of those stem cell products are disclosed. The invention also relates to methods for the use of such stem cells products in the regeneration and repair of soft tissue, and in cell-based therapies for of soft tissue conditions.

The present invention provides embodiments of methods for directing traffic between cells of different sizes. One embodiment of the method includes determining, at a mobile unit, whether to hand off from a source cell to a target cell based on information indicating sizes of coverage areas of the source cell and the target cell.

Various systems and methods for generating and/or ordering error indications are disclosed herein. In some cases, the error indication is used as an erasure pointer in a memory access system. As one particular example, a system for ordering erasure pointers is disclosed that includes a group of N sort cells, where N is a whole number. Each of the sort cells is operable to maintain a respective error indication that includes an error value and an associated error pointer. Further, the group of N sort cells is operable to receive an incoming error indication including error value and associated error pointer, and to update the error indication of one or more of the group of N sort cells based in part on the incoming error value. The system also includes a selector circuit that is operable to allow selectable access to each of the respective error pointers maintained in the group of N sort cells.

The present invention relates generally to the field of high content screening of particles, e.g., cells in a flow cytometric system. In particular, the present invention relates to devices, methods and systems to obtain line-scan images of particles, e.g., cells, of a plurality of different samples simultaneously, where the line-scan images can be used to identify cells based on at least one of a variety of phenotypic characteristics such as shape, asymmetry, and intracellular information for cell sorting and selection. In some embodiments, the line-scan images are obtained as the particles, e.g., cells, in a plurality of different samples flow through a plurality of microchannels, reducing the need and time for focusing of the image detection system. In some embodiments, the laser spot size has a small spatial resolution for rapid capturing of images of cells. In some embodiments, the laser spot size has a larger spatial resolution for imaging of larger particles or cells, e.g., rare cells in a sample. In some embodiments, the devices, methods and systems are automated for a high-throughput, high content screening of particles such as cells in a plurality of samples.

The instant invention provides stable and novel lineage I WNV reverse genetics systems, and methods for making the reverse genetics systems, specifically, a fully-infectious lineage I WNV cDNA or replicon system engineered with one or more nucleotide sequences each encoding a reporter gene to be used in high throughput cell-based screening assays for the identification of novel antiflaviviral chemotherapeutics and/or vaccines effective to treat and/or immunize against infections by WNV and other emerging flaviviruses, such as, for example, JEV, SLEV, AV, KV, JV, CV, YV, TBEV, DENV-1, DENV-2, DENV-3, DENV-4, YFV and MVEV. The present invention further provides methods of high throughput screening of antiflaviviral compounds or improved derivatives thereof using novel lineage I WNV reverse genetics systems and/or cell lines stably containing the reverse genetics systems. Also, the invention provides novel pharmaceutical compositions comprising an attenuated lineage I WNV that is less virulent but similarly immunogenic as the parent WNV and is capable of providing a protective immune response in a host.

In a unit cell, a first conductive type active region and a second conductive type active region are provided. Those two active regions extend in a first direction. Each of the active regions have first and second ends thereof. The first end of the second conductive type active region opposes the second end of the first conductive type active region. A conductive pattern is provided to extend in the first direction across the first conductive type active region and the second conductive type active region. A first contact region is arranged adjacent the first end of the first conductive type active region in the first direction. A second contact region is arranged adjacent the second end of the second conductive type active region in the first direction.

Disclosed are a wireless communication system, method, and information processing system for optimizing paging channel utilization. The method includes determining a mobility state of the wireless device (104). If the mobility state of the wireless device (104) is a mobile state, a signal is generated for a page to be transmitted to a set of base stations (110) in a paging area (402) that the wireless device (104) is currently located in. If the mobility state of the wireless device (104) is a stationary state, a subset of base stations from the set of base stations (110) within the paging area (402) is selected. A signal is then generated for a page to be transmitted to the subset of base stations.

The invention provides a channel detection notification method, a channel detection notification system and base stations used when an LTE system works at an unauthorized frequency band. The channel detection notification method includes the steps that the primary cell base station receives RRM measuring results, reported by a terminal, of multiple base stations at the unauthorized frequency band; according to the RRM measuring results of the base stations, the secondary cell base station is selected for the terminal; if it is determined that downlink traffic reaches a set first traffic threshold value, the secondary cell base station is informed to conduct downlink channel detection; if it is determined that uplink traffic reaches a set second traffic threshold value, the secondary cell base station and/or the terminal are/is informed to conduct uplink channel detection. According to the channel detection notification method, channel detection work conducted when the LTE system works at the unauthorized frequency band is managed by the primary cell base station in a united mode, the time delay generated when the secondary cell base station and/or the terminal carry/carries out channel detection can be effectively shortened, accuracy at which channel detection time is judged can be improved, and the resource utilization rate is increased when the LTE system works at the unauthorized frequency band.

An opening-sealing apparatus for a honeycomb molded body comprising:

a paste filling device equipped with a paste filling unit having an opening-sealing mask in which a number of openings are formed at predetermined positions and a paste supplying unit;

an image pickup device for picking up an image of the end face of the honeycomb molded body; and

an image analyzing device for analyzing the image obtained by the image pickup device, wherein

the image analyzing device analyzes the positions of the cells based upon the image of the end face picked up by the image pickup device; the opening-sealing mask is made in contact with the end face of the honeycomb molded body in such a manner that the positional error between the openings of the opening-sealing mask and the cells of the honeycomb molded body is reduced to a minimal level; and the plug material paste, which has been supplied from the paste supplying unit to the paste filling unit, is injected through the opening-sealing mask and filled in the end portion of the cells.

Cell-based compositions and methods of their use to inhibit an adverse immune response such as graft versus host disease or rejection of transplanted tissue in a transplant recipient that is histocompatibility mismatched to the transplant donor are disclosed. The compositions and methods utilize postpartum-derived cells, such as cells derived from the placenta or umbilicus.

Methods and devices are provided for improved thermal management for photovoltaic devices and assemblies. In one embodiment, the photovoltaic device comprises of at least one photovoltaic cell based on a thin-film photovoltaic stack deposited directly onto a thermally conductive substrate. The thermally conductive substrate is connected to a heat sink in a configuration to allow sufficient heat transfer that lowers a normal operating cell temperature (NOCT) of the photovoltaic cell, thus increasing the efficiency of the cell and the module.

Changes in wireless service user behavior are encouraged and produced to shape utilization patterns among cells within a rate plan region by using shaping rules which define potential discounts from a standard charge rate under certain cell-specific utilization conditions, analyzing the shaping rules and utilization statistics of a cell upon service initiation, generating a discount from the standard rate for underutilized cells. The user is notified of these discount opportunities using text messages, icons, or other means. Over time, the users learn that at certain places and times, significant discounts are offered, and thus changes their behavior to take advantage of those discounts, thereby shaping traffic in a manner desired by the service provider.

The invention provides a microfabricated device for sorting cells based on a desired characteristic, for example, reporter-labeled cells can be sorted by the presence or level of reporter on the cells. The device includes a chip having a substrate into which is microfabricated at least one analysis unit. Each analysis unit includes a main channel, having a sample inlet channel, typically at one end, and a detection region along a portion of its length. Adjacent and downstream from the detection region, the main channel has a discrimination region or branch point leading to at least two branch channels. The analysis unit may further include additional inlet channels, detection points, branch points, and branch channels as desired. A stream containing cells is passed through the detection region, such that on average one cell occupies the detection region at a given time. The cells can be sorted into an appropriate branch channel based on the presence or amount of a detectable signal such as an optical signal, with or without stimulation, such as exposure to light in order to promote fluorescence.

A novel protocol for scheduling of packets in high-speed cell based switches is provided. The switch is assumed to use a logical cross-bar fabric with input buffers. The scheduler may be used in optical as well as electronic switches with terabit capacity. The proposed round-robin greedy scheduling (RRGS) achieves optimal scheduling at terabit throughput, using a pipeline technique. The pipeline approach avoids the need for internal speedup of the switching fabric to achieve high utilization. A method for determining a time slot in a NxN crossbar switch for a round robin greedy scheduling protocol, comprising N logical queues corresponding to N output ports, the input for the protocol being a state of all the input-output queues, output of the protocol being a schedule, the method comprising: choosing input corresponding to i=(constant-k-1)mod N, stopping if there are no more inputs, otherwise choosing the next input in a round robin fashion determined by i=(i+1)mod N; choosing an output j such that a pair (i,j) to a set C={(i,j)| there is at least one packet from I to j}, if the pair (i,j) exists; removing i from a set of inputs and repeating the steps if the pair (i,j) does not exist; removing i from the set of inputs and j from a set of outputs; and adding the pair (i,j) to the schedule and repeating the steps.

Aspects of the invention pertain to matching a selected image/photograph against a database of reference images having location information. The image of interest may include some location information itself, such as latitude/longitude coordinates and orientation. However, the location information provided by a user's device may be inaccurate or incomplete. The image of interest is provided to a front end server, which selects one or more cells to match the image against. Each cell may have multiple images and an index. One or more cell match servers compare the image against specific cells based on information provided by the front end server. An index storage server maintains index data for the cells and provides them to the cell match servers. If a match is found, the front end server identifies the correct location and orientation of the received image, and may correct errors in an estimated location of the user device.

An apparatus, method and computer program product comprise controlling cellular network based communication in a primary cell on a frequency band related to the cellular network and by using an uplink and downlink configuration specific to the primary cell; controlling communication in a secondary cell on a frequency band related to a television white space channel and by using an uplink and downlink configuration specific to the secondary cell; measuring radio interference on a temporarily set uplink related carrier on the secondary cell based on information on the temporarily set uplink related carrier received on a downlink related carrier on the primary cell; and reporting results of radio interference measurement via the primary cell.

A method for making a land management decision comprises surveying a field with a location-determining receiver to determine position data and corresponding elevation data. A data processor or elevation module determines an average elevation data for a zone within the field around a particular cell. The data processor or classifier classifies each cell into classifications comprising a depression cell and a summit cell based on the determined elevation difference between the particular cell and the average elevation. The data processor and the prescription module generate a prescription for the cells in the field based on at least one of the classification and the determined elevation difference.

Aiming at the requirements of frequent cell handover, short handover time and high handover success rate in high-speed railway TD-LTE communication system, a fast handover method of TD-LTE communication system based on target cell pre-carrying is proposed. According to the train's running position, speed and direction, after the network planning is completed, a list of neighboring cells is generated in advance, and the switching position of each switching zone is preset, that is, the longitude and latitude position information. Before the train enters the overlapping area of ​​switching between two cells , when the distance from entering the handover zone is a certain value L, the source base station eNodeB determines and sends the pre-bearer information to the target base station eNodeB according to the measurement report of the user terminal UE, and the target base station eNodeB performs the evolution packet system ( Evolved Packet System (EPS) resources to bear the load, when the train enters the handover zone, if the train meets the handover criteria, the train will be handed over from the source cell to the target cell. Therefore, this method reduces the handover delay and is beneficial to improve the handover success rate. The method can dynamically adjust the switching method according to the mobile speed of the UE, solve the problem of fast switching in a high-speed mobile environment, reduce the number of communication drops, improve the success rate of switching, enhance the service quality of high-speed broadband mobile services, and promote high-speed railway trains. The development of domestic multimedia broadband mobile Internet services meets the growing needs of passengers for mobile communication services.

The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5A inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5A activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.