2770 results about "Cell based" patented technology

The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellular and subcellular level as well as temporal information about changes in physiological, biochemical and molecular activities. The present invention allows multiple types of cell interactions to be studied simultaneously by combining multicolor luminescence reading, microfluidic delivery, and environmental control of living cells in non-uniform micro-patterned arrays.

A two-way cable network offering high-speed broadband communications delivered via virtual private networks over a multi-channel shared media system. Bi-directional transmission of packet to ATM cell based communications is established between a head end communication controller and a number of subscriber terminal units, whereby individual cells are prioritized and routed according to a virtual connection. Virtual connections are organized to support multiple virtual private networks in a shared media CATV system. The virtual private network to which a particular STU belongs is user selectable and has the flexibility of handling multi up/downstream channels with different MAC domains. The present invention can also handle non-ATM MAC domains via the same common ATM switch. To overcome the limited number of addresses inherent to common ATM switches, a mapping/remapping function is implemented in the port cards. Furthermore, downstream as well as upstream traffic are filtered at each STU. In one embodiment, information pertaining to downstream traffic is used to implement predictive scheduling in order to improve the timing associated with the request/grant cycle. In another embodiment, a user has the ability to select a quality of service that best suits the needs of the current application. In a further embodiment, the scheduling function is associated with each of the receivers in order to provide improved scalability.

Timing synchronization between base stations of uncoordinated communication networks includes obtaining timing synchronization information from one base station, and adjusting a clock of the other station in response to the synchronization information. The timing synchronization information can be identified from a strongest synchronization signal from nearby uncoordinated base stations. The timing synchronization can accommodate clock offsets and frequency offsets.

This invention provides for a novel means for obtaining human idiologs for any non-human antibody to any target by epitope guided replacement of variable regions using competitive cell-based methods in which the competitor can be either the reference antibody or a ligand that binds to the same epitope on the target as the reference antibody.

The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the matrix forms a domain individually addressable by microfluidic channels in the device.

A Fibre Channel switch is presented that tracks the congestion status of destination ports in an XOFF mask at each input. A mapping is maintained between virtual channels on an ISL and the destination ports to allow changes in the XOFF mask to trigger a primitive to an upstream port that provides virtual channel flow control. The XOFF mask is also used to avoid sending frames to a congested port. Instead, these frames are stored on a single deferred queue and later processed in a manner designed to maintain frame ordering. A routing system is provided that applies multiple routing rules in parallel to perform line speed routing. The preferred switch fabric is cell based, with techniques used to manage path maintenance for variable length frames and to adapt to varying transmission rates in the system. Finally, the switch allows data and microprocessor communication to share the same crossbar network.

A method and an apparatus for scheduling transmissions of a plurality of cells in a wireless communications system including one or more base stations is provided. The method comprises providing a set of virtual channels to enable an intra-cell transmission orthogonal to another transmission within each cell of the plurality of cells and inter-cell transmissions orthogonal to other transmissions across a cluster of cells associated with the one or more base stations. The method further comprises exchanging signaling messages between two or more base stations to coordinate scheduling of the intra-cell transmission with the inter-cell transmissions for the cluster of cells. For optimizing a parameter associated with scheduling of a plurality of users from a cluster of cells in a wireless communication system, an optimal power level for the parameter of each active user may be searched to maximize an indication of system capacity of the wireless communication system. This enables a coordinated jointly scheduling of the users active in the cluster of cells based on the optimal power levels such that the total interference within the cluster may be minimized to maximize the system throughput/capacity.

The present invention comprises compositions and methods for treating a tumor or neoplastic disease in a host, The methods employ conjugates comprising superantigen polypeptides or nucleic acids with other structures that preferentially bind to tumor cells and are capable of inducing apoptosis. Also provided are superantigen-glycolipid conjugates and vesicles that are loaded onto antigen presenting cells to activate both T cells and NKT cells. Cell-based vaccines comprise tumor cells engineered to express a superantigen along with glycolipids products which, when expressed, render the cells capable of eliciting an effective anti-tumor immune response in a mammal into which these cells are introduced. Included among these compositions are tumor cells, hybrid cells of tumor cells and accessory cells, preferably dendritic cells. Also provided are T cells and NKT cells activated by the above compositions that can be administered for adoptive immunotherapy.

Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.). Specifically this invention discloses a few sorting schemes for stem cells, whole blood and circulating tumor cells and also extracting serum from whole blood. Further medical diagnostics technology utilizing high throughput single cell PCR is described using immiscible fluidics couple with single or multi cells trapping technology.

The invention provides a computer implemented, methods, systems, software program devices, and a Multi-Tier Graphical Interface level General User Interface (GUI) screen designed to support data integration processes for IT and Subject Matter Experts User access and use of structured data sources. The software enables create, extract, transform, programs, processes, and load data integration application Data Integration Application (Composite Object)s through an object based software design enabling efficient and rapid retrieval, processing, and positioning of structured data directly from one or multiple data sources to the required formats, processes, and application support at the skills set levels of the user. The software is a command and processes design for Data Integration Application (Composite Object) that can be transaction oriented, recurring process, as well as periodic The software is an open, data oriented system design for rapid generation and support of Data Integration Application (Composite Object)s using a Multi-Tier three dimensional graphical interface design for cell based data applications. The Data Integration Application (Composite Object) are compiled, independent object applications residing in an object library designated by the user/user IT organization. The compiled data application object are run on the organization's existing computing systems under standard compute processing procedures as either independent applications or in support of the organizations ongoing business/operational requirements for data use requirements.

This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

A system and method for providing cell-based statistics for messages related to the same call. The system and method can receive messages into a message coverage area, link the messages with a call with which they are associated, determine a radio link associated with the messages, create a data record if the radio link has been added, and providing the cell-based statistics that are associated with the messages and the message coverage area to the data record.

Stem cells products having the potential to support cells of a soft tissue lineage, and methods of preparation and use of those stem cell products are disclosed. The invention also relates to methods for the use of such stem cells products in the regeneration and repair of soft tissue, and in cell-based therapies for of soft tissue conditions.

The present invention provides embodiments of methods for directing traffic between cells of different sizes. One embodiment of the method includes determining, at a mobile unit, whether to hand off from a source cell to a target cell based on information indicating sizes of coverage areas of the source cell and the target cell.

The present invention provides a method and an apparatus for balancing traffic load between a plurality of users on one or more shared wireless channels, e.g., from a communication node associated with a network of a plurality of cells including a first and a second cell. The method comprises determining a first indication of traffic load for a first cell and a second indication of traffic load for a second cell on the one or more shared wireless channels and redistributing the traffic load on the one or more shared wireless channels associated with the first cell and the second cell based on the first indication of traffic load for the first cell and the second indication of traffic load for the second cell. A scheduler, e.g., at a Node B and a decision algorithm at a controller, e.g., a radio network controller may be used in a wireless telecommunication system that uses wireless channels including a shared channel, a forward access channel, a random access channel, as well as a dedicated channel to switch traffic associated with at least one user of a multiplicity of users on a shared wireless channel from a cell to another cell. In this manner, for user equipment, e.g., a Universal Mobile Telecommunications System mobile station, a decision algorithm in a Universal Mobile Telecommunications System Terrestrial Radio Access Network may direct at least a part of the traffic load on a shared channel from a source cell to a target cell by moving a cell border without affecting a traffic load on a dedicated channel.