50 results about "Organ function" patented technology

1. Name of the product in this design: Organ Function Breathing Trainer. 2. Purpose of this design: For organ function breathing training. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: 3D view 1.

This application relates to a device for detecting organ function and its control method, as well as a dietary management method and system, belonging to the technical field of medical device testing. The control method compares and analyzes changes in the microscopic features of the same area of ​​the tongue before and after eating, and calculates the corresponding metabolic index change rate, constructing a mapping relationship between the tongue's microscopic morphology and organ function, providing a basis for assessing internal physiological function through external characterization. Simultaneously, the dietary management method uses physiological responses before and after eating as real-time biofeedback signals to generate dynamically adjusted dietary management plans, forming a personalized health management closed loop of "monitoring-assessment-intervention-remonitoring," achieving precise adaptive adjustment of intervention strategies.

Systems, devices, and methods for affecting a patient's organ function by innervating one or more organs of the patient are described herein. Innervating one or more organs of the patient is induced via electrical stimulation to nerve fibers, such as afferent nerve fibers, of one or more of the patient's dorsal roots. Electrical stimulation to dorsal root nerve fibers is delivered using at least one intravenous electrode disposed within a vein of the patient proximate to the dorsal root nerve fibers.

The invention discloses an application of glucopyranose galactooligosacharide in preparation of a medicine for treating and / or preventing allergic asthma. The invention finds that the glucopyranose galactooligosaccharide can obviously relieve airway inflammatory reaction of an allergen-induced allergic asthma model, including reducing airway inflammatory factor level, improving airway hyperreactivity and reducing lung inflammatory cell infiltration, and has no abnormal influence on blood routine and main organ functions; the composition has the advantages of small drug application dosage, low pharmaceutical cost, high safety, remarkable drug effect and the like, and has a wide application prospect.

A diagnostic system for determining a health condition of an organ of a patient that has been administered a radioisotope dose uptaken by the organ, comprises at least one processor configured for receiving image data acquired from the patient when the radioisotope dose is active in the patient, analyzing the received image data to determine a functional organ volume index and an individual organ function index, staging a health of the organ based on the determined functional organ volume index and the determined individual organ function index. The diagnostic system further comprises a user interface device configured for communicating the staged health of the organ to a clinician.

The invention belongs to the technical field of medical equipment, and particularly discloses a reversible electroporation combined medical kit for organ transplantation and transfer and application of the reversible electroporation combined medical kit. According to the medical kit for organ transplantation, a novel electric pulse device is additionally designed on the basis of original design, a large amount of emergency response generated after organ transplantation can be remarkably reduced, and the survival rate of organs is increased. The novel electric pulse device is designed to be attached to the inner wall of the box body, the designed electric pulse electrode plate is attached to the buffer pad, the buffer pad is made of an insulating non-toxic heat preservation material, and organ preservation liquid is contained in the organ preservation bag. According to the medical kit for organ transplantation, the additional electrodes can be used for applying electric pulses to organs in the organ storage bag, medicine in the organ storage liquid is promoted to enter the organs, meanwhile, the optimal applied pulse intensity is confirmed in combination with cell experiments, the potential distribution condition is simulated and confirmed in combination with simulation software, and emergency reaction generated after perfusion can be reduced; therefore, normal organ functions are ensured, and the success rate of transplantation is improved.

1. Name of the product in this design: Organ Function Breathing Trainer (Two-way Self-switching). 2. Purpose of this design: Organ function breathing training. 3. The key design feature of this product is its shape. 4. The image or photograph that best illustrates the design's key points: a 3D model.

This document discloses compositions and methods involving glycosaminoglycan components. For example, administering a composition comprising a glycosaminoglycan component to an organ before, during, or after ex vivo organ perfusion can improve organ transplantation. These improvements include reduced MMP levels, reduced apoptosis markers, reduced endothelial cell activation, and increased organ function. Such methods and compositions can be used for organ and tissue transplantation, as well as for the storage or transport of acquired organs and tissues.

The invention discloses a traditional Chinese medicine composition for treating rheumatic bone pain and a preparation method of the traditional Chinese medicine composition, and relates to the technical field of traditional Chinese medicines. The ointment consists of traditional Chinese medicine components and auxiliary materials, wherein the traditional Chinese medicine components of the ointment are prepared from the following components: unprocessed radix aconiti, unprocessed radix aconiti kusnezoffii, scorpio, centipede, earthworm, frankincense, myrrh, notopterygium root, radix angelicae pubescentis, radix clematidis, gentiana macrophylla, lycopodium clavatum, safflower and phryma leptostachya; the decoction is prepared from the following components: eucommia ulmoides, longspur epimedium, radix rehmanniae preparata, raw astragalus membranaceus, teasel root, semen cuscutae, radix achyranthis bidentatae, radix clematidis, salvia miltiorrhiza, radix aconiti preparata, prepared kusnezoff monkshood root, angelica sinensis and liquorice. According to the invention, a treatment mode of combining external use of ointment and oral administration of decoction is innovatively adopted, aiming at the pathogenesis characteristics of rheumatism ostalgia, local symptoms are rapidly relieved through the external ointment, the internal organ function is fundamentally conditioned through the oral decoction, the treatment strategy of treating symptoms in emergency and treating root causes in slow is realized, and the clinical curative effect is remarkably improved.

The application relates to the technical field of medical data processing, and discloses a critical patient multi-organ function failure evolution path prediction system, which comprises a collection and preprocessing module, an adaptive dynamic characteristic extraction module, a physical dissipation constraint causal topology analysis module, a closed-loop feedback controller and a cascade failure path deduction module. The system extracts dynamic characteristics and calculates a physical effectiveness coefficient based on multi-modal physiological signals, uses the coefficient to correct transfer entropy to construct a multi-organ coupling network; the closed-loop feedback controller dynamically adjusts the embedding dimension parameter of the front-end characteristic extraction according to the total in-degree coupling strength of the network, forming a bidirectional constraint closed loop between the physical layer and the information layer. The application can effectively identify a pathological driving source, deduce the cascade propagation sequence of organ function failure, eliminate false causal connections through physical mechanism constraint and feedback regulation, and improve the accuracy of evolution path prediction.

The application discloses a biological age evaluation method and system based on multi-modal clinical data, wherein the evaluation method comprises the following steps: step 1, data acquisition and multi-modal construction; step 2, data preprocessing and feature expression; step 3, reference population construction and feature screening; step 4, biological age prediction model training and verification; step 5, biological age acceleration index calculation; and step 6, standardization and risk assessment output. By fusing heart ultrasound examination data and blood biomarker data, the application realizes comprehensive characterization of the aging state of an individual, further calculates a biological age acceleration index, and uses the biological age acceleration index for cardiovascular disease risk assessment, so as to solve the problems that a single-modal biological age model in the prior art cannot comprehensively depict the aging process and cannot simultaneously reflect changes in organ function and changes in systemic physiological state.

The invention relates to the technical field of organ preservation, in particular to an isolated organ preservation device and a preservation method.The isolated organ preservation device comprises a placement frame, a plurality of placement modules are arranged on the inner side face of the placement frame, each placement module comprises a placement box, three placement cavities are formed in the side face of each placement box, and communicating grooves are formed in the tops of the inner side faces of the placement cavities; and a storage module is arranged in the placement cavity, and the top of the inner side face of the placement cavity is slidably connected with a blocking frame corresponding to the communicating groove. According to the device, the top of the inner side face of each placement cavity is slidably connected with a blocking frame, when organs need to be taken out, a first cover plate and the blocking frames can move downwards, the blocking frames move to the bottoms of communicating grooves, and cold air in the communicating grooves can penetrate through the tops of the blocking frames to flow into the next placement cavity at the moment; the device does not affect the interiors of other placement cavities, so that organs in other placement cavities can be continuously preserved at low temperature, the organ function protection effect can be enhanced, and organ preservation research is facilitated.

This invention discloses a method, system, and medium for dynamic prediction of pregnancy complications in SLE patients, belonging to the field of medical information technology. It aims to solve the technical problems of existing risk assessment methods, such as the inability to effectively integrate multi-dimensional time-series data and the lack of causal mechanism analysis of the dynamic evolution of risk, resulting in biased, delayed, and clinically inoperable prediction results. The method includes the following steps: S1: Acquiring multimodal health data of the target patient during pregnancy as a time series; S2: Based on the multimodal health data, constructing and updating a dynamic patient profile reflecting the patient's psychosocial state, immune inflammatory activity, and target organ function; S3: Inputting the dynamic patient profile into a trained risk prediction model. This invention, by constructing a dynamic patient profile and employing a time-series deep learning model for risk prediction, achieves a comprehensive, dynamic, and mechanistically transparent risk assessment of pregnancy complications in SLE patients.

The compositions and methods reduce the biological age of an adult animal and / or reduce the rate of increase in the biological age of an adult animal. More specifically, the present disclosure relates to administering formulations comprising an effective amount of spermidine, alone or in combination with a dietary regimen such as a standard diet, caloric restriction, elderly diet, or high protein diet. The preparation can simultaneously reduce the biological age of tissues, organs or physiological systems in adult animals in need; or treating, preventing or delaying the onset of organ disease, or the decline of organ function, or a condition associated therewith, in an adult animal in need thereof.

This application relates to the field of health food technology, specifically disclosing a method for preparing a multi-functional, synergistic, calming, kidney-tonifying, and liver-nourishing health-preserving wine. The product comprises five categories of medicinal materials categorized by efficacy and texture: a thick root and rhizome tonifying group, a fruit and seed group, etc., as well as a guiding herb group, auxiliary components, and a mixed base of sorghum liquor and glutinous rice wine. It utilizes ingredients that are both medicinal and edible, with each group of medicinal materials exhibiting complementary effects. The preparation method includes: targeted pretreatment of medicinal materials, blending of two base wines, graded extraction, directional pH control, graded merging and maturation, fine filtration, static bottling, and bottling. This product can be used for the health-preserving and conditioning of the body's organ functions, synergistically exerting calming, kidney-tonifying, and liver-nourishing effects. It possesses the advantages of synergistic ingredient compatibility and targeted medicinal properties. The preparation method employs a refined, segmented process, adaptable to the different textures of medicinal materials, ensuring full dissolution of effective components, reducing losses, improving raw material utilization and wine stability, and meeting the daily health needs of modern consumers.

The invention belongs to the technical field of biomedicine, and particularly relates to a responsive near-infrared first-zone fluorescent compound as well as a preparation method and application thereof. The compound mainly comprises a fluorescent probe of three functional modules including a fluorescent chromophore, a fibrosis specific enzyme response group and a quenching group, and on the basis, an active / passive targeting group of a targeted disease organ is introduced to form a more excellent fluorescent probe of four functional modules. The effect of the probe is verified in a time-varying progress experiment of a fibrosis disease model, and the probe not only has high specificity and sensitivity, but also has relatively good safety and biocompatibility; the near-infrared first-area fluorescent compound and pharmaceutically acceptable salts or solvates, enantiomers, diastereoisomers and tautomers thereof can be used for preparing fluorescent molecular probes, and diagnosis, intraoperative navigation treatment, tissue and organ function evaluation and the like can be more accurately carried out on diseases.

Systems, methods and devices for controlled sympathectomy procedures for neuromodulation in the treatment of subjects having neoplastic conditions are disclosed. Systems, methods, and devices for interventionally treating a cancerous tumor and cancer related pain are disclosed.

The invention discloses a sepsis risk multi-modal prediction method and system based on deep learning, and belongs to the technical field of intelligent analysis of medical data, and the method comprises the following steps: a multi-modal data collection step: collecting vital sign sequences, bedside instant inspection, laboratories, microbial culture, images and medical history data; in the time sequence feature coding step, a time sequence embedded vector is extracted through a multi-scale time sequence coding network; the cross-modal fusion prediction step is based on the dynamic attention mechanism fusion features and predicts the sepsis occurrence probability; the organ function dynamic evaluation step is used for estimating a missing test result and calculating an organ function score; the risk layering early warning step outputs four-level risk layering results and feeds back optimized coding parameters, early warning can be output 4-8 hours before the diagnosis standard is met, and compared with qSOFA, the AUC is improved by 0.15 or above.

This invention relates to the field of biomedical technology, specifically disclosing a modular interactive organ-on-a-chip and its application method. The chip body includes an inlet and an outlet, a flow channel at the bottom of the chip body connecting the inlet and outlet, multiple chambers on the chip body, an endothelial barrier installed within each chamber, and an organoid culture device. The bottoms of the multiple chambers are connected to the flow channel. The inlet, outlet, and chambers form a dynamic circulation system. This invention effectively achieves physiological coupling between organs, establishing bidirectional feedback regulation between organs; it also supports the large-scale expansion of multiple culture chambers to form more complex multi-organ networks; it enables the construction of a cross-chip microphysiological communication network covering multiple human systems; and by achieving cross-scale parameter monitoring from molecular transport to organ function, it provides highly scalable and efficient measurement capabilities for pathophysiological research of complex multi-organ systems and high-throughput drug screening.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for improving lung deficiency type primary dysmenorrhea and a preparation method and application thereof. The traditional Chinese medicine composition specifically comprises multiple traditional Chinese medicine components including rhizoma polygonati, Chinese yam, rhizoma smilacis glabrae, radix salviae miltiorrhizae, yam rhizome, codonopsis pilosula, radix ophiopogonis from Sichuan of China, exocarpium citri grandis, spina date seeds, radix bupleuri, radix clematidis, morinda officinalis, rhodiola rosea, peach kernels, caulis spatholobi, southern apricot kernels and prepared rehmannia roots. The composition effectively relieves pain and improves accompanying symptoms through multi-target synergistic effects of promoting blood circulation to remove blood stasis, reinforcing qi and nourishing lung, warming kidney and strengthening spleen, regulating qi and relieving pain and the like. The formula follows the monarch, minister, assistant and guide theory of traditional Chinese medicine, is rigorous in compatibility, can comprehensively regulate qi, blood and viscera functions of a patient, is especially suitable for dysmenorrhea caused by deficiency of lung qi and unsmooth qi and blood circulation, and shows the advantages of overall treatment of traditional Chinese medicine. The preparation method is stable in process and easy to implement, and a safe and effective new choice for traditional Chinese medicine treatment is provided for lung deficiency type primary dysmenorrhea.

The present application relates to nano gold loaded NS9283 targeted long-acting analgesic drug and preparation method. NS9283 is loaded on the surface of sodium citrate coated gold nanoparticles by ligand exchange method, and then Pickering emulsion method is used to construct amphiphilic Janus AuNPs self-assembly microcapsules. The drug has the following advantages: stability is improved, long-term activity is maintained at room temperature; targeted controlled release, in vivo fluorescence imaging shows that the drug is continuously enriched at the nerve injury site for more than 7 days; long-acting analgesia: analgesic effect lasts for 28 days after local administration, which is at least 4 times higher than that of free NS9283; safety guarantee: no neurotoxicity is caused after continuous administration for 14 days, and there is no significant difference in mouse weight, motor coordination and main organ function compared with the control group. The drug provides a safe and efficient treatment scheme for chronic pain.

This invention relates to the field of biopsy cutting technology, and specifically discloses an adjustable anastomosis device and a biopsy cutting apparatus, including a connecting base and a cutting assembly. A second connecting cylinder is fixedly connected to the front end of the connecting base. A first connecting cylinder is connected to the free end of the second connecting cylinder through a limiting assembly. A top clamp is hinged to the free end of the first connecting cylinder. A clamp seat is hinged to the bottom end of the top clamp through a pair of collars. The cutting assembly includes a pair of staple seats disposed between the clamp seats. A cutting blade is slidably mounted on the inner side of each of the two staple seats. A support assembly is disposed between the two cutting blades. The cutting assembly of this invention can simultaneously sample the cutting edge when cutting a tumor, and can control the direction of the anastomosis side on the cutting edge. This allows the device to perform unilateral or bilateral anastomosis on the cutting edge while sampling the tissue at the cutting edge, helping medical personnel to reconstruct organ function in some scenarios. At the same time, the direction and number of anastomosis sides can be selected by adjusting the type of staple seats installed.

This invention relates to the fields of biomedical engineering and temperature control technology, and discloses a method and system for predicting the three-dimensional temperature field during the cooling and rewarming process of organ cryopreservation. The method includes: constructing and preprocessing a simulation dataset and a real experimental dataset covering the cooling and rewarming process; constructing a transient temperature query network, fusing global physical field features, multi-scale local features, and spatial location information; training the model using a fusion physical constraint loss function containing data fitting loss and spatial smoothing loss; and inputting the thermophysical parameters of the organ to be predicted and sparse temperature observation data to achieve accurate prediction of transient temperature at any spatial location. This invention effectively alleviates the prediction bias caused by the difference between simulation and real distributions, improves the model's generalization performance and the physical rationality of the prediction results, and can be directly applied to fine-grained temperature control systems for organ preservation, providing reliable support for organ function protection and improved transplant success rates, thus possessing significant clinical application value.

This invention belongs to the field of traditional Chinese medicine technology, and relates to a topical Chinese medicine composition, topical drug, topical patch, acupoint patch, and preparation method and application for treating nausea and vomiting caused by chemotherapy for intracranial tumors. The Chinese medicine composition consists of the following raw materials in parts by weight: 1-2 parts of Ligusticum chuanxiong, 1-2 parts of Gastrodia elata, 2-4 parts of Uncaria rhynchophylla, 1-2 parts of Citrus aurantium, 1-2 parts of Sinapis alba, 1-2 parts of Clematis chinensis, 0.5-1 part of Melia toosendan, 0.5-1 part of Panax ginseng, 1-2 parts of Pinellia ternata, 1-2 parts of Albizia julibrissin bark, 0.5-1 part of Lentinus edodes, and 1-2 parts of Astragalus membranaceus. This Chinese medicine composition has the effects of relieving nausea and vomiting, soothing the liver and strengthening the spleen, detoxifying and eliminating turbidity, calming the liver and extinguishing wind, and calming the mind and soothing the nerves. It not only effectively controls the nausea and vomiting symptoms caused by chemotherapy for intracranial tumors, but also harmonizes the body's Qi and organ functions. The Chinese medicine composition has a simple formula, widely available ingredients, and a simple preparation method; it is for topical application, convenient for clinical use, and has low adverse reactions.

A system can include an imaging device, and a computing device in communication with the imaging device. The computing device can be configured to receive, from the imaging device, a plurality of images of an organ of a subject, each image of the plurality of images being acquired by light reflected off the organ, isolate the organ in each image of the plurality of images to generate a plurality of organ images, generate a plurality of markers overlaid on each organ image of the plurality of organ images, track a position of each marker of the plurality of markers across the plurality of organ images, determine an organ function of the organ, based on the tracking of the plurality of markers, and provide an action for the organ, based on the organ function.

A powder formulation for preserving tissue and organ function, and more particularly to shelf stable powder formulations that can be reconstituted at point of use, including during a fat grafting process, coronary artery bypass graft surgery, and peripheral bypass surgery, or other grafting / transplant surgery prior to or during the medical procedure to preserve the tissues / organs used in these procedures. The powder formulation includes a reducing agent; an antioxidant; a sugar; a nitric oxide substrate; a buffering agent; and physically acceptable salt. Also provided are a method of preparing an organ or tissue preservation solution by reconstituting the powder formulation, and a method of preserving tissue or an organ using same.

A venous drainage catheter is an apparatus for normothermic regional perfusion (NRP) to prevent blood flow to the lower limbs when assessing organ function for patients. The apparatus includes a main cannula, an inflation cannula, and an occluding balloon. The main cannula draws blood from the inferior vena cava (IVC). The blood then flows into a reservoir of a cardiopulmonary bypass circuit (CPB) machine. Once inserted within the IVC and inflated, the occluding balloon prevents blood flow towards the lower limbs of the patient. The inflation cannula enables the occluding balloon to inflate and deflate while inserted within the IVC. A main cannula inlet receives blood flowing down within the IVC and the main cannula outlet disperses the blood towards the reservoir of the CPB machine. A plurality of holes positioned about the main cannula inlet drains the blood flow from the IVC to the reservoir.

To provide support by supplying cultured organs to subjects at the time they need them. [Solution] The medical information processing device according to this embodiment acquires medical information, performs organ simulation to predict changes in the state of the patient's organs related to the disease, including at least one of changes in an indicator related to organ size and changes in an indicator related to organ function, calculates the time required for transplantation, acquires culture information related to the patient's organ culture, including at least one of the proliferation characteristics of cells related to organ culture and the progress of organ culture, calculates an organ culture schedule based on the organ simulation and the culture information, including a start time to begin organ culture, a predicted completion time when organ culture is completed, and a storage period during which the cultured organs can be stored in a state suitable for transplantation, and presents the results of the organ simulation, information representing the time required for transplantation, and the culture schedule together.

The embodiment of the invention provides an organ perfusion system. The organ perfusion system comprises a pump, a venous cannula, an arterial cannula, a balloon driving device and a control device. The near end of the venous cannula and the near end of the arterial cannula are connected with a pump. The far end of the venous cannula is provided with a first opening and used for being inserted into tissue veins without blocking the tissue veins. The far end of the arterial cannula is provided with a balloon and a second opening, the second opening is located in the far end side of the balloon, and the far end of the arterial cannula is used for being inserted into a tissue artery. The control device is electrically connected with the pump and the balloon driving device. The control device is used for controlling the pump to operate so as to extract blood of tissue veins and inject the blood into tissue arteries; the control device is further used for controlling the balloon driving device to drive the balloon to expand so as to block the tissue artery when the blood is injected into the tissue artery, and controlling the balloon driving device to drive the balloon to contract so as to conduct the tissue artery after the blood is injected into the tissue artery. The organ perfusion system can perfuse organs to improve organ functions.

The invention relates to the field of microorganisms. Specifically, the Hungata bacteria provided by the invention can metabolize uric acid in a culture medium, part of the bacteria can completely metabolize about 2000 [mu] g / mL of uric acid in the culture medium within 8 h, and meanwhile, in-vivo experiments also show that the content of uric acid in serum, urine and excrement of different hyperuricemia model mice can be remarkably reduced, gout is reduced, and the Hungata bacteria can be used for treating hyperuricemia. Pathological injuries of kidneys and intestinal tracts of hyperuricemia mice are relieved, organ functions are protected, pains of patients are reduced, uric acid excretion is promoted, the level of serum uric acid is reduced, intestinal barrier is maintained, intestinal environment is protected, and health of the mice is promoted. Therefore, the Hungata bacterium provided by the invention can hopefully replace or partially replace the existing compound medicine, and has a wide application prospect.