The invention relates to the technical field of traditional Chinese medicines, particularly to a medical composition for treating hysteromyoma and a preparation method of the medical composition. The composition disclosed by the invention comprises the medicines of prepared rhizomes of rehmannia, cinnamon, baked ginger, ephedra sinica stapf, sinapis alba, sliced deerhorn, epimedium, Chinese angelica, peach kernels, roots of herbaceous peonys, saffron, ligusticum wallichii, Chinese thorowax, nutgrass galingale rhizomes, radix curcumae, immature tangerine peel, cassia twigs, common selfheal fruit-spikes, figwort, fritillaria thunbergii, calcined oysters, snakegourd fruits, pinellia tubers, Chinese honeylocust spines, pangolin scales, turtle shells, rhizoma spargani, curcuma zedoaria, pseudobulbus cremastrae seu pleiones, catclaw buttercup roots, forsythia suspensa, pseudo-ginseng, tangerine seed and lychee seed. The preparation method disclosed by the invention comprises the following steps: uniformly mixing the medicines in parts by weight, drying the medicines at a low temperature, crushing the dried medicines into 300-mesh medicinal powder, using pure water as an adhesive, making the medicinal powder into watered pill products according to the conventional method, and performing bacteria disinfection so as to obtain the medical composition. The medical composition disclosed by the invention can effectively regulate the endocrine function of a human body and thoroughly eliminate the hysteromyoma at the same time so as to achieve the purpose of treating both manifestation and root cause of the hysteromyoma, the medical composition is safe in treatment of the hysteromyoma and is precise in curative effect, and the total effective rate achieves 98%.